TSUCHIKAWA HIROSHI 土川博史

Researcher Number	30460992
Other IDs
Affiliation (Current)	2025: 九州大学, 理学研究院, 准教授 2025: 大分大学, 医学部, 特任講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 大分大学, 医学部, 特任講師 2021: 大阪大学, 理学研究科, 助教 2020: 大分大学, 全学研究推進機構, 客員研究員 2016 – 2019: 大阪大学, 理学研究科, 助教 2012 – 2016: 大阪大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Chemical biology / Living organism molecular science Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Science and Engineering / Biomolecular chemistry / Chemical biology
Keywords	Principal Investigator 化学合成 / 構造解析 / Diels-Alder反応 / スピロリド / 作用機構 / ペプチド擬態 / 生理活性天然物 / 競合結合実験 / 不斉合成 / 狂犬病ウイルス … More / 側鎖 / 構造展開 / アミノ酸側鎖 / ファーマコフォア / アセチルコリン受容体 / F-NMR / Bafilomycin / V-ATPase / 固体NMR / フッ素標識 / ATPアーゼ / バフィロマイシン / 構造決定 / 全合成 / スピロイミン / スピロアセタール … More Except Principal Investigator 脂質ラフト / 脂質二重膜 / 同位体標識脂質 / 脂肪鎖の指組構造 / 非対称脂質二重膜 / 糖脂質 / 生体モデル膜 / ATPアーゼ / ＡＴＰアーゼ / ATPアーゼ阻害剤 / 膜貫通ドメイン / 細胞膜作動性リガンド / イオンチャネル / 化学コミュニケーション / 天然物リガンド / 動的配座 / 古細菌脂質 / ドメイン構造 / スフィンゴミエリン / 重水素固体ＮＭＲ / 表面プラズモン共鳴 / 重水素固体NMR / 小分子プローブ / コレステロール Less

Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions
- Principal Investigator
  
  村田道雄
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
Protein function control starting from the pharmacophore skeleton of natural products for the development of new bioactive compoundsPrincipal Investigator
- Principal Investigator
  
  Tsuchikawa Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Oita University
Dynamic conformation and domain structure of lipid molecules in model biomembranes
- Principal Investigator
  
  Murata Michio
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka University
Dynamic conformation and domain structure of lipid molecules in model biomembranes
- Principal Investigator
  
  MURATA Michio
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Structural analysis of bafilomycin bound to V-ATPase for elucidating its inhibition mechanism based on synthetic chemistryPrincipal Investigator
- Principal Investigator
  
  Tsuchikawa Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids
- Principal Investigator
  
  Murata Michio
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
Total synthesis of spirolide C for elucidation of its potent inhibitory mechanism on acetylcholine receptorsPrincipal Investigator
- Principal Investigator
  
  TSUCHIKAWA HIROSHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study2022
- Author(s)
  Umegawa Yuichi、Yamamoto Tomoya、Dixit Mayank、Funahashi Kosuke、Seo Sangjae、Nakagawa Yasuo、Suzuki Taiga、Matsuoka Shigeru、Tsuchikawa Hiroshi、Hanashima Shinya、Oishi Tohru、Matsumori Nobuaki、Shinoda Wataru、Murata Michio
- Journal Title
  
  Science Advances
  
  Volume: 8 Issue: 24 Pages: 2658-2658
- DOI
  10.1126/sciadv.abo2658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19115, KAKENHI-PROJECT-20H00405, KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers2022
- Author(s)
  Hanashima Shinya、Ikeda Ryuji、Matsubara Yuki、Yasuda Tomokazu、Tsuchikawa Hiroshi、Slotte J. Peter、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 121 Issue: 7 Pages: 1143-1155
- DOI
  10.1016/j.bpj.2022.02.037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-20K05730, KAKENHI-PROJECT-21H04707
[Journal Article] LnDOTA-d8 , a versatile chemical-shift thermometer for 2 H solid-state NMR2022
- Author(s)
  Umegawa Yuichi、Shimonishi Takeshi、Tsuchikawa Hiroshi、Murata Michio
- Journal Title
  
  Magnetic Resonance in Chemistry
  
  Volume: 60 Issue: 10 Pages: 1005-1013
- DOI
  10.1002/mrc.5303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers2022
- Author(s)
  Tsuchikawa Hiroshi、Monji Mami、Umegawa Yuichi、Yasuda Tomokazu、Slotte J. Peter、Murata Michio
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 18 Pages: 5515-5524
- DOI
  10.1021/acs.langmuir.2c00092
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] Conformation and Orientation of Branched Acyl Chains Responsible for the Physical Stability of Diphytanoylphosphatidylcholine.2020
- Author(s)
  Hiroshi Tsuchikawa, Takuya Ono, Masaki Yamagami, Yuichi Umegawa, Wataru Shinoda, Michio Murata
- Journal Title
  
  Biochemistry
  
  Volume: 59 Issue: 40 Pages: 3929-3938
- DOI
  10.1021/acs.biochem.0c00589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05730, KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains2020
- Author(s)
  Yano Yo、Hanashima Shinya、Tsuchikawa Hiroshi、Yasuda Tomokazu、Slotte J. Peter、London Erwin、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 119 Issue: 3 Pages: 539-552
- DOI
  10.1016/j.bpj.2020.06.028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning2019
- Author(s)
  Hanashima Shinya、Ibata Yuki、Watanabe Hirofumi、Yasuda Tomokazu、Tsuchikawa Hiroshi、Murata Michio
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 37 Pages: 8601-8610
- DOI
  10.1039/c9ob01342c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-16H06315
[Journal Article] The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model2019
- Author(s)
  Yamamoto Tomoya、Umegawa Yuichi、Yamagami Masaki、Suzuki Taiga、Tsuchikawa Hiroshi、Hanashima Shinya、Matsumori Nobuaki、Murata Michio
- Journal Title
  
  Biochemistry
  
  Volume: 印刷中 Issue: 17 Pages: 2282-2291
- DOI
  10.1021/acs.biochem.9b00180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Average Conformation of Branched Chain Lipid PGP-Me That Accounts for the Thermal Stability and High-Salinity Resistance of Archaeal Membranes.2019
- Author(s)
  Yamagami, M., Tsuchikawa, H., Cui, J., Umegawa, Y., Miyazaki, Y., Seo, S., Shinoda, W., Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 37 Pages: 3869-3879
- DOI
  10.1021/acs.biochem.9b00469
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] Small　structural　alterations　greatly　influence　the　membrane　affinity　of　lipophilic　ligands:　Membrane　interactions　of　bafilomycinA1 and　its desmethyl　derivative　bearing 19F-labeling.2019
- Author(s)
  Tatsuru　Hayashi,　Hiroshi　Tsuchikawa,　Yuichi　Umegawa,　Michio　Murata.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 27 Issue: 8 Pages: 1677-1682
- DOI
  10.1016/j.bmc.2019.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-17J00021
[Journal Article] Synthesis of 7,6-Spirocyclic Imine with Butenolide Ring Provides Evidence for the Relative Configuration of Marine Toxin 13-desMe Spirolide C.2019
- Author(s)
  Kou Minamino, Michio Murata, Hiroshi Tsuchikawa.
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 22 Pages: 8970-8975
- DOI
  10.1021/acs.orglett.9b03373
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] Impact of Acyl Chain Mismatch on the Formation and Properties of Sphingomyelin-Cholesterol Domains.2019
- Author(s)
  Nyholm, Thomas K. M.; Engberg, Oskar; Hautala, Victor; Tsuchikawa, Hiroshi; Lin, Kai-Lan; Murata, Michio; Slotte, J. Peter
- Journal Title
  
  Biophys. J.
  
  Volume: 117 Issue: 9 Pages: 1577-1588
- DOI
  10.1016/j.bpj.2019.09.025
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06315
[Journal Article] Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup2019
- Author(s)
  Hanashima Shinya、Murakami Kazuhiro、Yura Michihiro、Yano Yo、Umegawa Yuichi、Tsuchikawa Hiroshi、Matsumori Nobuaki、Seo Sangjae、Shinoda Wataru、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 117 Issue: 2 Pages: 307-318
- DOI
  10.1016/j.bpj.2019.06.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Amphotericin B-Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly.2019
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Kosuke Funahashi, Sangjae Seo, Wataru Shinoda, Michio Murata.
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 51 Pages: 5188-5196
- DOI
  10.1021/acs.biochem.9b00835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Stereoselective Construction of Cisoidal Bisspiroacetal Frameworks through Magnesium Coordination of the Bilateral Acetal Oxygen Atoms2018
- Author(s)
  Yoshifumi Yasukawa, Hiroshi Tsuchikawa, Yasuto Todokoro, and Michio Murata
- Journal Title
  
  Asian Journal of Organic Chemistry
  
  Volume: - Issue: 6 Pages: 1101-1106
- DOI
  10.1002/ajoc.201800074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01821, KAKENHI-PROJECT-16H06315
[Journal Article] Highly efficient syntheses of C-N axially chiral 1‐(ortho‐hydroxyaryl)uracil using a chiral auxiliary and a chiral base.2018
- Author(s)
  Hasegawa, F., Yasukawa, Y., Kawamura, K., Tsuchikawa, H., Murata. M.
- Journal Title
  
  Asian J. Org. Chem.
  
  Volume: 7 Issue: 8 Pages: 1648-1653
- DOI
  10.1002/ajoc.201800247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315
[Journal Article] Sphingomyelin Stereoisomers Reveal That Homophilic Interactions Cause Nanodomain Formation2018
- Author(s)
  Yano Yo、Hanashima Shinya、Yasuda Tomokazu、Tsuchikawa Hiroshi、Matsumori Nobuaki、Kinoshita Masanao、Al Sazzad Md. Abdullah、Slotte J. Peter、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 115 Issue: 8 Pages: 1530-1540
- DOI
  10.1016/j.bpj.2018.08.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19149, KAKENHI-PROJECT-16H06315, KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121
[Journal Article] Efficient access to functionalized bicyclic pharmacophore of spirolide C via selective Diels-Alder reaction.2017
- Author(s)
  Hiroshi Tsuchikawa, Kou Minamino, Sho Hayashi, Michio Murata.
- Journal Title
  
  Asian J. Org. Chem.
  
  Volume: 6 Issue: 9 Pages: 1322-1327
- DOI
  10.1002/ajoc.201700164
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406
[Journal Article] Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor.2017
- Author(s)
  Futoshi Hasegawa, Kazushi Kawamura, Hiroshi Tsuchikawa, Michio Murata.
- Journal Title
  
  Bioorg. Med Chem.
  
  Volume: 25 Issue: 16 Pages: 4056-4511
- DOI
  10.1016/j.bmc.2017.06.042
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06406
[Journal Article] Bafilomycin analogue site-specifically fluorinated at the pharmacophore macrolactone ring has potent vacuolar-type ATPase inhibitory activity2016
- Author(s)
  Hiroshi Tsuchikawa, Tatsuru Hayashi, Hajime Shibata, Michio Murata, Yoko Nagumo, Takeo Usui
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 57 Issue: 22 Pages: 2426-2429
- DOI
  10.1016/j.tetlet.2016.04.075
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K01821, KAKENHI-PROJECT-26430140
[Journal Article] The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores2016
- Author(s)
  Yasuo Nakagawa, Yuichi Umegawa, Naohiro Matsushita, Tomoya Yamamoto, Hiroshi Tsuchikawa, Shinya Hanashima, Tohru Oishi, Nobuaki Matsumori, Michio Murata
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 24 Pages: 3392-3402
- DOI
  10.1021/acs.biochem.6b00193
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-16H06315
[Journal Article] Formation of Gel-like Nanodomains in Cholesterol-Containing Sphingomyelin or Phosphatidylcholine Binary Membrane As Examined by Fluorescence Lifetimes and H-2 NMR Spectra2016
- Author(s)
  Yasuda, T; Matsumori, N; Tsuchikawa, H; Lonnfors, M; Nyholm, TKM; Slotte, JP; Murata, M
- Journal Title
  
  LANGMUIR
  
  Volume: 31 Issue: 51 Pages: 13783-13792
- DOI
  10.1021/acs.langmuir.5b03566
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102527, KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-15H03121
[Journal Article] Deuterium NMR of Raft Model Membranes Reveals Domain-Specific Order Profiles and Compositional Distribution2015
- Author(s)
  Yasuda, T; Tsuchikawa, H; Murata, M; Matsumori, N
- Journal Title
  
  BIOPHYSICAL JOURNAL
  
  Volume: 108 Issue: 10 Pages: 2502-2506
- DOI
  10.1016/j.bpj.2015.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26102527, KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-15H03121
[Journal Article] Modification of Bafilomycin Structure to Efficiently Synthesize Solid-State NMR Probes that Selectively Bind to Vacuolar-Type ATPase.2015
- Author(s)
  Shibata H, Tsuchikawa H, Hayashi T, Matsumori N, Murata M, Usui T.
- Journal Title
  
  Chem Asian J.
  
  Volume: 2015 Issue: 4 Pages: 915-924
- DOI
  10.1002/asia.201403299
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26102731, KAKENHI-PROJECT-25242073
[Journal Article] Axial Hydrogen at C7 Position and Bumpy Tetracyclic Core Markedly Reduce Sterol’s Affinity to Amphotericin B in Membrane2015
- Author(s)
  Nakagawa, Y., Umegawa, Y., Nonomura, K., Matsushita, N., Takano, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N., and Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 2 Pages: 303-312
- DOI
  10.1021/bi5012942
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J01527, KAKENHI-PROJECT-25750383, KAKENHI-PUBLICLY-26102527, KAKENHI-PROJECT-25242073
[Journal Article] Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane.2015
- Author(s)
  Yamamoto, T., Umegawa, Y., Tsuchikawa, H., Matsumori, N., Hanashima, S., Murata, M., Haser, R., Rawlings, B. J., Caffrey, P.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 17 Pages: 5782-5788
- DOI
  10.1016/j.bmc.2015.07.009
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-15H03121
[Journal Article] Design and Synthesis of 24-Fluorinated Bafilomycin Analogue as an NMR Probe with Potent Inhibitory Activity to Vacuolar-type ATPase2014
- Author(s)
  Shibata H, Tsuchikawa H, Matsumori N, Murata M, Usui T
- Journal Title
  
  Chem. Lett.
  
  Volume: 43 Issue: 4 Pages: 474-476
- DOI
  10.1246/cl.131099
- NAID
  130004868062
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25242073
[Journal Article] Effect of sterol side chain on ion channel formation by amphotericin B in lipid bilayers.2014
- Author(s)
  Nakagawa, Y., Umegawa, Y., Takano, T., Tsuchikawa, H., Matsumori, N., and Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 53 Issue: 19 Pages: 3088-3094
- DOI
  10.1021/bi500122c
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J01527, KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-25750383, KAKENHI-PUBLICLY-26102527
[Patent] ＲＳウイルス感染症の処置および／または予防用医薬としてのヘテロシクロアルキル置換ポリヘテロアゾール誘導体2021
- Inventor(s)
  松岡　茂, 土川博史, 山田健太郎, 加藤明良
- Industrial Property Rights Holder
  松岡　茂, 土川博史, 山田健太郎, 加藤明良
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-20K05730
[Presentation] Elucidation of inter-leaflet coupling in asymmetric membranes induced by very long chain sphingomyelin based on solid-state NMR2021
- Author(s)
  Keeratisakulsith, T., Umegawa, Y., Tsuchikawa, H., Hanashima, S., Murata, M., Shinoda, W.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] ヤマイモサポニン・Diosgenin 配糖体のモデル膜における膜脂質との相互作用2021
- Author(s)
  Ondevilla, J, C., 花島慎弥、Garza, D, L., 土川博史、梅川雄一、村田道雄
- Organizer
  第63回天然有機化合物討論会
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] 水和脂質膜の固体NMR測定による高度不飽和脂肪酸結合リン脂質の分子機構の解明2021
- Author(s)
  大田英和、梅川雄一、花島慎弥、土川博史、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 位置選択的標識化脂質を用いた固体NMRによる内葉構成リン脂質の膜物性解析2020
- Author(s)
  向川茜、土川博史、梅川雄一、村田道雄
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Stereochemical determination of marine toxin spirolide homologues based on efficient synthesis of the 7,6-spirocyclic imine moiety2020
- Author(s)
  Kou Minamino, Sho Hayashi, Michio Murata, Noriko Shimada Keiichi Konoki, Hiroshi Tsuchikawa
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-20K05730
[Presentation] Stereochemical determination of marine toxin spirolide homologues based on efficient synthesis of the 7,6-spirocyclic imine moiety.2020
- Author(s)
  Kou Minamino, Sho Hayashi, Michio Murata, Noriko Shimada, Keiichi Konoki, Hiroshi Tsuchikawa.
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Efficient Synthesis of 7,6-Spirocyclic Imine and Stereochemical Determination of Marine Toxin Spirolide Homologues.2020
- Author(s)
  MINAMINO, Kou; TSUCHIKAWA, Hiroshi; MURATA, Michio; SHIMADA, Noriko; KONOKI, Keiichi
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] 非対称膜におけるスフィンゴミエリンとコレステロールの脂質間相互作用の固体NMR解析2019
- Author(s)
  矢野陽、花島慎弥、土川博史、村田道雄、London Erwin
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脂質膜中ドメイン形成の機構解明を目指したスフィンゴミエリンのNMR緩和時間による回転相関時間の測定とクラスターサイズの推定2019
- Author(s)
  木下雄哉、梅川雄一、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 水和脂質膜中での高度不飽和脂肪酸脂質の運動性解析2019
- Author(s)
  大田英和，梅川雄一, 花島慎弥, 土川博史, 村田道雄
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Synthesis of novel 13C, 2H-labeled Amphotericin B and the conformational analysis of glycosidic linkage in lipid bilayers.2019
- Author(s)
  Yamamoto, T., Umegawa, Y., Suzuki, T., Tsuchikawa, H., Hanashima, S., Murata, M., Matsumori, N., Seo, S., Funahashi, K., Shinoda, W.
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 新規コレステロール側鎖重水素標識体の開発とそれを用いた三成分膜での相状態の解明2019
- Author(s)
  井端悠貴、花島慎弥、安田智一、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] メチル分岐アシル基含有リン脂質DPhPCが示す二重膜の安定性を担う分子配向・配座の解析2019
- Author(s)
  斧拓冶、土川博史、山上正輝、梅川雄一、村田道雄、篠田渉
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] スピロイミン環を有する海洋天然物の生物活性中心構造の合成とそのニコチン性アセチルコリン受容体阻害能の評価2019
- Author(s)
  南野　宏・土川　博史・村田　道雄・此木　敬一
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] 混合モデル二重膜における極長鎖スフィンゴミエリンの内葉・外葉間相互作用の解明2019
- Author(s)
  足立美和子、森内舞、土川博史・Seo Sangjae、篠田渉、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素標識化脂質を用いた流動相における相分離二重膜の精密 NMR 解析2019
- Author(s)
  山中彩菜, 井端悠貴, 土川博史, 花島慎弥, 村田道雄
- Organizer
  第9回CSJ化学フェスタ2019
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] アミロイドペプチドへの結合モチーフとしての各種梯子状ポリエーテル化合物の評価と相互作用についての考察2019
- Author(s)
  Xiong Weiqi、土川博史、原利明、村田道雄、佐竹真幸
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 古細菌脂質 PGP-Me が形成する二重膜の構造解析による特徴的な膜物性の解明2019
- Author(s)
  土川博史
- Organizer
  第 3 回生体膜と生体モデル膜セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Chemistry-based approach to lipid-protein interactions.2019
- Author(s)
  Murata, M., Yano, Y., Yasuda, T., Umegawa, U., Tsuchikawa, H., Hanashima, S.
- Organizer
  ICBL
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] メチル分岐アシル基含有リン脂質DPhPCが示す二重膜の安定性を担う分子配向・配座の解明2019
- Author(s)
  斧拓冶、土川博史、山上正輝、梅川雄一、村田道雄、篠田渉
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Analysis of Inhibitory Mechanism of Bafilomycin against Vacuolar-type ATPase by Solid-state NMR.2019
- Author(s)
  Hiroshi Tsuchikawa
- Organizer
  GRC-Osaka U Bilateral Symposium
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] 天然物リガンドの合成を基盤とした脂質二重膜および膜タンパク質との相互作用解析2019
- Author(s)
  土川博史
- Organizer
  理工学部講演会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] アミロイドペプチドへの結合モチーフとしての各種梯子状ポリエーテル化合物の評価と相互作用についての考察2019
- Author(s)
  Xiong　Weiqi・土川　博史・原　利明・村田　道雄・佐竹　真幸
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] 位置選択的重水素標識体を用いた内葉構成リン脂質の固体NMRによる脂質間相互作用の解明2019
- Author(s)
  向川茜、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 2H,13C-二重標識スフィンゴミエリンを用いた脂質二重膜におけるアシル鎖の配座・配向の固体NMR解析2019
- Author(s)
  今井茅希、梅川雄一、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Chemical Communication between Lipids and Proteins in Archaeal Membrane.2019
- Author(s)
  Hiroshi Tsuchikawa, Masaki Yamagami, Yuichi Umegawa, Sho Kato, Jin Cui, Satoshi Kawatake, Shigeru Matsuoka, Sangjae Seo, Wataru Shinoda, Michio Murata.
- Organizer
  新学術領域研究(研究領域提案型)「化学コミュニケーションのフロンティア」第1回国際シンポジウム（ISCC2019）（第4回公開シンポジウム）
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Analysis of the raft-like nanodomains using sphingomyelin antipode2018
- Author(s)
  Yano Yo、Hanashima Shinya、Yasuda Tomokazu、Tsuchikawa Hiroshi、Murata Michio、Kinoshita Masanao、Matsumori Nobuaki、Suzuki Kenichi、J. Peter. Slotte、Erwin London
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 特異な膜挙動を示す極長鎖スフィンゴミエリンの混合モデル膜中における運動性解析2018
- Author(s)
  足立美和子、森内舞、土川博史、村田道雄
- Organizer
  日本ケミカルバイオロジー学会第十三回年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Stereoselective construction of spiroacetal framework and evaluation of its thermodynamic/kinetic stability.2018
- Author(s)
  YASUKAWA, Yoshifumi; TSUCHIKAWA, Hiroshi; MURATA, Michio.
- Organizer
  日本化学会第98春季年会（2018）
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Synthesis and biological evaluation of natural product-mimicking 7,6-spirocyclic imine compounds toward a specific inhibitor of neuronal nicotinic acetylcholine receptor.2018
- Author(s)
  MINAMINO, Kou; TSUCHIKAWA, Hiroshi; MURATA, Michio; KONOKI, Keiichi.
- Organizer
  日本化学会第98春季年会（2018）
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Molecular orientation and conformation of archaeal membrane lipid PGP-Me by solid-state NMR and its interaction with bacteriorhodopsin2018
- Author(s)
  Yamagami Masaki、Tsuchikawa Hiroshi、Cui Jin、Kawatake Satoshi、Sato Fuminori、Umegawa Yuichi、Murata Michio、Seo Sangjar、Shinoda Wataru
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脂肪酸結合タンパク質FABP7の選択的阻害剤の開発を目指した環状脂肪酸誘導体の合成と親和性評価2018
- Author(s)
  永安　麻優・土川　博史・杉山　成・松岡　茂・原　利明・村田　道雄・島本　知英・吉川　武男
- Organizer
  日本化学会第98春季年会（2018）
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] アンフォテリシンBとステロールが形成するチャネル複合体の構造研究2018
- Author(s)
  山本智也、梅川雄一、中川泰男、鈴木大河、山上正輝、土川博史、花島慎弥、村田道雄、松森信明、Seo Sangjaed、篠田渉
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRを用いたメチル分枝フィタノイル脂肪酸を有するリン脂質の特異な膜物性の解析2018
- Author(s)
  斧拓冶、土川博史、山上正輝、梅川雄一、村田道雄
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Analysis of Inhibitory Mechanism of Bafilomycin against Vacuolar-type ATPase by Solid-state NMR.2018
- Author(s)
  Tsuchikawa, H.
- Organizer
  2018 GRC-Osaka U Bilateral Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素化スフィンゴミエリンのアシル鎖の深度依存的な配座の赤外分光解析とコレステロールの添加効果2018
- Author(s)
  佐伯直香、土川博史、門司真美、梅川雄一、村田道雄、J. Peter Slotte
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Membrane behavior of very long chain sphingomyelin in lipid bilayers deduced from solid state NMR.2018
- Author(s)
  Tsuchikawa, H., Moriuchi, M., Adachi, M., Murata, M., Slotte, J. P.
- Organizer
  International Workshop on Biological Membranes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Elucidation of Bafilomycin-Vacuolar-type ATPase interaction based on solid-state NMR2018
- Author(s)
  Tatsuru Hayashi, Hiroshi Tsuchikawa, Yuichi Umegawa, Michio Murata, Yoko Nagumo, Takeo Usui
- Organizer
  日本化学会　第98春季年会
- Data Source
  KAKENHI-PROJECT-15K01821
[Presentation] Elucidation of Bafilomycin-Vacuolar-type ATPase interaction based on solid-state NMR.2018
- Author(s)
  HAYASHI, Tatsuru; TSUCHIKAWA, Hiroshi; UMEGAWA, Yuichi; MURATA, Michio; NAGUMO, Yoko; USUI, Takeo.
- Organizer
  日本化学会第98春季年会（2018）
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] 梯子状ポリエーテル化合物のアミロイドβ凝集阻害活性および相互作用の評価2018
- Author(s)
  Xiong　Weiqi・原　利明・土川　博史・村田　道雄・佐竹　真幸
- Organizer
  日本化学会第98春季年会（2018）
- Data Source
  KAKENHI-PLANNED-17H06406
[Presentation] Investigation of the Interaction between Vacuolar-type ATPase and Bafilomycin by Solid-state NMR2017
- Author(s)
  Hayashi, T, Tsuchikawa, H, Shibata, H, Murata, M, Nagumo, Y, Usui, T
- Organizer
  18th Tetrahedron Symposium Asia Edition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01821
[Presentation] 同位体標識スフィンゴミエリンの緩和時間測定に基づく脂質分子運動の新しい評価方法の開発2017
- Author(s)
  木下雄哉、梅川雄一、土川博史、村田道雄
- Organizer
  第7回CSJ化学フェスタ
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Solid state NMR study for the molecular orientation of amphotericin B in membrane2017
- Author(s)
  Yamamoto Tomoya、Umegawa Yuichi、Yamagami Masaki、Hanashima Shinya、Tsuchikawa Hiroshi、Matsumori Nobuaki、Murata Michio
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] スフィンゴミエリン鏡像体を用いたラフトモデル膜中での脂質間相互作用解析2017
- Author(s)
  矢野陽、花島慎弥、土川博史、村田道雄、木下祥尚、松森信明、J. Peter Slotte
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRを用いた脂質二重膜におけるスフィンゴミエリン頭部の動的な配座解析2017
- Author(s)
  村上量弘、花島慎弥、梅川雄一、土川史、村田道雄、松森信明、J. Peter Slotte
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Enantioselective total synthesis of purple membrane lipid PGP-Me toward elucidation of protein- lipid interactions2017
- Author(s)
  Yamagami Masaki、Cui Jin、Tsuchikawa Hiroshi、Umegawa Yuichi、Hanashima Shinya、Murata Michio
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Design and Synthesis of CD1d Ligands for Precise Binding Mode Investigation of Ligand-Bound CD1d.2016
- Author(s)
  HOSSAIN, Md. Imran; HANASHIMA, Shinya; TSUCHIKAWA, Hiroshi; MURATA
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Design and Synthesis of Heavy Atom Labelled GalCers for X-ray Co-crystalization with CD1d.2016
- Author(s)
  Md. Imran Hossain, Shinya Hanashima, Hiroshi Tsuchikawa, Michio Murata,
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  大阪
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 重水素固体NMR測定における水和二重膜の温度測定のための金属錯体の合成と評価2016
- Author(s)
  下西剛史、梅川雄一、門司真美、花島慎弥、土川博史、村田道雄
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Chemical Approach to Fishing New Binding Proteins with the Ladder shaped Polyether Yessotoxin.2016
- Author(s)
  YEUNG, Clarisse1; TSUCHIKAWA, Hiroshi; HANASHIMA, Shinya; MATSUMORI, Nobuaki; MURATA, Michio
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 脂質ラフトにおけるスフィンゴミエリン頭部の動的挙動解析のための重水素標識体の合成2016
- Author(s)
  村上量弘・花島慎弥・土川博史・松森信明・村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] スピロリドＣの効率的合成を目指した2－シリル置換ジエン基質による選択的Diels-Alder 反応の開発2016
- Author(s)
  南野宏・土川博史・林翔・村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Characterization of the Binding Proteins with the Ladder-shaped Polyether, Yessotoxin, through Magnetic Beads Pull-Down Assay.2016
- Author(s)
  YEUNG, Clarisse; HAYASHI, Kanako; KURNIATI, Dian; TSUCHIKAWA, Hiroshi; HANASHIMA, Shinya; MATSUMORI, Nobuaki; MURATA, Michio
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  大阪
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] スフィンゴミエリンのアシル鎖における深度依存的な融解現象の観測2016
- Author(s)
  門司真美・土川博史・花島慎弥・安田智一・村田道雄・松森信明・Slotte J. Peter
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] ガングリオシドGM1 およびスフィンゴミエリンが共存するリン脂質膜におけるドメイン形成の蛍光イメージング解明2016
- Author(s)
  高田美沙・花島慎弥・土川博史・安田智一・村田道雄・木下祥尚・松森信明・安藤弘宗・木曽真・鈴木健一・楠見明弘・J. Peter Slotte
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Microdomain formation in sphingomyelin antipode-containing membrane for investigating lipid-lipid interactions2016
- Author(s)
  YANO, Yo; HANASHIMA, Shinya; TSUCHIKAWA, Hiroshi; YASUDA, Tomokazu; KINOSHITA, Masanao; MATSUMORI, Nobuaki; MURATA, Michio; SUZUKI, Kenichi; KUSUMI, Akihiro
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 水和脂質二重膜の固体NMR 測定のための化学シフト温度計の開発2016
- Author(s)
  下西剛史・梅川雄一、花島慎弥、土川博史、村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Stereoselective Construction of 6,5,5-tricyclic bisspiroacetal structure specific to spirolides.2016
- Author(s)
  YASUKAWA, Yoshifumi; TSUCHIKAWA, Hiroshi; MURATA, Michio
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 固体NMRによる配座解析を目指したフッ素標識化バフィロマイシンの合成と生物活性評価2016
- Author(s)
  林達・柴田一・土川博史1・村田道雄・臼井健郎
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] アンフォテリシンBのチャネル形成機構解明を目指した構造活性相関研究2016
- Author(s)
  山本智也、梅川雄一、土川博史、松森信明、花島慎弥、村田道雄、Resul Hauser、Bernard J. Rawlings、Patrick Caffrey
- Organizer
  日本薬学会　第１３６回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 固体NMRによる配座解析を目指したフッ素標識化バフィロマイシンの合成と生物活性評価2016
- Author(s)
  ○林達・柴田一・土川博史・村田道雄・臼井健郎
- Organizer
  日本化学会　第96春季年会
- Place of Presentation
  同志社大学京田辺キャンパス
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K01821
[Presentation] 極長鎖スフィンゴミエリンの脂質モデル膜に与える影響と相挙動解析2016
- Author(s)
  森内舞・土川博史・花島慎弥・安田智一・村田道雄・松森信明・Slotte J. Peter
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Synthesis of purple membrane lipid PGP-Me for investigating bacteriorhodopsin-lipid interactions.2016
- Author(s)
  YAMAGAMI, Masaki; JIN, Cui; TSUCHIKAWA, Hiroshi; UMEGAWA, Yuichi
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 2H,19F NMRを用いた脂質膜中におけるアンフォテリシンBの配向解析2016
- Author(s)
  山本智也、梅川雄一、山上正輝、花島慎弥、土川博史、松森信明、村田道雄
- Organizer
  第55回NMR討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脂肪酸結合タンパク質FABPの基質認識機構の解明を目指した環状脂肪酸の合成と親和性評価2016
- Author(s)
  永安麻優、土川博史、杉山成、松岡茂、原利明、村田道雄
- Organizer
  CSJ化学フェスタ2016
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] スフィンゴミエリン鏡像体で構成したラフトモデル膜の膜物性と脂質相互作用2015
- Author(s)
  矢野陽、花島慎弥、土川博史、村田道雄、木下祥尚、松森信明、J Peter Slotte
- Organizer
  日本ケミカルバイオロジー学会第10回年会
- Place of Presentation
  仙台
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 分子間距離情報に基づくアンフォテリシンB－エルゴステロール相互作用様式の解析2015
- Author(s)
  梅川雄一、中川泰男、松下直広、土川博史、花島慎弥、大石徹、松森信明、村田道雄
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Role of the polyol moiety of amphotericin B in permeabilizing membrane.2015
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Shinya Hanashima, Michio Murata, Resul Haser, Bernard J. Rawlings, Patrick Caffrey
- Organizer
  16th Tetrahedron Symposium Asia Edition
- Place of Presentation
  上海
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Design, synthesis and biological evaluation of fluorinated bafilomycin analogues as an NMR probe to analyze the interaction with vacuolar-type ATPase2015
- Author(s)
  H. Tsuchikawa, H. Shibata, T. Hayashi, S, Hanashima, N. Matsumori, M. Murata, T. Usui
- Organizer
  PACIFICHEM　2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01821
[Presentation] Design and Synthesis of Heavy Atom Labelled GalCers for X-ray Co-crystalization with CD1d.2015
- Author(s)
  Md. Imran Hossain, Shinya Hanashima, Hiroshi Tsuchikawa, Michio Murata
- Organizer
  16th Tetrahedron Symposium Asia Edition
- Place of Presentation
  上海
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 海洋生物毒スピロリドCの全合成を目指した6,5,5-ビススピロアセタール環の合成研究2014
- Author(s)
  安川佳史、脇坂智広、土川博史、村田道雄
- Organizer
  第34回有機合成若手セミナー
- Place of Presentation
  大阪
- Year and Date
  2014-08-05
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] 海洋生物毒スピロリドCの全合成を目指した6,5,5-ビススピロアセタール環の合成研究2014
- Author(s)
  安川佳史, 脇坂智広, 土川博史, 村田道雄
- Organizer
  第34回有機合成若手セミナー「明日の有機合成を担う人のために」
- Place of Presentation
  大阪
- Year and Date
  2014-08-05
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 新規重水素化アンフォテリシンB誘導体の合成と固体NMRによる配向解析2014
- Author(s)
  山本智也・梅川雄一・土川博史・花島慎弥・松森信明・村田道雄
- Organizer
  日本化学会第９４春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 固体NMRを用いた脂質ラフトにおけるスフィンゴミエリン極性部分の構造解析2014
- Author(s)
  由良理陽・土川博史・松森信明・村田道雄
- Organizer
  日本化学会第９４春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 海洋生物毒スピロリドＣのスピロイミン環部分の効率的合成を目指した選択的Diels-Alder反応の検討2014
- Author(s)
  林　翔・土川博史・松森信明・村田道雄
- Organizer
  第９４春季年会
- Place of Presentation
  愛知県名古屋大学
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] 脂質二重膜に形成されるアンフォテリシンB複合体の分子間距離情報に基づく構造解析2014
- Author(s)
  中川泰男・梅川雄一・土川博史・松森信明・村田道雄
- Organizer
  日本化学会第９４春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 海洋生物毒スピロリドＣの全合成に向けた5,5,6-ビススピロケタール環部分の構築2013
- Author(s)
  脇坂智広、土川博史、松森信明、村田道雄
- Organizer
  第93春季年会
- Place of Presentation
  滋賀県、立命館大学
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] Stereocontrolled synthesis of the 5,5,6-bisspiroacetal ring moiety of spirolide C2013
- Author(s)
  Hiroshi Tsuchikawa, Tomohiro Wakisaka, Yoshifumi Yasukawa, Michio Murata
- Organizer
  The First Asian Conference for“MONODUKURI”Strategy by Synthetic Organic Chemistry
- Place of Presentation
  Okinawa, JAPAN
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] 海洋生物毒スピロリドＣのＡ,Ｅ，Ｆ環部分の効率的合成を目指した選択的Diels-Alder反応の検討2013
- Author(s)
  林　翔・土川博史・松森信明・村田道雄
- Organizer
  第３回ＣＳＪ化学フェスタ２０１３
- Place of Presentation
  東京都　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] 海洋生物毒 Spirolide Cの全合成を目指した 5,5,6-ビススピロケタール環部分の構築
- Author(s)
  脇坂智広、土川博史、梅川雄一、松森信明、村田道雄
- Organizer
  第32回有機合成若手セミナー
- Place of Presentation
  兵庫県　神戸薬科大学
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] 配座制御による立体選択的アセタール化反応を鍵としたスピロリドCのスピロアセタール環部分の合成研究
- Author(s)
  安川佳史・土川博史・脇坂智広・村田道雄
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  東京
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24710249
[Presentation] New synthetic route for labelled Amphotericin B derivative via beta glycosidation
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata
- Organizer
  The 3rd International Symposium on Chemical Biology of Natural Products, Target ID and Regulation of Bioactivity
- Place of Presentation
  大阪
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 重水素標識スフィンゴ糖脂質の合成と固体NMR を用いたコレステロールとの分子間相互作用の解析
- Author(s)
  南角拓実, 池田竜二, 土川博史, 花島慎弥, 村田道雄
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] スフィンゴミエリンアシル鎖の深度依存的融解現象の観測
- Author(s)
  門司真美, 土川博史, 花島慎弥, 松森信明, 村田道雄
- Organizer
  第4回CSJ化学フェスタ
- Place of Presentation
  東京
- Year and Date
  2014-10-14 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] ポリオール部分の相互作用解明を目指した新規アンフォテリシンB 誘導体の調製とイオンチャネル活性
- Author(s)
  山本智也, 梅川雄一, 土川博史, 花島慎弥, 村田道雄, 松森信明, Patrick Caffrey
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 配座制御による立体選択的アセタール化反応を鍵としたスピロリドC のスピロアセタール環部分の合成研究
- Author(s)
  安川佳史, 土川博史, 脇坂智広, 村田道雄
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 液胞型ATPアーゼに対する阻害機構の解明を目指したフッ素標識化バフィロマイシンの合成と生物活性
- Author(s)
  林　達, 土川博史, 柴田一, 松森信明, 村田道雄, 臼井健郎
- Organizer
  第4回CSJ化学フェスタ
- Place of Presentation
  東京
- Year and Date
  2014-10-14 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 液胞型ATPアーゼと阻害剤バフィロマイシンの複合体構造のNMR構造解析を目指した新規フッ素標識体の合成
- Author(s)
  柴田一, 林達, 土川博史, 松森信明, 村田道雄, 臼井健郎
- Organizer
  第56回天然有機化合物討論会
- Place of Presentation
  高知
- Year and Date
  2014-10-15 – 2014-10-17
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Stereoselective Construction of 6,5,5-Bis-spiroacetal Ring of Spirolide C
- Author(s)
  Yoshifumi Yasukawa, Tomohiro Wakisaka, Hiroshi Tsuchikawa and Michio Murata
- Organizer
  The 4th Junior International Conference on Cutting-Edge Organic Chemistry in Asia (JICCEOCA-4)
- Place of Presentation
  Thailand
- Year and Date
  2014-11-28 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-24710249

1. Murata Michio (40183652)

# of Collaborated Projects: 4 results

# of Collaborated Products: 83 results
2. 梅川雄一 (20587779)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
3. 花島慎弥 (50373353)

# of Collaborated Projects: 3 results

# of Collaborated Products: 42 results
4. 松森信明 (50314357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 26 results
5. 松岡茂 (60456184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 篠田渉 (70357193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. 三浦薫 (90353515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 櫻井香里 (50447512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 此木敬一 (40292825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 山下まり (50192430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 西川俊夫 (90208158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUCHIKAWA HIROSHI 土川 博史

Research Projects

Research Products

Co-Researchers

Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions

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Protein function control starting from the pharmacophore skeleton of natural products for the development of new bioactive compoundsPrincipal Investigator

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Dynamic conformation and domain structure of lipid molecules in model biomembranes

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Dynamic conformation and domain structure of lipid molecules in model biomembranes

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Structural analysis of bafilomycin bound to V-ATPase for elucidating its inhibition mechanism based on synthetic chemistryPrincipal Investigator

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Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids

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Total synthesis of spirolide C for elucidation of its potent inhibitory mechanism on acetylcholine receptorsPrincipal Investigator

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[Journal Article] Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study2022

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[Journal Article] Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers2022

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[Journal Article] LnDOTA-d8 , a versatile chemical-shift thermometer for 2 H solid-state NMR2022

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[Journal Article] Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers2022

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[Journal Article] Conformation and Orientation of Branched Acyl Chains Responsible for the Physical Stability of Diphytanoylphosphatidylcholine.2020

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[Journal Article] Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains2020

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[Journal Article] Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning2019

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TSUCHIKAWA HIROSHI 土川博史

[Journal Article] Small　structural　alterations　greatly　influence　the　membrane　affinity　of　lipophilic　ligands:　Membrane　interactions　of　bafilomycinA1 and　its desmethyl　derivative　bearing 19F-labeling.2019