Kinoshita Hideyuki 木下秀之

… Alternative Names

KINOSHITA Hideyuki 木下秀之

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Researcher Number	30467477
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 京都大学, 医学研究科, 特定准教授 2015 – 2016: 京都大学, 医学(系)研究科(研究院), 准教授 2013 – 2014: 京都大学, 医学(系)研究科(研究院), その他 2013: 京都大学, 医学(系)研究科(研究院), 医員 2013: 京都大学, 大学院・医学研究科, 助教 … More 2012: 京都大学, 医学(系)研究科(研究院), 助教 2011: 京都大学, 医学(系)研究科(研究院), 特定助教 2011: 京都大学, 医学研究科, 特定助教 2009 – 2011: Kyoto University, 医学研究科, 助教 2009: Kyoto University, 大学院・医学研究科, 助教 2008: Kyoto University, 医学研究科, 研修員 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine
Keywords	Principal Investigator 心不全 / 肺動脈性肺高血圧症 / CNP / TRPC / ナトリウム利尿ペプチド / 肺高血圧症 / 肺動脈リモデリング / 右心不全 / TRPCチャネル / Caチャネル … More / 肺動脈性肺高血圧 / 右室肥大 / 受容体活性化型Caチャネル / 病的心臓リモデリング / 受容体活性化型Ca2+チャネル / 肺血管リモデリング / 肺高血圧 / 慢性心不全 / 分子心臓病態学 / 心筋リモデリング / イオンチャネル … More Except Principal Investigator 心不全 / エピゲノム / 転写因子 / 遺伝子 / シグナル伝達 / 転写調節 / 心臓病 / 分子心臓病学 / シグナル経路 / シグナル伝達経路 / 分子心臓学 / 転写 / TRPC6 / TRPC3 / TRPチャネル / カルシウムシグナル / 心筋 / 発現制御 / 循環器・高血圧 / 循環器 / エピジェネティクス / 転写制御 / イオンチャネル / 遺伝子発現 Less

Investigation of Cardiac Epigenomic Circuit in the Development of Heart Failure and Identification of Potential Therapeutic Targets
- Principal Investigator
  
  桑原宏一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Shinshu University
心不全患者におけるTRPC3/C6シグナルのバイオマーカーとしての潜在的意義の検討
- Principal Investigator
  
  森内健史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
肺動脈性肺高血圧症におけるTRPC6, CNP経路の研究Principal Investigator
- Principal Investigator
  
  木下秀之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University
Elucidation of transcriptional and epigenomic circuit ro reveal molecular mechanisms underlying heart failure and identify novel therapeutic targets
- Principal Investigator
  
  Kuwahara Koichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Shinshu University
Potential significance of TRPC3/6 and CNP as novel therapeutic targets of pulmonary arterial hypertensionPrincipal Investigator
- Principal Investigator
  
  Hideyuki Kinoshita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University
Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function
- Principal Investigator
  
  Kuwahara Koichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shinshu University
Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial HypertensionPrincipal Investigator
- Principal Investigator
  
  Kinoshita Hideyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
- Principal Investigator
  
  KUWAHARA Koichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shinshu University
  Kyoto University
Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pathological Cardiac RemodelingPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Hideyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Elucidation of transcriptional and epigenomic regulation in the development of heart failure
- Principal Investigator
  
  KUWAHARA Koichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heartPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Hideyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Elucidation of roles of TRPC ion channels in pathological cardiac remodelingPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Hideyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University

[Book] 右心不全を識り評価して治療に活かす右心不全・肺高血圧症治療に使用する薬剤一覧2015
- Author(s)
  木下秀之
- Total Pages
  6
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15K09137
[Journal Article] NRSF- GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis2022
- Author(s)
  Inazumi Hideaki、Kuwahara Koichiro、Nakagawa Yasuaki、et al.
- Journal Title
  
  Circulation Research
  
  Volume: 130 Issue: 2 Pages: 234-248
- DOI
  10.1161/circresaha.121.318898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07297, KAKENHI-PROJECT-19K08580, KAKENHI-PROJECT-19K16497, KAKENHI-PROJECT-20H03673, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-19K07299, KAKENHI-PROJECT-21K08126, KAKENHI-PROJECT-20K17077, KAKENHI-PROJECT-22K08099
[Journal Article] Patient Journey and Disease-Related Burden in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension: A Mixed Methods Study.2021
- Author(s)
  Kinoshita H, Aoki T, Motoki H, Wakita T, Onishi Y, Watanabe-Fujinuma E, Kuwahara K.
- Journal Title
  
  Value Health Reg Issues.
  
  Volume: 24 Pages: 17-23
- DOI
  10.1016/j.vhri.2020.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03673
[Journal Article] EXPRESS: Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice2018
- Author(s)
  Kobayashi Hatasu、Kabata Risako、Kinoshita Hideyuki、Morimoto Takaaki、Ono Koh、Takeda Midori、Choi Jungmi、Okuda Hiroko、Liu Wanyang、Harada Kouji H、Kimura Takeshi、Youssefian Shohab、Koizumi Akio
- Journal Title
  
  Pulmonary Circulation
  
  Volume: - Issue: 3 Pages: 204589401877815-204589401877815
- DOI
  10.1177/2045894018778155
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J04066, KAKENHI-PROJECT-15K09137, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06397
[Journal Article] Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP:Case report.2017
- Author(s)
  Nakagawa Y, Nishikimi T, Sakai H, Ohno S, Kinoshita H, Inazumi H, Moriuchi K, Kuwahara K, Horie M, Kimura T.
- Journal Title
  
  Clinical Biochemistry
  
  Volume: 52 Pages: 148-152
- DOI
  10.1016/j.clinbiochem.2017.10.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09498, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-16K15442, KAKENHI-PROJECT-18K08103
[Journal Article] Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity.2017
- Author(s)
  Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K
- Journal Title
  
  Hypertension.
  
  Volume: 69 Issue: 2 Pages: 286-296
- DOI
  10.1161/hypertensionaha.116.08219
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-16K15495, KAKENHI-PROJECT-16K15442, KAKENHI-PROJECT-16K09498, KAKENHI-PROJECT-26461380, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-15K09137, KAKENHI-PROJECT-15K09138
[Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.2017
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 6 Issue: 2
- DOI
  10.1161/jaha.116.003601
- NAID
  120007100125
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-16K15495, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-16K14695, KAKENHI-PROJECT-16K09498, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-16K15442
[Journal Article] B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction　― Relevance to Age-Related Left Ventricular Modeling in Japanese ―2017
- Author(s)
  Tanabe N, Ikeda S, Tahara N, Fukuda K, Hatano M, Ito H, Nakayama T, Anzai T, Hashimoto A, Inoue T, Kajinami K, Kihara Y, Kinoshita H, Kuwahara K, Murohara T, Okazaki O, Sakai S, Satoh T, Takeda Y, Takeishi Y, Taniguchi M, Watanabe H, Yamamoto T, Yamauchi-Takihara K, Yoshioka K, Sasayama S.
- Journal Title
  
  Circ J
  
  Volume: 81 Issue: 7 Pages: 1006-1013
- DOI
  10.1253/circj.CJ-16-1282
- NAID
  130006887044
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-16K15442
[Journal Article] The renin-angiotensin system promotes arrhythmogenic substrates andalethal arrhythmias in mice with non-ischemic cardiomyopathy2016
- Author(s)
  Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, , Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T
- Journal Title
  
  Cardiovascular Research
  
  Volume: 109 Issue: 1 Pages: 162-173
- DOI
  10.1093/cvr/cvv248
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09078, KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-15K19377, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-16K09498
[Journal Article] 2.Outcomes of various transplant procedures (single, sparing, inverted) in living-donor lobar lung transplantation.2016
- Author(s)
  Date H, Aoyama A, Hijiya K, Motoyama H, Handa T, Kinoshita H, Baba S, Mizota T, Minakata K, Chen-Yoshikawa TF
- Journal Title
  
  J Thorac Cardiovasc Surgery
  
  Volume: 144 Pages: 710-715
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09137
[Journal Article] Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model.2015
- Author(s)
  Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T.
- Journal Title
  
  Science Report
  
  Volume: 5 Issue: 1 Pages: 7826-7826
- DOI
  10.1038/srep07826
- NAID
  120007100130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-26250029, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-26640085, KAKENHI-PROJECT-26670400
[Journal Article] Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.2015
- Author(s)
  Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 309 Issue: 6 Pages: R639-R649
- DOI
  10.1152/ajpregu.00074.2015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-15K19377, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-26293187
[Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.2014
- Author(s)
  Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
- Journal Title
  
  Cardiovasc Research
  
  Volume: 104 Issue: 1 Pages: 183-193
- DOI
  10.1093/cvr/cvu185
- NAID
  120005619790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25460749, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-25860596, KAKENHI-PROJECT-25860597, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-26670458
[Journal Article] The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis.2014
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K.
- Journal Title
  
  PLoS One
  
  Volume: 25 Issue: 3 Pages: e92314-e92314
- DOI
  10.1371/journal.pone.0092314
- NAID
  120007100132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23310155, KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386, KAKENHI-PUBLICLY-25126712, KAKENHI-PROJECT-25460749, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-25860596, KAKENHI-PROJECT-25860597, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-26670458
[Journal Article] The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis2014
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K
- Journal Title
  
  PLoS One
  
  Volume: 9(3)
- NAID
  120007100132
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy2013
- Author(s)
  Yasuno, S., Kuwahara, K., Kinoshita, H., Yamada, C., Nakagawa, Y., Usami, S., Kuwabara, Y., Ueshima, K., Harada, M., Nishikimi, T., Nakao, K.
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 170(7) Issue: 7 Pages: 1384-1395
- DOI
  10.1111/bph.12328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386, KAKENHI-PROJECT-25460749, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-25860596
[Journal Article] Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.2013
- Author(s)
  Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N.
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 7 Pages: 544-553
- DOI
  10.1111/gtc.12055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-25860045
[Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure2013
- Author(s)
  Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K
- Journal Title
  
  PLoS One
  
  Volume: 8(1)
- NAID
  120005241437
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] Angiotensin II Type 1a receptor signaling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy2013
- Author(s)
  Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K
- Journal Title
  
  Br J Pharmacol
  
  Volume: 170(7) Pages: 1384-95
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts.2013
- Author(s)
  Kuwabara, Y., Kuwahara, K., Takano, M., Kinoshita, H., Arai, Y., Yasuno, S., Nakagawa, Y., Igata, S., Usami, S., Minami, T., Yamada, Y., Nakao, K., Yamada, C., Shibata, J., Nishikimi, T., Ueshima, K., Nakao, K.
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 2(3) Issue: 3
- DOI
  10.1161/jaha.113.000150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-24300145, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386, KAKENHI-PROJECT-25460749, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-25860596, KAKENHI-PROJECT-25860597
[Journal Article] Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts2013
- Author(s)
  Kuwabara Y, Kuwahara K, Takano M, Kinoshita H, Arai Y, Yasuno S, Nakagawa Y, Igata S, Usami S, Minami T, Yamada Y, Nakao K, Yamada C, Shibata J, Nishikimi T, Ueshima K, Nakao K
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 2(3)
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure2013
- Author(s)
  Nishikimi, T., Okamoto, H., Nakamura, M., Ogawa, N., Horii, K., Nagata, K., Nakagawa, Y., Kinoshita, H., Yamada, C., Nakao, K., Minami, T., Kuwabara, Y., Kuwahara, K., Masuda, I., Kangawa, K., Minamino, N., Nakao, K.
- Journal Title
  
  PLoS ONE
  
  Volume: 8(1) Issue: 1 Pages: e53233-e53233
- DOI
  10.1371/journal.pone.0053233
- NAID
  120005241437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-22590810, KAKENHI-PROJECT-23591041, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386, KAKENHI-PROJECT-25860596, KAKENHI-PROJECT-25860597
[Journal Article] Association of Takayasu arteritis with HLA-B*67:01 and two amino acids in HLA-B protein.2013
- Author(s)
  Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T
- Journal Title
  
  Rheumatology
  
  Volume: 52(10) Issue: 10 Pages: 1769-1774
- DOI
  10.1093/rheumatology/ket241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659461, KAKENHI-PUBLICLY-25112706, KAKENHI-PROJECT-25860809
[Journal Article] Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf162013
- Author(s)
  Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N
- Journal Title
  
  Genes Cells
  
  Volume: 18(7) Pages: 544-553
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure2012
- Author(s)
  Nishikimi T, Nakao K, et al
- Journal Title
  
  Heart
  
  Volume: 98 Issue: 2 Pages: 152-161
- DOI
  10.1136/heartjnl-2011-300102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PUBLICLY-23126511, KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-23591041, KAKENHI-PROJECT-24659386
[Journal Article] In vivo site-specific transfection of naked plasmid DNA in mice using a tissue suction device2012
- Author(s)
  Shimizu K, Kawakami S, Hayashi K, Kinoshita H, Kuwahara K, Nakao K, Hashida M, Konishi S
- Journal Title
  
  Plos One
  
  Volume: 7(7)
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice.2012
- Author(s)
  Minami T, Nakao K, et al
- Journal Title
  
  EMBO J.
  
  Volume: 31 Issue: 23 Pages: 4428-4440
- DOI
  10.1038/emboj.2012.296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-22390159, KAKENHI-PROJECT-22590810, KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-23591041, KAKENHI-PROJECT-23659404, KAKENHI-PROJECT-24390100, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386, KAKENHI-PROJECT-24659392, KAKENHI-PUBLICLY-23110510, KAKENHI-PUBLICLY-23117717, KAKENHI-PUBLICLY-23126511
[Journal Article] In vivo site-specific transfection of naked plasmid DNA in mice using a tissue suction device2012
- Author(s)
  Shimizu K, Nakao K, et al
- Journal Title
  
  PloS One
  
  Volume: 0 Issue: 7 Pages: e41319-e41319
- DOI
  10.1371/journal.pone.0041319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386
[Journal Article] The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure2012
- Author(s)
  Nishikimi T, Ikeda M, Takeda Y, Ishimitsu T, Shibasaki I, Fukuda H, Kinoshita H, Nakagawa Y, Kuwahara K, Nakao K
- Journal Title
  
  Heart
  
  Volume: 98(2) Pages: 152-61
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] The effect of glycosylationon plasma N-terminal proBNP-76 levelsin patients with heart or renalfailure2012
- Author(s)
  Nishikimi T, Kinoshita H, Kuwahara K, (他7名)
- Journal Title
  
  Heart
  
  Volume: 98(2) Pages: 152-161
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice2012
- Author(s)
  Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R and Nakao K
- Journal Title
  
  EMBO J
  
  Volume: 31(23) Pages: 4428-40
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure2012
- Author(s)
  Nishikimi T, Kinoshita H, Kuwahara K, 他7名
- Journal Title
  
  Heart
  
  Volume: 98(2) Pages: 152-161
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes2011
- Author(s)
  Hata L, Murakami M, Kuwahara K, Nakagawa Y, Kinoshita H, Usami S, Yasuno S, Fujiwara M, Kuwabara Y, Minami T, Yamada Y, Yamada Y, Nakao K, Ueshima K, Nishikimi T, and Nakao K
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 50(6) Pages: 972-981
- Data Source
  KAKENHI-PROJECT-23390210
[Journal Article] Zinc-finger protein 90 negatively regulates neuron-restritive silencer factor-mediated transcriptional repression of fetal cardiac genes2011
- Author(s)
  Hata L, Murakami M, Kuwahara K, Kinoshita H, 他13名
- Journal Title
  
  Journal of Cellular and Melecular Cardiology
  
  Volume: 50(6) Pages: 972-981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Zinc-finger protein 90 negatively regulates neuron-restritive silencer factor-mediated transcriptional repression of fetal cardiac genes.2011
- Author(s)
  Hata L, Murakami M, Kuwahara K, Kinoshita H, 他13名
- Journal Title
  
  Journal of Cellular and Melecular Cardiology
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Zinc-finger protein 90 negatively regulatesneuron-restritive silencer factor-mediated transcriptional repression of fetal cardiacgenes2011
- Author(s)
  Hata L, Murakami M, Kuwahara K, Kinoshita H, (他13名)
- Journal Title
  
  Journal of Cellular and Molecular Cardiology
  
  Volume: 56(6) Pages: 972-981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.2010
- Author(s)
  Kinoshita H, Kuwahara K, 他14名
- Journal Title
  
  Circulation Research
  
  Volume: 106 Pages: 1849-1860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.2010
- Author(s)
  Small EM, Kuwahara K, Kinoshita H, 他7名
- Journal Title
  
  Circulation Research
  
  Volume: 107 Pages: 294-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Myocardin-related transcriptional factor A is a common mediator of mechanical stress-and neurohumoralstimulation-induced cardiachypertrophic signaling leading to activation of brain natriureticpeptide gene expression2010
- Author(s)
  Kuwahara K, Kinoshita H, (他7名)
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 30 Pages: 4134-4148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor.2010
- Author(s)
  Takano M, Kinoshita H, 他4名
- Journal Title
  
  Circulation Journal
  
  Volume: 74 Pages: 2712-2719
- NAID
  10027424735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Myocardin-related transcriptional factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression.2010
- Author(s)
  Kuwahara K, Kinoshita H, 他7名
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 30 Pages: 4134-4148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Inhibition of TRPC6 channel activity contributes to the antihypertrophiceffects of natriureticpeptides-guanylyl cyclase-A signaling in the heart2010
- Author(s)
  Kinoshita H, Kuwahara K, (他14名)
- Journal Title
  
  Circulation Reserch
  
  Volume: 106 Pages: 1849-1860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Path physiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor2010
- Author(s)
  Takano M, Kinoshita H, (他4名)
- Journal Title
  
  Circulation Journal
  
  Volume: 74 Pages: 1849-1860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Myocardin-relatedtranscription factor-a controlsmyofibroblast activation and fibrosis in response to myocardial infarction2010
- Author(s)
  Small EM, Kuwahara K, Kinoshita H, (他7名)
- Journal Title
  
  Circulation Research
  
  Volume: 107 Pages: 294-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790702
[Journal Article] Natriuretic peptide receptor/guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart.2009
- Author(s)
  Li Y, Kinoshita H, 他10名
- Journal Title
  
  Endocrinology. 150
  
  Pages: 3759-3765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.2009
- Author(s)
  Nakagawa Y, Kinoshita H, 他14名
- Journal Title
  
  Circulation Research. 105
  
  Pages: 746-754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] Natriuretic peptide receptor/guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart2009
- Author(s)
  Li Y, Kinoshita H, 他10名
- Journal Title
  
  Endocrinology 150
  
  Pages: 3759-3765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts2009
- Author(s)
  Nakagawa Y, Kinoshita H, 他14名
- Journal Title
  
  Circulation Research 105
  
  Pages: 746-754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF22009
- Author(s)
  Yasuno S, Kinoshita H, 他10名
- Journal Title
  
  American Journal of Physiology, Heart and Circulatory Physiology 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.2009
- Author(s)
  Kinoshita H, Kuwahara K, 他11名
- Journal Title
  
  Circulation. 120
  
  Pages: 743-752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] T-type Ca^<2+> channel blockade prevents sudden death in mice with heart failure2009
- Author(s)
  Kinoshita H, Kuwahara K, 他11名
- Journal Title
  
  Circulation 120
  
  Pages: 743-752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death.2009
- Author(s)
  Yasuno S, Kinoshita H, 他10名
- Journal Title
  
  American Journal of Physiology, Heart and Circulatory Physiology. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart.2008
- Author(s)
  Hotta Y, Sasaki S, Konishi M, Kinoshita H, Kuwahara K, Nakao K, Itoh N
- Journal Title
  
  Developmental Dynnamics 237
  
  Pages: 2947-2954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Journal Article] Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart2008
- Author(s)
  Hotta Y, Sasaki S, Konishi M, Kinoshita H. Kuwahara K. Nakao K. Itoh N
- Journal Title
  
  Developmental Dynnamics 237
  
  Pages: 2947-2954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Genetic and pharmacological inhibition of TRPC3/6 ameliorates pulmonary arterial hypertension in rodent models.2022
- Author(s)
  1.森内健史、中川靖章、木下秀之、西田基宏、森泰生、永田龍、中村一文、錦見俊雄、稲住英明、柳澤洋、金森敬彦、大矢未来、中尾一和、桑原宏一郎、木村剛.
- Organizer
  第39回国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-22K08180
[Presentation] 肺高血圧症の新規治療ターゲットとしてのTRPC3/C62022
- Author(s)
  5.森内健史、中川靖章、木下秀之、西田基宏、森泰生、永田龍、中村一文、錦見俊雄、稲住英明、柳澤洋、金森敬彦、大矢未来、中尾一和、桑原宏一郎、木村剛
- Organizer
  第26回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08180
[Presentation] 肺疾患を合併した肺動脈性肺高血圧症に対するマシテンタンの効果2020
- Author(s)
  嶋本光兵,木下秀之,柳澤洋,森内健史,稲住英明,中川靖章,桑原宏一郎,木村剛
- Organizer
  第 5 回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08034
[Presentation] Endothelial CNP-GC-B system plays a protective role in the development of pulmonary hypertension.2020
- Author(s)
  Hiromu Yanagisawa, Yasuaki Nakagawa, Kenji Moriuchi, Hideaki Inazumi, Hideyuki Kinoshita, Toshio Nishikimi, Miku Oya, Kazuwa Nakao, Koichiro Kuwahara, Takeshi Kimura.
- Organizer
  第 4 回日本循環器学会基礎研究フォーラム(BCVR)
- Data Source
  KAKENHI-PROJECT-18K08034
[Presentation] 呼吸器疾患を合併した肺動脈性肺高血圧症の治療を考える2020
- Author(s)
  木下秀之
- Organizer
  第 60 回日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08034
[Presentation] 膠原病に伴う肺動脈性肺高血圧症の診断とマネジメントにおける問題点を考える2020
- Author(s)
  木下秀之
- Organizer
  第 48 回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08034
[Presentation] Increased Gao expression underlies cardiac dysfunction and lethal arrhythmias accompanied with abnormal Ca2+ handling2019
- Author(s)
  Inazumi H, Kuwahara K, Kuwabara Y, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Oya M, Yamada M, Kashihara T, Kurebayashi N, Sugihara M, Nakao K, Kimura T.
- Organizer
  ESC Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] Increased expression of Gαo plays a pivotal role in the progression of heart failure by impairing Ca2+ homeostasis2019
- Author(s)
  H Inazumi, K Kuwahara, Y Kuwabara, Y Nakagawa, H Kinoshita, K Moriuchi, H Yanagisawa , T Nishikimi , M Oya, M Yamada, T Kashihara, N Kurebayashi, M Sugihara, K Nakao, T Kimura
- Organizer
  第36回国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] 抑制性Ｇ蛋白サブユニットＧαoの発現亢進はCa2+ handlingの異常を介して心不全進展にかかわる2019
- Author(s)
  稲住英明桑原宏一郎桒原佳宏中川靖章木下秀之森内健史柳澤洋錦見俊雄大矢未来山田充彦柏原俊英呉林なごみ中尾一和木村剛
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] Macitentan for the Treatment of Pulmonary Arterial Hypertnsion with Lung Disease.2019
- Author(s)
  Hideyuki Kinoshita, Hiromu Yanagisawa, Kenji Moriuchi, Hideaki Inazumi, Yasuaki Nakagawa, Koichiro Kuwahara, Takeshi Kimura
- Organizer
  The 16th International Conference of Endothelin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08034
[Presentation] Increased Gαo expression plays a pivotal role in the progression of heart failure by impairing Ca2+ handling2019
- Author(s)
  Hideaki Inazumi, Koichiro Kuwahara, Yoshihiro Kuwabara, Yasuaki Nakagawa, Hideyuki Kinoshita、Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi,Kazuwa Nakao, Takeshi Kimura
- Organizer
  BCVS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] Possibility of proBNP Measurement as a New Method for Evaluating the Heart Disease.2018
- Author(s)
  中川靖章、桑原宏一郎、錦見俊雄、木下秀之、稲住英明、森内健史、柳沢　洋、南野直人、中尾一和、木村　剛．
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] Prediction of Poor Outcome after PAH Targeted Therapy in Pulmonary Arterial Hypertension Patients with Lung Disease2017
- Author(s)
  H. Kinoshita , T. Fujita , T. Handa , H. Yanagisawa , K moriuchi, H. Inazumi , N Saito, Y. Nakagawa , Kuwahara , K. Ono , T. Kimura
- Organizer
  第81回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 肺高血圧症治療が変わる～セレキシパグの可能性を踏まえて～2017
- Author(s)
  木下秀之
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Prediction of Poor Outcome after PAH Targeted Therapy in Pulmonary Arterial Hypertension Patients with Lung Disease2017
- Author(s)
  H. Kinoshita , T. Fujita , T. Handa , H. Yanagisawa , K moriuchi, H. Inazumi , N Saito, Y. Nakagawa , Kuwahara , K. Ono , T. Kimura
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] マクロproBNP血症の一例2017
- Author(s)
  中川靖章、錦見俊雄、酒井宏、大野聖子、木下秀之、稲住英明、森内健史、柳澤洋、桑原宏一郎、堀江稔、木村剛
- Organizer
  第21回心血管内分泌代謝学会(CVMW2017)
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] 脂肪由来のアドレノメデュリンは加齢および肥満に伴う血圧上昇を抑制する2017
- Author(s)
  趙晃済、桑原宏一郎、南丈也、錦見俊雄、南野直人、中川靖章、木下秀之、稲住英明、森内健史、寒川賢治、中尾一和、木村剛
- Organizer
  第５４回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] A case of Macro-pro-B-Type Natriuretic Peptide (proBNP)2017
- Author(s)
  Yasuaki Nakagawa, Toshio Nishikimi, Hiroshi Sakai, Seiko Ohno, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Koichiro Kuwahara, Minoru Horie, Takeshi kimura
- Organizer
  第21回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] O-linked oligosaccharaide attachment underestimates N-treminal proBNP-76(NT-proBNP) levels in heart failure(HF) and chronic renal failure (CRF) on hemodialysis (HD)2017
- Author(s)
  Nishikimi T, Nakagawa Y, Kinoshita H, Moriuchi K, Inazumi H, Kuwahara K, Nakao K, Kimura T.
- Organizer
  ESC Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] 呼吸器疾患を合併した肺動脈性肺高血圧症2017
- Author(s)
  木下秀之
- Organizer
  第57回日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Clinical features of the Systemic Sclerosis associated Pulmonary Arterial Hypertension with Left Heart Disease2017
- Author(s)
  柳澤洋、木下秀之、桑原宏一郎、吉藤元、森内健史、稲住英明、斎藤成達、中川靖章、尾野亘、木村剛
- Organizer
  第21回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Endothelium-derived C-type natriuretic peptide regulates blood pressure through the maintenance of endothelial function2017
- Author(s)
  Kuwahara K, Nakao K, Nishikimi T, Nakagawa Y, Kinoshita H, Tokudome T, Minamino N, Kimura T, Kangawa K, Nakao K
- Organizer
  Heart Failure 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04174
[Presentation] MiR30-GALNT1/2 axis-mediatede glycosylation regulates the increase in inactive human pro-BNP secretion from failing heart.2016
- Author(s)
  Kuwahara K, Nakagawa Y, Nishikimi T, Kinoshita H, Okamoto H, Kato T, Kangawa K, Minamino N, Nakao K, Kimura T
- Organizer
  Hypertension Seoul 2016, The 26th Scientific meeting of the International Society of Hypertension
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 維持血液透析患者における肺高血圧症合併頻度とその臨床的特徴2016
- Author(s)
  家村知樹, 木下秀之, 齋藤成達, 柳澤洋, 森内健史、稲住英明、中川靖章, 桑原宏一郎, 尾野亘, 木村剛
- Organizer
  第1回日本肺高血圧・肺循環学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 肺移植待機中の肺動脈性肺高血圧症患者における予後予測指標の検討2016
- Author(s)
  山上新太郎, 木下秀之, 本山秀樹, 土屋恭子, 青山晃博, 陳豊史, 中川靖章, 桑原宏一郎, 伊達洋至, 木村剛
- Organizer
  第1回日本肺高血圧・肺循環学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Pulmonary Edema in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension receiving Pulmonary Vasodilator Therapies2016
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, Hiromu Yanagisawa, Hajime Yoshifuji, Chinatsu Yamada, Yoshihiro Kuwabara, Yasuaki Nakagawa, Takeru Makiyama, Satoshi Shizuta, Koh Ono, Takesyi Kimura
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-19
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Survival prospects of Patients with Pulmonary Artery Hypertension Referred for Lung Transplantation2016
- Author(s)
  Shintaro Yamabgami, Hideyuki Kinoshita, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Yoyofimi Chin, Akira Tshujimura, Hiromu Yanagisawa, Chinatsu Yamada, Takeru Makiyama, Yasuaki Nakagawa, Satoshi Shizuta, Koichiro Kuwahara, Koh Ono, Hiroshi Date, Takeshi Kimura
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-19
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 肺高血圧症治療の新たな展望～PGI2を考える～2016
- Author(s)
  木下秀之
- Organizer
  第20回日本新血管内分泌代謝学会学術集会、第33回国際心臓研究学会日本部会、第20回日本適応医学会学術集会　合同集会
- Place of Presentation
  東京
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Guideline of the treatment of CTEPH2016
- Author(s)
  木下秀之
- Organizer
  Complex Cardiovascular Therapeutics 2016
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] Unprocessed proBNP secretion is regulated by MiR30-GALNTs axis dependent O-glycosylation in the pathological myocardium.2016
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Kinoshita H, Yamada C, Inazumi H, Nakao K, Kimura T
- Organizer
  AHA BCVS2016
- Place of Presentation
  Phoenix, Arizona, USA
- Year and Date
  2016-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Secretion of proBNP is regulated by MiR30-GALNTs axis dependent O-linked glycosylation in the pathological myocardium2016
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Kinoshita H, Inazumi H, Moriuchi K, Kato T, Minamino N, Nakao K, Kimura T
- Organizer
  AHA Scientific Session 2016
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] CTEPHに対する経皮的肺動脈拡張術(BPA)と薬物治療の治療効果の比較検討2016
- Author(s)
  木下秀之
- Organizer
  Complex Cardiovascular Therapeutics 2016
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 脳死肺移植術後にPGI2を漸減し心機能を評価したIPAHの１例2016
- Author(s)
  米田智也, 木下秀之, 中島康弘, 本山秀樹, 土屋恭子, 青山晃博, 陳豊史, 桑原宏一郎, 木村剛, 伊達洋至, 一山智
- Organizer
  第1回日本肺高血圧・肺循環学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 肺血管拡張薬を投与した透析関連肺高血圧症の1症例の報告と、当院の透析患者における心エコーによる肺高血圧症症例の特徴2016
- Author(s)
  家村知樹、木下秀之、山田千夏、辰島正二郎、渡部宏俊、中川靖章、静田聡、桑原宏一郎、尾野亘、木村剛
- Organizer
  第113回　日本内科学会総会
- Place of Presentation
  東京
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 当院におけるILD-PHに対する肺血管拡張療法の効果の検討2015
- Author(s)
  藤田啓誠、木下秀之、半田知宏，谷澤公伸、室繁郎、佐藤晋、山田千夏、中川靖章、静田聡、桑原宏一郎、木村剛
- Organizer
  第4回日本肺循環学会（JPCS）第3回日本肺高血圧学会（JPHS）合同学術集
- Place of Presentation
  ステーションコンファレンス東京、東京
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] O型糖鎖修飾を介したヒトBNPプロセシング調節に関与する糖転移酵素についての検討2015
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之,山田千夏、南野直人、中尾一和、木村剛
- Organizer
  第19回　日本心血管内分泌代謝学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] HRCTにて肺静脈病変合併が示唆されるCTD-PAHに対する肺血管拡張療法の効果2015
- Author(s)
  柳澤洋、木下秀之、吉藤元、半田知宏、藤井隆夫、牧山武、中川靖章、静田聡、桑原宏一郎、三森経世、木村剛
- Organizer
  第4回日本肺循環学会（JPCS）第3回日本肺高血圧学会（JPHS）合同学術集
- Place of Presentation
  ステーションコンファレンス東京、東京
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 重症PAHにおける肺移植術後急性期の右室および左室機能の検討2015
- Author(s)
  米田智也、木下秀之、中島康弘、本山秀樹、土屋恭子、青山晃博、陳豊史、桑原宏一郎、木村剛、伊達洋至、一山智
- Organizer
  第4回日本肺循環学会（JPCS）第3回日本肺高血圧学会（JPHS）合同学術集
- Place of Presentation
  ステーションコンファレンス東京、東京
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 著明な低酸素血症を認めた重症特発性肺動脈性肺高血圧症の１症例2015
- Author(s)
  相澤卓範、木下秀之、中西直彦、今井逸雄、牧山武、中川靖章、静田聡、桑原宏一郎、青山晃博、伊達洋至、木村剛
- Organizer
  第4回日本肺循環学会（JPCS）第3回日本肺高血圧学会（JPHS）合同学術集
- Place of Presentation
  ステーションコンファレンス東京、東京
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 肺高血圧症の最新治療戦略　－病態に応じた治療法の選択－2015
- Author(s)
  木下秀之
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場、大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09137
[Presentation] 心不全患者におけるproBNPの分泌と代謝についての検討2015
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之,山田千夏、南野直人、中尾一和、木村剛
- Organizer
  第19回　日本心血管内分泌代謝学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] N-type Ca2+ channels blockade restores the cardiac autonomic balance and prevents lethal arrhythmias in mice with dilated cardiomyopathy2015
- Author(s)
  Koichiro Kuwahara, Yuko Yamada, Hideyuki Kinoshita, Yasuaki Nakagawa, Kazuwa Nakao and Takeshi Kimura
- Organizer
  25th European Meeting on Hypertension and Cardiovascular Protection　(European Society of Hypertension)
- Place of Presentation
  ミラノ
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Elucidation of molecular mechanism of human proBNP : role of O-glycosylation in N-terminal region of proBNP2014
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Yamada C, Ueshima K, Minamino N, Kimura T, Nakao K
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 遠隔地に居住しているPGI2持続静注療法施行中の肺動脈性肺高血圧症患者における訪問看護を介した地域連携の取り組み2014
- Author(s)
  水口果奈、長谷川友美、木下秀之、奥田菜央、中村友美、松本紀子、長野仁美、田中澄江、小田亮子、牧山武、桑原宏一郎、木村剛
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Molecular mechanism of lower processing rate in human proBNP : importance of the distance between the O-glycosylation and cleavage sites2014
- Author(s)
  Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Ishimitsu T, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Kangawa K, Kuwahara K, Nakao K
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] TRPC3/6 as Potentially Novel Therapeutic Targets for the Treatment of Pulmonary Arterial Hypertension2014
- Author(s)
  木下秀之、桑原宏一郎
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] TRPC3/6 as Potentially Novel Therapeutic Targets for the Treatment of Pulmonary Arterial Hypertension2014
- Author(s)
  Kinoshita H, Kuwahara K
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 肺動脈性肺高血圧症に対する新規治療標的としてのTRPC3/6阻害効果の検討2013
- Author(s)
  木下秀之, 桑原宏一郎, 清中茂樹, 森泰生, 赤木達, 中村一文, 桒原佳宏, 中川靖章, 錦見俊雄, 中尾一和
- Organizer
  第2回日本肺循環学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 維持血液透析患者におけるproBNPについての検討2013
- Author(s)
  中川靖章, 錦見俊雄, 桑原宏一郎, 保野慎治, 木下秀之, 桒原佳宏, 中尾一泰, 山田千夏, 上嶋健治, 中尾一和
- Organizer
  第17回日本心不全学会学術集会
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 拡張型心筋症モデルマウスにおける左室リモデリング及び不整脈源性基質形成におけるレニン―アンジオテンシン系の意義2013
- Author(s)
  山田千夏, 桑原宏一郎,木下秀之, 錦見俊雄, 中尾一泰, 桒原佳宏,中川靖章, 中尾一和
- Organizer
  第50回　臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] O-glycosylated Pro B-type Natriuretic Peptide is Cleaved intracellularly By Furin in Ventricular Myocytes and Atrial Myocytes : Importance of the Distance Between the O-glycosylation Sites and Cleaved Sites2013
- Author(s)
  Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Ishimitsu T, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Kangawa K, Kuwahara K, Nakao K
- Organizer
  AHA Scientific Sessoins 2013
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Hickmanカテーテル関連血流感染症に対し抗生剤ロック療法を行った1症例の検討2013
- Author(s)
  廣田圭昭、木下秀之、山田千夏、中尾一泰、南丈也、桒原佳宏、保野慎治、宇佐美覚、中川靖章、牧山武、錦見俊雄、上嶋健治、桑原宏一郎、木村剛
- Organizer
  第116回日本循環器学会近畿地方会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 肺動脈性肺高血圧症に対する新規治療法としてのTRPC3/6阻害効果の検討2013
- Author(s)
  木下秀之、桑原宏一郎、清中茂樹、森泰生、赤木達、中村一文、桒原佳宏、中川靖章、錦見俊雄、中尾一和
- Organizer
  第2回日本肺循環学会学術集会
- Place of Presentation
  東京ステーションコンファレンス
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 血管壁ナトリウム利尿ペプチド系の意義の解明－血管内皮細胞特異的C型ナトリウム利尿ペプチド(CNP)ノックアウトマウスの解析－2013
- Author(s)
  中尾一泰　桑原宏一郎　錦見俊雄　中川靖章　木下秀之　宇佐美覚　桑原佳宏　南丈也　山田千夏　山田優子　保野慎治上嶋健治曽根正勝寒川賢治　中尾一和
- Organizer
  第50回　臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 肺ランゲルハンス細胞組織球症に合併した肺高血圧症に対しエポプロステノールを使用した１症例2013
- Author(s)
  波多腰桃子、木下秀之、西川隆介、山田千夏、中尾一泰、南丈也、桑原佳宏、保野慎治、宇佐美覚、中川靖章、牧山武、錦見俊雄、上嶋健治、桑原宏一郎、木村剛
- Organizer
  第116回日本循環器学会近畿地方会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Blockade of TRPC6 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling2013
- Author(s)
  Kinoshita H, Kuwahara K, Nishida M, Kurose H, Kiyonaka S, Mori Y, Yamada C, Kuwabara Y, Yasuno S, Nakagawa Y, Nishikimi T, Ueshima K, Nakao K
- Organizer
  International Conference on Endothelin ET-13
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 肺動脈性肺高血圧症に対する新規治療標的としてのTRPC3/6阻害効果の検討2013
- Author(s)
  木下秀之、桑原宏一郎、清中茂樹、森泰生、赤木達、中村一文、桒原佳宏、中川靖章、錦見俊雄、中尾一和
- Organizer
  第2回　日本肺循環学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] TRPC3/6阻害による肺動脈性肺高血圧症抑制効果の検討2013
- Author(s)
  木下秀之、桑原宏一郎、清中茂樹、森泰生、赤城達、中村一文、山田千夏、桒原佳宏、中川靖章、中尾一和
- Organizer
  第1回肺高血圧学会学術集会
- Place of Presentation
  慶応義塾大学　日吉キャンパス
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Glycosylation of plasma N-terminal proBNP and its effect on NT-proBNP assay in hemodyalysis patients2013
- Author(s)
  Yasuaki Nakagawa, Toshio Nishikimi, , Koichiro Kuwahara Yoshihiro Kuwabara, , Hideyuki Kinoshita, Makoto Takano, Satoru Usami, Kazuhiro Nakao, Takeya Minami, Yuko Yamada, Chinatsu Yamada, Junko Shibata, Kenji Ueshima and Kazuwa Nakao
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] PGI2持続点滴療法中の強皮症関連肺高血圧症に発症した右心不全に対しトルバプタンを使用した1症例の検討2013
- Author(s)
  森内健治、木下秀之、山田千夏、中尾一泰。桒原佳宏、保野慎治、中川靖章、錦見俊雄、上嶋健治、桑原宏一郎、中尾一和
- Organizer
  第115回日本循環器学会近畿地方会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 抗生剤ロック療法が有効であったカテーテル関連血流感染症の1例2013
- Author(s)
  小山和、奥田菜央、高橋恵子、中村友美、波多野雅子、松本紀子、長野仁美、田中澄江、木下秀之、桑原宏一郎
- Organizer
  第1回肺高血圧学会学術集会
- Place of Presentation
  慶応義塾大学　日吉キャンパス
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Transcriptional Repressor NRSF Plays an Essential Role in Maintaining Normal Cardiac Structure and Function After Birt2013
- Author(s)
  桑原佳宏, 桑原宏一郎, 木下秀之, 中川靖章, 宇佐美覚, 保野慎治, 中尾一泰, 南丈也, 山田優子, 山田千夏, 桑原純子, 錦見俊雄, 上嶋健治, 中尾一和
- Organizer
  日本循環器病学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 維持血液透析患者における血中B型(脳性)ナトリウム利尿ペプチド前駆体についての検討2013
- Author(s)
  中川靖章, 錦見俊雄, 桑原宏一郎, 保野慎治, 木下秀之, 桒原佳宏, 中尾一泰, 山田千夏, 上嶋健治, 中尾一和
- Organizer
  第17回日本心血管内分泌代謝学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 透析患者における血中B型(脳性)ナトリウム利尿ペプチド前駆体proBNPについての検討2013
- Author(s)
  中川靖章, 錦見俊雄, 桑原宏一郎, 保野慎治, 木下秀之, 桒原佳宏, 中尾一泰, 山田千夏, 上嶋健治, 中尾一和
- Organizer
  第61回心臓病学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Effect of hemodyalysis on precursor proBNP and glycosylated NT-proBNP in end-stage renal disease patients2013
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Yamada C, Nakao K, Ueshima K, Nakao K
- Organizer
  European Society of Cardiology 2013 (ESC 2013)
- Place of Presentation
  Amsterdam, Netherland
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 当院における強皮症、間質性肺炎を伴う肺高血圧症患者2症例に対するPGI2持続静注療法導入の試み2013
- Author(s)
  中村友美、長野仁美、龍英美子、高橋恵子、木下秀之、桒原佳宏、中川靖章、桑原宏一郎、山本善博、中尾一和
- Organizer
  第2回日本肺循環学会学術集会
- Place of Presentation
  東京ステーションコンファレンス
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Blockade of TRPC6 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling2013
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, Motohiro Nishida, Hitoshi Kurose, Shigeki Kiyonaka, Yasuo Mori, Chinatsu, Yamada, Yoshihiro Kuwabara, Shinji Yasuno, Yasuaki, Nakagawa, Toshio Nishikimi, Kenji Ueshima, Kazuwa Nakao
- Organizer
  The Thirteenth International Conference on Endothelin
- Place of Presentation
  University of Tsukuba, Tokyo Campus
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニンーアンジオテンシン系の検討2013
- Author(s)
  山田千夏、桑原宏一郎、木下秀之、錦見俊雄、中尾一泰、桒原佳宏、保野慎治、中川靖章、上嶋健治、中尾一和
- Organizer
  第86回　日本内分泌学会学術総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 大動脈病変を合併した側頭動脈炎と考えられた１症例の検討2013
- Author(s)
  川原さよ、木下秀之、米田智也、山田千夏、中尾一泰、桒原佳宏、保野慎治、中川靖章、錦見俊雄、上嶋健治、桑原宏一郎、中尾一和
- Organizer
  第115回日本循環器学会近畿地方会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 透析患者における血中N端proBNPの糖鎖修飾と測定系への影響について2013
- Author(s)
  中川靖章, 錦見俊雄, 桑原宏一郎, 保野慎治, 木下秀之, 桒原佳宏, 中尾一泰, 山田千夏, 上嶋健治, 中尾一和
- Organizer
  第2回臨床高血圧フォーラム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 受容体活性化型Ca2+チャネルTRPC3/6阻害の病的心肥大抑制効果2012
- Author(s)
  木下秀之、桑原宏一郎, 他
- Organizer
  第84回日本内分泌学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2012-04-22
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] TRPC3/6 Ion Channels as Potentially Novel Therapeutic Targets against Pulmonary Arterial Hypertension2012
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, Shigeki Kiyonaka, Yasuo Mori, Junko Shibata, Chinatu Yamada, Takeya Minami, Kazuhiro Nakao, Yoshihiro Kuwabara, Shinji Yasuno, Satoru Usami, Yasuaki Nakagawa, Toshio Nishikimi, Kenji Ueshima, KazuwaNakao
- Organizer
  The76th Annual Scientific Meeting of The Japanese CirculationSociety
- Place of Presentation
  Fukuoka International Congress Center, Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 肺動脈性肺高血圧症に対する新規治療法としてのTR PC3/6阻害の可能性2012
- Author(s)
  木下秀之, 桑原宏一郎, 清中茂樹, 森泰生, 赤木達, 中村一文, 桑原佳宏, 中川靖章, 錦見俊雄, 中尾一和
- Organizer
  第109回日本内科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] ｍｉＲ－１を介したＲｈｏ依存性転写共役因子ＭＲＴＦ－Ａ発現制御の血管リモデリングにおける意義2012
- Author(s)
  南　丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・錦見俊雄・中尾一和
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Overexpression of HCN Channels in Failing Heart Contributes to Increased Ventricular Arrhythmicity2012
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Hideyuki Kinoshita, Makoto Takano, Yasuaki Nakagawa, Satoru Usami, Kazuhiro Nakao, Takeya Minami, Yuko Yamada, Chinatsu Yamada, Kazuwa Nakao, et al.
- Organizer
  Basic Cardiovascular Sciences 2012 Scientific Sessions
- Place of Presentation
  New orleans
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニン阻害の有用性の検討2012
- Author(s)
  山田千夏桑原宏一郎木下秀之錦見俊雄桑原佳宏南丈也中尾一泰中川靖章中尾一和
- Organizer
  第15回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 血管リモデリングにおける新規治療標的としてのRho依存性転写共役因子MRTF-Aの意義2012
- Author(s)
  南　丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・錦見俊雄・中尾一和
- Organizer
  第49回日本臨床分子医学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 受容体活性化型Ca2+チャネルTRPC3/6阻害の病的心肥大抑制効果2012
- Author(s)
  木下秀之、桑原宏一郎, 他
- Organizer
  第84回日本内分泌学会学術集会
- Place of Presentation
  神戸国際会議場・神戸
- Year and Date
  2012-04-22
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] 慢性心不全・突然死モデルマウスの不整脈源性基質形成における、レニンーアンジオテンシン系の関与の検討2012
- Author(s)
  山田千夏　桑原宏一郎　木下秀之　桒原佳宏　南丈也　中尾一泰　宇佐美覚　保野慎治　中川靖章錦見俊雄　上嶋健治　中尾一和
- Organizer
  第29回日本心電学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure2012
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, Yoshihiro Kuwabara, Yasuaki Nakagawa, Chinatsu Yamada, Takeya Minami, Shinji Yasuno, Kazuhiro Nakao, Kazuwa Nakao, et al.
- Organizer
  第29回国際心臓研究学会(ISHR)日本部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] TRPC3/6 Ion Channels as potentially Novel Therapeutic Targets against Pulmonary Arterial Hypertension2012
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  Annual Scientific Meeting of the Japanese Circulation
- Place of Presentation
  福岡国際会議場・福岡
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Reciprocal expression of MRTF-A and myocardin mediated by miR-1 is crucial for phenotypic modulation of vascular smooth muscle cells2012
- Author(s)
  Takeya Minami, Koichiro Kuwahara, Yasuaki Nakagawa, Hideyuki Kinoshita, Kazuhiro Nakao, Yoshihiro Kuwabara, Yuko Yamada, Chinatsu Yamada, Junko Shibata, Kazuwa Nakao, et al.
- Organizer
  Arteriosclerosis, Thrombosis and Vascular BiologyScientific Session 2012
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Direct Renin Inhibitor Strongly Prevents Ventricular Arrhythmogenic Remodeling and Sudden Cardiac Death in Mice with Dilated Cardiomyopathy2012
- Author(s)
  Chinatsu Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, Yoshihiro Kuwabara, Takeya Minami, Kazuhiro Nakao, Shinji Yasuno, Yasuaki Nakagawa, Kenji Ueshima, Kazuwa Nakao,
- Organizer
  2012年米国心臓病学会議
- Place of Presentation
  Los Angelえs
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Overexpression of HCN Channels in Failing Heart Contributes to Increased Ventricular Arrhythmicity2012
- Author(s)
  Y. Kuwabara, K. Kuwahara, M. Takano, H. Kinoshita, Y. Nakagawa, S. Usami, K. Nakao, T. Minami, Y. Yamada, C. Yamada, J. Shibata, S. Yasuno, T. Nishikimi, K. Ueshima, K. Nakao
- Organizer
  Basic Cardiovascular Science 2012
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] TRPC3/6 Ion Channels as Potentially Novel Therapeutic Targets against Pulmonary Arterial Hypertension2012
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  The76th Annual Scientific Meeting of The Japanese CirculationSociety
- Place of Presentation
  福岡国際会議場・福岡
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] TRPC3/6 Ion Channels as potentially Novel Therapeutic Targets against Pulmonary Arterial Hypertension2012
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  The 76th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  福岡国際会議場・福岡
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] 拡張型心筋症マウスにおけるN型Ca2+チャネル阻害による自律神経活性調節を介した不整脈突然死予防の有用性2012
- Author(s)
  山田優子、桑原宏一郎、木下秀之、桑原佳宏、中川靖章、柴田純子、山田千夏、南丈也、保野慎治、宇佐美覚、中尾一泰、錦見俊雄、上嶋健治、森泰生、中尾一和
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Reciprocal expression of MRTF-A and Myocardin is crucial for pathological vascular remodeling in mice2012
- Author(s)
  Takeya Minami, Koichiro Kuwahara, Yasuaki Nakagawa, Hideyuki Kinoshita, Kazuhiro Nakao, Yoshihiro Kuwabara, Toshio Nishikimi, Kazuwa Nakao
- Organizer
  第29回国際心臓研究学会(ISHR)日本部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Direct renin inhibitor prevents ventricular remodeling and sudden arrhythmic death in mice with dilated cardiomyopathy2012
- Author(s)
  C. Yamada, K. Kuwahara, T. Minami, Y. Kuwabara, K. Nakao, H. Kinoshita, S. Usami, Y. Nakagawa, T. Nishikimi, K. Nakao
- Organizer
  2012年欧州心臓学会議
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Caチャネル阻害の有用性の検討2011
- Author(s)
  山田優子、桑原宏一郎、木下秀之, 他
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  栃木県総合文化センター・宇都宮
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] 受容体活性化型Ca2+チャネルTRPC3/6阻害の病的心肥大抑制効果2011
- Author(s)
  木下秀之、桑原宏一郎, 他
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸国際会議場・神戸
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Blockade of TRPC6/3 is a Novel Therapeutic Approach for Preventing Pathological Cardiac Hypertrophy2011
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, Motohiro Nishida, Hitoshi Kurose, Shigeki Kiyonaka, Yasuo Mori, Yoshihiro Kuwabara, Yasuaki Nakagawa, Kenji Ueshima, Kazuwa Nakao
- Organizer
  European Society of Cardiology Congress
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] N-Type Ca2+Channel Blocker is Effective to Prevent Sudden Cardiac Death in Mice with Heart Failure2011
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  Scientific Session of the American Heart Association 2011
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Blockade of TRPC6 is a Novel Therapeutic Approach Against Pathological Cardiac Hypertrophy2011
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  Congress of the European Society ofCardiology 2010
- Place of Presentation
  Paris, France
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] A Case of Severe Chronic Heart Failure Successfully Controlled with Long Term Administration of Tolvaptan ; a V(2)-specific Vasopressin Receptor Antagonists2011
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  第15回日本心不全学会学術集会
- Place of Presentation
  鹿児島市民文化ホール・鹿児島
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Inhibition of HCN Overexpressed in Failing Heart of Dilated Cardiomyopathy Mouse Model by Ivabradine Prevents Sudden Arrhythmic Death2011
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  第28回日本心電学会学術集会
- Place of Presentation
  ヒルトン福岡シーホーク・福岡
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure2011
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  第28回日本心電学会学術集会
- Place of Presentation
  ヒルトン福岡シーホーク・福岡
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Inhibition of HCN Over expressed in Failing Heart of Dilated Cardiomyopathy Mouse Model by Ivabradine Prevents Sudden Arrhythmic Death2011
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  Scientific Session of the American Heart Association 2011
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Blockade of TRPC6 is a Novel Therapeutic Approach Against Pathological Cardiac Hypertrophy2011
- Author(s)
  Hideyuki Kinoshita, Koichro Kuwahara, 他
- Organizer
  Congress of the European Society of Cardiology 2010
- Place of Presentation
  Paris, France
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] TRPC3/6 as Potentially Novel Therapeutic Targets for The Treatment of Pulmonary Arterial Hypertension2011
- Author(s)
  Hideyuki Kinoshita, Koichro Kuwahara, 他
- Organizer
  第15回日本心不全学会学術集会
- Place of Presentation
  鹿児鳥市民文化ホール・鹿児鳥
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Inhibition of HCN Overexpressed in Failing Heart of Dilated Cardiomyopathy Mouse Model by Ivabradine Prevents Sudden Arrhythmic Death2011
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  Scientific Session of the American Heart Association 2011
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] BNP遺伝子発現調節領域におけるserum response factor応答領域の新たなる同定とその心筋細胞肥大反応における意義2011
- Author(s)
  桑原宏一郎・木下秀之・桒原佳宏・中川靖章・南丈也・山田千夏・柴田純子・宇佐美覚・錦見俊雄・中尾一和
- Organizer
  第15回日本心血管内分泌学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] Inhibition of HCN Over expressed in Failing Heart of Dilated Cardiomyopathy Mouse Model by Ivabradine Prevents Sudden Arrhythmic Death2011
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  第28回日本心電学会学術集会
- Place of Presentation
  ヒルトン福岡シーホーク・福岡
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] 拡張型心筋症・不整脈刺モデルマウスにおけるN型Caチャネル阻害の有用性の検討2011
- Author(s)
  山田優子、桑原宏一郎、木下秀之, 他
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  栃木県総合文化センター・宇都宮
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Blockade of TRPC6/3 is a Novel Therapeutic Approach for Preventing Pathological Cardiac Hypertrophy2011
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  European Society of Cardiology Congress2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23390210
[Presentation] TRPC3/6 as Potentially Novel Therapeutic Targets for The Treatment of Pulmonary Arterial Hypertension2011
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  第15回日本心不全学会学術集会
- Place of Presentation
  鹿児島市民文化ホール・鹿児島
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] N-Type Ca2+Channel Blockade Prevents Sudden Death in Mice with Heart Failure2011
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  第28回日本心電学会学術集会
- Place of Presentation
  ルトン福岡シーホーク・福岡
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] N-Type Ca2+ Channel Blocker is Effective to Prevent Sudden Cardiac Death in Mice with Heart Failure2011
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  Scientific Session of the American Heart Association 2011
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Natriuretic Peptides-Guanylyl Cyclase-A Signaling Pathway Inhibits TRPC6-Mediated Pro-Hypertrophic Signaling in the Hearts2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara
- Organizer
  Scientific Session of the American Heart Association 2010
- Place of Presentation
  Chicago
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Blockade of TRPC6 is a novel therapeutic approach against pathological cardiac remodeling2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara
- Organizer
  第14回日本心不全学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] 新規心肥大治療法としてのTRPC阻害の効果2010
- Author(s)
  木下秀之、桑原宏一郎, 他.
- Organizer
  日本臨床分子医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure2010
- Author(s)
  木下秀之、桑原宏一郎
- Organizer
  第27回日本心電学会学術集会
- Place of Presentation
  大分
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Blockade of TRPC Channel Prevents Pathological Cardiac Hypertrophy2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  Scientific Session of the American Heart Association 2010
- Place of Presentation
  Chicago
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Blockade of TRPC6 is anovel therapeutic approach against pathological cardiac remodeling2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  第14回日本心不全学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Natriuretic Peptides-Guanylyl Cyclase-A Signaling Pathway Inhibits TRPC6-Mediated Pro-Hypertrophic Signaling in the Hearts2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara
- Organizer
  Scientific Session of the American Heart Associatinon 2010
- Place of Presentation
  Chicago
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] T-type Ca2+Channel Blockade Improved Cardiac Autonomic Nervous System Imbalance and Reduced Sudden Death in Mice Model of Chronic Heart Failure2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  Congress of the European Society of Cardiology 2010
- Place of Presentation
  Stockholm
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Natriuretic Peptides-Guanylyl Cyclase-A Signaling Pathway Inhibits TRPC6-Mediated Po-Hypertrophic Signaling in the Hearts2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara, 他
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Natriuretic Peptides-Guanylyl Cyclase-A Signaling Pathway Inhibits TRPC6-Mediated Po-Hypertrophic Signaling in the Hearts.2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism March
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] T-type Ca2+channelblockade in proved survival and arrhythmogenicity in the mouse model of myocardial infarction2010
- Author(s)
  Yoshihiro Kuwabara, KoichiroKuwahara, Yasuaki Nakagawa, HideyukiKinoshita, 他
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] N-Type Ca2+Channel Blockade Prevents Sudden Death in Mice With Heart Failure2010
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Rho and actin dynamics-dependent nuclear translocation of MRTF-A is a common molecular mechanisms underlying both mechanical stretch and neurohumoral stimulation -induced cardiac hypertrophy2010
- Author(s)
  Koichiro Kuwahara, Hideyuki Kinoshita
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure2010
- Author(s)
  Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] 新規心肥大治療法としてのTRPC阻害の効果2010
- Author(s)
  木下秀之、桑原宏一郎, 他
- Organizer
  臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2010-04-11
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Inhibition of TRPC6 channel activity mediates the anti-hypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.2010
- Author(s)
  木下秀之
- Organizer
  The73rd Annual Scientific Meeting of The Japanese CirculationSociety
- Place of Presentation
  京都
- Year and Date
  2010-03-07
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] T-Type Ca2+Channel Blockade Prevents Sudden Death in Mice With Heart Failure2010
- Author(s)
  木下秀之、桑原宏一郎, 他
- Organizer
  第27回日本心電学会学術集会
- Place of Presentation
  大分
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Rho and actindynamics-dependent nucleartranslocation fo MRTF-A is a common molecular mechanisms underlying both mechanical stretch-and neurohumoralstimulation. induced cardiachypertrophy2010
- Author(s)
  Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Inhibition of TRPC6 channel activity mediates the anti-hypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart2010
- Author(s)
  木下秀之
- Organizer
  The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- Place of Presentation
  京都
- Year and Date
  2010-03-07
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Essential role of p300 in maintaining mitochondrial gene expression and cell survival in the postnatal heart2010
- Author(s)
  Yasuaki Nakagawa, Koichiro Kuwahara, Hideyuki Kinoshita, 他
- Organizer
  14th Annual Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism
- Place of Presentation
  Nara, Japan
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] T-type Ca2+ Channel Blockade Improved Cardiac Autonomic Nervous System Imbalance and Reduced Sudden Death in Mice Model of Chronic Heart Failure2010
- Author(s)
  Hideyuki Kinoshita, Koichiro Kuwahara
- Organizer
  Congress of the European Society of Cardiology 2010
- Place of Presentation
  Stockholm
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-22790702
[Presentation] Cardiac natriuretic peptides inhibit TRPC6-mediated pro-hypertrophic signaling.2009
- Author(s)
  木下秀之
- Organizer
  第10回US-Japan-Asia Dialogue on Cardiovascular Diseases.
- Place of Presentation
  東京
- Year and Date
  2009-08-22
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] ナトリウム利尿ペプチドの心保護作用におけるTRPC6の役割2009
- Author(s)
  木下秀之
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋、群馬
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Protein Kinase G-mediated inhibition of TRPC6 channel activity participates in anti-hypertrophic effect of cardiac natriuretic peptides2009
- Author(s)
  Kinoshita H, Kuwahara K, Nakao K, et.al.
- Organizer
  The 73rd Annual Scientific Meeting of the Japanese Circulation Scoiety
- Place of Presentation
  大阪市、大阪府
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Cardiac ntriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway.2009
- Author(s)
  木下秀之
- Organizer
  4th International Conference on cGMP.
- Place of Presentation
  Regensburg, Germany
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] ナトリウム利尿ペプチドの抗心肥大作用におけるTRPC6抑制の役割.2009
- Author(s)
  木下秀之
- Organizer
  第13回Molecular Cardiovascular Conference
- Place of Presentation
  キロロ、北海道
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Cardiac natriuretic peptides inhibit TRPC6-mediated pro-hypertrophic signaling2009
- Author(s)
  木下秀之
- Organizer
  第10回US-Japan-Asia Dialogue on Cardiovascular Diseases
- Place of Presentation
  東京
- Year and Date
  2009-08-22
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] ナトリウム利尿ペプチドの抗心肥大作用におけるTRPC6抑制の役割2009
- Author(s)
  木下秀之
- Organizer
  第13回Molecular Cardiovascular Conference
- Place of Presentation
  キロロ、北海道
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Cardiac ntriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway2009
- Author(s)
  木下秀之
- Organizer
  4^<th> International Conference on cGMP
- Place of Presentation
  Regensburg, Germany
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Protein Kinase G-mediated inhibition of TRPC6 channel activity participates in anti-hypertrophic effect of cardiac natriuretic peptides.2009
- Author(s)
  Kinoshita H
- Organizer
  The 73rd Annual Scientific Meeting of the Japanese Circulation Scoiety.
- Place of Presentation
  大阪市、大阪府
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] ナトリウム利尿ペプチドの心保護作用におけるTRPC6の役割.2009
- Author(s)
  木下秀之
- Organizer
  第82回日本内分泌学会学術総会.
- Place of Presentation
  前橋、群馬
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Blockade of T-type Ca2+ channel corrects imbalance in cardiac autonomic nerve activity and prevents sudden arrhythmic death in chronic heart failure in mice.2008
- Author(s)
  Kinoshita, K
- Organizer
  Basic Cardiovascular Science Conference 2008.
- Place of Presentation
  Keystone, Colorado
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Blockade of T-type Ca^<z+> channel corrects imbalance in cardiac autonomic nerve activity and prevents sudden arrhythmic death in chronic heart failure in mice2008
- Author(s)
  Kinoshita,K, Kuwahara K, et.al.
- Organizer
  Basic Cardiovascular Science Conference 2008
- Place of Presentation
  Keystone, Colorado
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] T型カルシウムチャンネルは心不全モデルにおいて自律神経機能を介して、致死性不整脈発症に関与する.2008
- Author(s)
  木下秀之
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本市、熊本県
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] T型カルシウムチャンネルは心不全モデルにおいて自律神経機能を介して、致死性不整脈発症に関与する2008
- Author(s)
  木下秀之、桑原宏一郎、中尾一和、他
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本市、熊本県
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-20790526
[Presentation] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice
- Author(s)
  Minami T, Kuwahara K, Kuwabara Y, Cho K, Kinoshita H, Nakagawa Y, Ueda K, Kimura T.
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto
- Year and Date
  2014-04-14 – 2014-04-18
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Role of O-glycosylation in N-terminal region of human proBNP in its processing mechanisms
- Author(s)
  Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Shinji Yasuno, Hideyuki Kinoshita, Yoshihiro Kuwabara, Kazuhiro Nakao, Chinatsu Yamada, Kenji Ueshima, Naoto Minamino, Takeshi Kimura, Kazuwa Nakao
- Organizer
  AHA Scientific Sessoins
- Place of Presentation
  Chicago
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 肺血管拡張薬中止理由の検討と病棟専従薬剤師の役割の考察
- Author(s)
  吉田優子、吉田詩織、木下美津子、松原和夫、木下秀之、中川靖章、牧山武、静田聡、桑原宏一郎、木村剛
- Organizer
  第2回日本肺高血圧学会（JPHS）第3回日本肺循環学会（JPCS）合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Role of O-glycosylation in N-terminal region of human proBNP in its processing mechanisms
- Author(s)
  Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Shinji Yasuno, Hideyuki Kinoshita, Yoshihiro Kuwabara, Kazuhiro Nakao, Chinatsu Yamada, Kenji Ueshima, Naoto Minamino, Takeshi Kimura, Kazuwa Nakao
- Organizer
  AHA Scientific Sessoins 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] C-type Natriuretic Peptide Derived from Vascular Endothelial Cells Contributes to the Regulation of Blood Pressure
- Author(s)
  Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Tokudome T, Sone M, Kimura T, Kangawa,K and Nakao K
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto
- Year and Date
  2014-04-14 – 2014-04-18
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 肺動脈性肺高血圧症における肺移植術後早期の左室機能の検討
- Author(s)
  米田智也、木下秀之、土井孝浩、山田徹、佐藤雅昭、青山晃博、陳豊史、桑原宏一郎、伊達洋至、木村剛
- Organizer
  第2回日本肺高血圧学会（JPHS）第3回日本肺循環学会（JPCS）合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Pivotal involvement of renin-angiotensin system in promoting arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
- Author(s)
  Chinatsu Yamada, Koichiro Kuwahara, Hideyuki Kinoshita,Yasuaki Nakagawa, Toshio　Nishikimi Kazuwa Nakao, Takeshi Kimura
- Organizer
  第18回日本心不全学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-10 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Increased Expression of HCN channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Makoto Takano, Hideyuki Kinoshita, Yuji Arai, Yasuaki Nakagawa, Shinji Ysuno, Sachiyo Igata, Satoru Usami, Takeya Minami, Yuko Yamada, Kazuhiro Nakao, Chinatsu Yamada, Junko Shibata, Toshio Nishikimi,Kenji Ueshima, Kazuwa Nakao
- Organizer
  第31回日本心電学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Pivotal involvement of renin-angiotensin system in promoting arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
- Author(s)
  Chinatsu Yamada, Koichiro Kuwahara, Hideyuki Kinoshita,Yasuaki Nakagawa, Toshio　Nishikimi Kazuwa Nakao, Takeshi Kimura
- Organizer
  第18回日本心不全学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-10 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 肺高血圧症合併肺ランゲルハンス細胞組織球症に対する治療経過
- Author(s)
  柳澤洋、木下秀之、中川靖章、牧山武、静田聡、桑原宏一郎、木村剛山田徹、伊達洋至
- Organizer
  第2回日本肺高血圧学会（JPHS）第3回日本肺循環学会（JPCS）合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Increased Expression of HCN channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Makoto Takano, Hideyuki Kinoshita, Yuji Arai, Yasuaki Nakagawa, Shinji Ysuno, Sachiyo Igata, Satoru Usami, Takeya Minami, Yuko Yamada, Kazuhiro Nakao, Chinatsu Yamada, Junko Shibata, Toshio Nishikimi,Kenji Ueshima, Kazuwa Nakao
- Organizer
  第31回日本心電学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 肺動脈性肺高血圧症患者に対する最新の治療を考える
- Author(s)
  木下秀之、柳澤洋、山田千夏、中川靖章、牧山武、静田聡、桑原宏一郎、木村剛
- Organizer
  日本心臓病学会・日本心臓リハビリテーション学会ジョイントシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-09-26 – 2014-09-28
- Invited
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] Critical involvement of renin-angiotensin system for developing arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
- Author(s)
  C. Yamada, K. Kuwahara, Y. Kuwabara, H. Kinoshita, Y. Nakagawa, T. Nihikimi, K. Nakao, T. Kimura
- Organizer
  ESC 2014.8.30-9.3
- Place of Presentation
  Barcelona
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Critical involvement of renin-angiotensin system for developing arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
- Author(s)
  C. Yamada, K. Kuwahara, Y. Kuwabara, H. Kinoshita, Y. Nakagawa, T. Nihikimi, K. Nakao, T. Kimura
- Organizer
  European Society of Cardiology
- Place of Presentation
  Barcelona
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 拡張型心筋症モデルマウスにおけるN型Ca2+チャネル阻害は自律神経バランスを改善し突然死を予防する
- Author(s)
  桑原宏一郎、山田優子、木下秀之、中川靖章、柴田純子、山田千夏、森泰生、中尾一和、木村剛
- Organizer
  第37回　日本高血圧学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-24591095
[Presentation] 拡張型心筋症モデルマウスにおけるN型Ca2+チャネル阻害は自律神経バランスを改善し突然死を予防する
- Author(s)
  桑原宏一郎、山田優子、木下秀之、中川靖章、柴田純子、山田千夏、森泰生、中尾一和、木村剛
- Organizer
  第37回　日本高血圧学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 脳性(B型)ナトリウム利尿ペプチド前駆体proBNPプロセシングにおける糖鎖結合の役割
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之、桒原佳宏、山田千夏、中尾一泰、保野慎治、上嶋健治、木村剛、南野直人、中尾一和
- Organizer
  第51回　日本臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 脳性(B型)ナトリウム利尿ペプチド前駆体proBNPプロセシングにおける糖鎖結合の役割
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之、桒原佳宏、山田千夏、中尾一泰、保野慎治、上嶋健治、木村剛、南野直人、中尾一和
- Organizer
  第51回　日本臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-24591095

1. KUWAHARA Koichiro (30402887)

# of Collaborated Projects: 9 results

# of Collaborated Products: 118 results
2. NAKAGAWA Yasuaki (70452357)

# of Collaborated Projects: 7 results

# of Collaborated Products: 63 results
3. NISHIDA Motohiro (90342641)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. MORI Yasuo (80212265)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
5. TAKANO Makoto (30236252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. ARAI Yuji (30202724)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. NISHIKIMI Toshio (80291946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 43 results
8. YAMADA mitsuhiko (10263237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. 元木博彦 (50532058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 野村征太郎 (10722118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 牧山武 (30528302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 森内健史 (50872941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 泉知里 (70768100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 北井豪 (10470204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Neubig Richard

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Olson Eric N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIURA Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. YAMAZAKI Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中尾一和

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
20. 南野直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 前川平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 本荘晴朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoshita Hideyuki 木下 秀之

KINOSHITA Hideyuki 木下 秀之

Research Projects

Research Products

Co-Researchers

Investigation of Cardiac Epigenomic Circuit in the Development of Heart Failure and Identification of Potential Therapeutic Targets

Principal Investigator

Project Period (FY)

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心不全患者におけるTRPC3/C6シグナルのバイオマーカーとしての潜在的意義の検討

Principal Investigator

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肺動脈性肺高血圧症におけるTRPC6, CNP経路の研究Principal Investigator

Principal Investigator

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Review Section

Research Institution

Elucidation of transcriptional and epigenomic circuit ro reveal molecular mechanisms underlying heart failure and identify novel therapeutic targets

Principal Investigator

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Review Section

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Potential significance of TRPC3/6 and CNP as novel therapeutic targets of pulmonary arterial hypertensionPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function

Principal Investigator

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Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial HypertensionPrincipal Investigator

Principal Investigator

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Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism

Principal Investigator

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Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pathological Cardiac RemodelingPrincipal Investigator

Principal Investigator

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Research Institution

Elucidation of transcriptional and epigenomic regulation in the development of heart failure

Principal Investigator

Project Period (FY)

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Research Institution

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heartPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Elucidation of roles of TRPC ion channels in pathological cardiac remodelingPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 右心不全を識り評価して治療に活かす 右心不全・肺高血圧症治療に使用する薬剤一覧2015

Author(s)

Total Pages

Kinoshita Hideyuki 木下秀之

KINOSHITA Hideyuki 木下秀之

[Book] 右心不全を識り評価して治療に活かす右心不全・肺高血圧症治療に使用する薬剤一覧2015

[Journal Article] B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction　― Relevance to Age-Related Left Ventricular Modeling in Japanese ―2017