Bakalova Rumiana Rumiana Bakalova

… Alternative Names

RUMIANA Bakalova RUMIANA Bakalova

BAKALOVA Rumiana バカロバルミアナ

Less

Researcher Number	30469936
Other IDs	https://orcid.org/0000-0003-3653-0823
Affiliation (based on the past Project Information) *help	2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 主任研究員(任常) 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所・分子イメージング診断治療研究部, 主任研究員(任常) 2019: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, 主任研究員(任常) 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 主任研究員(任常) 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 2013: 独立行政法人放射線医学総合研究所, 分子イメージングセンター, 主任研究員 2008 – 2012: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員
Review Section/Research Field	Principal Investigator Basic Section 28040:Nanobioscience-related / Chemical biology / Biomedical engineering/Biological material science Except Principal Investigator Medical Physics/Radiological Technology
Keywords	Principal Investigator 蛍光イメージング / MRI / 量子ドット / センサー / fluorescent imaging / Nitroxides / Quantum dots / 腫瘍 / Oxidative Stress Mapping / Fluorescence Imaging … More / hypercholesterolemia / mitochondria / Nitroxyl Radical / Redox / in vivo / redox status / molecular sensors / quantum dots / EPR / Nitroxide / redox / 反応性造影剤 / 蛍光 / 酸化還元 / レドックス / ニトロキシルラジカル / cancer / EPR imaging / nitroxides / quantum dot / polymersomes / nanoparticles / drug-delivery systems / in vivo イメージング / DDS / ニトロキシラジカル / 量子ドッド / Cancer / Drug delivery systems / Polymersomes / in vivoイメージング / マルチモーダル / 大腸癌 / 大腸がん / シリカ / マルチプローブ / 複合画像 / 分子イメージング / ナノバイオ材料 … More Except Principal Investigator neuroblastoma / nitroxide / 電子スピン共鳴 / フリーラジカル / 高磁場MRI / 大腸がん / 酸化還元状態 / マウス / ESR / 酸化還元 / ニトロキシルラジカル / Nitroxyl / Cancer / MRI Less

New quantum biosensors for quantitative molecular imaging assays of oxidative stressPrincipal Investigator
- Principal Investigator
  
  Bakalova Rumiana
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Quantum dot/nitroxide-based sensing platform for image-guided drug delivery in cancerPrincipal Investigator
- Principal Investigator
  
  RUMIANA Bakalova
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  National Institute of Radiological Sciences
Originally Synthesized Oxy-Redox Sensitive Contrast Substances for in vivo Mapping of Tissue Redox and Oxidant Status in Cancer Using High Field MRI
- Principal Investigator
  
  ZHELEV Zhivko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical Physics/Radiological Technology
- Research Institution
  National Institute of Radiological Sciences
Nanobioprobes for Multimodal Imaging Diagnostics of Cancer in Experimental AnimalsPrincipal Investigator
- Principal Investigator
  
  RUMIANA Bakalova
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Institute of Radiological Sciences

All 2021 2020 2019 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging2021
- Author(s)
  Lazarova Dessislava、Semkova Severina、Zlateva Genoveva、Tatsuya Higashi、Aoki Ichio、Bakalova Rumiana
- Journal Title
  
  Analytical Chemistry
  
  Volume: 93 Issue: 5 Pages: 2828-2837
- DOI
  10.1021/acs.analchem.0c04116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant2020
- Author(s)
  Bakalova Rumiana、Semkova Severina、Ivanova Donika、Zhelev Zhivko、Miller Thomas、Takeshima Tsuguhide、Shibata Sayaka、Lazarova Dessislava、Aoki Ichio、Higashi Tatsuya
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2020 Pages: 1-30
- DOI
  10.1155/2020/6212935
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration?2020
- Author(s)
  Bakalova Rumiana、Zhelev Zhivko、Miller Thomas、Aoki Ichio、Higashi Tatsuya
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2020 Pages: 1-12
- DOI
  10.1155/2020/1504048
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin2020
- Author(s)
  SEMKOVA SEVERINA、ZHELEV ZHIVKO、MILLER THOMAS、SUGAYA KIMIHIKO、AOKI ICHIO、HIGASHI TATSUYA、BAKALOVA RUMIANA
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 4 Pages: 1963-1972
- DOI
  10.21873/anticanres.14151
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy2020
- Author(s)
  Bakalova Rumiana、Zhelev Zhivko、Miller Thomas、Aoki Ichio、Higashi Tatsuya
- Journal Title
  
  Redox Biology
  
  Volume: 28 Pages: 101357-101357
- DOI
  10.1016/j.redox.2019.101357
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN382020
- Author(s)
  NIKOLOVA BILIANA、SEMKOVA SEVERINA、TSONEVA IANA、STOYANOVA ELENA、LEFTEROV PAVEL、LAZAROVA DESSISLAVA、ZHELEV ZHIVKO、AOKI ICHIO、HIGASHI TATSUYA、BAKALOVA RUMIANA
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 9 Pages: 5159-5170
- DOI
  10.21873/anticanres.14519
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress.2019
- Author(s)
  Lazarova D., Shibata S., Ishii I., Zlateva G., Zhelev Z., Aoki I., Higashi T., Bakalova R.
- Journal Title
  
  Gen. Physiol. Biophys.
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Imaging of redox-balance and oxidative stress in kidney in vivo, induced by dietary cholesterol.2019
- Author(s)
  Lazarova D., Shibata S., Ishii I., Zlateva G., Zhelev Z., Aoki I., Bakalova R.
- Journal Title
  
  Biotechnol. Biotehnol. Equip.
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes2019
- Author(s)
  IVANOVA DONIKA、ZHELEV ZHIVKO、SEMKOVA SEVERINA、AOKI ICHIO、BAKALOVA RUMIANA
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 7 Pages: 3745-3755
- DOI
  10.21873/anticanres.13523
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18F18766, KAKENHI-PROJECT-18K04909
[Journal Article] “Redox imaging” to distinguish cells with different proliferative indexes: Superoxide, hydroperoxides and their ration as potential biomarkers.2019
- Author(s)
  Zhelev Z., Georgieva E., Lazarova D., Semkova S., Aoki I., Higashi T., Bakalova R.
- Journal Title
  
  Oxid. Med. Cell. Long.
  
  Volume: なし Pages: 6373685-6373685
- DOI
  10.1155/2019/6373685
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress2019
- Author(s)
  Lazarova D.、Shibata S.、Ishii I.、Zlateva G.、Zhelev Z.、Aoki I.、Higashi T.、Bakalova Rumiana
- Journal Title
  
  General physiology and biophysics
  
  Volume: 38 Issue: 03 Pages: 191-204
- DOI
  10.4149/gpb_2019001
- Data Source
  KAKENHI-PROJECT-18K04909
[Journal Article] Lymph node mapping using quantum dot-labeled polymersomes.2015
- Author(s)
  Bakalova R., Z. Zhelev, B. Nikolova, S. Murayama, I. Tsoneva, I. Aoki, T. Saga.
- Journal Title
  
  Gen. Physiol. Biophys.
  
  Volume: 0 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] Delivery of size-controlled long-circulating polymersomes in solid tumors, visualized by quantum dots and optical imaging in vivo2014
- Author(s)
  2.Bakalova R., D. Lazarova, B. Nikolova, S. Atanasova, G. Zlateva, Z. Zhelev, and I. Aoki.
- Journal Title
  
  Biotechnol. Biotechnol. Equip
  
  Volume: 0 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] Delivery of size-controlled long-circulating polymersomes in solid tumors, visualized by quantum dots and optical imaging in vivo.2014
- Author(s)
  R. Bakalova, Z. Zhelev, D. Lazarova, I. Aoki, T. Saga.
- Journal Title
  
  Biotechnol. Biotechnol. Equip.
  
  Volume: 0 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] In vivo visualization of electro-assisted delivery of nanoparticles in cancer using optical imaging,2014
- Author(s)
  3.Atanasova S., D. Lazarova, B. Nikolova, Z. Zhelev, T. Tsoneva, I. Aoki, and R. Bakalova
- Journal Title
  
  Anticancer Res.
  
  Volume: 34 Pages: 5819-5821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle.2013
- Author(s)
  Z. Zhelev, I. Aoki, V. Gadjeva, B. Nikolova, R. Bakalova, T. Saga.
- Journal Title
  
  Eur. J. Cancer
  
  Volume: 49（６） Issue: 6 Pages: 1467-1478
- DOI
  10.1016/j.ejca.2012.10.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer.2013
- Author(s)
  Z. Zhelev, R. Bakalova, I. Aoki, T. Saga.
- Journal Title
  
  Clin. Cancer Res.,
  
  Volume: 19（９） Pages: 2503-2517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] Cell-penetrating nitroxides as molecular sensors for imaging of cancer in vivo, based on tissue redox activity2012
- Author(s)
  Zhelev Z, Gadjeva V, Aoki I, Bakalova R, Saga T
- Journal Title
  
  Molecular BioSystems
  
  Volume: 8 Issue: 10 Pages: 2733-2740
- DOI
  10.1039/c2mb25128k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510321
[Journal Article] Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics2011
- Author(s)
  Bakalova R., Zhelev Z., Kokuryou D., Spasov L., Aoki I., Saga T.
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 6:1719 Pages: 1719-1732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics2011
- Author(s)
  Bakalova R, Zhelev Z, Kokuryo D, Spasov L, Aoki I, Saga T
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 6 Pages: 1719-32
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Nitroxide derivatives for imaging of hypercholesterolemia-induced kidney dysfunction and assessing the effectiveness of antilipidemic drugs2011
- Author(s)
  Tomizawa A, Hadjidekov G, Ishii I, Bakalova R, Zhelev Z, Aoki I, Saga T, Kitada M
- Journal Title
  
  Mol Pharm
  
  Volume: 8(5) Pages: 1962-9
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Chemical nature and structure of organic coating of quantum dots iscrucial for their application in imaging diagnostic in vivo2011
- Author(s)
  Bakalova R., Z.Zhelev, D.Kokuryo, L.Spasov, I.Aoki, S.Saga
- Journal Title
  
  International Journal of Nanomedicine
  
  Volume: in Press(Peer-review)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Nitroxide derivatives for imaging of hypercholesterolemia-induced kidney dysfunction and assessing the effectiveness of antilipidemic drugs2011
- Author(s)
  Tomizawa A., Hadjidekov G., Ishii II., Bakalova R., Zheliv Z., Aoki I., Saga T., Kitada M.
- Journal Title
  
  Mol Pharm
  
  Volume: 3;8(5):1962-9 Pages: 1962-1969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Chemical nature and structure of organic coating of quantum dots iscrucial for their application in imaging diagnostic in vivo2011
- Author(s)
  Bakalova R., Z.Zhelev, D.Kokuryo, L.Spasov, I.Aoki, S.Saga
- Journal Title
  
  International Journal of Nanornedicine
  
  Volume: in Press(Peer-review)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Carbamoyl-PROXYL-enhanced MRI detects very small disruptions in brain vascular permeability induced by dietary cholesterol2011
- Author(s)
  Tomizawa A, Ishii I, Zhelev Z, Aoki I, Shibata S, Kitada M, Bakalova R
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1810(12) Pages: 1309-16
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Imaging of cancer by redox-mediated mechanism : a radical diagnostic approach2010
- Author(s)
  Zhelev Z, Bakalova R, Aoki I, Gadjeva V, Kanno I
- Journal Title
  
  Mol Biosyst
  
  Volume: 6(12) Pages: 2386-8
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Imaging of cancer by redox mediated mechanism : a radical diagnostic approach2010
- Author(s)
  Zhivko Zhelev, Rumiana Bakalova-Zheleva, Ichio Aoki, Gadjeva Veselina, Iwao Kanno
- Journal Title
  
  Molecular BioSystems
  
  Volume: 6(12) Pages: 2386-2388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Contribution of nitric oxide to cerebral blood flow regulationunder hypoxia in rats.2010
- Author(s)
  Hiroyuki Takuwa, Tetsuya Matsuura, Rumiana Bakalova-Zheleva.Takayuki Obata, Iwao Kanno
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 60(6) Pages: 399-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Imaging of cancer by redox-mediated mechanism : a radical diagnostic approach.2010
- Author(s)
  Zhelev Z, Bakalova R, Aoki I, Gadjeva V, Kanno I
- Journal Title
  
  Mol Biosyst.(Epub 2010 Oct 8. PubMed PMID : 20936212) 6(12)
  
  Pages: 2386-8
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Imaging of cabcer bt redix mediated mechanism : a redical diagnostic approach2010
- Author(s)
  Zhivko Zhelev.Rumiana Bakalova-Zheleva, Ichio Aoki, Gadjeva Veselina, Iwao Kanno
- Journal Title
  
  Molecular BioSystems
  
  Volume: 6(12) Pages: 2386-2388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier : relationship between structure, blood clearance, and MRI signal dynamic in the brain.2009
- Author(s)
  Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I
- Journal Title
  
  Mol Pharm.(PubMed PMID : 19718801) 6(2)
  
  Pages: 504-12
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier : relationship between structure, blood clearance, and MRI signal dynamic in the brain2009
- Author(s)
  Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I
- Journal Title
  
  Mol Pharm
  
  Volume: 6(2) Pages: 504-12
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] EPR signal reduction kinetic of several nitroxyl derivatives in blood in vitro and in vivo2009
- Author(s)
  Zhelev Z, Matsumoto K, Gadjeva V, Bakalova R, Aoki I, Zheleva A, Anzai K
- Journal Title
  
  Gen Physiol Biophys
  
  Volume: 28(4) Pages: 356-62
- Data Source
  KAKENHI-PROJECT-21611011
[Journal Article] Nitroxyl radicals as low toxic spin-labels for non-invasivemagnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics.2009
- Author(s)
  Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I
- Journal Title
  
  Chem Commun (Camb).(Epub 2008 Nov 13. PubMed PMID : 19081996) 7;(1)
  
  Pages: 53-5
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Nitroxyl Radicals for Labeling of Conventional Therapeutics and Noninvasive Magnetic Resonance Imaging of Their Permeability for Blood-Brain Barrier : Relationship between Structure, Blood Clearance, and MRI Signal Dynamic in the Brain.2009
- Author(s)
  Zhelev Z, Bakalova R, Aoki I, Matsumoto KI, Gadjeva V, Anzai K, Kanno I
- Journal Title
  
  Mol Pharm.(PubMed PMID : 19206512) (Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] EPR signal reduction kinetic of several nitroxyl derivatives in blood in vitro and in vivo.2009
- Author(s)
  Zhelev Z, Matsumoto K, Gadjeva V, Bakalova R, Aoki I, Zheleva A, Anzai K
- Journal Title
  
  Gen Physiol Biophys.(PubMed PMID : 20097958) 28(4)
  
  Pages: 356-62
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Quantum dots versus organic fluorophores in fluorescent deep-tissue imaging--merits and demerits.2008
- Author(s)
  Bakalova R, Zhelev Z, Gadjeva V
- Journal Title
  
  Gen Physiol Biophys.(PubMed PMID : 19202196) 27(4)
  
  Pages: 231-42
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Quantum dots versus organic fluorophores in fluorescent deep-tissue imaging-merits and demerits2008
- Author(s)
  Bakalova R., Zhelev Z., Gadjeva V.
- Journal Title
  
  General Physiology & Biophysics 27
  
  Pages: 231-242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Multimodal silica-shelled quantum dots : Direct intracellular delivery, photosensitization, toxic and microcirculation effects2008
- Author(s)
  Bakalova R., Zhelev Z., Aoki I., Masamoto K., Mileva M., Obata T., Higuchi M., Gadjeva V., Kanno I.
- Journal Title
  
  Bioconjugate Chemistry 19
  
  Pages: 1135-1142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500415
[Journal Article] Multimodal silica-shelled quantum dots : direct intracellular delivery, photosensitization, toxic, and microcirculation effects.2008
- Author(s)
  Bakalova R, Zhelev Z, Aoki I, Masamoto K, Mileva M, Obata T, Higuchi M, Gadjeva V, Kanno I
- Journal Title
  
  Bioconjug Chem.(Epub 2008 May 22. PubMed PMID : 18494515) 19(6)
  
  Pages: 1135-42
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Quantum sensors for mapping of oxidative stress in cells and tissues using EPR, MRI and optical imaging2019
- Author(s)
  Rumiana Bakalova, Severina Semkova, Zhivko Zhelev, Ichio Aoki
- Organizer
  第14回日本分子イメージング学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K04909
[Presentation] New redoxomic-based strategy in cancer – predictive medicine2019
- Author(s)
  Severina Semkova, Desislava Lazarova, Zhivko Zhelev, Biliana Pancheva Nikolova-Lefterova, Rumiana Bakalova, Ichio Aoki
- Organizer
  International Congress of Medical Sciences 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04909
[Presentation] Imaging of Tissue redox activity from early to terminal stage of cancer development using nitroxide enhanced MRI.2013
- Author(s)
  3. Bakalova R., Z. Zhelev, D. Kokuryo,. I. Aoki, V, Gadjeva, and T. Saga.
- Organizer
  6th World Molecular Imaging Congress,
- Place of Presentation
  Savannah, Georgia, USA,
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] Tissue redox activity as a sensing platform for imaging of cancer, based on nitroxide redox ｃｙｃle.2013
- Author(s)
  2. Bakalova R., Z. Zhelev, I. Aoki, D. Kokuryo,V. Gadjeva, and T. Saga.
- Organizer
  ISMRM 21st Annual Meeting and Exhibition,
- Place of Presentation
  Salt Lake, Utah, US,
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] – Delivery of quantum dots in cancer using size-controlled long-circulating polymersomes, International Conference “Bioscience –2013
- Author(s)
  4. Lazarova D., Z. Zhelev, G. Zlateva, I. Aoki, and R. Bakalova.
- Organizer
  Development and New Opportunities
- Place of Presentation
  Sofia, Bulgaria.
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] Cell-penetrating nitroxides, but not non-penetrating, are molecular sensors for imaging of cancer in vivo based on tissue redox activity2012
- Author(s)
  Bakalova R, Zhelev Z, Gadjeva V, Aoki I, Kokuryo D, Saga T
- Organizer
  第7回日本分子イメージング学会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] Tissue Redox Activity as a Sensing Platform for Magnetic Resonance Imaging of Cancer: Diagnostic and Therapeutic Aspects2012
- Author(s)
  Bakalova R., Zhelev Z., Kokuryo D., Aoki I., Gadjeva V., Saga T
- Organizer
  World Molecular Imaging Congress 2012
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] -Magnetic resonance imaging of redox activity in the brain of normal and cancer-bearing mammalians : a radical diagnostic approach2011
- Author(s)
  Zhelev, Z., R. Bakalova, S. Shibata, L. Spasov, and I. Aoki
- Organizer
  XXVth International Symposium on Ccerebral Blood Flow, Metabolism and Function
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] -Nitroxide probes as redox sensors for imaging of cancer in vivo2011
- Author(s)
  Bakalova, R., Z. Zhelev, S. Shibata, L. Spasov, and I. Aoki
- Organizer
  International Conference on Biomaterials Science
- Place of Presentation
  Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] -Magnetic resonance imaging of very small disruptions of blood vessel permeability in hypercholesterolemia mice using nitroxide probes2010
- Author(s)
  Bakalova, R., I. Ishii, Z. Zhelev, S. Shibata, I. Aoki, and M. Kitada
- Organizer
  Annual Conference of the Japanese Society for Molecular Imaging
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Diagnostic Potential of Nitroxide Radicals in Cancer Using Magnetic Resonance Imaging Tomography2010
- Author(s)
  Rumiana Bakalova-Zheleva, Zhivko Zhelev, Gadjeva Veselina, Ichio Aoki
- Organizer
  日本分子イメージング学会
- Place of Presentation
  日本大津市(ポスター発表)
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Diagnostic Potential of Nitroxide Radicals in Cancer Using Magnetic Resonance Imaging Tomography2010
- Author(s)
  Zhivko Zhelev, Rumiana Bakalova-Zheleva, Ichio Aoki, Gadjeva Veselina, Iwao Kanno
- Organizer
  日本分子イメージング学会
- Place of Presentation
  日本大津市(口頭発表)
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Magnetic Resonance Imaging of Cancer Based on Tissue Redlox Activity2010
- Author(s)
  Zhivko Zhelev Rumiana Bakalova-Zheleva, Ichio Aoki, Sayaka Shibata, Gadjeva Veselina, Iwao Kanno
- Organizer
  The Society for Molecular Imaging
- Place of Presentation
  日本京都市
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Magnetic Resonance Imaging of Cancer Based on issue Red/ox Activity2010
- Author(s)
  Zhivko Zhelev, Rumiana Bakalova-Zheleva, Ichio Aoki, Sayaka Shibata, Gadjeva Veselina, Iwao Kanno
- Organizer
  The Society for Molecular Imaging
- Place of Presentation
  日本京都市
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Diagnostic Potential of Nitroxide Radicals in Cancer Using Magnetic Resonance Imaging Tomography2010
- Author(s)
  Zhivko Zhelev, Rumiana Bakalova-Zheleva, Ichio Aoki, Gadjeva Veselina, Iwao Kanno
- Organizer
  日本分子イメージング学会
- Place of Presentation
  日本大津市(口頭発表)
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Magnetic Resonance Imaging of Very Small Disruptions of Blood Vessel Permeability in Hypercholesterolemia Mice Using Nitroxide Probes2010
- Author(s)
  Rumiana Bakalova-Zheleva, Itsuko Ishii, Zhivko Zhelev, Ichio Aoki, Iwao Kanno, et.al
- Organizer
  日本分子イメージング学会
- Place of Presentation
  日本大津市(ポスター発表)
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Magnetic Resonance Imaging of Very Small Disruptions of Blood Vessel Permeability in Hypercholesterolemia Mice Using Nitroxide Probes2010
- Author(s)
  Rumiana Bakalova-Zheleva, Itsuko Ishii, Zhivko Zhelev, Ichio Aoki, Iwao Kanno, et.al
- Organizer
  日本分子イメージング学会
- Place of Presentation
  日本大津市
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Diagnostic Potential of Nitroxide Radicals in Cancer Using Magnetic Resonance Imaging Tomography2010
- Author(s)
  Zhivko Zhelev, Rumiana Bakalova-Zheleva, Ichio Aoki, Gadjeva Veselina, Iwao Kanno
- Organizer
  日本分子イメージング学会
- Place of Presentation
  日本大津市(ポスター発表)
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Nitroxide radicals in brain imaging using T_1 weighted MRI2009
- Author(s)
  Zhelev Z., Bakalova R., Matsumoto K., Aoki I., et al.
- Organizer
  JSMI
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Multimodal quantum dot probe for imaging of colon cancer2009
- Author(s)
  Bakalova R., Zhelev Z., Kokuryo D., et al.
- Organizer
  4th European Molecular Imaging Meeting
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] -Nitroxide radicals in brain imaging using T1 weighted MRI2009
- Author(s)
  Zhelev Z., Bakalova R., Matsumoto K., Aoki I., Gadjeva V., Anzai K., Kanno I
- Organizer
  Annual Meeting of the Japanese Society for Molecular Imaging
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Multimodal quantum dot probe for optical imaging and MRI of colon cancer2009
- Author(s)
  Bakalova R., Zhelev Z., Kokuryo D., et al.
- Organizer
  JSMI
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] -Diagnostic Potential of Nitroxide Radicals in Cancer Using Magnetic Resonance Imaging Tomography2009
- Author(s)
  Zhelev Z., Bakalova R., Saito S., Aoki I., Gadjeva V., Kanno I.
- Organizer
  First International Workshop Antioxidants and Health Protection
- Place of Presentation
  Stara Zagora, Bulgaria
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] -Real-time MRI of blood-brain barrier permeability of conventional therapeutics using nitroxides as spin-labels2009
- Author(s)
  Zhelev Z., Bakalova R., Matsumoto K., Aoki I., Gadjeva V., Zheleva A., Anzai K., Kanno I.
- Organizer
  4th European Molecular Imaging Meeting
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Diagnostic potential of nitroxide radicals in cancer using MRI2009
- Author(s)
  Bakalova R., Zhelev Z., Gadjeva V., Aoki I.
- Organizer
  First International Workshop "Antioxidants and Health Protection"
- Place of Presentation
  Stara Zagora, Bulgaria
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Multimodal quantum dots : Direct intracellular delivery, photosensitization, and cytotoxic effects2008
- Author(s)
  Zhelev Z., I.Aoki, R.Bakalova, V.Gadjeva, I.Kanno
- Organizer
  5^<th> International Conference on Nanoscience & Nanotechnologies (NN08)
- Place of Presentation
  Thessaloniki, Greece(poster)
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] -EPR signal dynamic of several nitroxyl-labeled anticancer drugs in blood in vitro and in vivo2008
- Author(s)
  Zhelev Z., K. Matsumoto, V. Gadjeva, A. Zheleva, R. Bakalova, I. Aoki, and K. Anzai
- Organizer
  5th International Conference on Nitroxide Radicals SPIN' 2008
- Place of Presentation
  Ancona, Italy
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Quantum dots in multimodal imaging : Probe design and application2008
- Author(s)
  Zhelev Z., Aoki I., Bakalova R., et al.
- Organizer
  World Molecular Imaging Congress
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Multimodal quantum dots : Direct intracellular delivery, photosensitization and cytotoxic effects2008
- Author(s)
  Zhelev Z., Aoki I., Bakalova R., et al.
- Organizer
  5^<th> International Conference on Nanoscience & Nanotechnologies NN08
- Place of Presentation
  Thessaloniki, Greece
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] -Nitroxyl labels in brain imaging using T1-weighted MRI2008
- Author(s)
  Zhelev Z., R. Bakalova, K. Matsumoto, I. Aoki, V. Gadjeva, K. Anzai, and I. Kanno
- Organizer
  5th International Conference on Nitroxide Radicals SPIN' 2008
- Place of Presentation
  Ancona, Italy
- Data Source
  KAKENHI-PROJECT-21611011
[Presentation] Nanoparticles for multimodal molecular imaging : synthesis, spectral characteristics and application2008
- Author(s)
  Zhelev Z., Bakalova R., Aoki I., et al.
- Organizer
  E-MRS 2008 Spring Meeting
- Place of Presentation
  Strasbourg, France
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Sensitization of cancer cells to radiation using hybrid nanoparticles : Activation of apoptotic factors2008
- Author(s)
  Zhelev Z., R.Bakalova, I.Aoki, M.Mileva, V.Gadjeva, I.Kanno
- Organizer
  5^<th> International Conference on Nanoscience & Nanotechnologies (NN08)
- Place of Presentation
  Thessaloniki, Greece(poster)
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Nanobioprobes for multimodal molecular imaging (oral presentation)2008
- Author(s)
  Bakalova R., Zhelev Z., Aoki I., et al.
- Organizer
  5^<th> International Conference on Nanoscience & Nanotechnologies NN08
- Place of Presentation
  Thessaloniki, Greece
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Multimodal molecular probes : chemical design, spectral characteristics and application for in vitro and in vivo imaging2008
- Author(s)
  Bakalova R., Zhelev Z., Aoki I., et al.
- Organizer
  Annual Conference of the Japanese Society for Molecular Imaging
- Place of Presentation
  Fukui, Japan
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Nanobioprobes for multimodal molecular imaging : Chemical design, spectral characteristics and biomedical applications2008
- Author(s)
  Bakalova R., Z.Zhelev, I.Aoki, K.Matsumoto, V.Gadjeva, I.Kanno
- Organizer
  5^<th> International Conference on Nanoscience & Nanotechnologies (NN08)
- Place of Presentation
  Thessaloniki, Greece(oral presentation)
- Data Source
  KAKENHI-PROJECT-20500415
[Presentation] Electro-assisted drug delivery in cancer using size-controlled long-circulating polymer nanoparticles,
- Author(s)
  1.Atanasova S., D. Lazarova, B. Nikolova, Z. Zhelev, Y. Tsoneva, L. Spasov, and R. Bakalova
- Organizer
  24th International Conference of the Society of Bulgarian Scientists
- Place of Presentation
  Stara Zagora, Bulgaria
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] Systematic study on the cytotoxic and/or cytostatic effects of over twenty anticancer drugs: The crucial importance of the analytical approach and data processing
- Author(s)
  4.Ivanova D., D. Lazarova, E. Georgieva, I. Aoki, Z. Zhelev, and R. Bakalova
- Organizer
  9th International Conference of Anticancer Research
- Place of Presentation
  Sithonia, Greece,
- Year and Date
  2014-10-06 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] In vivo visualization of electro-assisted delivery of nanoparticles in cancer using optical imaging
- Author(s)
  2.Atanasova S., D. Lazarova, B. Nikolova, Z. Zhelev, T. Tsoneva, I. Aoki, and R. Bakalova
- Organizer
  9th International Conference of Anticancer Research,
- Place of Presentation
  Sithonia, Greece,
- Year and Date
  2014-10-06 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24510321
[Presentation] In vitro analysis of redox status of normal and tumor cells using nitroxide radicals and EPR spectroscopy
- Author(s)
  3.Georgieva E., D. Ivanova, D. Lazarova, R. Bakalova, I. Aoki, and Z. Zhelev
- Organizer
  9th International Conference of Anticancer Research
- Place of Presentation
  Sithonia, Greece,
- Year and Date
  2014-10-06 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24510321

1. AOKI Ichio (10319519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 67 results
2. ZHIVKO Zhelev (60511532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 49 results
3. SEMKOVA SEVERINA

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Bakalova Rumiana Rumiana Bakalova

RUMIANA Bakalova RUMIANA Bakalova

BAKALOVA Rumiana バカロバ ルミアナ

Research Projects

Research Products

Co-Researchers

New quantum biosensors for quantitative molecular imaging assays of oxidative stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Quantum dot/nitroxide-based sensing platform for image-guided drug delivery in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Originally Synthesized Oxy-Redox Sensitive Contrast Substances for in vivo Mapping of Tissue Redox and Oxidant Status in Cancer Using High Field MRI

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nanobioprobes for Multimodal Imaging Diagnostics of Cancer in Experimental AnimalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration?2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN382020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress.2019

Author(s)

Journal Title

Data Source

[Journal Article] Imaging of redox-balance and oxidative stress in kidney in vivo, induced by dietary cholesterol.2019

Author(s)

Journal Title

Data Source

[Journal Article] Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] “Redox imaging” to distinguish cells with different proliferative indexes: Superoxide, hydroperoxides and their ration as potential biomarkers.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress2019

Author(s)

BAKALOVA Rumiana バカロバルミアナ