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harada shigeyoshi  原田 恵嘉

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HARADA Shigeyoshi  原田 恵嘉

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Researcher Number 30508643
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立感染症研究所 エイズ研究センター, 室長
Affiliation (based on the past Project Information) *help 2020 – 2024: 国立感染症研究所, エイズ研究センター, 室長
2016 – 2020: 国立感染症研究所, エイズ研究センター, 主任研究官
2014 – 2015: 国立感染症研究所, その他部局等, 主任研究官
2013: 東京大学, 医科学研究所, 特任研究員
2012: 国立感染症研究所, エイズ研究センター, 研究員
2010 – 2011: 熊本大学, エイズ学研究センター, COEリサーチ・アソシエイト
Review Section/Research Field
Principal Investigator
Basic Section 54030:Infectious disease medicine-related / Medical pharmacy
Keywords
Principal Investigator
HIV / AIDS / 臨床分離株 / 耐性誘導 / 抗HIV療法 / 薬剤耐性 / SARS-CoV-2 / 抗体 / 抗HIV阻害剤 / 免疫学 … More / 感染症 / ウイルス / HIV-1 / オーダーメード医療 Less
  • Research Projects

    (6 results)
  • Research Products

    (103 results)
  • Co-Researchers

    (6 People)
  •  抗体活性増強を基軸とするHIV治癒へ繋ぐADCC活性に関する基盤研究Principal Investigator

    • Principal Investigator
      原田 恵嘉
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      National Institute of Infectious Diseases
  •  抗HIV薬研究を起点とする新規SARS-CoV-2治療戦略探索とウイルス性状解析Principal Investigator

    • Principal Investigator
      原田 恵嘉
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      National Institute of Infectious Diseases
  •  Comprehensive study on HIV-specific ADCC responses using library clinical isolatesPrincipal Investigator

    • Principal Investigator
      Shigeyoshi Harada
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      National Institute of Infectious Diseases
  •  Countermeasure study on HIV Env diversity using library clinical isolatesPrincipal Investigator

    • Principal Investigator
      Harada Shigeyoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Infectious Diseases
  •  Establishment of in vitro selection system by multi anti-HIV drugsPrincipal Investigator

    • Principal Investigator
      HARADA Shigeyoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Infectious Diseases
      The University of Tokyo
  •  Establishment of in vitro selection system using recent primary isolates, and a new efficient treatment for HIVPrincipal Investigator

    • Principal Investigator
      HARADA Shigeyoshi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kumamoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

  • [Book] HIVエンベロープの治療標的構造研究:新規治療法における侵入阻害剤と中和抗体の関係2016

    • Author(s)
      原田恵嘉,吉村和久
    • Total Pages
      8
    • Publisher
      日本エイズ学会誌
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Journal Article] Late-Stage Derivatization of Oleanolic Acid-Based Anti-HIV-1 Compounds2024

    • Author(s)
      Takeuchi Reon、Fujimoto Junko、Taguchi Yoshinori、Ide Ryuji、Kyan Ryuji、Sato Kohei、Mase Nobuyuki、Yokoyama Masaru、Harada Shigeyoshi、Narumi Tetsuo
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 72 Issue: 3 Pages: 330-335

    • DOI

      10.1248/cpb.c23-00891

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2024-03-25
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K05349
  • [Journal Article] Plasmacytoid dendritic cells stimulated with Lactococcus lactis strain Plasma produce soluble factors to suppress SARS-CoV-2 replication2023

    • Author(s)
      Ishii Hiroshi、Jounai Kenta、Tsuji Ryohei、Ohshio Konomi、Kaneda Daiki、Okazaki Midori、Harada Shigeyoshi、Fujiwara Daisuke、Matano Tetsuro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 662 Pages: 26-30

    • DOI

      10.1016/j.bbrc.2023.04.046

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-21H02745
  • [Journal Article] Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors2022

    • Author(s)
      Wang Rongyi、Tsuji Kohei、Kobayakawa Takuya、Liu Yishan、Yoshimura Kazuhisa、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 76 Pages: 117083-117083

    • DOI

      10.1016/j.bmc.2022.117083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
  • [Journal Article] Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques2022

    • Author(s)
      Ode Hirotaka、Saito Akatsuki、Washizaki Ayaka、Seki Yohei、Yoshida Takeshi、Harada Shigeyoshi、Ishii Hiroshi、Shioda Tatsuo、Yasutomi Yasuhiro、Matano Tetsuro、Miura Tomoyuki、Akari Hirofumi、Iwatani Yasumasa
    • Journal Title

      Journal of General Virology

      Volume: 103 Issue: 10 Pages: 001790-001790

    • DOI

      10.1099/jgv.0.001790

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-23K24144
  • [Journal Article] Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T?cell responses2022

    • Author(s)
      Ishii H, Nomura T, Yamamoto H, Nishizawa M, Thu Hau TT, Harada S, Seki S, Nakamura-Hoshi M, Okazaki M, Daigen S, Kawana-Tachikawa A, Nagata N, Iwata-Yoshikawa N, Shiwa N, Suzuki T, Park ES, Ken M, Onodera T, Takahashi Y, Kusano K, Shimazaki R, Suzaki Y, Ami Y, Matano T
    • Journal Title

      Cell Reports Medicine

      Volume: 3 Issue: 2 Pages: 100520-100520

    • DOI

      10.1016/j.xcrm.2022.100520

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02745, KAKENHI-PROJECT-20K20498, KAKENHI-PROJECT-20K21666, KAKENHI-PROJECT-21K20767, KAKENHI-PROJECT-21K08501
  • [Journal Article] Association of envelope-specific B-cell differentiation and viral selective pressure signatures in HIV-1 CRF01_AE infection2022

    • Author(s)
      Hau Trang Thi Thu、Nishizawa Masako、Harada Shigeyoshi、Phan My Ha、Kanno Yoshiaki、Nomura Takushi、Matsuoka Saori、Kawana-Tachikawa Ai、Hall William W.、Matano Tetsuro、Nguyen Lan Anh Thi、Yamamoto Hiroyuki
    • Journal Title

      AIDS

      Volume: 36 Issue: 12 Pages: 1629-1641

    • DOI

      10.1097/qad.0000000000003323

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-21H02745
  • [Journal Article] Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors2022

    • Author(s)
      Tsuji Kohei、Kobayakawa Takuya、Konno Kiju、Masuda Ami、Takahashi Kohei、Ohashi Nami、Yoshimura Kazuhisa、Kuwata Takeo、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 56 Pages: 116616-116616

    • DOI

      10.1016/j.bmc.2022.116616

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20H03362
  • [Journal Article] Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds2022

    • Author(s)
      Takeuchi Reon、Ogihara Kasumi、Fujimoto Junko、Sato Kohei、Mase Nobuyuki、Yoshimura Kazuhisa、Harada Shigeyoshi、Narumi Tetsuo
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 69 Pages: 128768-128768

    • DOI

      10.1016/j.bmcl.2022.128768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K05349
  • [Journal Article] Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors2021

    • Author(s)
      Kobayakawa Takuya、Tsuji Kohei、Konno Kiju、Himeno Ai、Masuda Ami、Yang Tingting、Takahashi Kohei、Ishida Yusuke、Ohashi Nami、Kuwata Takeo、Matsumoto Kaho、Yoshimura Kazuhisa、Sakawaki Hiromi、Miura Tomoyuki、Harada Shigeyoshi、Matsushita Shuzo、Tamamura Hirokazu
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 64 Issue: 3 Pages: 1481-1496

    • DOI

      10.1021/acs.jmedchem.0c01153

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K08501
  • [Journal Article] Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+?T cells in?cynomolgus?macaques2021

    • Author(s)
      Nomura T, Yamamoto H, Nishizawa M, Hau TTT, Harada S, Ishii H, Seki S, Nakamura-Hoshi M, Okazaki M, Daigen S, Kawana-Tachikawa A, Nagata N, Iwata-Yoshikawa N, Shiwa N, Iida S, Katano H, Suzuki T, Park ES, Maeda K, Suzaki Y, Ami Y, Matano T
    • Journal Title

      PLOS Pathogens

      Volume: 17 Issue: 7 Pages: 1-16

    • DOI

      10.1371/journal.ppat.1009668

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02745, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20K20498, KAKENHI-PROJECT-20K21666
  • [Journal Article] Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s.2019

    • Author(s)
      NAKATA H, MAEDA K, DAS D, CHANG SB, MATSUDA K, RAO KV, HARADA S, YOSHIMURA K, GHOSH AK, MITSUYA H.
    • Journal Title

      Scientific Reports.

      Volume: 18 Issue: 5 Pages: 4828-4828

    • DOI

      10.1016/j.bmcl.2019.01.011

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Journal Article] Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s2019

    • Author(s)
      Hirotomo Nakata, Kenji Maeda, Debananda Das, Simon B. Chang, Kouki Matsuda, Kalapala Venkateswara Rao, Shigeyoshi Harada, Kazuhisa Yoshimura, Arun K. Ghosh & Hiroaki Mitsuya
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 4828-4828

    • DOI

      10.1038/s41598-019-41080-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08436, KAKENHI-PROJECT-18K08458
  • [Journal Article] Flexibility of small molecular CD4 mimics as HIV entry inhibitors.2018

    • Author(s)
      KOBAYAKAWA T, OHASHI N, HIROTA Y, TAKAHASHI K, YAMADA Y, NARUMI T, YOSHIMURA K, MATSUSHITA S, HARADA S, TAMAMURA H
    • Journal Title

      Bioorganic & Medical Chemistry

      Volume: 26 Issue: 21 Pages: 5664-5671

    • DOI

      10.1016/j.bmc.2018.10.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-18H02854
  • [Journal Article] Isolation and structure determination of a new lasso peptide specialicin based on genome mining.2018

    • Author(s)
      KAWEEWAN I, HEMMI H, KOMAKI H, HARADA S, KODANI S.
    • Journal Title

      Bioorganic & Medical Chemistry

      Volume: 26 Issue: 23-24 Pages: 6050-6055

    • DOI

      10.1016/j.bmc.2018.11.007

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-16K01913
  • [Journal Article] Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution2017

    • Author(s)
      Shigeyoshi Harada and Kazuhisa Yoshimura
    • Journal Title

      Frontiers in Microbiology

      Volume: 8: 390 Pages: 390-390

    • DOI

      10.3389/fmicb.2017.00390

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Journal Article] A minimally cytotoxic CD4 mimic as an HIV entry inhibitor2016

    • Author(s)
      Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Issue: 2 Pages: 397-400

    • DOI

      10.1016/j.bmcl.2015.11.103

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26105721, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-16K01931
  • [Journal Article] Biphasic CD8+ T-cell defense in elite SIV control by acute-phase passive neutralizing antibody immunization2016

    • Author(s)
      Iseda S, Takahashi N, Poplimont H, Nomura T, Seki S, Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S, Harada S, Naruse TK, Kimura A, Matano T, Yamamoto H
    • Journal Title

      J Virol

      Volume: 90 Issue: 14 Pages: 6276-6290

    • DOI

      10.1128/jvi.00557-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01271, KAKENHI-PROJECT-15H04737, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15K19119
  • [Journal Article] Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.2016

    • Author(s)
      Nami Ohashi1, Shigeyoshi Harada, Takaaki Mizuguchi1, Yu Irahara1, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura.
    • Journal Title

      Chem Med Chem

      Volume: 19 Issue: 8 Pages: 940-946

    • DOI

      10.1002/cmdc.201500590

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16K01931, KAKENHI-PROJECT-16K15139
  • [Journal Article] Impact of the Maraviroc-Resistant Mutation M434I in the C4 Region of HIV-1 gp120 on Sensitivity to Antibody-Mediated Neutralization2016

    • Author(s)
      Samatchaya Boonchawalit, Shigeyoshi Harada, Noriko Shirai, Hiroyuki Gatanaga, Shinichi Oka, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Journal Title

      Jpn J Infect Dis

      Volume: 69 Issue: 3 Pages: 236-243

    • DOI

      10.7883/yoken.JJID.2015.310

    • NAID

      130005151997

    • ISSN
      1344-6304, 1884-2836
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04870
  • [Journal Article] A novel dual luciferase assay for the simultaneous monitoring of HIV infection and cell viability2016

    • Author(s)
      Mitsuki Y-y, Yamamoto T, Mizukoshi F, Momota M, Terahara K, Yoshimura K, Harada S, Tsunetsugu-Yokota Y
    • Journal Title

      Journal of Virological Methods

      Volume: 231 Pages: 25-33

    • DOI

      10.1016/j.jviromet.2016.02.006

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460500, KAKENHI-PROJECT-15K08125
  • [Journal Article] Fibrocytes differ from macrophages but can be infected with HIV-1.2015

    • Author(s)
      M. Hashimoto, H. Nasser, F. Bhuyan, N. Kuse, Y. Satou, S. Harada, K. Yoshimura, J. Sakuragi, K. Monde, Y. Maeda, S. Welbourn, K. Strebel, E.W.A. El-Wahab, M. Miyazaki , S. Hattori, N. Chutiwitoonchai, M. Hiyoshi, S. Oka, M. Takiguchi, S. Suzu.
    • Journal Title

      The Journal of Immunology

      Volume: 195 Issue: 9 Pages: 4341-4350

    • DOI

      10.4049/jimmunol.1500955

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-26461407, KAKENHI-PROJECT-26461428, KAKENHI-PROJECT-15J07744, KAKENHI-PROJECT-25460567, KAKENHI-PROJECT-26670226
  • [Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014

    • Author(s)
      Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, Yoko Kawanami, Shuzo Matsushita.
    • Journal Title

      Journal of General Virology

      Volume: 95 Issue: 8 Pages: 1816-1826

    • DOI

      10.1099/vir.0.062885-0

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
  • [Journal Article] Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.2013

    • Author(s)
      Shigeyoshi Harada, Kazuhisa Yoshimura, Aki Yamaguchi, Samatchaya Boonchawalit, Keisuke Yusa, Shuzo Matsushita.
    • Journal Title

      Journal of General Virology

      Volume: 94 Issue: 5 Pages: 933-943

    • DOI

      10.1099/vir.0.047167-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
  • [Journal Article] A CD4 Mimic as an HIV Entry Inhibitors: Pharmacokinetics2013

    • Author(s)
      Hashimoto, C., Narumi, T., Otsuki, H., Hirota, Y., Arai, H., Yoshimura, K., Harada, S., Ohashi, N., Nomura, W., Miura, T., Igarashi, T., Matsuhita, S., Tamamura, H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21 Issue: 24 Pages: 7884-7889

    • DOI

      10.1016/j.bmc.2013.10.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24105507, KAKENHI-PUBLICLY-24119506, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107, KAKENHI-PROJECT-25410171
  • [Journal Article] CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.2013

    • Author(s)
      Narumi, T., Arai, H., Yoshimura, K., Harada, S., Hirota, Y., Ohashi, N., Hashimoto, C.. Nomura, W., Matsushita, S. and Tamamura, H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 8 Issue: 9 Pages: 2518-2526

    • DOI

      10.1016/j.bmc.2013.02.041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J05127, KAKENHI-PUBLICLY-24105507, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107
  • [Journal Article] Small molecular CD4 mimics as HIV entry inhibitors2011

    • Author(s)
      Narumi, T., Arai, H., Yoshimura, K., Harada, S., Nomura, W., Matsushita, S., Tamamura. H
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 6735-6742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Journal Article] In vitro and In vivo Resistance to Human Immunodeficiency Virus Type 1 Entry Inhibitors2011

    • Author(s)
      Maeda, Y., Yoshimura, K., Miyamoto, F., Kodama, E., Harada, S., Yuan, Y., Harada, S., and Yusa, K
    • Journal Title

      J AIDS Clinic Res

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds2010

    • Author(s)
      Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita S
    • Journal Title

      J. Virol

      Volume: 84 Pages: 7558-7568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Journal Article] CD4 mimics targeting the mechanism of HIV entry2010

    • Author(s)
      Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi, T., Nomura, W., Harada, S., Matsushita, S., Tamamura. H
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 20 Pages: 354-358

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Journal Article] CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist2010

    • Author(s)
      Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka, T., Nomura, W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S., Tamamura, H
    • Journal Title

      Bioorg Med Chem Lett

      Pages: 5853-5858

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Journal Article] HIV-1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V22010

    • Author(s)
      Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita S
    • Journal Title

      J. Gen. Virol

      Volume: 91 Pages: 1335-1345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Patent] 抗HIV活性を有するCD4ミミック化合物2019

    • Inventor(s)
      松下修三, 吉村和久, 玉村啓和, 原田恵嘉, 他4名
    • Industrial Property Rights Holder
      松下修三, 吉村和久, 玉村啓和, 原田恵嘉, 他4名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-195967
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Patent] オレアノール酸誘導体2018

    • Inventor(s)
      鳴海哲夫, 原田恵嘉, 他4名
    • Industrial Property Rights Holder
      鳴海哲夫, 原田恵嘉, 他4名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Patent] HIV感染阻害剤2015

    • Inventor(s)
      玉村啓和、野村渉、鳴海哲夫、松下修三、吉村和久、原田恵嘉、他
    • Industrial Property Rights Holder
      玉村啓和、野村渉、鳴海哲夫、松下修三、吉村和久、原田恵嘉、他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-25
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] HIV侵入阻害剤の開発2020

    • Author(s)
      原田恵嘉
    • Organizer
      第34回日本エイズ学会学術集会・総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] Triterpene derivative NAT-078 as a novel bifunctional HIV-1 entry inhibitor2019

    • Author(s)
      Shigeyoshi Harada, Tetsuo Narumi, Yuta Hikichi, Tetsuro Matano, Kazuhisa Yoshimura
    • Organizer
      10th IAS Conference on HIV Science (IAS 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] 新規トリテルペン誘導体の抗HIV作用および耐性機序に対する詳細解析2019

    • Author(s)
      原田恵嘉、引地優太、俣野哲朗、吉村和久
    • Organizer
      第29回 抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] Efficacy of a novel triterpene derivative in combination with neutralizing antibodies against HIV-1 infection2019

    • Author(s)
      Shigeyoshi Harada, Tetsuo Narumi, Tetsuro Matano, Kazuhisa Yoshimura
    • Organizer
      2019 Cold Spring Harbor meeting: Retroviruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] 網羅的Env標的阻害剤ライブラリーの構築-32018

    • Author(s)
      原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 竹内怜音, 紺野奇重, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
    • Organizer
      第32回 日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] Mutations in the gp41 ectodomain can contribute to HIV-1 resistance to smFIs2018

    • Author(s)
      HARADA S, HIKICHI Y, NARUMI T, YOSHIMURA K
    • Organizer
      26th Conference on Retroviruses and Opportunistic Infections (CROI 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] Triterpene derivative NAT-078 as a novel bifunctional HIV-1 entry inhibitor2018

    • Author(s)
      HARADA S, NARUMI T, HIKICHI Y, MATANO T, YOSHIMURA K
    • Organizer
      第66回 日本ウイルス学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08458
  • [Presentation] Synergistic anti-HIV effect of combination of a novel entry inhibitor and NAbs2018

    • Author(s)
      HARADA S, MATANO T, YOSHIMURA K
    • Organizer
      20th International Conference on Emerging Infectious Diseases in the Pacific Rim and Meetings of the AIDS (Joint with Immunology Board)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Identification of novel HIV-1 Env inhibitors by structure-based in silico screening2017

    • Author(s)
      HARADA S, YOKOYAMA M, OGIHARA K, HIKICHI Y, SATO H, NARUMI T, MATANO T, YOSHIMURA K
    • Organizer
      18th Kumamoto AIDS Seminar, Kumamoto
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Bifunctional抗HIV侵入阻害剤ライブラリーの構築およびその最新知見2017

    • Author(s)
      原田恵嘉, 引地優太, 俣野哲朗, 吉村和久
    • Organizer
      第19回 白馬シンポジウム
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Synthesis and properties of novel soluble bifunctional CD4-mimetic small molecules containing pyridine moiety2017

    • Author(s)
      HARADA S, KONNO K, HIKICHI Y, MATSUOKA S, M ATANO T, TAMAMURA H, YOSHIMURA K
    • Organizer
      9th IAS Conference on HIV Science (IAS 2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] 網羅的Env標的阻害剤ライブラリーの構築-22017

    • Author(s)
      原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 林宏典, 紺野奇重, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Discovery of novel bifunctional HIV-1 entry inhibitors using structure-based in silico screening2017

    • Author(s)
      HARADA S, YOKOYAMA M, OGIHARA K, HIKICHI Y, SATO H, NARUMI T, MATANO T, YOSHIMURA K
    • Organizer
      The 65th Annual Meeting of the Japanese Society for Virology
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Bi-functional entry inhibitors sensitize macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) to antibodies generated in HIV-1mt-infected macaques2017

    • Author(s)
      HARADA S, HIKICHI Y, SEKI Y, SAITO A, YOSHIDA T, ODE H, IWATANI Y, YASUTOMI Y, MIURA T, MATANO T, AKARI H, YOSHIMURA K
    • Organizer
      35th Annual Symposium on Nonhuman Primate Models for AIDS (NHP2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Identification of novel HIV-1 gp120 CD4 binding site inhibitors using structure-based in silico screening2017

    • Author(s)
      HARADA S, YOKOYAMA M, OGIHARA K, HIKICHI Y, SATO H, NARUMI T, MATANO T, YOSHIMURA K
    • Organizer
      42nd Annual Meeting of Cold Spring Harbor Laboratory on Retroviruses
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Structure-based virtual screeningによる新規bifunctional抗HIV侵入阻害剤の探索2017

    • Author(s)
      原田恵嘉, 荻原香澄, 横山勝, 引地優太, 佐藤裕徳, 俣野哲朗, 鳴海哲夫, 吉村和久
    • Organizer
      第27回 抗ウイルス療法学会総会,
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] 作用部位の異なるEnv標的阻害剤ライブラリーの構築およびその最新知見2016

    • Author(s)
      原田恵嘉, 引地優太, 俣野哲朗, 吉村和久
    • Organizer
      第18回 白馬シンポジウム
    • Place of Presentation
      山梨県北杜市
    • Year and Date
      2016-10-07
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Molecular Dynamics of the CD4-Mimetic Resistant HIV-1 Gp120 by MD Simulation2016

    • Author(s)
      Shigeyoshi Harada, Masaru Yokoyama, Shuzo Matsushita, Hironori Sato, Tetsuro Matano, Kazuhisa Yoshimura
    • Organizer
      23th Conference on Retroviruses and Opportunistic Infections (CROI 2016)
    • Place of Presentation
      Boston, MA, U.S.A.
    • Year and Date
      2016-02-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] 6.Detection of potency and breadth of anti-HIV-1 neutralizing antibodies in two macaque-tropic HIV-1 infected cynomolgus monkeys that were different response by CD8 depletion2016

    • Author(s)
      Shigeyoshi Harada, Akatsuki Saito, Yohei Seki, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
    • Organizer
      2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar, Kumamoto
    • Place of Presentation
      Kumamoto
    • Year and Date
      2016-10-31
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Development of novel bifunctional entry inhibitors that target non-CD4-binding site of HIV-12016

    • Author(s)
      Shigeyoshi Harada, Kasumi Ogihara, Yuta Hikichi, Tetsuro Matano, Tetsuo Narumi, Kazuhisa Yoshimura
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Comparison of plasma neutralizing antibodies in two macaque-tropic HIV-1 infected macaques that were different response by CD8 depletion2016

    • Author(s)
      Shigeyoshi Harada, Yohei Seki, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
    • Organizer
      34th Annual Symposium on Nonhuman Primate Models for AIDS (NHP2016),
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Design, Synthesis, and Antiviral Activity of Novel Bifunctional CD4-Mimetic Small Molecules Containing Mono-Cyclohexyl Moieties, YIR-819 and YIR-8212016

    • Author(s)
      Shigeyoshi Harada, Yu Irahara, Yuta Hikichi, Nami Ohashi, Wataru Nomura, Shuzo Matsushita, Tetsuro Matano, Hirokazu Tamamura, Kazuhisa Yoshimura
    • Organizer
      HIVR4P 2016
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-10-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] CD4 mimicと結合領域が異なる新規bifunctional抗HIV侵入阻害剤の開発2016

    • Author(s)
      原田恵嘉, 荻原香澄, 俣野哲朗, 鳴海哲夫, 吉村和久
    • Organizer
      第26回 抗ウイルス療法学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2016-05-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] 網羅的Env標的阻害剤ライブラリーの構築-12016

    • Author(s)
      原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 林宏典, 荻原香澄, 石田有佑, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
    • Organizer
      第30回日本エイズ学会学術集会・総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2016-11-24
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Genetic and molecular dynamics studies of the NBD-556, YYA-021 and JRC-II-191 binding to the wild type and mutant HIV-1 gp1202015

    • Author(s)
      Shigeyoshi Harada, Masaru Yokoyama, Shuzo Matsushita, Hironori Sato, Kazuhisa Yoshimura
    • Organizer
      The 15th Kumamoto AIDS Seminar
    • Place of Presentation
      熊本県阿蘇市
    • Year and Date
      2015-10-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] gp120相互作用強化型CD4ミミック化合物の開発2015

    • Author(s)
      原田恵嘉
    • Organizer
      第18回 日本レトロウイルス研究会 夏期セミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2015-07-10
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Asp368およびVal430と相互作用を有する新規CD4類似低分子化合物の開発2015

    • Author(s)
      原田恵嘉、苛原優、玉村啓和、俣野哲朗、吉村和久
    • Organizer
      第25回 抗ウイルス療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Detection of potency and breadth of HIV-1 neutralizing antibodies in macaque-tropic HIV-1 infected cynomolgus monkeys using novel test panel viruses2015

    • Author(s)
      Shigeyoshi Harada, Akatsuki Saito, Takeshi Yoshida, Yohei Seki, Yuji Watanabe, Yasumasa Iwatani, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
    • Organizer
      33rd Annual Symposium on Nonhuman Primate Models for AIDS
    • Place of Presentation
      Monterey, CA, U.S.A.
    • Year and Date
      2015-10-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Design, synthesis and virological evaluation of novel CD4-mimetic small molecules2015

    • Author(s)
      Shigeyoshi Harada, Yu Irahara, Hirokazu Tamamura, Shuzo Matsushita, Tetsuro Matano, Kazuhisa Yoshimura
    • Organizer
      第63回 日本ウイルス学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] CD4類似低分子化合物誘導体(CD4MCs)の耐性機序解析2015

    • Author(s)
      原田恵嘉、横山勝、佐藤裕徳、松下修三、俣野哲朗、玉村啓和、吉村和久
    • Organizer
      第29回 日本エイズ学会学術集会・総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-30
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Asp368およびVal430と相互作用を有する新規CD4類似低分子化合物の開発2015

    • Author(s)
      原田恵嘉、苛原優、玉村啓和、俣野哲朗、吉村和久
    • Organizer
      第17回 白馬シンポジウム
    • Place of Presentation
      鳥取県米子市
    • Year and Date
      2015-06-19
    • Data Source
      KAKENHI-PROJECT-15K08125
  • [Presentation] Impact of CD4 mimetics-resistant mutations on susceptibilities to anti-Env nMAbs.2014

    • Author(s)
      Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      21th Conference on Retroviruses and Opportunistic Infections (CROI 2014)
    • Place of Presentation
      Boston, MA, U.S.A.
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Impact od deletion in cytoplasmic tail on Env incorporation into HIV/SIV particles.2013

    • Author(s)
      五領舞衣, 原田恵嘉, 石井洋,俣野哲朗, 吉村和久.
    • Organizer
      第15回 白馬シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] 細胞内ドメイン欠損Envを有するHV/SIV粒子の作製.2013

    • Author(s)
      五領舞衣, 原田恵嘉, 石井洋, 吉村和久, 俣野哲朗.
    • Organizer
      第27回 日本エイズ学会学術集会・総会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Characterization of highly neutralizing antibody sensitive HIV-1 gp120 induced under high concentrations of maraviroc (MVC) in vitro. AIDS Vaccine 20132013

    • Author(s)
      Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      AIDS Vaccine 2013
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] バルクおよびクローンウイルスを用いたCD4類似低分子化合物誘導体に対するin vitro 耐性ウイルス誘導.2013

    • Author(s)
      原田恵嘉, 鳴海哲夫, Samatchaya Boonchawalit, 玉村啓和, 松下修三, 吉村和久.
    • Organizer
      第27回 日本エイズ学会学術集会・総会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] バルクおよびクローンウイルスを用いたCD4類似低分子化合物の耐性誘導.2013

    • Author(s)
      原田恵嘉.
    • Organizer
      第16回 日本レトロウイルス研究会 夏期セミナー
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Analysis of relationships between Maraviroc (MVC) resistant mutations and sensitivity to antibody-mediated neutralization.2013

    • Author(s)
      Samatchaya Boonchawalit, 原田恵嘉, 松下修三, 吉村和久.
    • Organizer
      第27回 日本エイズ学会学術集会・総会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Analysis of relationships between Maraviroc (MVC) resistant mutations and sensitivity to antibody-mediated neutralization.2013

    • Author(s)
      Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      14th Kumamoto AIDS Seminar, Kumamoto
    • Place of Presentation
      Kumamoto, Japan
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] 抗V3抗体および低分子CD4ミミック曝露後投与によるアカゲザルでのSHIV複製抑制.2013

    • Author(s)
      大附寛幸,丸田泰広,橋本智恵,鳴海哲夫,廣田雄樹, 原田恵嘉, 三浦智行, 吉村和久,玉村啓和,松下修三, 五十嵐樹彦.
    • Organizer
      第27回 日本エイズ学会学術集会・総会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] インテグラーゼ阻害剤ラルテグラビルがMVC耐性HIV-1 Env領域に与える影響.2013

    • Author(s)
      原田恵嘉, Samatchaya Boonchawalit, 松下修三, 吉村和久.
    • Organizer
      第61回 日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] CD4 Mimic Small Compounds, NBD-556 and Its Analogues Bind at 3 Amino Acid Positions in the gp120 CD4 Cavity2013

    • Author(s)
      Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, and Kazuhisa Yoshimura
    • Organizer
      20th Conference on Retroviruses and Opportunistic Infections (CROI)
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Impact of Maraviroc-resistant and Low CCR5-adapted Mutations Induced in vitro Passage on Sensitivity to Anti-Env Neutralizing Antibodies2013

    • Author(s)
      Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, and Shuzo Matsushita
    • Organizer
      20th Conference on Retroviruses and Opportunistic Infections (CROI)
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] In vitro selection of bifunctional CD4 mimic small compounds (NBD analogues) using bulk and cloned primary isolates.2013

    • Author(s)
      原田恵嘉, Samatchaya Boonchawalit, 松下修三, 吉村和久.
    • Organizer
      第15回 白馬シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] In vitro selection of bifunctional CD4 mimic small compounds (NBD analogues) using bulk and cloned primary isolates.2013

    • Author(s)
      Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      14th Kumamoto AIDS Seminar, Kumamoto
    • Place of Presentation
      Kumamoto, Japan
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Analysis of interaction between gp120 and CD4 mimic small compounds that enhance the activity of anti-HIV neutralizing antibodies.2013

    • Author(s)
      Shigeyoshi Harada, Samatchaya Boonchawalit, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      AIDS Vaccine 2013
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] R5臨床分離株を用いた10種のCD4類似低分子化合物に対するin vitro 耐性ウイルス誘導2012

    • Author(s)
      原田 恵嘉
    • Organizer
      第14回白馬シンポジウム
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] CD4類似低分子化合物の耐性機序および結合部位の検討.2012

    • Author(s)
      原田 恵嘉
    • Organizer
      第15回 SUMMER RETROVIRUS CONFERENCE
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] In vitro induction of ten CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1.2012

    • Author(s)
      Shigeyoshi Harada, Hiroshi Arai, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, and Kazuhisa Yoshimura
    • Organizer
      19th International AIDS Conference.
    • Place of Presentation
      Washington, D.C., U.S.A.
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] HIV-1におけるCD4類似低分子化合物に対する耐性機序および結合部位の検討2012

    • Author(s)
      原田 恵嘉
    • Organizer
      第9回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      静岡県熱海市
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] R5臨床分離株を用いたCD4類似低分子化合物誘導体に対するin vitro 耐性ウイルス誘導2012

    • Author(s)
      原田恵嘉、鳴海哲夫、玉村啓和、松下修三、吉村和久
    • Organizer
      第26回日本エイズ学会学術集会・総会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011

    • Author(s)
      Harada, S.
    • Organizer
      6th IAS Conference on HIV Pathogenesis, Treatment and Prevention
    • Place of Presentation
      Auditorium Parco della Musica (Roma, Italy)
    • Year and Date
      2011-07-17
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011

    • Author(s)
      Harada, S.
    • Organizer
      12th Kumamoto AIDS Seminar GCOE Joint International Symposium
    • Place of Presentation
      Aso Resort GRANDVRIO Hotel (Kumaraoto, Japan)
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] Evolution and selection of the env gene of HIV-1 primary isolates during in vitro selection of raltegravir2011

    • Author(s)
      Harada S., Hamji A., Matsushita S., Yoshimura K
    • Organizer
      11th Kumamoto AIDS Seminar GCOE Joint International Symposium
    • Place of Presentation
      Aso Resort GRANDVRIO Hotel(Kumamoto, Japan)
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] 抗HIV剤がEnv多様性に与える影響2011

    • Author(s)
      原田恵嘉
    • Organizer
      第25回日本エイズ学会学術集会・総会
    • Place of Presentation
      ハイアット リージェンシー東京(東京都)
    • Year and Date
      2011-12-01
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] 抗HIV剤がEnv多様性に与える影響2011

    • Author(s)
      原田恵嘉、濱治有希、遊佐敬介、松下修三、吉村和久
    • Organizer
      第25回日本エイズ学会学術集会・総会
    • Place of Presentation
      ハイアットリージェンシー東京(東京)
    • Year and Date
      2011-12-01
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011

    • Author(s)
      Harada S., Ishikawa T., Hamji A., Matsushita S., Yoshimura K
    • Organizer
      6th IAS Conference on HIV Pathogenesis, Treatment and Prevention
    • Place of Presentation
      Auditorium Parco della Musica(Roma, Italy)
    • Year and Date
      2011-07-17
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011

    • Author(s)
      Harada S., Ishikawa T., Hamji A., Matsushita S., Yoshimura K
    • Organizer
      12th Kumamoto AIDS Seminar GCOE Joint International Symposium
    • Place of Presentation
      Aso Resort GRANDVRIO Hotel(Kumamoto, Japan)
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] ラルテグラビルはHIV-1のin vitro馴化におけるEnv選択に影響する2010

    • Author(s)
      原田恵嘉
    • Organizer
      第24回日本エイズ学会学術集会・総会
    • Place of Presentation
      (東京)グランドプリンスホテル高輪
    • Year and Date
      2010-11-25
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] ラルテグラビルはHIV-1のin vitro馴化におけるEnv選択に影響する2010

    • Author(s)
      原田恵嘉、濱治有希、松下修三、吉村和久
    • Organizer
      第24回日本エイズ学会学術集会・総会
    • Place of Presentation
      ザ・プリンスさくらタワー東京(東京)
    • Year and Date
      2010-11-25
    • Data Source
      KAKENHI-PROJECT-22790163
  • [Presentation] 新規エントリー阻害剤の組み合わせによる抗ウイルス効果と耐性変異の解析.

    • Author(s)
      原田恵嘉, 横山勝, Samatchaya Boonchawalit, 佐藤裕徳, 松下修三, 吉村和久.
    • Organizer
      第16回 白馬シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2014-06-13 – 2014-06-14
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Mutations at the bottom of the Phe43 cavity are responsible for cross-resistance to NBD analogues.

    • Author(s)
      Shigeyoshi Harada, Yu Irahara, Samatchaya Boonchawalit, Mai Goryo, Hirokazu Tamamura, Tetsuro Matano, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      22th Conference on Retroviruses and Opportunistic Infections (CROI 2015)
    • Place of Presentation
      Seattle, WA, U.S.A.
    • Year and Date
      2015-02-23 – 2015-02-26
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Impact of maraviroc (MVC)-resistant mutations in the C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization.

    • Author(s)
      Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      15th Kumamoto AIDS Seminar
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] CD4類似低分子化合物 (CD4MCs) とgp120.

    • Author(s)
      原田恵嘉
    • Organizer
      第28回 日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-03 – 2014-12-05
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Resistance Profile of CD4 Mimic Small Compounds (CD4MCs) and the Structure Analysis by Molecular Dynamic (MD) Simulation.

    • Author(s)
      Shigeyoshi Harada, Masaru Yokoyama, Samatchaya Boonchawalit, Hironori Sato, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      HIV Research for Prevention 2014
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2014-10-28 – 2014-10-31
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] 新規エントリー阻害剤の組み合わせによる抗ウイルス効果と耐性変異の解析.

    • Author(s)
      原田恵嘉.
    • Organizer
      第17回 日本レトロウイルス研究会 夏期セミナー
    • Place of Presentation
      静岡
    • Year and Date
      2014-07-03 – 2014-07-05
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] CD4類似低分子化合物誘導体 (CD4MCs) の耐性プロファイルと分子動力学的機構解析.

    • Author(s)
      原田恵嘉, 横山勝, Samatchaya Boonchawalit, 佐藤裕徳, 松下修三, 吉村和久.
    • Organizer
      第62回 日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-24590199
  • [Presentation] Impact of Maraviroc (MVC)-resistant mutations in C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization.

    • Author(s)
      amatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
    • Organizer
      20th International AIDS Conference Melbourne
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-07-20 – 2014-07-25
    • Data Source
      KAKENHI-PROJECT-24590199
  • 1.  NARUMI Tetsuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 2.  TERAHARA Kazutaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  俣野 哲朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 4.  辻 耕平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  中田 浩智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  横田 恭子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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