Makinoshima Hideki 牧野嶋秀樹

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MAKINOSHIMA Hideki 牧野嶋秀樹

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Researcher Number	30510573
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 2019 – 2022: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 2017 – 2018: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2015: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2014: 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 研究員 2012 – 2013: 独立行政法人国立がん研究センター, 臨床開発センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Tumor biology / Tumor therapeutics / Tumor biology
Keywords	Principal Investigator 肺小細胞がん / 核酸生合成経路 / プリン塩基 / 小細胞肺がん / プリン代謝 / 核酸生合成 / サルベージ経路 / 癌 / PI3K/mTOR経路 / 核酸代謝 … More / プリンヌクレオチド / PI3K/mTOT経路 / がんの代謝 / RET / 遺伝子発現 / トランスレーショナルリサーチ / シグナル伝達 / 薬剤耐性 / 肺がん / 融合遺伝子 / 幹細胞 / 分子標的療法 / チロシンリン酸化 / フォスファターゼ / PTPRZ1 / チロシンフォスファターゼ / がん幹細胞 Less

小細胞肺癌のRNRとDDRを標的とする新規治療法の開発と代謝バイオマーカーの探索Principal Investigator
- Principal Investigator
  
  牧野嶋秀樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Elucidation of cell growth control mechanism via purine salvage pathway in small cell lung carcinomaPrincipal Investigator
- Principal Investigator
  
  MAKINOSHIMA Hideki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
Elucidation of regulated mechanism in controlling purine metabolism through PI3K/mTOR pathway in small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Makinoshima Hideki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Elucidation of the mechanism how Vandetanib kills RET-positive lung cancer cellsPrincipal Investigator
- Principal Investigator
  
  Makinoshima Hideki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  National Cancer Center Japan
Role of PTPRZ1 to maintain cancer stemness in small-cell lung carcinomaPrincipal Investigator
- Principal Investigator
  
  MAKINOSHIMA Hideki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Center of Neurology and Psychiatry

All 2022 2021 2019 2018 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma2021
- Author(s)
  Ami Maruyama, Yuzo Sato, Joji Nakayama, Junko Murai, Takamasa Ishikawa, Tomoyoshi Soga, Hideki Makinoshima
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 13474-13474
- DOI
  10.1038/s41598-021-92948-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07627
[Journal Article] メタボロミクスの臨床応用への挑戦2021
- Author(s)
  牧野嶋秀樹
- Journal Title
  
  Precision Medicine
  
  Volume: 12 Pages: 1-1
- Data Source
  KAKENHI-PROJECT-20K07627
[Journal Article] Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma2021
- Author(s)
  Yuzo Sato, Masaru Tomita, Tomoyoshi Soga, Atsushi Ochiai, Hideki Makinoshima
- Journal Title
  
  Front Pharmacol
  
  Volume: 12 Pages: 718675-718675
- DOI
  10.3389/fphar.2021.718675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07627
[Journal Article] Extraction of Aqueous Metabolites From Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry2019
- Author(s)
  Ami Maruyama, Kenjiro Kami, Kazunori Sasaki, Hajime Sato, Yuzo Sato, Katsuya Tsuchihara, Hideki Makinoshima
- Journal Title
  
  J Vis Exp
  
  Volume: 148 Issue: 148 Pages: 59551-59551
- DOI
  10.3791/59551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07189
[Journal Article] Extraction of aqueous metabolites from cultured adherent cells for metabolomic analysis by capillary electrophoresis-mass spectrometry2019
- Author(s)
  Ami Maruyama, Kenjiro Kami, Kazunori Sasaki, Hajime Sato, Yuzo Sato, Katsuya Tsuchihara and Hideki Makinoshima
- Journal Title
  
  J. Exp. Vis.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07189
[Journal Article] Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis2018
- Author(s)
  Udagawa Hibiki、Umemura Shigeki、Murakami Isao、Mimaki Sachiyo、Makinoshima Hideki、Ishii Genichiro、Miyoshi Tomohiro、Kirita Keisuke、Matsumoto Shingo、Yoh Kiyotaka、Niho Seiji、Tsuchihara Katsuya、Goto Koichi
- Journal Title
  
  Lung Cancer
  
  Volume: 126 Pages: 182-188
- DOI
  10.1016/j.lungcan.2018.11.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07189
[Journal Article] Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.2018
- Author(s)
  Sato Y, Matsuda S, Maruyama A, Nakayama J, Miyashita T, Udagawa H, Umemura S, Yanagihara K, Ochiai A, Tomita M, Soga T, Tsuchihara K, Makinoshima H.
- Journal Title
  
  Front Pharmacol.
  
  Volume: 9 Pages: 1129-1129
- Data Source
  KAKENHI-PROJECT-17K07189
[Journal Article] Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.2018
- Author(s)
  Makinoshima H, Umemura S, Suzuki A, Nakanishi H, Maruyama A, Udagawa H, Mimaki S, Matsumoto S, Niho S, Ishii G, Tsuboi M, Ochiai A, Esumi H, Sasaki T, Goto K, Tsuchihara K.
- Journal Title
  
  Cancer Res.
  
  Volume: 78 Pages: 2179-2190
- Data Source
  KAKENHI-PROJECT-17K07189
[Journal Article] Metabolic determinants of sensitivity to phosphatidylinositol 3-kinase pathway inhibitor in small-cell lung carcinoma2018
- Author(s)
  Makinoshima H et al.
- Journal Title
  
  Cancer Research
  
  Volume: - Issue: 9 Pages: 2179-2190
- DOI
  10.1158/0008-5472.can-17-2109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07189, KAKENHI-PROJECT-16K14619, KAKENHI-PROJECT-17K07194, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17H03980, KAKENHI-PLANNED-15H05899
[Journal Article] Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment.2015
- Author(s)
  Suzuki A, Matsushima K, Makinoshima H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y.
- Journal Title
  
  Genome Biol.
  
  Volume: 16 Issue: 1 Pages: 66-66
- DOI
  10.1186/s13059-015-0636-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300345, KAKENHI-PROJECT-221S0002, KAKENHI-PROJECT-26830121
[Journal Article] Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines.2014
- Author(s)
  Ayako Suzuki , Hideki Makinoshima, Hiroyuki Wakaguri, Hiroyasu Esumi, Sumio Sugano, Takashi Kohno, Katsuya Tsuchihara, Yutaka Suzuki
- Journal Title
  
  Nucleic Acids Reseach
  
  Volume: 42(22) Issue: 22 Pages: 13557-13572
- DOI
  10.1093/nar/gku885
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J05406, KAKENHI-PROJECT-24300345, KAKENHI-PROJECT-26830121, KAKENHI-PROJECT-221S0002
[Journal Article] PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma2012
- Author(s)
  Makinoshima H, Ishii G, Kojima M, Fujii S, Higuchi Y, Kuwata T, Ochiai A
- Journal Title
  
  BMC Cancer
  
  Volume: 12 Issue: 1 Pages: 537-537
- DOI
  10.1186/1471-2407-12-537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700990
[Presentation] 葉酸代謝拮抗薬の薬剤耐性化に関与する核酸代謝調節機構2022
- Author(s)
  牧野嶋秀樹
- Organizer
  鶴岡カンファレンスメタボローム解析の臨床応用
- Invited
- Data Source
  KAKENHI-PROJECT-20K07627
[Presentation] がんにおける核酸代謝制御機構の解明2021
- Author(s)
  牧野嶋秀樹
- Organizer
  第15回メタボロームシンポジウム
- Data Source
  KAKENHI-PROJECT-20K07627
[Presentation] がん細胞における核酸サルベージ経路の重要性2019
- Author(s)
  牧野嶋　秀樹
- Organizer
  核酸代謝鶴岡カンファレンス
- Data Source
  KAKENHI-PROJECT-17K07189
[Presentation] 受容体型チロシン脱リン酸化酵素PTPRZ1による肺小細胞がん進展の制御機構とがん幹細胞マーカーの可能性2013
- Author(s)
  牧野嶋秀樹、石井源一郎、小嶋基寛、藤井誠志、樋口洋一、桑田健、土原一哉、落合淳志
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24700990
[Presentation] 神経内分泌腫瘍で過剰発現するPTPRZ1の肺小細胞がん進展における機能解析2012
- Author(s)
  牧野嶋秀樹、石井源一郎、小嶋基寛、藤井誠志、樋口洋一、桑田健、落合淳志
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24700990
[Presentation] 受容体型チロシン脱リン酸化酵素PTPRZ1による肺小細胞がん進展の制御機構とがん幹細胞マーカーの可能性
- Author(s)
  牧野嶋秀樹、石井源一郎、小嶋基寛、藤井誠志、樋口洋一、桑田健、土原一哉、落合淳志
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24700990

1. 土原一哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Makinoshima Hideki 牧野嶋 秀樹

MAKINOSHIMA Hideki 牧野嶋 秀樹

Research Projects

Research Products

Co-Researchers

小細胞肺癌のRNRとDDRを標的とする新規治療法の開発と代謝バイオマーカーの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of cell growth control mechanism via purine salvage pathway in small cell lung carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of regulated mechanism in controlling purine metabolism through PI3K/mTOR pathway in small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism how Vandetanib kills RET-positive lung cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of PTPRZ1 to maintain cancer stemness in small-cell lung carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] メタボロミクスの臨床応用への挑戦2021

Author(s)

Journal Title

Data Source

[Journal Article] Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extraction of Aqueous Metabolites From Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extraction of aqueous metabolites from cultured adherent cells for metabolomic analysis by capillary electrophoresis-mass spectrometry2019

Author(s)

Journal Title

Data Source

[Journal Article] Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.2018

Author(s)

Journal Title

Data Source

[Journal Article] Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.2018

Author(s)

Journal Title

Data Source

[Journal Article] Metabolic determinants of sensitivity to phosphatidylinositol 3-kinase pathway inhibitor in small-cell lung carcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment.2015

Author(s)

Journal Title

DOI

Makinoshima Hideki 牧野嶋秀樹

MAKINOSHIMA Hideki 牧野嶋秀樹