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Makinoshima Hideki  牧野嶋 秀樹

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MAKINOSHIMA Hideki  牧野嶋 秀樹

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Researcher Number 30510573
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Affiliation (based on the past Project Information) *help 2024: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
2019 – 2022: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
2017 – 2018: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
2015: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
2014: 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 研究員
2012 – 2013: 独立行政法人国立がん研究センター, 臨床開発センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Tumor biology / Tumor therapeutics / Tumor biology
Keywords
Principal Investigator
肺小細胞がん / 核酸生合成経路 / プリン塩基 / 小細胞肺がん / プリン代謝 / 核酸生合成 / サルベージ経路 / 癌 / PI3K/mTOR経路 / 核酸代謝 … More / プリンヌクレオチド / PI3K/mTOT経路 / がんの代謝 / RET / 遺伝子発現 / トランスレーショナルリサーチ / シグナル伝達 / 薬剤耐性 / 肺がん / 融合遺伝子 / 幹細胞 / 分子標的療法 / チロシンリン酸化 / フォスファターゼ / PTPRZ1 / チロシンフォスファターゼ / がん幹細胞 Less
  • Research Projects

    (5 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (1 People)
  •  小細胞肺癌のRNRとDDRを標的とする新規治療法の開発と代謝バイオマーカーの探索Principal Investigator

    • Principal Investigator
      牧野嶋 秀樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  Elucidation of cell growth control mechanism via purine salvage pathway in small cell lung carcinomaPrincipal Investigator

    • Principal Investigator
      MAKINOSHIMA Hideki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      National Cancer Center Japan
  •  Elucidation of regulated mechanism in controlling purine metabolism through PI3K/mTOR pathway in small cell lung cancerPrincipal Investigator

    • Principal Investigator
      Makinoshima Hideki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      National Cancer Center Japan
  •  Elucidation of the mechanism how Vandetanib kills RET-positive lung cancer cellsPrincipal Investigator

    • Principal Investigator
      Makinoshima Hideki
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      National Cancer Center Japan
  •  Role of PTPRZ1 to maintain cancer stemness in small-cell lung carcinomaPrincipal Investigator

    • Principal Investigator
      MAKINOSHIMA Hideki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      National Center of Neurology and Psychiatry

All 2022 2021 2019 2018 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma2021

    • Author(s)
      Ami Maruyama, Yuzo Sato, Joji Nakayama, Junko Murai, Takamasa Ishikawa, Tomoyoshi Soga, Hideki Makinoshima
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 13474-13474

    • DOI

      10.1038/s41598-021-92948-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07627
  • [Journal Article] メタボロミクスの臨床応用への挑戦2021

    • Author(s)
      牧野嶋秀樹
    • Journal Title

      Precision Medicine

      Volume: 12 Pages: 1-1

    • Data Source
      KAKENHI-PROJECT-20K07627
  • [Journal Article] Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma2021

    • Author(s)
      Yuzo Sato, Masaru Tomita, Tomoyoshi Soga, Atsushi Ochiai, Hideki Makinoshima
    • Journal Title

      Front Pharmacol

      Volume: 12 Pages: 718675-718675

    • DOI

      10.3389/fphar.2021.718675

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07627
  • [Journal Article] Extraction of Aqueous Metabolites From Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry2019

    • Author(s)
      Ami Maruyama, Kenjiro Kami, Kazunori Sasaki, Hajime Sato, Yuzo Sato, Katsuya Tsuchihara, Hideki Makinoshima
    • Journal Title

      J Vis Exp

      Volume: 148 Issue: 148 Pages: 59551-59551

    • DOI

      10.3791/59551

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07189
  • [Journal Article] Extraction of aqueous metabolites from cultured adherent cells for metabolomic analysis by capillary electrophoresis-mass spectrometry2019

    • Author(s)
      Ami Maruyama, Kenjiro Kami, Kazunori Sasaki, Hajime Sato, Yuzo Sato, Katsuya Tsuchihara and Hideki Makinoshima
    • Journal Title

      J. Exp. Vis.

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07189
  • [Journal Article] Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis2018

    • Author(s)
      Udagawa Hibiki、Umemura Shigeki、Murakami Isao、Mimaki Sachiyo、Makinoshima Hideki、Ishii Genichiro、Miyoshi Tomohiro、Kirita Keisuke、Matsumoto Shingo、Yoh Kiyotaka、Niho Seiji、Tsuchihara Katsuya、Goto Koichi
    • Journal Title

      Lung Cancer

      Volume: 126 Pages: 182-188

    • DOI

      10.1016/j.lungcan.2018.11.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07189
  • [Journal Article] Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.2018

    • Author(s)
      Sato Y, Matsuda S, Maruyama A, Nakayama J, Miyashita T, Udagawa H, Umemura S, Yanagihara K, Ochiai A, Tomita M, Soga T, Tsuchihara K, Makinoshima H.
    • Journal Title

      Front Pharmacol.

      Volume: 9 Pages: 1129-1129

    • Data Source
      KAKENHI-PROJECT-17K07189
  • [Journal Article] Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.2018

    • Author(s)
      Makinoshima H, Umemura S, Suzuki A, Nakanishi H, Maruyama A, Udagawa H, Mimaki S, Matsumoto S, Niho S, Ishii G, Tsuboi M, Ochiai A, Esumi H, Sasaki T, Goto K, Tsuchihara K.
    • Journal Title

      Cancer Res.

      Volume: 78 Pages: 2179-2190

    • Data Source
      KAKENHI-PROJECT-17K07189
  • [Journal Article] Metabolic determinants of sensitivity to phosphatidylinositol 3-kinase pathway inhibitor in small-cell lung carcinoma2018

    • Author(s)
      Makinoshima H et al.
    • Journal Title

      Cancer Research

      Volume: - Issue: 9 Pages: 2179-2190

    • DOI

      10.1158/0008-5472.can-17-2109

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07189, KAKENHI-PROJECT-16K14619, KAKENHI-PROJECT-17K07194, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17H03980, KAKENHI-PLANNED-15H05899
  • [Journal Article] Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment.2015

    • Author(s)
      Suzuki A, Matsushima K, Makinoshima H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y.
    • Journal Title

      Genome Biol.

      Volume: 16 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s13059-015-0636-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24300345, KAKENHI-PROJECT-221S0002, KAKENHI-PROJECT-26830121
  • [Journal Article] Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines.2014

    • Author(s)
      Ayako Suzuki , Hideki Makinoshima, Hiroyuki Wakaguri, Hiroyasu Esumi, Sumio Sugano, Takashi Kohno, Katsuya Tsuchihara, Yutaka Suzuki
    • Journal Title

      Nucleic Acids Reseach

      Volume: 42(22) Issue: 22 Pages: 13557-13572

    • DOI

      10.1093/nar/gku885

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-12J05406, KAKENHI-PROJECT-24300345, KAKENHI-PROJECT-26830121, KAKENHI-PROJECT-221S0002
  • [Journal Article] PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma2012

    • Author(s)
      Makinoshima H, Ishii G, Kojima M, Fujii S, Higuchi Y, Kuwata T, Ochiai A
    • Journal Title

      BMC Cancer

      Volume: 12 Issue: 1 Pages: 537-537

    • DOI

      10.1186/1471-2407-12-537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24700990
  • [Presentation] 葉酸代謝拮抗薬の薬剤耐性化に関与する核酸代謝調節機構2022

    • Author(s)
      牧野嶋秀樹
    • Organizer
      鶴岡カンファレンスメタボローム解析の臨床応用
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07627
  • [Presentation] がんにおける核酸代謝制御機構の解明2021

    • Author(s)
      牧野嶋秀樹
    • Organizer
      第15回メタボロームシンポジウム
    • Data Source
      KAKENHI-PROJECT-20K07627
  • [Presentation] がん細胞における核酸サルベージ経路の重要性2019

    • Author(s)
      牧野嶋 秀樹
    • Organizer
      核酸代謝鶴岡カンファレンス
    • Data Source
      KAKENHI-PROJECT-17K07189
  • [Presentation] 受容体型チロシン脱リン酸化酵素PTPRZ1による肺小細胞がん進展の制御機構とがん幹細胞マーカーの可能性2013

    • Author(s)
      牧野嶋秀樹、石井源一郎、小嶋基寛、藤井誠志、樋口洋一、桑田健、土原一哉、落合淳志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24700990
  • [Presentation] 神経内分泌腫瘍で過剰発現するPTPRZ1の肺小細胞がん進展における機能解析2012

    • Author(s)
      牧野嶋秀樹、石井源一郎、小嶋基寛、藤井誠志、樋口洋一、桑田健、落合淳志
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24700990
  • [Presentation] 受容体型チロシン脱リン酸化酵素PTPRZ1による肺小細胞がん進展の制御機構とがん幹細胞マーカーの可能性

    • Author(s)
      牧野嶋秀樹、石井源一郎、小嶋基寛、藤井誠志、樋口洋一、桑田健、土原一哉、落合淳志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-24700990
  • 1.  土原 一哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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