HIDEYAMA TAKUTO 日出山拓人

… Alternative Names

Hideyama Takuto 日出山拓人

日出山拓人ヒデヤマタクト

HIDEYAMA Takuto 日出山拓人

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Researcher Number	30511456
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 東京医科大学, 医学部, 講師 2011: 東京大学, 保健・健康推進本部, 助教 2009: The University of Tokyo, 保健・健康推進本部, 助教 2008: The University of Tokyo, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related
Keywords	Principal Investigator GluA2 / AMPA受容体 / RNA編集 / 筋萎縮性側索硬化症 / ADAR2 / 神経細胞死 / ノックアウトマウス / TDP-43 / 上位運動ニューロン / ALS … More / 孤発性 / GluR2 Q / R部位 / GluR2Q / 剖検脳脊髄組織 / RNA編集異常 / 筋萎縮性側索硬化症(ALS) Less

Exploration of pathogenesis for upper motor neuron dysfunction of sporadic ALS employing sporadic ALS model micePrincipal Investigator
- Principal Investigator
  
  Hideyama Takuto
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tokyo Medical University
孤発性筋萎縮性側索硬化症の剖検脳脊髄組織におけるRNA編集酵素活性異常の解析Principal Investigator
- Principal Investigator
  
  日出山拓人
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Analysis of RNA editing enzyme abnormality in the spinal motor neurons of sporadic amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  HIDEYAMA Takuto
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] 内科救急診療指針20222022
- Author(s)
  一般社団法人日本内科学会専門医制度審議会救急委員会（分担執筆：日出山拓人，頭痛）
- Total Pages
  424
- Publisher
  総合医学社
- ISBN
  4883787214
- Data Source
  KAKENHI-PROJECT-19K07967
[Book] ポケット版検査値ガイド2012
- Author(s)
  日出山拓人, ら
- Publisher
  総合医学社(In Press)
- Data Source
  KAKENHI-PROJECT-23790978
[Book] ナースのための検査値ガイド　分担執筆2012
- Author(s)
  日出山拓人ら
- Total Pages
  283
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-23790978
[Book] 神経疾患最新の治療（2012-14年度）分担執筆2012
- Author(s)
  日出山拓人ら
- Total Pages
  446
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23790978
[Book] 郭伸 : 髄液, 髄液オリゴクローナルバンド, 髄液ミエリン塩基性蛋白, パーフェクトガイド検査値事典2010
- Author(s)
  日出山拓人
- Publisher
  総合医学社(In press)
- Data Source
  KAKENHI-PROJECT-20890054
[Book] パーフェクトガイド検査値事典(分担項目,髄液細胞数,蛋白,糖,髄液オリゴクローナルバンド,髄液ミエリン塩基性蛋白など)2010
- Author(s)
  日出山拓人, 郭伸
- Total Pages
  10
- Publisher
  総合医学社(In Press)
- Data Source
  KAKENHI-PROJECT-20890054
[Book] Annual Review 神経 20082008
- Author(s)
  日出山拓人
- Total Pages
  15
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20890054
[Book] 郭伸 : 孤発性筋萎縮性側索硬化症とAMPA仮説, Annual Review 神経20082008
- Author(s)
  日出山拓人
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression2023
- Author(s)
  Kato Haruhisa、Naito Makiko、Saito Tomoko、Hideyama Takuto、Terashi Hiroo、Kwak Shin、Aizawa Hitoshi
- Journal Title
  
  Journal of Clinical Neurology
  
  Volume: 19 Issue: 3 Pages: 280-280
- DOI
  10.3988/jcn.2022.0213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07967, KAKENHI-PROJECT-22H04923
[Journal Article] Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice2023
- Author(s)
  Naito Makiko、Hideyama Takuto、Teramoto Sayaka、Saito Tomoko、Kato Haruhisa、Terashi Hiroo、Kwak Shin、Aizawa Hitoshi
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 444 Pages: 120520-120520
- DOI
  10.1016/j.jns.2022.120520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07967, KAKENHI-PROJECT-22H04923
[Journal Article] AMPA 受容体と運動ニューロン死2023
- Author(s)
  日出山拓人，郭伸
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 41巻 3号 Pages: 351-356
- Data Source
  KAKENHI-PROJECT-19K07967
[Journal Article] Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis2022
- Author(s)
  Kato Haruhisa、Naito Makiko、Saito Tomoko、Hideyama Takuto、Suzuki Yasuhiro、Kimura Takashi、Kwak Shin、Aizawa Hitoshi
- Journal Title
  
  Journal of Clinical Neurology
  
  Volume: 18 Issue: 4 Pages: 463-463
- DOI
  10.3988/jcn.2022.18.4.463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07967
[Journal Article] Nuclear pore destruction and loss of nuclear TDP-43 in FUS mutation-related amyotrophic lateral sclerosis motor neurons2022
- Author(s)
  Aizawa Hitoshi、Teramoto Sayaka、Hideyama Takuto、Kato Haruhisa、Terashi Hiroo、Suzuki Yasuhiro、Kimura Takashi、Kwak Shin
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 436 Pages: 120187-120187
- DOI
  10.1016/j.jns.2022.120187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07537, KAKENHI-PROJECT-19K07967, KAKENHI-PROJECT-22H04923
[Journal Article] Clinicopathologic Features of Oculopharyngodistal Myopathy With LRP12 CGG Repeat Expansions Compared With Other Oculopharyngodistal Myopathy Subtypes.2021
- Author(s)
  Kumutpongpanich T, Ogasawara M, Ozaki A, et al., Hamano T, Sugie K, et al.,
- Journal Title
  
  JAMA Neurol.
  
  Volume: 78(7) Issue: 7 Pages: 853-853
- DOI
  10.1001/jamaneurol.2021.1509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07909, KAKENHI-PROJECT-20H03588, KAKENHI-PROJECT-19K07967, KAKENHI-PROJECT-20K07890, KAKENHI-PROJECT-21K06961
[Journal Article] 筋萎縮性側索硬化症の基礎研究：ADAR2発現低下と孤発性ALS2012
- Author(s)
  日出山拓人他
- Journal Title
  
  脳21
  
  Volume: Vol.15 No.1 Pages: 34-40
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.2012
- Author(s)
  Hideyama T, Yamashita T, Aizawa H, Tsuji S, Kakita A, Takahashi H, Kwak S.
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 45(3) Pages: 1121-1128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2.2012
- Author(s)
  Yamashita T, Tadami C, Nishimoto Y, Hideyama T, Kimura D, Suzuki T, Kwak S.
- Journal Title
  
  Neurosci Res.
  
  Volume: 73(1) Pages: 42-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] ALSに対する治療方法の開発2012
- Author(s)
  日出山拓人, 郭伸
- Journal Title
  
  難病と在宅ケア
  
  Volume: (In Press)
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] Co-occurrence of TDP-43 mislocalization with reduced RNA editing enzyme, ADAR2, in aged mouse motor neurons: implications for age-related acceleration of ALS2012
- Author(s)
  Hideyama T, Teramoto S, Hachiga K, Yamashita T, Kwak S
- Journal Title
  
  PLoS One
  
  Volume: 7,(8) Issue: 8 Pages: e43469-e43469
- DOI
  10.1371/journal.pone.0043469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390173, KAKENHI-PROJECT-23790977, KAKENHI-PROJECT-23790978
[Journal Article] The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons.2012
- Author(s)
  Yamashita T, Hideyama T, Teramoto S, Kwak S.
- Journal Title
  
  Neurosci Res.
  
  Volume: 2012 Mar 10.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] When Does ALS Start? ADAR2-GluA2 Hypothesis for the Etiology of Sporadic ALS.2011
- Author(s)
  Hideyama T, Kwak S.
- Journal Title
  
  Front Mol Neurosci.
  
  Volume: 4 Pages: 33-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] 興奮性毒性とAMPA受容体編集異常2011
- Author(s)
  日出山拓人他
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29巻9号 Pages: 1011-1015
- Data Source
  KAKENHI-PROJECT-23790978
[Journal Article] ALSにおけるRNA editing異常2010
- Author(s)
  日出山拓人, 郭伸
- Journal Title
  
  Clinical Neuroscicence Vol.28, no.3
  
  Pages: 246-247
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] AMPA receptor-mediated neuronal death in sporadic ALS2010
- Author(s)
  Kwak S, Hideyama T, Yamashita T, Aizawa H
- Journal Title
  
  Neuropathology 30 (2)
  
  Pages: 182-8
- NAID
  10029320530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] 臨床医学の展望, 神経病学, 血管系を除く2010
- Author(s)
  辻省次, 岩田淳, 古和久朋, 日出山拓人, 石浦浩之, 代田悠一郎, 長島優
- Journal Title
  
  日本医事新報 4484
  
  Pages: 46-59
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR22010
- Author(s)
  Aizawa H, Sawada J, 日出山拓人, Yamashita T, Katayama T, Hasebe N, Kimura T, Yahara O, Kwak S
- Journal Title
  
  Acta Neuropathol. Apr 7(In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] Novel etiological and therapeutic strategies for neurodiseases-RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis2010
- Author(s)
  日出山拓人, Yamashita T, Nishimoto Y, Suzuki T, Kwak S
- Journal Title
  
  J Pharmacol Sci. Apr 16
  
  Pages: 9-13
- NAID
  10027744823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] Novel etiological and therapeutic strategies for neurodiseases- RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis2010
- Author(s)
  Hideyama T, Yamashita T, Nishimoto Y, Suzuki T, Kwak S
- Journal Title
  
  J Pharmacol Sci. 113(1)
  
  Pages: 9-13
- NAID
  10027744823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] 郭伸 : グルタミン酸受容体と運動ニューロン変性2010
- Author(s)
  日出山拓人, 山下雄也
- Journal Title
  
  実験医学
  
  Pages: 745-753
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] AMPA receptor-mediated neuronal death in sporadic ALS.2010
- Author(s)
  Kwak S, 日出山拓人, Yamashita T, Aizawa H
- Journal Title
  
  Neuropathology Jan 19
  
  Pages: 182-188
- NAID
  10029320530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] グルタミン酸受容体と運動ニューロン変性2010
- Author(s)
  日出山拓人, 山下雄也, 郭伸
- Journal Title
  
  実験医学 Vol.28, no.5
  
  Pages: 745-753
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] 郭伸 : 臨床に必要な神経薬理・化学 : ALSにおけるRNA editing 異常2009
- Author(s)
  日出山拓人
- Journal Title
  
  Clinical Neuroscience
  
  Pages: 246-7
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] AMPA receptor-mediated neuronal death in motor neuron diseases. In : Amino Acid Receptor Research, Eds. Paley BF, Warfield TE2008
- Author(s)
  Kwak S, Hideyama T, Yamashita T
- Journal Title
  
  Nova Science Publishers Inc. NY
  
  Pages: 293-310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] Case of primary intraocular central nervous system lymphoma with high interleukin 10 level and positive cytology in cerebrospinal fluid2008
- Author(s)
  Hideyama T, Tanaka H, Uesaka Y, Kunimoto M, Miwa A.
- Journal Title
  
  臨床神経学第48巻第6号
  
  Pages: 415-8
- NAID
  10021187774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] Determination of editors at the novel A-to-I editing positions2008
- Author(s)
  Nishimoto Y, Yamashita T, Hideyama T, Tsuji S, Suzuki N, Kwak S
- Journal Title
  
  Neurosci Res. 61(2)
  
  Pages: 201-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] 郭伸 : 孤発性ALSと興奮性アミノ酸2008
- Author(s)
  日出山拓人
- Journal Title
  
  Clinical Neuroscience 26巻3号
  
  Pages: 303-305
- Data Source
  KAKENHI-PROJECT-20890054
[Journal Article] TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2
- Author(s)
  Aizawa H, Sawada J, Hideyama T, Yamashita T, Katayama T, Hasebe N, Kimura T, Yahara O, Kwak S
- Journal Title
  
  Acta Neuropathol (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Analysis of TDP-43 pathology for upper motor neurons in ADAR2-conditional knockout mice2023
- Author(s)
  T Hideyama, S Teramoto, M Naito, J Yamazaki, T Saito, H Kato, S Kwak, H Aizawa, H Terashi
- Organizer
  第64回神経学会大会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] 内科救急：脳卒中2022
- Author(s)
  日出山拓人
- Organizer
  第119回日本内科学会総会・講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Nuclear pore destruction in FUS mutation-related ALS motor neurons2022
- Author(s)
  H Aizawa, T Hideyama, H Kato, H Terashi, Y Suzuki, T Kimura, S Kwak
- Organizer
  第63回神経学会大会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Research of pathogenesis for upper motor neuron dysfunction of ALS in conditional ADAR2 knockout mice2022
- Author(s)
  T Hideyama, M Naito, S Teramoto, T Saito, J Yamazaki, H Kato, S Kwak, H Aizawa
- Organizer
  第63回神経学会大会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] 嚥下障害を生じた脳梗塞の検討2022
- Author(s)
  日出山拓人,金丸晃大,新井礼美,大場俊輔,古城健,木村亮之,山崎純,渡邊江莉,秋庭優樹,齊藤智子,内藤万希子,菊野宗明,井戸信博,加藤陽久,赫寛雄,相澤仁志
- Organizer
  Stroke 2022
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] 免疫チェックポイント阻害薬による末梢神経障害を呈した75歳男性例2022
- Author(s)
  細谷早枝子，内藤万希子，渡邊江莉，日出山拓人，加藤陽久，嶋田喜久，赫寛雄，相澤仁志
- Organizer
  第240回日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] 左虚血性視神経症と左腓骨神経麻痺を呈したEGPAの64歳女性例2021
- Author(s)
  秋庭優樹、石川瞳、新井礼美、山崎純、日出山拓人、井戸信博、加藤陽久、赫寛雄、相澤仁志
- Organizer
  第239回日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Analysis of pathogenesis for upper motor neuron dysfunction of ALS using ADAR2 knockout mice2021
- Author(s)
  T Hideyama, M Naito, S Teramoto, T Saito, H Kato, S Kwak, H Aizawa
- Organizer
  第62回神経学会大会(2021年5月)
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] 基礎疾患なく脳幹・小脳に生じた進行性多巣性白質脳症の62歳男性例2021
- Author(s)
  石川瞳、秋庭優樹、山崎純、新井礼美、井戸信博、日出山拓人、加藤陽久、赫寛雄、相澤仁志
- Organizer
  第238回日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] 小脳失調で発症した抗SOX-1抗体陽性肺小細胞癌の40歳台男性例2021
- Author(s)
  渡邊江莉，田口丈士，山口早由美，上田優樹，日出山拓人，相澤仁志
- Organizer
  第236回日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Characteristics of glial cells in the anterior horn of the spinal cord in ADAR2 knockout mice2021
- Author(s)
  M Naito, T Hideyama, S Teramoto, T Saito, H Kato, S Kwak, H Aizawa
- Organizer
  第62回神経学会大会(2021年5月)
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Pathological findings of glial cells in the anterior horn of the spinal cord in sporadic ALS using ADAR2 knockout mice2021
- Author(s)
  M Naito, T Hideyama, S Teramoto, T Saito, H Kato, S Kwak, H Aizawa
- Organizer
  第62回日本神経病理学会総会学術研究会(2021年5月)
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Exploration of pathogenesis for upper motor neuron dysfunction of sporadic ALS employing model mice2020
- Author(s)
  Takuto Hideyama, Sayaka Teramoto, Makiko Naito, Tomoko Saito, Haruhisa Kato, Kwak Shin, Hitoshi Aizawa
- Organizer
  第61回日本神経学会学術大会(2020.5月）岡山
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Exploration of pathogenesis for central nervous system dysfunction and changes in glial cells of sporadic ALS employing model mice2020
- Author(s)
  M Naito, T Hideyama, S Teramoto, T Saito, H Kato, S Kwak, H Aizawa
- Organizer
  第186回東京医科大学医学会総会(2020年11月)
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Disrupted nuclear pore complex with mislocalization of TDP-43 in sporadic amyotrophic lateral sclerosis motor neurons2019
- Author(s)
  相澤仁志，山下雄也，加藤陽久，木村　隆，齋藤智子，寺本さやか，日出山拓人，郭　伸
- Organizer
  第60回日本神経病理学会学術大会 (2019.7.14-16) 名古屋
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] Impaired nucleoporins in sporadic ALS motor neurons that exhibit mislocalization of TDP-432019
- Author(s)
  Aizawa H, Yamashita T, Kato H, Kimura T, Saito T, Teramoto S, Hideyama T, Kwak S
- Organizer
  第60回日本神経学会学術大会(2019.5.22-25)大阪
- Data Source
  KAKENHI-PROJECT-19K07967
[Presentation] コンディショナルADAR2ノックアウトマウスの電顕的検討2012
- Author(s)
  佐々木彰一, 日出山拓人, 郭伸
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] 加齢が孤発性ALSの危険因子であることの分子病態の検討2012
- Author(s)
  日出山拓人, ら
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] Inefficient RNA editing of GluA2 with ADAR2 downregulation and sporadic ALS.2011
- Author(s)
  Hideyama T, et al
- Organizer
  8th International Brain Research Organization World Of Neuroscience
- Place of Presentation
  Fortezza da Basso（イタリア，フィレンツェ）
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] Downregulation of RNA editing enzyme ADAR2 and sporadic ALS.2011
- Author(s)
  Hideyama T, et al
- Organizer
  The 22nd International Symposium on MND/ALS
- Place of Presentation
  Hilton Sydney（オーストラリア，シドニー）
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] 孤発性筋萎縮性側索硬化症におけるRNA編集異常のメカニズムと運動ニューロン死2011
- Author(s)
  日出山拓人他
- Organizer
  第52回神経学会総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons2011
- Author(s)
  Yamashita T, Hideyama T et al.
- Organizer
  Neuroscience2011
- Place of Presentation
  Walter E. Washington Convention Center（アメリカ，ワシントンDC)
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] Abnormal GluR2 RNA editing and TDP-43 pathology in ALS motor neurons，2011
- Author(s)
  山下雄也，日出山拓人他
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23790978
[Presentation] 孤発性筋萎縮性側索硬化症とRNA編集異常2010
- Author(s)
  日出山拓人, 山下雄也, 相澤仁志, 柿田明美, 高橋均, 辻省次, 郭伸
- Organizer
  第51回神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis2009
- Author(s)
  Hideyama T, Yamashita T, Suzuki T, Kimura D, Tsuji S, Higuchi M, Peter H, Seeburg, Takahashi R, Misawa H, Kwak S
- Organizer
  第82回日本薬理学会 (招待口演)
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] 孤発性筋萎縮性側索硬化症モデルマウスの開発と病態解析2009
- Author(s)
  日出山拓人, 山下雄也, 鈴木岳之, 辻省次, 高橋良輔, 三澤日出巳, Miyoko Higuchi, Peter H.Seeburg, 郭伸
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  東北大学ホール
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] 郭伸 : 孤発性筋萎縮性側索硬化症モデルマウスの開発と病態解析2009
- Author(s)
  日出山拓人, 山下雄也, 鈴木岳之, 辻省次, 高橋良輔, 三澤日出巳^4, Miyoko Higuchi, Peter H. Seeburg^3
- Organizer
  第50回神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Analysis of neuronal death pathway in conditional ADAR2 knockout mice(AKAMON)2009
- Author(s)
  Yamashita T, 日出山拓人, Kwak S
- Organizer
  第32回日本神経科学大会(Neuro2009)
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis2009
- Author(s)
  日出山拓人, Yamashita T, 鈴木岳之, 辻省次, Higuchi M, Peter H.Seeburg, 高橋良輔, 三澤日出巳, Kwak S
- Organizer
  The 20^<th> International Symposium on MND/ALS
- Place of Presentation
  Berlin・ドイツ
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Analysis of neuronal death pathway in conditional ADAR2 knockout mice (AKAMON)2009
- Author(s)
  Yamashita T, Hideyama T, Kwak S
- Organizer
  第32回日本神経科学大会 (Neuro 2009)
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] RNA編集酵素ADAR2コンディショナルノックアウトによる孤発性ALSモデルマウスの分子病態解析2009
- Author(s)
  日出山拓人
- Organizer
  平成20年度「筋萎縮性側索硬化症の病態に基づく画期的治療法の開発」班
- Place of Presentation
  東京
- Year and Date
  2009-01-15
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis2009
- Author(s)
  Hideyama T, Yamashita T, Suzuki T, Tsuji S, Higuchi M, Peter H. Seeburg, Takahashi R, Misawa H, Kwak S
- Organizer
  The 20^<th> International Symposium on MND/ALS
- Place of Presentation
  Berlin(Germany)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis(シンポジウム)2009
- Author(s)
  T Hideyama
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Motor neurons of sporadic ALS patients express abundant Q/R Slow neuronal death of motor neurons in sporadic ALS mouse model by RNA editing enzyme ADAR2 knockout2008
- Author(s)
  T Hideyama
- Organizer
  Neurosciece2008
- Place of Presentation
  Washington D. C.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Slow death of motor neurons in sporadic ALS mouse model by conditional targeting of RNA editing enzyme ADAR22008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Misawa H, Takahasi R, Suzuki T, Kwak S
- Organizer
  19^<th> ALS/MND International Symposium
- Place of Presentation
  Birmingham (UK)
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Neuronal death induced by deficient ADAR2 in tamoxifen-driven conditional knockout mice2008
- Author(s)
  Kimura D, Hideyama T, Suzuki T, Kwak S
- Organizer
  第81回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Mouse model of sporadic ALS by targeting RNA editing enzyme in motor neurons2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Misawa H, Takahasi R, Suzuki T, Kwak S
- Organizer
  6^<th> FENS Forum of European Neurosicence
- Place of Presentation
  Geneva (Switzerland)
- Year and Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Slow death of motor neurons in sporadic ALS mouse model by conditional targeting of RNA editing enzyme ADAR22008
- Author(s)
  T Hideyama
- Organizer
  第19^h ALS/MND Internatignal Symposium
- Place of Presentation
  Birmingham
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation]2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Misawa H, Takahasi R, Suzuki T, Kwak S
- Organizer
  Slow neuronal death of motor neurons in sporadic ALS mouse model by RNA editing enzyme ADAR2 knockout mice
- Place of Presentation
  Washington. D.C (USA)
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Mouse model of sporadic ALS by abnormality of RNA editing enzyme2008
- Author(s)
  Hideyama T, Yamashita T, Tsuji S, Misawa H, Takahasi R, Suzuki T, Kwak S
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-06
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] RNA編集異常による孤発性ALSモデルマウスの開発2008
- Author(s)
  日出山拓人, 山下雄也, 辻省次, 高橋良輔, 三澤日出巳, 鈴木岳之, 郭伸
- Organizer
  第49回神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] ALS運動ニューロンにおけるGluR2 RNA編集異常の解析2008
- Author(s)
  日出山拓人
- Organizer
  2008年度病態脳(統合脳,第5領域)
- Place of Presentation
  東京
- Year and Date
  2008-12-23
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] ALS運動ニューロンにおけるGluR2 RNA編集異常の解析2008
- Author(s)
  日出山拓人
- Organizer
  2008年度厚労省変性班会議
- Place of Presentation
  東京
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-20890054
[Presentation] Mouse model of sporadic ALS by targeting RNA editing enzyme in motor neurons.2008
- Author(s)
  T. Hideyama
- Organizer
  6^<th> FENS Forum of European Neurosicence
- Place of Presentation
  Geneva
- Year and Date
  2008-07-14
- Data Source
  KAKENHI-PROJECT-20890054

1. 浜野忠則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 郭伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 相澤仁志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIDEYAMA TAKUTO 日出山 拓人

Hideyama Takuto 日出山 拓人

日出山 拓人 ヒデヤマ タクト

HIDEYAMA Takuto 日出山 拓人

Research Projects

Research Products

Co-Researchers

Exploration of pathogenesis for upper motor neuron dysfunction of sporadic ALS employing sporadic ALS model micePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

孤発性筋萎縮性側索硬化症の剖検脳脊髄組織におけるRNA編集酵素活性異常の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Analysis of RNA editing enzyme abnormality in the spinal motor neurons of sporadic amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 内科救急診療指針20222022

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[Book] ポケット版検査値ガイド2012

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[Book] ナースのための 検査値ガイド 分担執筆2012

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[Book] 神経疾患最新の治療（2012-14年度）分担執筆2012

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[Book] 郭伸 : 髄液, 髄液オリゴクローナルバンド, 髄液ミエリン塩基性蛋白, パーフェクトガイド検査値事典2010

Author(s)

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Data Source

[Book] パーフェクトガイド検査値事典(分担項目,髄液細胞数,蛋白,糖,髄液オリゴクローナルバンド,髄液ミエリン塩基性蛋白など)2010

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[Book] Annual Review 神経 20082008

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[Book] 郭伸 : 孤発性筋萎縮性側索硬化症とAMPA仮説, Annual Review 神経20082008

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[Journal Article] Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression2023

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[Journal Article] Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice2023

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[Journal Article] AMPA 受容体と運動ニューロン死2023

Author(s)

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[Journal Article] Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis2022

Author(s)

Journal Title

HIDEYAMA TAKUTO 日出山拓人

Hideyama Takuto 日出山拓人

日出山拓人ヒデヤマタクト

HIDEYAMA Takuto 日出山拓人

[Book] ナースのための検査値ガイド　分担執筆2012