OGASAWARA Hiroshi 小笠原寛

Researcher Number	30535232
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院総合人間科学系, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 信州大学, 学術研究院総合人間科学系, 准教授 2017 – 2020: 信州大学, 学術研究院総合人間科学系, 助教 2015 – 2016: 信州大学, 学術研究院繊維学系, 助教 2011 – 2013: 信州大学, ヒト環境科学研究支援センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 38020:Applied microbiology-related / Applied microbiology Except Principal Investigator Applied microbiology
Keywords	Principal Investigator Escherichia coli / 大腸菌 / Two-component system / CsgD / HprS/HprR / Biofilm formation / CsgA / バイオフィルム / Transcription / Biofilm … More / Salmonella / ROS/RCS / ペリプラズム / Hydrogen peroxide / hydrogen peroxide / H2O2 / HprS/R / Oxidative stress / Periplasmic space / ROS / Organic compounds / 転写因子 / アミロイド線維 / Curli線毛 / Periplasm / Transcription factor / Biofilm inhibition / Amyloid fimbriae / 転写制御 / Curli / signal transduction / curli / csgD … More Except Principal Investigator 細胞壁 / 立体構造解析 / 発現制御 / 細胞増殖 / 細胞表層 / シグマ因子 / ペプチドグリカン / 枯草菌 / 表層タンパク質 / インヒビター / 細胞壁溶解酵素 / 細胞形態 / 表層蛋白質 / 微生物機能 Less

貪食細胞ファゴソーム内部環境におけるグラム陰性細菌ROS/RCS防御機構の解明Principal Investigator
- Principal Investigator
  
  小笠原寛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Shinshu University
Elucidation of the mechanism of action of plant-derived natural organic compounds in regulating bacterial biofilm formationPrincipal Investigator
- Principal Investigator
  
  OGASAWARA Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Shinshu University
Elucidation of a novel mechanism for repairing oxidized proteins in the bacterial periplasmic spacePrincipal Investigator
- Principal Investigator
  
  OGASAWARA Hiroshi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Shinshu University
Elucidation of molecular mechanisms involved in bacterial biofilm inhibitionPrincipal Investigator
- Principal Investigator
  
  OGASAWARA Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Shinshu University
Characterization of the environmental signal transduction system in bacterial cell-cell communication and cell aggregationPrincipal Investigator
- Principal Investigator
  
  OGASAWARA Hiroshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Shinshu University
Mechanisms of cell growth, morphology, and maintenance by bacterial cell surface regulation
- Principal Investigator
  
  SEKIGUCHI Junichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied microbiology
- Research Institution
  Shinshu University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Novel regulators of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli K-122020
- Author(s)
  Ogasawara H., Ishizuka T., Hotta S., Aoki M., Shimada T., Ishihama A.
- Journal Title
  
  Microbiology
  
  Volume: 166 Issue: 9 Pages: 880-890
- DOI
  10.1099/mic.0.000947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05388
[Journal Article] Regulatory Role of Pyruvate-Sensing BtsSR in Biofilm Formation by Escherichia Coli K-122019
- Author(s)
  Ogasawara H., Ishizuka T., Yamaji K., Kato Y., Shimada T., Ishihama A.
- Journal Title
  
  FEMS microbiology letters
  
  Volume: 366 Issue: 24
- DOI
  10.1093/femsle/fnz251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05388
[Journal Article] Single-target regulators form a minor group of transcription factors in Escherichia coli K-122018
- Author(s)
  Shimada Tomohiro、Ogasawara Hiroshi、Ishihama Akira
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 46 Issue: 8 Pages: 3921-3936
- DOI
  10.1093/nar/gky138
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07195, KAKENHI-PROJECT-15K18670, KAKENHI-PROJECT-18K05388
[Journal Article] Genomic SELEX Screening of Regulatory Targets of Escherichia coli Transcription Factors2018
- Author(s)
  Shimada Tomohiro、Ogasawara Hiroshi、Ishihama Akira
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1837 Pages: 49-69
- DOI
  10.1007/978-1-4939-8675-0_4
- ISBN
  9781493986743, 9781493986750
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07195, KAKENHI-PROJECT-18K05388
[Journal Article] A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation2017
- Author(s)
  Sugino Hirotaka、Usui Takanori、Shimada Tomohiro、Nakano Masahiro、Ogasawara Hiroshi、Ishihama Akira、Hirata Akira
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 13 Pages: 2019-2031
- DOI
  10.1002/1873-3468.12713
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06975, KAKENHI-PROJECT-15K18670
[Journal Article] Repression of flagellar genes in exponential phase by CsgD and CpxR, two crucial modulators of Escherichia coli biofilm formation.2014
- Author(s)
  Dudin O, Geiselmann J, Ogasawara H, Ishihama A, Lacour S.
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 196 Issue: 3 Pages: 707-715
- DOI
  10.1128/jb.00938-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24780070, KAKENHI-PROJECT-25430173
[Journal Article] Screening of promoter-specific transcription factors: multiple regulators for the sdiA gene involved in cell division control and quorum sensing.2013
- Author(s)
  Shimada K, Ogasawara H, Yamada K, Shimura M, Kori A, Shimada T, Yamanaka Y, Yamamoto K, Ishihama A.
- Journal Title
  
  Microbiology
  
  Volume: 159 Issue: Pt_12 Pages: 2501-2512
- DOI
  10.1099/mic.0.067538-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780070
[Journal Article] Identification of the set of genes, including non-annotated morA, under the direct control of ModE in Escherichia coli2013
- Author(s)
  Kurata, T., Katayama, A., Hiramatsu, M., Kiguchi, Y., Takeuch, M., Watanabe, T., Ogasawara, H., Ishihama, A., Yamamoto, K.
- Journal Title
  
  Bacteriol
  
  Volume: 195 Pages: 4496-4505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780070
[Journal Article] Identification of the set of genes, including nonannotated morA, under the direct control of ModE in Escherichia coli.2013
- Author(s)
  Kurata T, Katayama A, Hiramatsu M, Kiguchi Y, Takeuchi M, Watanabe T, Ogasawara H, Ishihama A, Yamamoto K.
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 195 Issue: 19 Pages: 4496-4505
- DOI
  10.1128/jb.00304-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780070, KAKENHI-PROJECT-25430173
[Journal Article] Screening of promoter-specific transcription factors : multiple regulators for the sdiA gene involved in cell division control and quorum sensing2013
- Author(s)
  Shimada, K., Ogasawara, H., Yamada, K., Shimura, M., Kori, A., Shimada, T., Yamanaka, Y., Yamamoto, K., Ishihama, A.
- Journal Title
  
  Microbiology
  
  Volume: 159 Pages: 2501-2512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780070
[Journal Article] A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli2012
- Author(s)
  Shimada, T., Katayama, Y., Kawakita, S., Ogasawara, H., Nakano, M., Yamamoto, K., Ishihama, A.
- Journal Title
  
  Microbiologyopen
  
  Volume: 1 Issue: 4 Pages: 381-394
- DOI
  10.1002/mbo3.42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658098, KAKENHI-PROJECT-24780070
[Journal Article] A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli2012
- Author(s)
  Shimada, T., Katayama, Y., Kawakita, S., Ogasawara, H., Nakano, M., Yamamoto, K., Ishihama, A.
- Journal Title
  
  Microbiologyopen
  
  Volume: 1 Pages: 381-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780070
[Journal Article] Novel regulation targets of the metal- response BasS-BasR two-component system of Escherichia coli2012
- Author(s)
  Ogasawara, H., Shinohara, S., Yamamoto, K., Ishihama, A.
- Journal Title
  
  Microbiology
  
  Volume: 158 Pages: 1482-1492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780070
[Journal Article] Regulation targets of metal-response BasS-BasR two-component system in Escherichia coli : Modification of cell membrane2012
- Author(s)
  Ogasawara, H., Shinohara, S., Ishihama, A.
- Journal Title
  
  Microbiology
  
  Volume: 158(In press) Issue: 6 Pages: 1482-1492
- DOI
  10.1099/mic.0.057745-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241047, KAKENHI-PROJECT-24780070
[Presentation] 大腸菌二成分制御系HprS/HprRの次亜塩素酸応答における作用機序2020
- Author(s)
  山路幸太郎、谷口瑠美音、小笠原寛
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K05388
[Presentation] 細菌ペリプラズム空間における過酸化水素感知センサーHprSの機能解析2019
- Author(s)
  山路幸太郎、浦野浩行、小笠原寛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K05388
[Presentation] 大腸菌K-12株のゲノム転写制御ネットワークにおけるSingle-target regulatorsの機能解析2018
- Author(s)
  島田友裕、小笠原寛、石浜明
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K05388
[Presentation] 大腸菌ペリプラズムタンパク質YccTによるアミロイド線維形成抑制機構の解明2017
- Author(s)
  佐野晃太郎、加藤佑輝、小笠原寛
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] 大腸菌アミロイド線維形成に関与する新規遺伝子群の同定と機能解明2017
- Author(s)
  井出有佳里、加藤佑輝、杉本真也、小笠原寛
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] 大腸菌の遊走性とバイオフィルム形成を制御する新規転写因子の同定と機能解明2016
- Author(s)
  増井祥平、石塚俊行、石浜明、小笠原寛
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] 大腸菌バイオフィルム形成統括因子CsgDの新規発現抑制機構の解明2016
- Author(s)
  石塚俊行、太田あず佐、石浜明、小笠原寛
- Organizer
  第10回日本ゲノム微生物学会年会
- Place of Presentation
  東京工業大学 (東京都目黒区)
- Year and Date
  2016-03-04
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] 大腸菌新規アミロイド線維形成抑制因子YccTの機能解明2016
- Author(s)
  佐野晃太郎、小笠原寛
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] バイオフィルム統括制御因子CsgDによって制御される新規アミロイド線維形成抑制因子YccTの機能解明2016
- Author(s)
  佐野晃太郎、加藤佑輝、小笠原寛
- Organizer
  第10回日本ゲノム微生物学会年会
- Place of Presentation
  東京工業大学 (東京都目黒区)
- Year and Date
  2016-03-04
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] バイオフィルム統括制御因子CsgDによって制御される新規Curli線毛抑制機構の解明2015
- Author(s)
  佐野晃太郎、小笠原寛
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場 (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] 大腸菌バイオフィルム形成統括因子CsgDの新規転写制御因子の同定と機能解明2015
- Author(s)
  石塚俊行、石浜明、小笠原寛
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場 (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18670
[Presentation] 大腸菌バイオフィルム形成統括制御因子CsgDの新規発現調節機構の探索と機能解析2014
- Author(s)
  小笠原寛、石塚俊行、石浜明
- Organizer
  第8回日本ゲノム微生物学会年会
- Place of Presentation
  東京農業大学(東京都世田谷区)
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 大腸菌バイオフィルム形成統括制御因子CsgDの新規発現調節機構の探索と機能解析2014
- Author(s)
  小笠原寛、石塚俊行、石浜明
- Organizer
  第8回日本ゲノム微生物学会年会
- Place of Presentation
  東京農業大学世田谷キャンパス
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] PS-TF (promoter-specific TF) screening systemによる大腸菌多因子プロモーター解析2013
- Author(s)
  小笠原寛
- Organizer
  遺伝研研究集会「大腸菌ゲノム転写研究全体像の分析と転写データベース構築」
- Place of Presentation
  遺伝学研究所(静岡県三島市)
- Invited
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 細菌のふたつの生存形態間バランスの多因子による制御機構2013
- Author(s)
  小笠原寛
- Organizer
  遺伝研研究集会「細菌細胞の増殖と代謝研究会（スイッチング制御）」
- Place of Presentation
  遺伝学研究所(静岡県三島市)
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 細菌細胞によるアミロイド様線維蛋白応答機構の解明2013
- Author(s)
  加藤佑輝、石浜明、小笠原寛
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] PS-TF screeningによる大腸菌バイオフィルム統括制御因子csgDプロモーター特異的転写因子の探索2013
- Author(s)
  小笠原寛、石塚俊行、石浜明
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] PS-TF (promoter-specific TF) screening systemによる大腸菌多因子プロモーター解析2013
- Author(s)
  小笠原寛
- Organizer
  遺伝研研究集会「大腸菌ゲノム転写研究全体像の分析と転写データベース構築」
- Place of Presentation
  国立遺伝学研究所(三島市)
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 細菌細胞によるアミロイド様線維蛋白応答機構の解明2013
- Author(s)
  加藤佑輝、石浜明、小笠原寛
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  ポートアイランド(兵庫県神戸市)
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] ひとつのプロモーターを制御するすべての転写因子のPS-TF法による探索 : 大腸菌細胞分裂分化制御因子SdiA遺伝子プロモーター2013
- Author(s)
  石浜明、島田佳織、小笠原寛、島田友裕、山田佳代子、郡彩子、山本兼由、川岸郁郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] PS-TF screeningによる大腸菌バイオフィルム統括制御因子csgDプロモーター特異的転写因子の探索2013
- Author(s)
  小笠原寛、石塚俊行、石浜明
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  ポートアイランド(兵庫県神戸市)
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 細菌のふたつの生存形態間バランスの多因子による制御機構2013
- Author(s)
  小笠原寛
- Organizer
  遺伝研研究集会「細菌細胞の増殖と代謝研究会(スイッチング制御)」
- Place of Presentation
  国立遺伝学研究所(三島市)
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 亜鉛による大腸菌バイオフィルム形成統括因子CsgDの発現抑制機構2012
- Author(s)
  小笠原寛、山本兼由、石浜明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 高グルコース環境下におけるバイオフィルム形成統括因子CsgDの発現制御機構の解明2012
- Author(s)
  小口卓也、島田友裕、石浜明、小笠原寛
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] プロモーター特異的転写因子(PS-TF)探索法の開発と大腸菌細胞分裂制御因子SdiA遺伝子調節転写因子の探索2012
- Author(s)
  島田佳織、志村美樹、山田佳代子、郡彩子、小笠原寛、島田友裕、山本兼由、石浜明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 亜鉛による大腸菌バイオフィルム形成統括因子CsgDの発現抑制機構
- Author(s)
  小笠原寛、山本兼由、石浜明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] 高グルコース環境下におけるバイオフィルム形成統括因子CsgDの発現制御機構の解明
- Author(s)
  小口卓也、島田友裕、石浜明、小笠原寛
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24780070
[Presentation] プロモーター特異的転写因子(PS-TF)探索法の開発と大腸菌細胞分裂制御因子SdiA遺伝子調節転写因子の探索
- Author(s)
  島田佳織、志村美樹、山田佳代子、郡彩子、小笠原寛、島田友裕、山本兼由、石浜明
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24780070

1. SEKIGUCHI Junichi (80111053)

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2. ARAI Ryoichi (50344023)

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3. YAMAMOTO Hiroki (20262701)

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4. ASAI Kei (70283934)

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5. HASHIMOTO Masayuki (80402139)

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# of Collaborated Products: 0 results
6. ISHIHAMA Akira (80019869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. KATO Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. ISHIZUKA Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SANO Kotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. MASHUI Shohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. HOTTA Shuhei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KOBAYASHI Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AOKI Michiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAMOTO Kaneyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. SHIMADA Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 平田章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OGASAWARA Hiroshi 小笠原 寛

Research Projects

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貪食細胞ファゴソーム内部環境におけるグラム陰性細菌ROS/RCS防御機構の解明Principal Investigator

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Elucidation of the mechanism of action of plant-derived natural organic compounds in regulating bacterial biofilm formationPrincipal Investigator

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Elucidation of a novel mechanism for repairing oxidized proteins in the bacterial periplasmic spacePrincipal Investigator

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Elucidation of molecular mechanisms involved in bacterial biofilm inhibitionPrincipal Investigator

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Characterization of the environmental signal transduction system in bacterial cell-cell communication and cell aggregationPrincipal Investigator

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Mechanisms of cell growth, morphology, and maintenance by bacterial cell surface regulation

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[Journal Article] Novel regulators of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli K-122020

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[Journal Article] Regulatory Role of Pyruvate-Sensing BtsSR in Biofilm Formation by Escherichia Coli K-122019

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[Journal Article] Single-target regulators form a minor group of transcription factors in Escherichia coli K-122018

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[Journal Article] Genomic SELEX Screening of Regulatory Targets of Escherichia coli Transcription Factors2018

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[Journal Article] A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation2017

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[Journal Article] Repression of flagellar genes in exponential phase by CsgD and CpxR, two crucial modulators of Escherichia coli biofilm formation.2014

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[Journal Article] Screening of promoter-specific transcription factors: multiple regulators for the sdiA gene involved in cell division control and quorum sensing.2013

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[Journal Article] Identification of the set of genes, including non-annotated morA, under the direct control of ModE in Escherichia coli2013

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OGASAWARA Hiroshi 小笠原寛