Ogasawara Satoshi 小笠原諭

… Alternative Names

OGASAWARA Satoshi 小笠原諭

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Researcher Number	30546685
Affiliation (Current)	2025: 千葉大学, 大学院理学研究院, 准教授 2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 千葉大学, 大学院理学研究院, 准教授 2023: 千葉大学, 大学院理学研究院, 特任准教授 2021: 千葉大学, 大学院理学研究院, 特任准教授 2017: 東北大学, 医学系研究科, 助教 2013 – 2015: 東北大学, 医学(系)研究科(研究院), 助教 … More 2014: 京都大学, 大学院医学研究科, 研究員 2012: 京都大学, 医学(系)研究科(研究院), 研究員 2012: 京都大学, 医学研究科, 研究員 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Structural biochemistry / Medium-sized Section 90:Biomedical engineering and related fields / Broad Section G / Applied molecular and cellular biology
Keywords	Principal Investigator モノクローナル抗体 / 構造解析 / アンジオテンシン変換酵素2(ACE2) / 新型コロナウイルス(SARS-CoV2) / X線結晶構造解析 / 多重特異性 / 膜タンパク質 / 立体構造解析 / 膜蛋白質 / ペプチドトランスポーター … More Except Principal Investigator … More GPCR / 輸送体 / 結晶構造解析 / X線結晶構造解析 / 構造解析 / 細胞イメージング / 異方性 / イオンチャネル / イオン濃度可視化 / イオンチャンネル活性評価 / 薬剤反応評価 / 単細胞可視化 / 電気インピーダンス・トモグラフィ / クライオ電子顕微鏡 / 生体膜 / 物質生産 / トランスポーター / 創薬 / 膜輸送体 / ヒスタミン / 花粉症 / アレルギー / G蛋白質共役型受容体 / 膜タンパク質 / 受容体 / X線結晶解析 Less

新型コロナウイルス感染阻害能を有する抗ACE2抗体の阻害機構に関する構造基盤解明Principal Investigator
- Principal Investigator
  
  小笠原諭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Chiba University
創薬評価技術の創出に向けたラベルフリーイオンチャネル異方性4Dセンシングへの挑戦
- Principal Investigator
  
  武居昌宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Chiba University
Structural dynamics of GPCR in cells
- Principal Investigator
  
  濡木理
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  The University of Tokyo
Study of allosteric regulation of solute transporter by a second-messenger and its structural analysis.
- Principal Investigator
  
  ABE Keietsu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Tohoku University
Improvement of the multi-specificity for anti-IDH1/2 mAb MsMab-1 and 2 based on structurePrincipal Investigator
- Principal Investigator
  
  Ogasawara Satoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tohoku University
Structure determination of human membrane transporters
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Structure determination of histamine H1 receptor
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
The transport mechanism of the peptide transporter by the X-ray structual anaysis.Principal Investigator
- Principal Investigator
  
  OGASAWARA Satoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tohoku University
  Kyoto University
Challenges for the structure determination of GPCR active conformation
- Principal Investigator
  
  SHIMAMURA Tatsuro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University

All 2022 2021 2017 2016 2014 2013 2012 2011

All Journal Article Presentation Book Patent

[Book] タンパク質結晶の最前線：　抗体を用いた膜タンパク質の結晶化2014
- Author(s)
  名倉　淑子、小笠原　諭、田辺　幹雄
- Total Pages
  10
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24770095
[Book] 「タンパク質結晶の最前線」:抗体を用いた膜タンパク質の結晶化2013
- Author(s)
  名倉淑子、小笠原諭、田辺幹雄
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24770095
[Journal Article] Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.2021
- Author(s)
  Tomita, A., Daiho, T., Kusakizako, T., Yamashita, K., Ogasawara, S., Murata, T., Nishizawa, T. and Nureki, O.
- Journal Title
  
  Mol. Cell
  
  Volume: 81 Issue: 23 Pages: 4799-4809
- DOI
  10.1016/j.molcel.2021.11.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-20J13299, KAKENHI-PROJECT-20K06534, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-21H05037
[Journal Article] 創薬ターゲット膜蛋白質の立体構造解析2012
- Author(s)
  島村達郎、小笠原諭、岩田想
- Journal Title
  
  内分泌・糖尿病・代謝内科
  
  Volume: 35 Pages: 557-564
- Data Source
  KAKENHI-PROJECT-24370044
[Journal Article] Production of the stable human histamine H(1) receptor in Pichia pastoris for structural determination2011
- Author(s)
  Shiroishi M, Kobayashi T, Shimamura T., et al
- Journal Title
  
  Methods
  
  Volume: 55 Issue: 4 Pages: 281-286
- DOI
  10.1016/j.ymeth.2011.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370043, KAKENHI-PROJECT-23657074
[Patent] 膜タンパク質のC末端に付加した His-tag に対する高親和性モノクローナル抗体 (cHis8)2022
- Inventor(s)
  小笠原諭、村田武士
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-21H05037
[Patent] アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体2012
- Inventor(s)
  小笠原諭日野智也島村達郎荒川孝俊万木貴美寿野千代村田武士小林拓也岩田想
- Industrial Property Number
  2012-049812
- Filing Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23657074
[Patent] アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体2012
- Inventor(s)
  小笠原諭, 島村達郎ら
- Industrial Property Rights Holder
  （独）科学技術振興機構
- Industrial Property Number
  2012-049812
- Filing Date
  2012
- Data Source
  KAKENHI-PROJECT-23657074
[Presentation] 乳酸菌由来アミノ酸トランスポーターの基質結合による熱安定化2017
- Author(s)
  金ななせ、千葉文香、小笠原諭、〇七谷圭、阿部敬悦
- Organizer
  第12回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-15K14911
[Presentation] Aspartate：Alanine 交換輸送体 AspT の立体構造解析に向けた高発現系・精製系の構築2017
- Author(s)
  宮本　あかり，〇國井　宏太，光岡　薫, 小笠原　諭，七谷　圭，阿部　敬悦
- Organizer
  酵素・補酵素研究会2017
- Data Source
  KAKENHI-PROJECT-15K14911
[Presentation] 乳酸菌 Tetragenococcus halophilus 由来 Aspartate:Alanine 交換輸送体AspT の高生産系の構築およびその解析2016
- Author(s)
  宮本あかり, 鈴木聡美, 小笠原諭, 七谷　圭, 阿部敬悦
- Organizer
  生体エネルギー研究会第42回討論会
- Place of Presentation
  名古屋工業大学, 名古屋
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-15K14911
[Presentation] 膜タンパク質の結晶化・構造解析を支援するモノクローナル抗体作製技術の開発2013
- Author(s)
  小笠原諭、Simon Newstead、小笠原かほり、日野智也、荒川孝俊、寿野千代、村田武士、加藤　幸成、岩田想
- Organizer
  日本生化学会東北支部第79回例会
- Place of Presentation
  東北大学　片平さくらホール
- Data Source
  KAKENHI-PROJECT-24770095
[Presentation] 膜タンパク質の結晶化・構造解析を支援するモノクローナル抗体作製技術の開発2013
- Author(s)
  小笠原諭、Simon Newstead、小笠原かほり、日野智也、荒川孝俊、寿野千代、村田武士、金子美華、加藤幸成、岩田想
- Organizer
  第79回日本生化学会東北支部例会
- Place of Presentation
  仙台
- Year and Date
  2013-05-11
- Data Source
  KAKENHI-PROJECT-24770095

1. SHIMAMURA Tatsuro (90391979)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. ASADA Hidetsugu (20399041)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HINO Tomoya (40373360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IWATA So (60452330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NOMURA Morimichi (10314246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANAKA Yoshiki (10632333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ARAKAWA Takatoshi (30523766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ABE Keietsu (50312624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. NANATANI Kei (00547333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 濡木理 (10272460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 井上飛鳥 (50525813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 藤芳暁 (70371705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 武居昌宏 (90277385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 川嶋大介 (10813785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 村田武士 (80415322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. LEURS Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIROISHI Mitsunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 小林拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogasawara Satoshi 小笠原 諭

OGASAWARA Satoshi 小笠原 諭

Research Projects

Research Products

Co-Researchers

新型コロナウイルス感染阻害能を有する抗ACE2抗体の阻害機構に関する構造基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

創薬評価技術の創出に向けたラベルフリーイオンチャネル異方性4Dセンシング への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural dynamics of GPCR in cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of allosteric regulation of solute transporter by a second-messenger and its structural analysis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of the multi-specificity for anti-IDH1/2 mAb MsMab-1 and 2 based on structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure determination of human membrane transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure determination of histamine H1 receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The transport mechanism of the peptide transporter by the X-ray structual anaysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Challenges for the structure determination of GPCR active conformation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] タンパク質結晶の最前線： 抗体を用いた膜タンパク質の結晶化2014

Author(s)

Total Pages

Publisher

Data Source

[Book] 「タンパク質結晶の最前線」:抗体を用いた膜タンパク質の結晶化2013

Author(s)

Publisher

Data Source

[Journal Article] Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 創薬ターゲット膜蛋白質の立体構造解析2012

Author(s)

Journal Title

Data Source

[Journal Article] Production of the stable human histamine H(1) receptor in Pichia pastoris for structural determination2011

Author(s)

Journal Title

Ogasawara Satoshi 小笠原諭

OGASAWARA Satoshi 小笠原諭

創薬評価技術の創出に向けたラベルフリーイオンチャネル異方性4Dセンシングへの挑戦

[Book] タンパク質結晶の最前線：　抗体を用いた膜タンパク質の結晶化2014

[Patent] 膜タンパク質のC末端に付加した His-tag に対する高親和性モノクローナル抗体 (cHis8)2022