Sivasundaram Karnan シバスンダランカルナン

… Alternative Names

SIVASUNDARAM Karnan シバスンダランカルナン

SHIBASUN Daran Karunan シバスダランカルナン

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Researcher Number	30557096
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 愛知医科大学, 医学部, 講師 2014 – 2023: 愛知医科大学, 医学部, 講師 2010 – 2013: 愛知医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Pathological medical chemistry / Tumor biology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 49020:Human pathology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / System genome science / Surgical dentistry / Gastroenterology / Carcinogenesis
Keywords	Principal Investigator ゲノム編集 / p16INK4a / 悪性胸膜中皮腫 / NF2 / 治療薬探索 / FASN / 二重破壊クローン / CRISPR-Cas9 / 新規分子標的薬 / 早期診断マーカー … More / デスモソーム / 脂肪酸合 / CAMK2D / BAP1 / CD24 / p16 / MPM / 気道上皮 / 肺癌 / 遺伝子改変 / 気管支上皮 / 気管支上皮細胞株 / 変異ノックイン / KRAS / ヒト細胞遺伝子改変 / BRCA1 / ヒト細胞遺伝子改変法 / がん制御遺伝子 … More Except Principal Investigator ゲノム編集 / CRISPR-cas9 / CRISPR-Cas9 / 標的治療 / 阻害剤 / 骨髄腫 / gene editing / target therapy / myeloma / RAS / KRAS / 高速シーケンサー / 悪性胸膜中脾腫 / ノックアウトマウス / 創薬 / セルベースアッセイ / 分子病態 / ゲノム異常 / PBK / 薬剤スクリーニング / 細胞生物学 / 治療標的分子 / 悪性化 / 多発性骨髄腫 / cytotoxic T-cell / immunotherapy / regulatory T-cell / RNAscope / TGF-b / CAF / M2マクロファージ / Treg / CTL / ADCC / MEK / TGF-β / ケモカイン受容体4 / 抗体依存性細胞傷害 / トラメチニブ / モガムリズマブ / CCR4 / TGFb / 口腔癌 / NK細胞 / 制御性T細胞 / 細胞傷害性T細胞 / 遺伝子変異 / alemtuzumab / ヒト急性白血病 / アレンツムマブ / 化合物ライブラリー / アレンツズマブ / CRISPR-Csa9 / ITD / アレムツズマブ / 白血病 / CD52 / FLT3 / ゲノム生物工学 / CRISPR/Cas9 / ニック / tandem paired nicking / ノックイン / nickase / Cas9 / CRISPR / 腫瘍 / マイクロアレイ / ゲノム / 実験腫瘍学 / エナメル上皮腫 / reactive oxygen species / TLR / ameloblastoma / オリゴＣＧＨアレイ / コリン欠乏食 / オリゴCGHアレイ / 肝発癌 / NASH / ヒト細胞遺伝子改変法 / ヒト細胞遺伝子改変 / ゲノム不安定性 / ハプロ不全 / BRCA1 Less

NF2/p16INK4a欠失を伴う中皮腫に対する抗癌剤併用療法の開発Principal Investigator
- Principal Investigator
  
  シバスンダランカルナン
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Medical University
悪性胸膜中皮腫の分子病理診断パネルの構築と分子サブタイプ特異的マーカーの同定
- Principal Investigator
  
  村上秀樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Aichi Medical University
ゲノム編集を利用したKRAS変異骨髄腫に対する新規治療標的薬の探索
- Principal Investigator
  
  花村一朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Aichi Medical University
The development of molecular-targeted drugs targeting lipid metabolism in NF2/CDKN2A-deficient malignant mesotheliomaPrincipal Investigator
- Principal Investigator
  
  シバスンダランカルナン
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Medical University
Development of novel cancer immunotheray by combining regulatory T-cell elimination and TGF-b inhibitors
- Principal Investigator
  
  Suzuki Susumu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Aichi Medical University
Establishment of the platform for a drug discovery of multiple myeloma by targeting PBK-related signaling pathway
- Principal Investigator
  
  Ota Akinobu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kinjo Gakuin University
  Aichi Medical University
Development of the novel target therapy for leukemia with FLT3 mutations, using genetically modified FLT3-mutation knock-in human myeloid leukemia cells
- Principal Investigator
  
  Hanamura Ichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Aichi Medical University
Elucidation of the pathogenesis of malignant mesothelioma based on genetic abnormalities and therapeutic targets for genomic medicinePrincipal Investigator
- Principal Investigator
  
  Sivasundaram Karnan
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Medical University
Genome editing without DNA double-strand breaks mediated by CRISPR-Cas9 nickases
- Principal Investigator
  
  Konishi Hiroyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  System genome science
- Research Institution
  Aichi Medical University
Genomic diagnosis of ameloblastoma by high-resolution array comparative genomic hybridization and development of molecular target drug
- Principal Investigator
  
  KAZAOKA YOSHIAKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Aichi Medical University
Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell linePrincipal Investigator
- Principal Investigator
  
  Sivasundaram Karnan
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Aichi Medical University
Cyclopedic investigation of genes for NASH-mediated carcinogenesis
- Principal Investigator
  
  YONEDA Masashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targeting
- Principal Investigator
  
  KONISHI Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Aichi Medical University
Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  SIVASUNDARAM Karnan
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Patent

[Journal Article] ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells.2024
- Author(s)
  Karnan S, Hanamura I, Ota A, Vu LQ, Uchino K, Horio T, Murakami S, Mizuno S, Rahman ML, Wahiduzzaman M, Hasan MN, Biswas M, Hyodo T, Ito H, Suzuki A, Konishi H, Tsuzuki S, Hosokawa Y, Takami A.
- Journal Title
  
  Cell Death Discov.
  
  Volume: 10(1):56. Issue: 1 Pages: 56-56
- DOI
  10.1038/s41420-024-01814-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08516, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-21K15579
[Journal Article] Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis.2024
- Author(s)
  Hyodo T, Asano-Inami E, Ito S, Sugiyama M, Nawa A, Rahman ML, Hasan MN, Mihara Y, Lam VQ, Karnan S, Ota A, Tsuzuki S, Hamaguchi M, Hosokawa Y, Konishi H.
- Journal Title
  
  FEBS J.
  
  Volume: 291(5) Issue: 5 Pages: 927-944
- DOI
  10.1111/febs.17017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426
[Journal Article] Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.2023
- Author(s)
  Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, Kondo S, Furuhashi A, Hayashi T, Hosokawa Y, Kazaoka Y.
- Journal Title
  
  Cancer Med.
  
  Volume: 12(15) Issue: 15 Pages: 16416-16430
- DOI
  10.1002/cam4.6282
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426
[Journal Article] Long noncoding RNA profile of the intracranial artery in patients with moyamoya disease2023
- Author(s)
  Mamiya Takashi、Kanamori Fumiaki、Yokoyama Kinya、Ota Akinobu、Karnan Sivasundaram、Uda Kenji、Araki Yoshio、Maesawa Satoshi、Yoshikawa Kazuhiro、Saito Ryuta
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: 138 Issue: 3 Pages: 709-716
- DOI
  10.3171/2022.5.jns22579
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-20K17961, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-22K08985
[Journal Article] <scp>PDZ</scp> ‐binding kinase inhibitor <scp>OTS514</scp> suppresses the proliferation of oral squamous carcinoma cells2023
- Author(s)
 Kato Mikako、Ota Akinobu、Ono Takayuki、Karnan Sivasundaram、Hyodo Toshinori、Rahman Md Lutfur、Hasan Muhammad Nazmul、Onda Maho、Kondo Sayuri、Ito Kunihiro、Furuhashi Akifumi、Hayashi Tomio、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka、Kazaoka Yoshiaki
- Journal Title
 
 Oral Diseases
 
 Volume: in press Pages: 223-234
- DOI
 10.1111/odi.14533
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985
[Journal Article] Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene.2023
- Author(s)
  Hasan MN, Hyodo T, Biswas M, Rahman ML, Mihara Y, Karnan S, Ota A, Tsuzuki S, Hosokawa Y, Konishi H.
- Journal Title
  
  PLoS One.
  
  Volume: 18(11) Issue: 11 Pages: 16416-16430
- DOI
  10.1371/journal.pone.0294146
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426
[Journal Article] Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens2023
- Author(s)
  Yamanaka S, Suzuki S, Ito H, Sivasundaram K, Hanamura I, Okubo I, Yoshikawa K, Ono S, Takahara T, Satou A, Tsuzuki T, Ueda R, Ogawa T, Fujimoto Y.
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 24 Issue: 2 Pages: 1722-1722
- DOI
  10.3390/ijms24021722
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07203, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-20K16205, KAKENHI-PROJECT-17K11301, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-22K08516, KAKENHI-PROJECT-22K08985
[Journal Article] CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma2023
- Author(s)
  Karnan Sivasundaram、Ota Akinobu、Murakami Hideki、Rahman Md. Lutfur、Wahiduzzaman Md、Hasan Muhammad Nazmul、Vu Lam Quang、Hanamura Ichiro、Inoko Akihito、Riku Miho、Ito Hideaki、Kaneko Yoshifumi、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka
- Journal Title
  
  Cell Death Discovery
  
  Volume: 9 Issue: 1 Pages: 257-257
- DOI
  10.1038/s41420-023-01552-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14488, KAKENHI-PROJECT-22K06988, KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08516, KAKENHI-PROJECT-21K08426
[Journal Article] BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia2022
- Author(s)
 Tsuzuki Shinobu、Yasuda Takahiko、Goto Hiroaki、Maeda Naoko、Akahane Koshi、Inukai Takeshi、Yamamoto Hideyuki、Karnan Sivasundaram、Ota Akinobu、Hyodo Toshinori、Konishi Hiroyuki、Hosokawa Yoshitaka、Kiyoi Hitoshi、Hayakawa Fumihiko
- Journal Title
 
 Haematologica
 
 Volume: 108 Issue: 2 Pages: 394-408
- DOI
 10.3324/haematol.2022.280879
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-23K24118, KAKENHI-PROJECT-23K24298, KAKENHI-PROJECT-23K24362
[Journal Article] Cell surface expression of human<scp>RP105</scp>depends onN‐glycosylation of<scp>MD</scp>‐12022
- Author(s)
 Biswas Mrityunjoy、Yamazaki Tatsuya、Tomono Susumu、Karnan Sivasundaram、Takagi Hidekazu、Ichimonji Isao、Inui Masanori、Nagaoka Fumiaki、Hosokawa Yoshitaka、Akashi‐Takamura Sachiko
- Journal Title
 
 FEBS Letters
 
 Volume: 596 Issue: 24 Pages: 3211-3231
- DOI
 10.1002/1873-3468.14452
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-19K07491, KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08611, KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-19K08500, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-20K11635, KAKENHI-PROJECT-22K08985
[Journal Article] Cytotoxicity of Callerya speciosa Fractions against Myeloma and Lymphoma Cell Lines2022
- Author(s)
  Lam Vu Quang、Anh La Hoang、Quan Nguyen Van、Xuan Tran Dang、Hanamura Ichiro、Uchino Kaori、Karnan Sivasundaram、Takami Akiyoshi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 7 Pages: 2322-2322
- DOI
  10.3390/molecules27072322
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-22K08985
[Journal Article] Accumulation of versican and lack of versikine ameliorate acute colitis2022
- Author(s)
  Islam Shamima、Jahan Nushrat、Shahida Arbee、Karnan Sivasundaram、Watanabe Hideto
- Journal Title
  
  Matrix Biology
  
  Volume: 107 Pages: 59-76
- DOI
  10.1016/j.matbio.2022.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02720, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-22K08985
[Journal Article] Correction of a CD55 mutation to quantify the efficiency of targeted knock-in via flow cytometry2022
- Author(s)
  Rahman Md. Lutfur、Hyodo Toshinori、Hasan Muhammad Nazmul、Mihara Yuko、Karnan Sivasundaram、Ota Akinobu、Tsuzuki Shinobu、Hosokawa Yoshitaka、Konishi Hiroyuki
- Journal Title
  
  Molecular Biology Reports
  
  Volume: - Issue: 7 Pages: 6241-6248
- DOI
  10.1007/s11033-022-07422-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-22K08985
[Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia2021
- Author(s)
  Karnan Sivasundaram、Hanamura Ichiro、Uchino Kaori、Murakami Satsuki、Wahiduzzaman Md、Quang Vu Lam、Rahman Md Lutfur、Hasan Muhammad Nazmul、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Yoshikawa Kazuhiro、Suzuki Susumu、Ueda Ryuzo、Ejiri Masayuki、Hosokawa Yoshitaka、Takami Akiyoshi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41420-021-00446-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K08825, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-19K09292
[Journal Article] Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP2021
- Author(s)
 Rahman Md.?Lutfur、Hyodo Toshinori、Hasan Muhammad?Nazmul、Mihara Yuko、Karnan Sivasundaram、Ota Akinobu、Tsuzuki Shinobu、Hosokawa Yoshitaka、Konishi Hiroyuki
- Journal Title
 
 Bioscience Reports
 
 Volume: 41 Issue: 12
- DOI
 10.1042/bsr20212231
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K09292
[Journal Article] The Clinical and Biological Effects of PD-1 Expression on Tumor Cells in Diffuse Large B-Cell Lymphoma2021
- Author(s)
  Hanamura Ichiro、Suzuki Susumu、Ota Akinobu、Murakami Satsuki、Satou Akira、Takahara Taishi、Karnan Sivasundaram、Lam Vu Quang、Nakamura Ayano、Takasugi Souichi、Yoshikawa Kazuhiro、Banno Shogo、Ejiri Masayuki、Tsuzuki Toyonori、Hosokawa Yoshitaka、Ueda Ryuzo、Takami Akiyoshi
- Journal Title
  
  Hemato
  
  Volume: 2 Issue: 2 Pages: 368-381
- DOI
  10.3390/hemato2020023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09292
[Journal Article] Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair2021
- Author(s)
  Kanamori Fumiaki、Yokoyama Kinya、Ota Akinobu、Yoshikawa Kazuhiro、Karnan Sivasundaram、Maruwaka Mikio、Shimizu Kenzo、Ota Shinji、Uda Kenji、Araki Yoshio、Okamoto Sho、Maesawa Satoshi、Wakabayashi Toshihiko、Natsume Atsushi
- Journal Title
  
  Neurosurgical Focus
  
  Volume: 51 Issue: 3 Pages: E3-E3
- DOI
  10.3171/2021.6.focus20870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-20K17961, KAKENHI-PROJECT-19K09292
[Journal Article] Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells2021
- Author(s)
  Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-Ichi Kudo, Akinobu Ota, Karnan Sivasundaram , Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 5216-5216
- DOI
  10.1038/s41598-021-84628-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08738, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-20K21846, KAKENHI-PROJECT-19K17275, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H02844, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K11647, KAKENHI-PROJECT-21K07681, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K09292
[Journal Article] Experimental strategies to achieve efficient targeted knock-in via tandem paired nicking2021
- Author(s)
  Rahman Md. Lutfur、Hyodo Toshinori、Karnan Sivasundaram、Ota Akinobu、Hasan Muhammad Nazmul、Mihara Yuko、Wahiduzzaman Md、Tsuzuki Shinobu、Hosokawa Yoshitaka、Konishi Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-021-01978-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292
[Journal Article] Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells2020
- Author(s)
  Kanasugi J, Hanamura I, Ota A, Karnan S, Vu LQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 999-999
- DOI
  10.1111/cas.14386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-17K07263
[Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells2020
- Author(s)
  Ota Akinobu、Hanamura Ichiro、Karnan Sivasundaram、Inaguma Shingo、Takei Norio、Lam Vu Quang、Mizuno Shohei、Kanasugi Jo、Wahiduzzaman Md、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Ikeda Hiroshi、Takami Akiyoshi、Hosokawa Yoshitaka
- Journal Title
  
  Journal of Interferon & Cytokine Research
  
  Volume: 40 Issue: 8 Pages: 389-405
- DOI
  10.1089/jir.2020.0111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07060, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
[Journal Article] Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma2020
- Author(s)
  KarnanS, Ota A, Murakami H, Rahman ML, Hasan 　MN, Wahiduzzaman MD, Hanamura I, Vu LQ, Inoko A, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 18 Issue: 1 Pages: 127-139
- DOI
  10.1038/s41420-020-00364-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07031, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
[Journal Article] Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma2020
- Author(s)
  Kondo Sayuri、Ota Akinobu、Ono Takayuki、Karnan Sivasundaram、Wahiduzzaman Md、Hyodo Toshinori、Lutfur Rahman Md、Ito Kunihiro、Furuhashi Akifumi、Hayashi Tomio、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka、Kazaoka Yoshiaki
- Journal Title
  
  Cancer Medicine
  
  Volume: 9 Issue: 8 Pages: 2904-2917
- DOI
  10.1002/cam4.2931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532019
- Author(s)
  Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H.
- Journal Title
  
  Cell Rep.
  
  Volume: 30 Issue: 4 Pages: 1195-1207
- DOI
  10.1016/j.celrep.2019.12.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19J40240, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Establishment and characterization of CRISPR/Cas9-mediated NF2(-/-) human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma2019
- Author(s)
  Wahiduzzaman Md、Karnan Sivasundaram、Ota Akinobu、Hanamura Ichiro、Murakami Hideki、Inoko Akihito、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 180-193
- DOI
  10.1111/cas.13871
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Inhibition of NADPH oxidase 2 induces apoptosis in osteosarcoma: The role of reactive oxygen species in cell proliferation2018
- Author(s)
  Kitamoto Kazumasa、Miura Yuji、Karnan Sivasundaram、Ota Akinobu、Konishi Hiroyuki、Hosokawa Yoshitaka、Sato Keiji
- Journal Title
  
  Oncology Letters
  
  Volume: 15 Pages: 7955-7962
- DOI
  10.3892/ol.2018.8291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
[Journal Article] Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo2018
- Author(s)
  Wahiduzzaman Md、Ota Akinobu、Karnan Sivasundaram、Hanamura Ichiro、Mizuno Shohei、Kanasugi Jo、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Takami Akiyoshi、Hosokawa Yoshitaka
- Journal Title
  
  Cancer Letters
  
  Volume: 433 Pages: 117-130
- DOI
  10.1016/j.canlet.2018.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-17K07263
[Patent] ＲＡＳ遺伝子変異体癌治療薬2022
- Inventor(s)
  シバスンダランカルナン、太田明伸、花村一朗、細川好孝
- Industrial Property Rights Holder
  シバスンダランカルナン、太田明伸、花村一朗、細川好孝
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-169541
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K08426
[Patent] 悪性中皮腫の治療薬2021
- Inventor(s)
  シバスンダランカルナン、太田明伸、細川好孝
- Industrial Property Rights Holder
  シバスンダランカルナン、太田明伸、細川好孝
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-169563
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] DISCOVERY OF NOVEL TARGETED DRUGS FOR K-RAS-MUTATED MYELOMA USING ISOGENIC K-RASMUTANT CELLS2024
- Author(s)
  Ichiro Hanamura, Karnan Sivasundaram, Akinobu Ota, Keichiro Mihara, Yoshitaka Hosokawa, Akiyoshi Takami
- Organizer
  EHA2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08516
[Presentation] LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis.2023
- Author(s)
  Toshinori Hyodo, Muhammad Nazmul Hasan, Mrityunjoy Biswas, Eri Inami, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi.
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] PBK阻害剤OTS514は口腔扁平上皮癌細胞においてE2F標的遺伝子の下方制御と細胞増殖を抑制する2023
- Author(s)
  太田明伸、カルナンシバスンラダン、小西裕之、都築忍、細川好孝、風岡宜暁
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene2023
- Author(s)
  Muhammad Nazmul Hasan, Toshinori Hyodo, Mrityunjoy Biswas, Md. Lutfur Rahman, Yuko Mihara, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, and Hiroyuki Konishi
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia2022
- Author(s)
  Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, Yasushi Miyazaki, Itaru Matsumura, Hitoshi Kiyoi, Yoshitaka Hosokawa, Hiroyuki Mano, Fumihiko Hayakawa
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] ゲノム編集法を用いた不死化ヒト中皮細胞株の形質転換に関わる分子機構の解析と悪性中皮腫に対する新規治療標的分子の探索2021
- Author(s)
  太田明伸、シバスンダランカルナン、細川好孝
- Organizer
  第2回日本石綿・中皮腫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] Tandem paired nicking法による高精度でDNA損傷反応を誘起しない塩基置換の特性解析2021
- Author(s)
  小西裕之, 兵頭寿典, Md. Lutfur Rahman, Muhammad Nazmul Hasan, 三原優子, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝. Tandem paired nicking法による高精度でDNA損傷反応を誘起しない塩基置換の特性解析
- Organizer
  日本ゲノム編集学会第6回大会
- Data Source
  KAKENHI-PROJECT-21K08426
[Presentation] p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2019
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, 小西裕之, 都築忍, 細川好孝
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] P16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2019
- Author(s)
  7.シバスンダランカルナン、太田明伸、花村一朗、村上秀樹、兵頭寿典、小西裕之、都築忍、細川好孝
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09292
[Presentation] CRISPR/Cas9 nickaseによるサイレント変異不要のノックイン2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, 豊田敦, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Tandem paired nicking using Cas9 nickases permits targeted knock-in without significant inhibition by p532019
- Author(s)
  Toshinori Hyodo, Md Lutfur Rahman, Atsushi Toyoda, Sivasundaram Karnan, Akinobu Ota, Shinobu Tuzuki, Yoshitaka Hosokawa, 〇Hiroyuki Konishi
- Organizer
  Frontiers in Genome Engineering 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9 nickaseによるサイレント変異不要のノックイン2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, 豊田敦, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 〇小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析2019
- Author(s)
  Sivasundaram Karnan, 太田明伸, 兵頭寿典, 小西裕之, 都築忍, 細川好孝
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Experimental conditions permitting efficient targeted knock-in using CRISPR/Cas9 nickases2019
- Author(s)
  Md Lutfur Rahman, 兵頭寿典, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9 nickaseによるノックインはp53を活性化しない2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 小西裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] DNA二重鎖切断を介さない変異ノックイン法2019
- Author(s)
  兵頭寿典, Md Lutfur Rahman, 豊田敦, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝, 〇小西裕之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPRCas9を用いたNF2及びCDKN2Aノックアウト人中皮腫細胞株の樹立と分子生物学的解析2019
- Author(s)
  6.Sivasundaram Karnan, Akinobu ota, Ichiro Hanamura, Hideki Murakami, Toshinori Hyodo, Wahiduzzanan Md, Hiroyuki Konishi , Shinobu Tsuzuki, Yoshitaka Hosokawa
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K09292
[Presentation] p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2018
- Author(s)
  2.Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, Md Wahiduzzaman, 兵頭寿典, 小西裕之, 都築忍, 細川好孝
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 悪性中皮腫細胞の増殖を特異的に抑制するAkt阻害剤の探索と同定2018
- Author(s)
  4.太田明伸, 山地雅之, Md Wahiduzzaman, Sivasundaram Karnan, 兵頭寿典, 小西裕之, 都築忍, 羽生田正行, 細川好孝
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 多発性骨髄腫の腫瘍増殖におけるPDZ binding kinaseの関与2018
- Author(s)
  3.太田明伸, 花村一朗, Sivasundaram Karnan, 小西裕之, 都築忍, 細川好孝
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells.2017
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 亜ヒ酸とシスプラチンによる併用療法はBcr-Abl陽性白血病細胞に対して相乗的な増殖抑制効果を示す2017
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 兵頭寿典, 小西裕之, 都築忍, 細川好孝.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Protein phosphatase 2Aの調節サブユニットPPP2R5Eは微小管架橋因子MTCL1の発現量を制御する.2017
- Author(s)
  兵頭寿典, 稲見恵理, 太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 新規Interleukin-6誘導因子PDZ binding kinaseは骨髄腫細胞の増殖と進展に関与する.2017
- Author(s)
  太田明伸, 花村一朗, Sivasundaram Karnan, Md Wahiduzzaman, 兵頭寿典, 小西裕之, 都築忍, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] SINGLE-NUCLEOTIDE POLYMORPHISM IN THE PBK GENE IS CLOSELY ASSOCIATED WITH MYELOMA CELL PROLIFERATION.2017
- Author(s)
  Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Md Wahiduzzaman, Shohei Mizuno, Kaori Uchino, Jo Kanasugi, Tomohiro Horio, Satsuki Murakami, Susumu Suzuki, Ryuzo Ueda, Shinobu Tsuzuki, Hiroyuki Konishi, Yoshitaka Hosokawa, Akiyoshi Takami.
- Organizer
  The 22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 悪性胸膜中皮腫の早期診断腫瘍マーカーの検討.2017
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, Md Wahiduzzaman, 小西裕之, 都築忍, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9を用いたNF2ノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析2017
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, Md Wahiduzzaman, 小西裕之, 都築忍, 細川好孝.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 遺伝子改変・ゲノム編集効率を測定するアッセイ系としてのPIGA遺伝子の利用2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in leukemic cell lines2016
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Hiroyuki Konishi, Yoshitaka Hosokawa
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NOX1はAKTシグナルを介して口腔扁平上非癌細胞の生存に寄与する2016
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 肝がん細胞株におけるp53アイソフォームdelta40p53の性状解析2016
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 悪性胸膜中皮腫の早期診断の腫瘍マーカーの検討2016
- Author(s)
  Sivasundaram Karnan, 太田明伸, Md Wahiduzzaman, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] CRISPR-Cas9システムによる変異ノックイン ― プロモータートラップ法の比較検討2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島国際会議場（広島・広島）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 癌原性KRAS変異をノックインしたヒト気管支上皮細胞株モデルの樹立と解析2015
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析2015
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] Delta40p53はHepG2細胞に対して細胞増殖抑制効果を示す2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒト細胞株のゲノム編集によるKRAS-PI3Kシグナル経路の解析.2013
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒ素は酸化LDL受容体LOX-1の発現を増加させることによりマウス血管内皮細胞の酸化LDL取り込み能を増強する.2013
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Damdindorj Lkhagvasuren, 小西裕子, 小西裕之, 細川好孝.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] PIGA遺伝子を利用したヒト体細胞株の遺伝子ターゲッティング効率の測定2012
- Author(s)
  シバスンダラン・カルナン
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト体細胞株におけるPIGA遺伝子を利用した遺伝子ターゲッティング効率定量系の作成2011
- Author(s)
  Sivasundaram Karnan
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト体細胞株におけるPIGA遺伝子を利用した遺伝子ターゲッティング効率定量系の作成2011
- Author(s)
  シバスンダラン・カルナン
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22700888
[Presentation] リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Shahnewaj Mannan, 小西裕之, 細川好孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都・京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] アデノ随伴ウイルスに基づく遺伝子改変ベクターにおいて薬剤耐性遺伝子の発現を制御するプロモーターと改変効率の関係
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] プランバギンは口腔扁平上皮癌に対して活性酸素産生を介した細胞増殖抑制効果を示す
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NF1関連の皮膚神経線維腫における400KオリゴアレイCGH解析
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395

1. Ota Akinobu (30438048)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. KONISHI Hiroyuki (20344335)

# of Collaborated Projects: 3 results

# of Collaborated Products: 34 results
3. Hanamura Ichiro (70440740)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 村上秀樹 (90303619)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. HOSOKAWA Yoshitaka (60229193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
6. Suzuki Susumu (70518422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. YONEDA Masashi (30261407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAO Haruhisa (60326139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKADE Haruhisa (70431400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAZAOKA YOSHIAKI (30233696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山田陽一 (20345903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大野隆之 (20434623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 兵頭寿典 (40710645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
14. 小川徹也 (40334940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 土本純 (70632868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 武井則雄 (50523461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 伊藤卓治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 高見昭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. 山崎達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 渡辺秀人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 津山尚宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 坂井晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 阿部悠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 陸美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sivasundaram Karnan シバスンダラン カルナン

SIVASUNDARAM Karnan シバスンダラン カルナン

SHIBASUN Daran Karunan シバス ダランカルナン

Research Projects

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Co-Researchers

NF2/p16INK4a欠失を伴う中皮腫に対する抗癌剤併用療法の開発Principal Investigator

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The development of molecular-targeted drugs targeting lipid metabolism in NF2/CDKN2A-deficient malignant mesotheliomaPrincipal Investigator

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Elucidation of the pathogenesis of malignant mesothelioma based on genetic abnormalities and therapeutic targets for genomic medicinePrincipal Investigator

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Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell linePrincipal Investigator

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Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cellsPrincipal Investigator

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Sivasundaram Karnan シバスンダランカルナン

SIVASUNDARAM Karnan シバスンダランカルナン

SHIBASUN Daran Karunan シバスダランカルナン

[Journal Article] BCL6 inhibition ameliorates resistance to ruxolitinib in <i>CRLF2</i>-rearranged acute lymphoblastic leukemia2022