NAGAI KAZUYUKI 長井和之

… Alternative Names

Nagai Kazuyuki 長井和之

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Researcher Number	30567871
Other IDs	https://orcid.org/0000-0003-2180-2056
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 京都大学, 医学研究科, 講師 2018 – 2021: 京都大学, 医学研究科, 特定病院助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 膵癌 / 癌オルガノイド / ニッチ / 微小環境 / 癌幹細胞 / 腫瘍内不均一性 / 胆道癌 / 脂肪酸 / 重症化 / ラットモデル … More / ゲル / 術後合併症 / 膵切除 / 膵切離 / 脂肪分解 / PEG / リパーゼ阻害 / 膵液瘻重症化因子 / 不飽和脂肪酸 / 遊離脂肪酸 / 膵液瘻 / 膵手術 … More Except Principal Investigator 脂肪分解 / drug delivery system / 膵液瘻 / 神経浸潤 / 幹細胞 / ウィントシグナル / 癌幹細胞 / ドパミン / 腫瘍内不均一性 / オルガノイド / 胆管癌 / 非自立的制御 / 膵臓 / 内分泌外分泌連関 / 膵内分泌細胞 / パラクライン / 外分泌内分泌連関 / CCL5 / 膵発生 / PDX1 / ケモカイン / 膵内分泌細胞増殖因子 / 内外分泌連関 Less

神経との相互作用に着目した胆道癌局所進展制御機構の究明と新規治療標的探索Principal Investigator
- Principal Investigator
  
  長井和之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
腹腔内脂肪分解抑制による術後膵液瘻重症化予防法の確立
- Principal Investigator
  
  笠井洋祐
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
胆道癌の腫瘍内不均一性を基盤とした新規治療標的の開発Principal Investigator
- Principal Investigator
  
  長井和之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Analysis of the mechanism of cholangiocarcinoma progression based on intertissue crosstalk
- Principal Investigator
  
  Masui Toshihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Islet Cell Growth Factors Focusing on Endocrine-External Secretory Linkage and Their Therapeutic Application
- Principal Investigator
  
  Masui Toshihiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
The elucidation of the exacerbating factors for pancreatic fistula and therapeutic application based on the prevention of intraperitoneal lipolysisPrincipal Investigator
- Principal Investigator
  
  Nagai Kazuyuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Inhibition of dopamine receptor <scp>D1</scp> signaling promotes human bile duct cancer progression via <scp>WNT</scp> signaling2022
- Author(s)
  Yogo Akitada、Masui Toshihiko、Takaishi Shigeo、Masuo Kenji、Chen Ru、Kasai Yosuke、Nagai Kazuyuki、Anazawa Takayuki、Watanabe Sadanori、Sakamoto Satoko、Watanabe Akira、Inagaki Ryosaku、Nakagawa Masahiro M.、Ogawa Seishi、Seno Hiroshi、Uemoto Shinji、Hatano Etsuro
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 4 Pages: 1324-1336
- DOI
  10.1111/cas.15676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08732, KAKENHI-PROJECT-22K08798, KAKENHI-PROJECT-23K27582
[Journal Article] Impact of vascular abnormality on contrast-enhanced CT and high C-reactive protein levels on postoperative pancreatic hemorrhage after pancreaticoduodenectomy: A multi-institutional, retrospective analysis of 590 consecutive cases2021
- Author(s)
  Yuichiro Uchida, Toshihiko Masui, Kazuki Hashida, Takafumi Machimoto, Kenzo Nakano, Akitada Yogo, Asahi Sato, Kazuyuki Nagai, Takayuki Anazawa, Kyoichi Takaori, Shinji Uemoto
- Journal Title
  
  Pancreatology
  
  Volume: 21 Issue: 1 Pages: 263-268
- DOI
  10.1016/j.pan.2020.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08702
[Journal Article] Combination of postoperative C-reactive protein value and computed tomography imaging can predict severe pancreatic fistula after pancreatoduodenectomy2020
- Author(s)
  Uchida Yuichiro、Masui Toshihiko、Nakano Kenzo、Yogo Akitada、Yoh Tomoaki、Nagai Kazuyuki、Anazawa Takayuki、Takaori Kyoichi、Uemoto Shinji
- Journal Title
  
  HPB
  
  Volume: 22 Issue: 2 Pages: 282-288
- DOI
  10.1016/j.hpb.2019.06.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08702
[Journal Article] Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response2020
- Author(s)
  Yamane Kei、Anazawa Takayuki、Tada Seiichiro、Fujimoto Nanae、Inoguchi Kenta、Emoto Norio、Nagai Kazuyuki、Masui Toshihiko、Okajima Hideaki、Takaori Kyoichi、Sumi Shoichiro、Uemoto Shinji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 12086-12086
- DOI
  10.1038/s41598-020-69009-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08677
[Journal Article] Chloroquine induces apoptosis in pancreatic neuroendocrine neoplasms via endoplasmic reticulum stress2020
- Author(s)
  Nakano Kenzo、Masui Toshihiko、Yogo Akitada、Uchida Yuichiro、Sato Asahi、Kasai Yosuke、Nagai Kazuyuki、Anazawa Takayuki、Kawaguchi Yoshiya、Uemoto Shinji
- Journal Title
  
  Endocrine-Related Cancer
  
  Volume: 27 Issue: 7 Pages: 431-439
- DOI
  10.1530/erc-20-0028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08677
[Journal Article] Postoperative pancreatic fistulas decrease the survival of pancreatic cancer patients treated with surgery after neoadjuvant chemoradiotherapy: A retrospective analysis2020
- Author(s)
  Uchida Yuichiro、Masui Toshihiko、Nagai Kazuyuki、Anazawa Takayuki、Yoshimura Michio、Uza Norimitsu、Takaori Kyoichi、Mizowaki Takashi、Uemoto Shinji
- Journal Title
  
  Surgical Oncology
  
  Volume: 35 Pages: 527-532
- DOI
  10.1016/j.suronc.2020.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08702
[Journal Article] Clinical and experimental studies of intraperitoneal lipolysis and the development of clinically relevant pancreatic fistula after pancreatic surgery2019
- Author(s)
  Uchida Y.、Masui T.、Nakano K.、Yogo A.、Sato A.、Nagai K.、Anazawa T.、Takaori K.、Tabata Y.、Uemoto S.
- Journal Title
  
  BJS
  
  Volume: 106 Issue: 5 Pages: 616-625
- DOI
  10.1002/bjs.11075
- Data Source
  KAKENHI-PROJECT-18K08702
[Journal Article] Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms2019
- Author(s)
  Masui Toshihiko、Sato Asahi、Nakano Kenzo、Uchida Yuichiro、Yogo Akitada、Anazawa Takayuki、Nagai Kazuyuki、Kawaguchi Yoshiya、Takaori Kyoichi、Uemoto Shinji
- Journal Title
  
  Surgery Today
  
  Volume: 未 Issue: 7 Pages: 593-600
- DOI
  10.1007/s00595-019-01779-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08677
[Journal Article] Computer tomographic assessment of postoperative peripancreatic collections after distal pancreatectomy2018
- Author(s)
  Uchida Yuichiro、Masui Toshihiko、Sato Asahi、Nagai Kazuyuki、Anazawa Takayuki、Takaori Kyoichi、Uemoto Shinji
- Journal Title
  
  Langenbeck's Archives of Surgery
  
  Volume: 403 Issue: 3 Pages: 349-357
- DOI
  10.1007/s00423-018-1668-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08702
[Presentation] Establishing a model of pancreatic fistula in rats and a novel approach to prevent pancreatic fistula2022
- Author(s)
  中村直人、長井和之、余語覚匡、金田明大、笠井洋祐、穴澤貴行、内田雄一郎、増井俊彦、波多野悦朗
- Organizer
  第34回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08702
[Presentation] 膵切除術後の膵液瘻に対する重症化因子のマーカーとしてドレーンCa値が有効となる可能性の検討2021
- Author(s)
  金田明大、内田雄一郎、余語覚匡、仲野健三、長井和之、穴澤貴行、増井俊彦
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08702
[Presentation] 脂肪分解阻害による膵液瘻予防　遊離脂肪酸に焦点を当てた新しい治療戦略2021
- Author(s)
  内田雄一郎、長井和之、増井俊彦
- Organizer
  第52回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-18K08702
[Presentation] 膵切除術における膵液瘻防止の工夫2018
- Author(s)
  増井俊彦、仲野健三、佐藤朝日、長井和之、穴澤貴行、高折恭一、上本伸二
- Organizer
  第118回外科学会総会
- Data Source
  KAKENHI-PROJECT-18K08702
[Presentation] 膵頭十二指腸切除術後早期CT検査の臨床的意義2018
- Author(s)
  内田雄一郎, 増井俊彦, 余語覚匡, 仲野健三, 佐藤朝日, 長井和之, 穴澤貴之, 高折恭一, 上本伸二
- Organizer
  第49回膵臓学会大会
- Data Source
  KAKENHI-PROJECT-18K08702

1. Masui Toshihiko (20452352)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. 上本伸二 (40252449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. 田畑泰彦 (50211371)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 波多野悦朗 (80359801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 笠井洋祐 (20812580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内田雄一郎 (00763997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGAI KAZUYUKI 長井 和之

Nagai Kazuyuki 長井 和之

Research Projects

Research Products

Co-Researchers

神経との相互作用に着目した胆道癌局所進展制御機構の究明と新規治療標的探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腹腔内脂肪分解抑制による術後膵液瘻重症化予防法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胆道癌の腫瘍内不均一性を基盤とした新規治療標的の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism of cholangiocarcinoma progression based on intertissue crosstalk

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Islet Cell Growth Factors Focusing on Endocrine-External Secretory Linkage and Their Therapeutic Application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the exacerbating factors for pancreatic fistula and therapeutic application based on the prevention of intraperitoneal lipolysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Inhibition of dopamine receptor <scp>D1</scp> signaling promotes human bile duct cancer progression via <scp>WNT</scp> signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of vascular abnormality on contrast-enhanced CT and high C-reactive protein levels on postoperative pancreatic hemorrhage after pancreaticoduodenectomy: A multi-institutional, retrospective analysis of 590 consecutive cases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of postoperative C-reactive protein value and computed tomography imaging can predict severe pancreatic fistula after pancreatoduodenectomy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chloroquine induces apoptosis in pancreatic neuroendocrine neoplasms via endoplasmic reticulum stress2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postoperative pancreatic fistulas decrease the survival of pancreatic cancer patients treated with surgery after neoadjuvant chemoradiotherapy: A retrospective analysis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and experimental studies of intraperitoneal lipolysis and the development of clinically relevant pancreatic fistula after pancreatic surgery2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms2019

Author(s)

Journal Title

DOI

NAGAI KAZUYUKI 長井和之

Nagai Kazuyuki 長井和之

[Presentation] 脂肪分解阻害による膵液瘻予防　遊離脂肪酸に焦点を当てた新しい治療戦略2021