HOSHINO DAISUKE 星野大輔

… Alternative Names

Daisuke Hoshino 星野大輔

HOSHINO Daisuke 星野大輔

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Researcher Number	30571434
Other IDs
Affiliation (Current)	2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん生物学部, 部門長 2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部長代理
Affiliation (based on the past Project Information) *help	2024: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん生物学部, 部門長 2020 – 2024: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部長代理 2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部門長 2016 – 2019: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技幹・主任研究員 2015: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 研究員 2013: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 56020:Orthopedics-related / Basic Section 52040:Radiological sciences-related / Complex systems / Tumor therapeutics / Tumor biology
Keywords	Principal Investigator 浸潤 / エクソソーム / がん / Hippo / EMT / 薬剤抵抗性 / 腫瘍内不均一性 / シングルセル / シングルセル培養 / 未分化癌 … More / 甲状腺 / シングルセルPDO / 薬剤耐性 / オルガノイド / 転移 / 細胞外小胞 / 血管新生 / フィロポディア / EV / 細胞運動 … More Except Principal Investigator オルガノイド / がん / アディポカイン / 脂肪細胞 / 骨転移 / がん微小環境 / 腫瘍関連脂肪細胞 / adipo-oncology / 甲状腺癌 / エピジェネティクス / 甲状腺未分化癌 / MT1-MMP / アディポネクチン / adipocytes / 良悪性鑑別 / 甲状腺濾胞性腫瘍 / 放射性ヨウ素 / 質量分析計 / HLA分子 / がん免疫治療 / 遺伝子変異 / ペプチドミクス解析 / ネオアンチゲン / 生体機能利用 / 癌 / 発生・分化 / プロテオーム / 細胞・組織 / 生体組織の構築と破綻 / 時系列画像データ / 多次元時系列データ / 逆相蛋白質アレイ（RPPA) / 間葉上皮移行(MET) / 上皮間葉移行（EMT） / 逆走蛋白質アレイ / 数理腫瘍学 / 上皮細胞 / 混合正規分布 / 層別化解析 / 数理モデル、 / 逆相タンパク質アレイ / プロテオミクス / チロシンキナーゼ受容体 / RPPA / シミュレーション / 上皮間葉転換（EMT） / 層化解析 / 数理モデル、シミュレーション / 上皮組織 / EMT / 受容体チロシンキナーゼ / 悪性化進展シグナル / 肝がん / 上皮間葉転換 / 肝がん幹細胞 / 生物統計 / 悪性化進展 / 数理シミュレーション / 数理モデル / 逆相タンパク質アレイ（RPPA） / 細胞シグナル / 幹細胞性 / 肝細胞がん / ホルモン / マウス転移モデル / エクソソーム / がん-間質相互作用 / 癌微小環境 / 分化誘導 / 動物モデル / 骨髄脂肪細胞 / AI解析 / 腫瘍免疫 / 治療抵抗性 / バイオマーカ― / 薬剤感受性 / 未分化転化 / 脱分化 / DZnep / 甲状腺分化マーカー / p53遺伝子変異 / DZNep / EZH2 / shedding / EphA2 / 分子標的薬耐性 / 分子標的薬 / ErbBファミリー / 細胞外マトリックス / vemurafenib / 細胞接着 / 薬剤耐性 / HIH-1 / p27RF-Rho / ZF21 / 細胞運動 / リン酸化 / Mint3 / FIH-1 / 増殖 / 浸潤 / がん細胞 / HIF-1 / HB-EGF / コラーゲン / プロテアーゼ / 腫瘍形成 / 浸潤・転移 Less

Hippo 経路と EMT 経路を基軸とした甲状腺未分化癌の病態解明Principal Investigator
- Principal Investigator
  
  星野大輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
甲状腺癌オルガノイドを用いた放射性ヨウ素治療抵抗性機序の解明
- Principal Investigator
  
  光武範吏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagasaki University
Development of benign/malignant differentiation method for thyroid follicular tumor using organoids
- Principal Investigator
  
  菅沼伸康
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yokohama City University
Investigation of the suppression mechanism of bone marrow adipocyte-derived adiponectin on bone metastatic cancer
- Principal Investigator
  
  佐藤慎哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Identification of cancer-specific neoantigens in organoid culture
- Principal Investigator
  
  Sasada Tetsuro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Establishment of single-cell organoid culture system and elucidation of drug resistance mechanisms.Principal Investigator
- Principal Investigator
  
  Hoshino Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
The role of adipocyte-derived hormones/extracellular vesicles on bone-metastasized cancer
- Principal Investigator
  
  Sato Shinya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Therapeutic strategy targeting epigenetics in anaplastic thyroid carcinoma
- Principal Investigator
  
  NAKAYAMA Hirotaka
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yokohama City University
Establishment of novel drug susceptibility testing and biomarker using anaplastic thyroid cancer organoid
- Principal Investigator
  
  SUGANUMA Nobuyasu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yokohama City University
  Kanagawa Cancer Center Research Institute
Molecular mechanism of cancer derived small vesicles related tumor malignanciesPrincipal Investigator
- Principal Investigator
  
  Daisuke Hoshino
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanagawa Cancer Center Research Institute
Analysis of the molecular mechanism for formation and breakdown of biotissues by mathematical modeling
- Principal Investigator
  
  Koshikawa Naohiko
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Institute of Technology
  Kanagawa Cancer Center Research Institute
Cleavage of EphA2 by MT1-MMP and its participation to drug resistance
- Principal Investigator
  
  KIKUCHI KEIJI
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kanagawa Cancer Center Research Institute
Molecular mechanism of tumour malignancy via exosomesPrincipal Investigator
- Principal Investigator
  
  Daisuke Hoshino
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanagawa Cancer Center Research Institute
Study of MT1-MMP in cancer
- Principal Investigator
  
  SEIKI Motoharu
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2017 2013 2012 2011 2010

All Journal Article Presentation Book

[Book] 膜タンパク質工学ハンドブック2020
- Author(s)
  室井　敦、星野大輔、清木元治、越川直彦
- Total Pages
  7
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PLANNED-17H06329
[Book] 「がん生物学」分担項目:細胞運動と浸潤2011
- Author(s)
  星野大輔、長野真、清木元治
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Novel chimeric antigen receptor‐expressing T cells targeting the malignant mesothelioma‐specific antigen sialylated HEG12024
- Author(s)
  Kouro Taku、Higashijima Naoko、Horaguchi Shun、Mano Yasunobu、Kasajima Rika、Xiang Huihui、Fujimoto Yuki、Kishi Hiroyuki、Hamana Hiroshi、Hoshino Daisuke、Himuro Hidetomo、Matsuura Rieko、Tsuji Shoutaro、Imai Kohzoh、Sasada Tetsuro
- Journal Title
  
  International Journal of Cancer
  
  Volume: 154 Issue: 10 Pages: 1828-1841
- DOI
  10.1002/ijc.34843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02995
[Journal Article] Validation of EZH2 Inhibitor Efficiency in Anaplastic Thyroid Carcinoma Cell Lines2023
- Author(s)
  NAKAYAMA HIROTAKA、SAITO NAO、KASAJIMA RIKA、SUGANUMA NOBUYASU、RINO YASUSHI、MASUDO KATSUHIKO、YAMAZAKI HARUHIKO、TODA SOJI、SEKIHARA KAZUMASA、IWASAKI HIROYUKI、HOSHINO DAISUKE
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 3 Pages: 1073-1077
- DOI
  10.21873/anticanres.16252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09052, KAKENHI-PROJECT-19K19206, KAKENHI-PROJECT-22K18202
[Journal Article] TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma2022
- Author(s)
  Toda Soji、Sato Shinya、Saito Nao、Sekihara Kazumasa、Matsui Ai、Murayama Daisuke、Nakayama Hirotaka、Suganuma Nobuyasu、Okubo Yoichiro、Hayashi Hiroyuki、Iwasaki Hiroyuki、Miyagi Yohei、Hoshino Daisuke
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 3 Pages: 579-579
- DOI
  10.3390/cancers14030579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18202, KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-19K19206
[Journal Article] Evaluation of X-ray and carbon-ion beam irradiation with chemotherapy for the treatment of cervical adenocarcinoma cells in 2D and 3D cultures2022
- Author(s)
  Sekihara Kazumasa、Himuro Hidetomo、Saito Nao、Ota Yukihide、Kouro Taku、Kusano Yohsuke、Minohara Shinichi、Hirayama Ryoichi、Katoh Hiroyuki、Sasada Tetsuro、Hoshino Daisuke
- Journal Title
  
  Cancer Cell International
  
  Volume: 22 Issue: 1 Pages: 391-391
- DOI
  10.1186/s12935-022-02810-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18202, KAKENHI-PROJECT-21H02995, KAKENHI-PROJECT-19K19206
[Journal Article] Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model2022
- Author(s)
  Azuma Koichi#、Xiang Huihui#、Tagami Tomoyuki、Kasajima Rika、Kato Yumiko、Karakawa Sachise、Kikuchi Shinya、Imaizumi Akira、Matsuo Norikazu、Ishii Hidenobu、Tokito Takaaki、Kawahara Akihiko、Murotani Kenta、Sasada Tetsuro、Miyagi Yohei、Hoshino Tomoaki (# Contributed equally)
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 5 Pages: e004420-e004420
- DOI
  10.1136/jitc-2021-004420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16585, KAKENHI-PROJECT-21H02995
[Journal Article] Clinical significance of peripheral TCR and BCR repertoire diversity in EGFR/ALK wild-type NSCLC treated with anti-PD-1 antibody2021
- Author(s)
  Nakahara Yoshiro、Matsutani Takaji、Igarashi Yuka、Matsuo Norikazu、Himuro Hidetomo、Saito Haruhiro、Yamada Kouzo、Murotani Kenta、Hoshino Tomoaki、Azuma Koichi、Sasada Tetsuro
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: なし Issue: 10 Pages: 2881-2892
- DOI
  10.1007/s00262-021-02900-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19867, KAKENHI-PROJECT-20K16812, KAKENHI-PROJECT-19K08637, KAKENHI-PROJECT-21H02995, KAKENHI-PROJECT-16H06277
[Journal Article] Machine learning-based image analysis for accelerating the diagnosis of complicated preneoplastic and neoplastic ductal lesions in breast biopsy tissues2021
- Author(s)
  Shinya Sato , Satoshi Maki, Takashi Yamanaka, Daisuke Hoshino, Yukihide Ota, Emi Yoshioka, Kae Kawachi, Kota Washimi, Masaki Suzuki, Yoichiro Ohkubo, Tomoyuki Yokose, Toshinari Yamashita, Seiji Ohtori, Yohei Miyagi
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: online ahead of print Issue: 3 Pages: 649-659
- DOI
  10.1007/s10549-021-06243-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09422
[Journal Article] Novel LAMC2 fusion protein has tumor‐promoting properties in ovarian carcinoma2021
- Author(s)
  Daisuke Hoshino、Kato Hisamori、Fukumura Kazuhiro、Mayeda Akila、Miyagi Yohei、Seiki Motoharu、Koshikawa Naohiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4957-4967
- DOI
  10.1111/cas.15149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07202, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-17H06329, KAKENHI-PROJECT-21K09840
[Journal Article] Sensitization of HT29 colorectal cancer cells to vemurafenib in three-dimensional collagen cultures2020
- Author(s)
  Keiji Kikuchi. Daisuke Hoshino
- Journal Title
  
  Cell Biology International
  
  Volume: 44 Issue: 2 Pages: 621-629
- DOI
  10.1002/cbin.11262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07190
[Journal Article] Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix2020
- Author(s)
  Yoshida Tatsuya、Suganuma Nobuyasu、Sato Shinya、Toda Soji、Nakayama Hirotaka、Masudo Katsuhiko、Okubo Yoichiro、Hayashi Hiroyuki、Yokose Tomoyuki、Koshikawa Naohiko、Rino Yasushi、Iwasaki Hiroyuki、Miyagi Yohei、Masuda Munetaka、Hoshino Daisuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 4 Pages: 1195-1200
- DOI
  10.1016/j.bbrc.2020.06.043
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08713, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-17H06329
[Journal Article] Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient2020
- Author(s)
  Osumi Hiroki、Muroi Atsushi、Sakahara Mizuho、Kawachi Hiroshi、Okamoto Takuya、Natsume Yasuko、Yamanaka Hitomi、Takano Hiroshi、Kusama Daisuke、Shinozaki Eiji、Ooki Akira、Yamaguchi Kensei、Ueno Masashi、Takeuchi Kengo、Noda Tetsuo、Nagayama Satoshi、Koshikawa Naohiko、Yao Ryoji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 17455-17455
- DOI
  10.1038/s41598-020-74530-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06333, KAKENHI-PROJECT-18H02684, KAKENHI-PROJECT-19K22570, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-17H06329
[Journal Article] Effectiveness of dispatcher instructions-dependent or independent bystander cardiopulmonary resuscitation on neurological survival among patients with out-of-hospital cardiac arrest2020
- Author(s)
  Hatakeyama Toshihiro、Kiguchi Takeyuki、Kobayashi Daisuke、Nakamura Naotoshi、Nishiyama Chika、Hayashida Sumito、Kiyohara Kosuke、Kitamura Tetsuhisa、Kawamura Takashi、Iwami Taku
- Journal Title
  
  Journal of Cardiology
  
  Volume: 75 Issue: 3 Pages: 315-322
- DOI
  10.1016/j.jjcc.2019.08.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09393, KAKENHI-PLANNED-17H06329
[Journal Article] NH2‐terminal fragment of ZF21 protein suppresses tumor invasion via inhibiting the interaction of ZF21 with FAK2020
- Author(s)
  Makoto Nagano, Daisuke Hoshino, Jiro Toshima, Motoharu Seiki, Naohiko Koshikawa
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4393-4404
- DOI
  10.1111/cas.14665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06571, KAKENHI-PROJECT-16H06277, KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06329
[Journal Article] The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia2013
- Author(s)
  Hoshino, D., Nagano, M., Saitoh, A., Koshikawa, N., Suzuki, T., and Seiki, M
- Journal Title
  
  PLos One
  
  Volume: 8(1)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia2013
- Author(s)
  Watanabe, A., Hoshino, D., Koshikawa, N., Seiki, M., Suzuki, T., and Ichikawa, K
- Journal Title
  
  PLos Comput Biol
  
  Volume: 9(5)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia.2013
- Author(s)
  Watanabe A, Hoshino D, Koshikawa N, Seiki M, Suzuki T, Ichikawa K.
- Journal Title
  
  PLoS Comput Biol.
  
  Volume: 9(5) Issue: 5 Pages: e1003086-e1003086
- DOI
  10.1371/journal.pcbi.1003086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05013, KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-25462471
[Journal Article] Control and inhibition analysis of complex formation processes2012
- Author(s)
  Saitou, T., Itano, K., Hoshino, D., Koshikawa, N., Seiki, M., Ichikawa, K., and Suzuki, T
- Journal Title
  
  Theor Biol Med Model
  
  Volume: 9 Pages: 33-33
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia.2012
- Author(s)
  Hoshino D, Nagano M, Saitoh A, Koshikawa N, Suzuki T, Seiki M.
- Journal Title
  
  PLoS One.
  
  Volume: 8(1) Issue: 1 Pages: 1-8
- DOI
  10.1371/journal.pone.0050825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23790109, KAKENHI-PROJECT-25462471
[Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies2012
- Author(s)
  Hoshino, D., N. Koshikawa, T . Suzuki, V . Quaranta, A. Weaver, M. Seiki and K. Ichikawa
- Journal Title
  
  PLos Computational Biology
  
  Volume: 8(4)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies2012
- Author(s)
  Hoshino, D., Koshikawa, N., Suzuki, T., Quaranta, V., Weaver, A.M., (Seiki, M.), Ichikawa, K.
- Journal Title
  
  PLoS Comp.Biol.
  
  Volume: 8 Issue: 4 Pages: e1002479-e1002479
- DOI
  10.1371/journal.pcbi.1002479
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117008, KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507
[Journal Article] Turnover of focal adhesions and cancer cell migration.2012
- Author(s)
  Nagano M, Hoshino D, Koshikawa N, Akizawa T, Seiki M.
- Journal Title
  
  Int J Cell Biol.
  
  Volume: 2012 Pages: 310616-310616
- DOI
  10.1155/2012/310616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23790109
[Journal Article] Control and inhibition analysis of complex formation processes.2012
- Author(s)
  Saitou T, Itano K, Hoshino D, Koshikawa N, Seiki M, Ichikawa K, Suzuki T.
- Journal Title
  
  Theor Biol Med Model.
  
  Volume: 3 Issue: 1 Pages: 33-33
- DOI
  10.1186/1742-4682-9-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PUBLICLY-23117507, KAKENHI-PLANNED-22117008
[Journal Article] Identification of proteins that associate with integrin alpha2 by proteomic analysis in human fibrosarcoma HT-1080 cells2012
- Author(s)
  Uematsu, T., C. Konishi, D. Hoshino, X. Han, Taizotomari, N. Egawa, Y. Takada, T. Isobe, M. Seiki, and N. Koshikawa
- Journal Title
  
  J Cell Physiol
  
  Volume: 8 Pages: 3072-9
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Detection of the heterogeneous O-glycosylation profile of MT1-MMP expressed in cancer cells by a simple MALDI-MS method2012
- Author(s)
  Shuo, T., Koshikawa, N., Hoshino, D., Minegishi, T., Ao-Kondo, H., Oyama, M., Sekiya, S., Iwamoto, S., Tanaka, K., and Seiki, M
- Journal Title
  
  PLos One
  
  Volume: 7(8)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis.2012
- Author(s)
  Hoshino D, Jourquin J, Emmons SW, Miller T, Goldgof M, Costello K, Tyson DR, Brown B, Lu Y, Prasad NK, Zhang B, Mills GB, Yarbrough WG, Quaranta V, Seiki M, Weaver AM.
- Journal Title
  
  Sci Signal.
  
  Volume: 5(241) Issue: 241
- DOI
  10.1126/scisignal.2002964
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCalpha invasive signaling axis2012
- Author(s)
  Hoshino, D., Jourquin, J., Emmons, S. W., Miller, T., Goldgof, M., Costello, K.Tyson, D. R., Brown, B., Lu, Y., Prasad, N. K., Zhang, B., Mills, G. B., Yarbrough, W. G., Quaranta, V., Seiki, M., and Weaver, A. M
- Journal Title
  
  Sci Signal
  
  Volume: 5(241)
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] Turnover of focal adhesions and cancer cell migration2012
- Author(s)
  Nagano, M., D. Hoshino, N. Koshikawa, T. Akizawa, and M. Seiki
- Journal Title
  
  Int J Cell Biol
  
  Volume: 2012 Pages: 310616-310616
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC2011
- Author(s)
  Hoshino, D., N. Koshikawa, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 286(4) Pages: 3139-48
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center2011
- Author(s)
  Nagano, M., D. Hoshino, T. Sakamoto, T. Akizawa, N. Koshikawa, and M. Seiki
- Journal Title
  
  Cell Adh Migr
  
  Volume: 5(1) Pages: 23-8
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC2011
- Author(s)
  星野大介、清木元治, 3/3番目
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 3139-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2011
- Author(s)
  Nagano M, Hoshino D, Koshiba S, Shuo T Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M
- Journal Title
  
  J Biol Chem.
  
  Volume: 286(36) Issue: 36 Pages: 31598-609
- DOI
  10.1074/jbc.m110.199430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-22591762, KAKENHI-PROJECT-22700375, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23790109
[Journal Article] ZF21 protein regulates cell adhesion and motility2010
- Author(s)
  Nagano, M., D. Hoshino, T. Sakamoto, N. Kawasaki, N. Koshikawa, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 285(27) Pages: 21013-22
- Data Source
  KAKENHI-PROJECT-22220014
[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2010
- Author(s)
  Nagano, M., D. Hoshino, S. Koshiba, T. Shuo, N. Koshikawa, T. Tomizawa, F. Hayashi, N. Tochio, T. Harada, T. Akizawa, S. Watanabe, N. Handa, M. Shirouzu, T. Kigawa, S. Yokoyama, and M. Seiki
- Journal Title
  
  J Biol Chem
  
  Volume: 286(36) Pages: 31598-609
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] 腎がん患者由来オルガノイドの樹立と免疫学的解析の試み2023
- Author(s)
  辻　嘉代子、中村有子、紅露　拓、魏　菲菲、眞野恭伸、洞口　俊、氷室秀知、星野大輔、川村　猛、笹田哲朗
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02995
[Presentation] Establishment of Organoids Derived from Renal Cell Cancer for Immunopeptidome Analysis2023
- Author(s)
  辻嘉代子、中村有子、上田宏生、紅露　拓、魏　菲菲、眞野恭伸、洞口　俊、氷室秀知、星野大輔、川村　猛、笹田哲朗
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02995
[Presentation] Identification of specific TCR by single-cell analysis of renal cancer-infiltrating T cells and verification of antitumor effect on renal cancer organoids2023
- Author(s)
  洞口　俊、紅露　拓、氷室秀知、魏　菲菲、眞野恭伸、辻嘉代子、神谷郁也、星野大輔、上原秀一郎、笹田哲朗
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02995
[Presentation] 子宮頸部腺がん三次元スフェロイドにおける炭素線照射の抗腫瘍効果.2022
- Author(s)
  関原和正, 氷室秀知, 齋藤菜緒, 太田幸秀, 笹田哲朗, 星野大輔．
- Organizer
  第81回日本癌学会総会.
- Data Source
  KAKENHI-PROJECT-21H02995
[Presentation] Identification of LAMC2-fusion gene as an oncoprotein produced by chromosomal translocation2022
- Author(s)
  Naohiko Koshikawa, Daisuke Hoshino, Yohei Miyagi
- Organizer
  第81回日本癌学会総会
- Data Source
  KAKENHI-PLANNED-17H06329
[Presentation] 甲状腺未分化癌細胞株に対するEZH2阻害薬の効果2021
- Author(s)
  中山博貴、星野大輔、菅沼伸康、戸田宗治、益戸功彦、宮城洋平、岩崎博幸、利野靖
- Organizer
  第54回日本内分泌外科学会学術大会
- Data Source
  KAKENHI-PROJECT-19K09052
[Presentation] Changes of peripheral TCR/BCR repertoire are predictive biomarker for the efficacy of ICI in NSCLC2021
- Author(s)
  Yoshiro Nakahara, Takaji Matsutani, Yuka Igarashi, Norikazu Matsuo, Hidetomo Himuro, Haruhiro Saito, Kouzo Yamada, Kenta Murotani, Tomoaki Hoshino, Koichi Azuma, Tetsuro Sasada
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02995
[Presentation] 逆相蛋白質アレイおよび数理モデルを用いた肝細胞がん悪性化制御シグナルの解析2019
- Author(s)
  室井敦、榎本将士、朝倉暢彦、森達樹、星野大輔、石渡道徳、鈴木貴、越川直彦
- Organizer
  第19回日本蛋白質化学学会年会、第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06329
[Presentation] 数理モデルを用いたがんの悪性化進展制御の解明、第92回日本生化学会大会2019
- Author(s)
  室井敦、榎本将士、森達樹、石渡道徳、星野大輔、鈴木貴、越川直彦
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06329
[Presentation] エクソソームは細胞膜突起構造を増強し、浸潤活性を惹起する2017
- Author(s)
  星野大輔、清木元治、越川直彦
- Organizer
  第76回日本癌学会学術総会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-17H06329
[Presentation] ヒト癌細胞においてインテグリンα2β1と複合体を形成する蛋白質のプロテオミクスによる同定と解析2012
- Author(s)
  小西知江子、星野大輔、越川直彦、清木元治
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22220014
[Presentation] ZF21, a novel focal adhesion-related protein, promotes cancer cell invasion2011
- Author(s)
  Nagano M, Hoshino D, Sakamoto T, Okihara R, Konishi M, Ko-shikawa N, Akizawa T, Seiki M
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22220014

1. SUGANUMA Nobuyasu (40724927)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. KOSHIKAWA Naohiko (70334282)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
3. NAKAYAMA Hirotaka (60438158)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Sato Shinya (30464564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 宮城洋平 (00254194)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 吉田達也 (70748350)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 比留間徹 (20254188)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 鷲見公太 (30716733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. SEIKI Motoharu (10154634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
10. FUKADA Satoshi (80527599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAKAMOTO Takeharu (70511418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. SYUUO Takuya (90399006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. NAGANO Makoto (50572715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
14. KIKUCHI KEIJI (90372094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Sasada Tetsuro (70293967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
16. 益田宗孝 (10190365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 利野靖 (50254206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石渡通徳 (30350458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 中村直俊 (30554472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 朝倉暢彦 (70308584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 室井敦 (60609402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. 板野景子 (00608416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 川村猛 (70306835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. 上田宏生 (70821916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 光武範吏 (50404215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 工藤崇 (20330300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 荻朋男 (80508317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ICHIKAWA Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. TOSHIMA Jiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 齋藤菜緒

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 氷室秀知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 大久保陽一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 八尾良司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 福村和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 項慧慧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 北村哲久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOSHINO DAISUKE 星野 大輔

Daisuke Hoshino 星野 大輔

HOSHINO Daisuke 星野 大輔

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Hippo 経路と EMT 経路を基軸とした甲状腺未分化癌の病態解明Principal Investigator

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Establishment of single-cell organoid culture system and elucidation of drug resistance mechanisms.Principal Investigator

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Molecular mechanism of cancer derived small vesicles related tumor malignanciesPrincipal Investigator

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Molecular mechanism of tumour malignancy via exosomesPrincipal Investigator

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HOSHINO DAISUKE 星野大輔

Daisuke Hoshino 星野大輔

HOSHINO Daisuke 星野大輔