SASANUMA Hiroki 笹沼寛樹

Researcher Number	30571707
Affiliation (based on the past Project Information) *help	2014: 埼玉医科大学, 医学部, 研究員 2010 – 2011: 埼玉医科大学, 医学部, 研究員
Review Section/Research Field	Except Principal Investigator Orthopaedic surgery
Keywords	Except Principal Investigator 骨形成 / 細胞・組織 / 分化 / 骨芽細胞 / 筋芽細胞 / 蛋白質 / 再生 / 細胞内情報伝達 / 運動器 / 骨格筋 … More / 細胞内伝達情報 / 転写因子 / 転写 / 遺伝子 / 骨組織 / 筋 Less

Analysis of the role of TGF-b family and Smad signaling in musculoskeletal regulation
- Principal Investigator
  
  YONEYAMA Katsumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Saitama Medical University
A novel model for connecting growth and differentiation
- Principal Investigator
  
  KATAGIRI Takenobu
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Saitama Medical University
BMPシグナル修飾因子の同定と機能解析
- Principal Investigator
  
  片桐岳信
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Saitama Medical University
Molecular mechanisms of regulation in locomotive tissues
- Principal Investigator
  
  KATAGIRI Takenobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Saitama Medical University

All 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes.2013
- Author(s)
  Shin M, Ohte S, Fukuda T, Sasanuma H, Yoneyama K, Kokabu S, Miyamoto A. Tsukamoto S, Hohjoh H, Jimi E, Katagiri T.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: 31 Issue: 1 Pages: 34-43
- DOI
  10.1007/s00774-012-0381-1
- NAID
  10031168835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390424, KAKENHI-PROJECT-24390226, KAKENHI-PROJECT-24592278, KAKENHI-PROJECT-24791559, KAKENHI-PROJECT-25670428
[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2012
- Author(s)
  Ohte S
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Issue: 3 Pages: 808-814
- DOI
  10.1002/jcb.23408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423, KAKENHI-PROJECT-22791795, KAKENHI-PROJECT-23659732, KAKENHI-PROJECT-24592278, KAKENHI-PLANNED-24115007
[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2011
- Author(s)
  Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, and Katagiri T
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Pages: 808-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659732
[Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H2011
- Author(s)
  Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Nanba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T and Katagiri T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 407 Pages: 213-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423
[Journal Article] Suppression of BMP-Smad axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase2011
- Author(s)
  Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, and Katagiri T
- Journal Title
  
  Mol Endocrinol
  
  Volume: 25 Pages: 474-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423
[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2011
- Author(s)
  Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, and Katagiri T
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Pages: 808-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423
[Journal Article] Dual roles of Smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins2010
- Author(s)
  Nojima J, Kanomata K, Takada Y, Fukuda T, Kokabu S, Ohte S, Takada T, Tsukui T, Yamamoto TS, SasanumaH, Yoneyama K, Ueno N, Okazaki Y, Kamijo R, Yoda T, and Katagiri T
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 15577-15586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423
[Journal Article] Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3・-dependent but a・-catenin-independent mechanism2010
- Author(s)
  Fukuda T, Kokabu S, Ohte S, Sasanuma H, Kanomata K, Yoneyama K, Kato H, Akita M, Oda H, and Katagiri T
- Journal Title
  
  Differentiation
  
  Volume: 80 Pages: 46-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390423
[Presentation] Establishmrent and analysis of Dox-inducible ALK2-expressiong C2C12 cell lines2012
- Author(s)
  Katsumi Yoneyama, Sho Tsukamoto, Satoshi Ohte, Hiroki Sasanuma, Mai Fujimoto, Arei Miyamoto, Takenobu Katagiri
- Organizer
  第10回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] リガンド特異的シグナル伝達をする構成的活性型 Smad の解析2012
- Author(s)
  塚本翔、大手聡、米山克美、笹沼寛樹、藤本舞、宮本阿礼、片桐岳信
- Organizer
  第19回BMP研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Molecular Mechanisms of Activation of Mutant ALK2 in FOP2012
- Author(s)
  Satoshi Ohte, Mai Fujimoto, Sho Tsukamoto, Arei Miyamoto, Hiroki Sasanuma, Masashi Shin, Katsumi Yoneyama, Toru Fukuda, Shoichiro Kokabu, Takenobu Katagiri
- Organizer
  International conference on bone morphogenetic protein
- Place of Presentation
  カリフォルニア（アメリカ）
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] BMP および TGF-b 特異的シグナルを伝達する構成的活性型Smadの解析2012
- Author(s)
  塚本翔、大手聡、米山克美、藤本舞、進正史、笹沼寛樹、自見英治郎、片桐岳信
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] 進行性骨化性線維異形成症における変異型 BMP 受容体 ALK2 の活性化機構2012
- Author(s)
  大手聡、藤本舞、米山克美、笹沼寛樹、進正史、塚本翔、宮本阿礼、福田亨、古株彰一郎、片桐岳信
- Organizer
  第19回BMP研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] A role of satellite cells in heterotopic bone formation in skeletal muscle induced by BMP signaling2012
- Author(s)
  Hiroki Sasanuma, Katsumi Yoneyama, Satoshi Ohte, Sho Tsukamoto, Mai Fujimoto, Arei Miyamoto, Takenobu Katagiri
- Organizer
  第10回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Functional analysis of novel ALK2 mutant identified in fibrodyaplasia ossificans progressiva.2012
- Author(s)
  Mai Fujimoto, Satoshi Ohte, Katsumi Yoneyama, Hiroki Sasanuma, Sho Tsukamoto, Arei Miyamoto, Naoto Suda, Takenobu Katagiri
- Organizer
  第10回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] 成熟骨芽細胞をモニターできる新しい蛍光タンパク質レポーターシステムの開発2012
- Author(s)
  曽根岳史、進正史、笹沼寛樹、大手聡、片桐岳信、三谷幸之介
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Identification of novel BMP-inducible transcript, BIT-1, by utilizing the conserved BMP-responsive elements in the id genes2012
- Author(s)
  Arei Miyamoto, Masashi Shin, Satoshi Ohte, Hiroki Sasanuma, Katsumi Yoneyama, Shoichiro Kokabu, Sho Tsukamoto, Takenobu Katagiri
- Organizer
  第10回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] I 型 BMP 受容体 ALK2 の活性化には II 型 BMP 受容体による GS ドメイン内 Thr203 のリン酸化が必須である2012
- Author(s)
  大手聡、藤本舞、米山克美、笹沼寛樹、進正史、塚本翔、福田亨、古株彰一郎、片桐岳信
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Activation mechanisms of mutant ALK2 found in fibrodysplasia ossificans progressiva by type II BMP receptor2012
- Author(s)
  Satohi Ohte, Mai Fujimoto, Sho Tsukamoto, Arei Miyamoto, Hiroki Sasanuma, Masashi Shin, Katsumi Yoneyama, Toru Fukuda, Shoichiro Kokabu, Takenobu Katagiri
- Organizer
  1st asia-pacific bone and mineral research meeting
- Place of Presentation
  パース（オーストラリア）
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] BMP 受容体 ALK2 の Tet-ON 誘導システムによる発現細胞の樹立2012
- Author(s)
  米山克美、塚本翔、大手聡、笹沼寛樹、進正史、藤本舞、片桐岳信
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Identification of a Novel BMP-inducible Transcript, BIT-1, by Utilizing the Conserved BMP-Responsive Elements in the Id Genes2012
- Author(s)
  Masashi Shin, Satoshi Ohte, Toru Fukuda, Hiroki Sasanuma, Katsumi Yoneyama, Shoichiro Kokabu, Sho Tsukamoto, Hirohoko Hohjoh, Eijiro Jimi, Takenobu Katagiri
- Organizer
  2012 ASBMR Annual Meeting
- Place of Presentation
  ミネアポリス（アメリカ）
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Id 遺伝子の BMP 応答領域の解析に基づく新規 BMP 応答性転写産物の同定2012
- Author(s)
  片桐岳信、進正史、大手聡、福田亨、笹沼寛樹、米山克美、古株彰一郎、宮本阿礼、塚本翔、自見英治郎
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Analysis of intracellular signaling pathway important for heterotopic bone-induction by BMPs2012
- Author(s)
  Sho Tsukamoto, Satoshi Ohte, Katsumi Yoneyama, Mai Fujimoto, Hiroki Sasanuma, Arei Miyamoto, Takenobu Katagiri
- Organizer
  第10回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Critical Role of ALK2 Phosphorylation at Thr203 in Activation by BMP type II Receptors2012
- Author(s)
  Satohi Ohte, Mai Fujimoto, Katsumi Yoneyama, Hiroki Sasanuma, Masashi Shin, Sho Tsukamoto, Arei Miyamoto, Toru Fukuda, Shoichiro Kokabu, Takenobu Katagiri
- Organizer
  2012 ASBMR Annual Meeting
- Place of Presentation
  ミネアポリス（アメリカ）
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] Thr203 in ALK2 is a critical residue for activation by BMP type II receptors.2012
- Author(s)
  Satoshi Ohte, Mai Fujimoto, Katsumi Yoneyama, Hiroki Sasanuma, Sho Tsukamoto, Arei Miyamoto, Shoichiro Kokabu, Takenobu Katagiri
- Organizer
  第10回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-24592278
[Presentation] 筋サテライト細胞はBMPシグナルにより骨芽細胞様細胞へ分化する2011
- Author(s)
  笹沼寛樹
- Organizer
  第9回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉県日高市
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-21390423
[Presentation] 筋サテライト細胞はBMPシグナルにより骨芽細胞様細胞へ分化する2011
- Author(s)
  笹沼寛樹, 他
- Organizer
  第9回RCGMフロンティアシンポジウム
- Place of Presentation
  埼玉県日高市
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-23659732
[Presentation] 骨格筋の再生と異所性骨化におけるサテライト細胞に対するBMPシグナルの役割2011
- Author(s)
  笹沼寛樹, 他
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪府大阪市
- Data Source
  KAKENHI-PROJECT-23659732
[Presentation] 骨格筋の再生と異所性骨化におけるサテライト細胞に対するBMPシグナルの役割2011
- Author(s)
  笹沼寛樹
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪府大阪市
- Data Source
  KAKENHI-PROJECT-21390423
[Presentation] 骨芽細胞分化におけるBMPとWntシグナルの相互作用の解明2010
- Author(s)
  笹沼寛樹
- Organizer
  第8回RCGMフロンティア国際シンポジウム
- Place of Presentation
  埼玉
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-21390423
[Presentation] 骨芽細胞分化におけるBMPとWntシグナルの相互作用の解明2010
- Author(s)
  笹沼寛樹
- Organizer
  第8回RCGMフロンティア国際シンポジウム
- Place of Presentation
  埼玉
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-22659277

1. KATAGIRI Takenobu (80245802)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
2. OHTE Satoshi (00547979)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
3. YONEYAMA Katsumi (20571574)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
4. SHIN Masashi (70549261)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. FUKUDA Toru (20301492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. JIMI Eijiro (40276598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. AKITA Masumi (60105905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MIYAMOTO Arei (70634591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
9. OSAWA Kenji (70638238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TSUKAMOTO Sho (20707658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results

SASANUMA Hiroki 笹沼 寛樹

Research Projects

Research Products

Co-Researchers

Analysis of the role of TGF-b family and Smad signaling in musculoskeletal regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel model for connecting growth and differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BMPシグナル修飾因子の同定と機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of regulation in locomotive tissues

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2011

Author(s)

Journal Title

Data Source

[Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H2011

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of BMP-Smad axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase2011

Author(s)

Journal Title

Data Source

[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2011

Author(s)

Journal Title

Data Source

[Journal Article] Dual roles of Smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins2010

Author(s)

Journal Title

Data Source

[Journal Article] Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3・-dependent but a・-catenin-independent mechanism2010

Author(s)

Journal Title

Data Source

[Presentation] Establishmrent and analysis of Dox-inducible ALK2-expressiong C2C12 cell lines2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] リガンド特異的シグナル伝達をする構成的活性型 Smad の解析2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular Mechanisms of Activation of Mutant ALK2 in FOP2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] BMP および TGF-b 特異的シグナルを伝達する構成的活性型Smadの解析2012

Author(s)

SASANUMA Hiroki 笹沼寛樹