Takeyama Masahiro 武山雅博

… Alternative Names

TAKEYAMA MASAHIRO 武山雅博

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Researcher Number	30572010
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 研究員 2025: 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 上席・主任研究員クラス
Affiliation (based on the past Project Information) *help	2023: 奈良県立医科大学, 医学部, 博士研究員 2021 – 2022: 奈良県立医科大学, 医学部, 准教授 2017 – 2020: 奈良県立医科大学, 医学部, 講師 2014 – 2017: 奈良県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Pediatrics
Keywords	Principal Investigator プロテインS / 活性型プロテインC / 血友病 / 第VIII因子 / 活性化プロテインC / 抗凝固 / 血液凝固 / 第X因子 / 第IX因子 Except Principal Investigator 血栓止血 … More / 血液 / 小児科 / 内科 / リン脂質 / 活性型第X因子 / 活性型第IX因子 / トロンビン / 遺伝子治療 / 高機能型 / 第X因子 / 第IX因子 / 第VIII因子 / 血友病A / 血友病 Less

活性化プロテインCおよびプロテインS制御による安定化第VIII因子製剤の開発Principal Investigator
- Principal Investigator
  
  武山雅博
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nara Medical University
Regulation of factor VIII by activated protein C and protein SPrincipal Investigator
- Principal Investigator
  
  Takeyama Masahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Studies on molecular pathology of hemophilia A and gain-of-function of FVIII
- Principal Investigator
  
  Midori Shima
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University
Research for the regulation of factor VIII by activated protein C and protein SPrincipal Investigator
- Principal Investigator
  
  TAKEYAMA MASAHIRO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nara Medical University

All 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] 血液病の外来診療2015
- Author(s)
  武山雅博
- Total Pages
  10
- Publisher
  血液フロンティア
- Data Source
  KAKENHI-PROJECT-26461592
[Journal Article] An anti-factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A.2020
- Author(s)
  Takeyama M, Nogami K, Matsumoto T, Noguchi-Sasaki M, Kitazawa T, Shima M.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 18 Issue: 4 Pages: 825-833
- DOI
  10.1111/jth.14746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10125
[Journal Article] valuation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system.2020
- Author(s)
  Nakajima Y, Nogami K, Yada K, Kawamura T, Ogiwara K, Furukawa S, Shimonishi N, Takeyama M, Shima M.
- Journal Title
  
  Int J Hematol.
  
  Volume: 111 Issue: 3 Pages: 369-377
- DOI
  10.1007/s12185-019-02782-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10128
[Journal Article] lasma-derived factors VIIa and X mixtures (Byclot) significantly improve impairment of coagulant potential ex vivo in plasmas from acquired hemophilia A patients.2020
- Author(s)
  Ochi S, Takeyama M, Shima M, Nogami K.
- Journal Title
  
  Int J Hematol.
  
  Volume: - Issue: 6 Pages: 779-785
- DOI
  10.1007/s12185-020-02837-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10125
[Journal Article] Global coagulation function assessed by rotational thromboelastometrypredicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis.2019
- Author(s)
  Yada K , Nogami K, Ogiwara K, Shida Y, Furukawa S, Yaoi H, Takeyama M, Kasai R,Shima M.
- Journal Title
  
  International Journal of Haematology
  
  Volume: 110(4) Issue: 4 Pages: 419-430
- DOI
  10.1007/s12185-019-02698-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10126
[Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor2018
- Author(s)
  Nogami K, Matsumoto T, Yada K, Ogiwara K, Furukawa S, Shida Y, Takeyama M, Shima M
- Journal Title
  
  Br J Haematol
  
  Volume: ahead of printing Issue: 4 Pages: 528-536
- DOI
  10.1111/bjh.15209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-18K07885
[Journal Article] A case of moderate haemophilia A with inhibitor, carrying the p.R1800H mutation, complicated with juvenile idiopathic arthritis2018
- Author(s)
  Yuka Kondo Yasuaki Shida Tomoaki Ishikawa Koji Yada Masahiro Takeyama Midori Shima Keiji Nogami
- Journal Title
  
  Haemophilia
  
  Volume: 25(1) Issue: 1 Pages: 51-54
- DOI
  10.1111/hae.13648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17K10125
[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogenic but not autologous factor VIII activity.2015
- Author(s)
  Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
- Journal Title
  
  J Thromb Haemost
  
  Volume: 13 Issue: 10 Pages: 1843-1853
- DOI
  10.1111/jth.13118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
[Journal Article] プロテインCおよびプロテインSによる凝固第VIII因子の制御機構の解明および新規血友病治療製剤への応用2015
- Author(s)
  武山雅博、野上恵嗣
- Journal Title
  
  母子健康協会小児医学助成研究報告書
  
  Volume: 1 Pages: 12-13
- Data Source
  KAKENHI-PROJECT-26461592
[Journal Article] 第VIII因子 ― Factor VIIIと活性型プロテインC/プロテインSを軸とした新規凝固制御メカニズム ―2014
- Author(s)
  武山雅博
- Journal Title
  
  日本血栓止血学会雑誌
  
  Volume: 25 Pages: 449-457
- NAID
  130004687760
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 後天性血友病Aの課題の克服～止血モニタリングとリハビリ～2019
- Author(s)
  武山雅博
- Organizer
  第13回日本血栓止血学会学術標準化委員会（SSC）シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 血友病一般（分子病態・診断・治療）2019
- Author(s)
  武山雅博
- Organizer
  Hemophilia Expert Seminar West Japan
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 心奇形のない乳児に発症したMRSAによる感染性心内膜炎の一例2019
- Author(s)
  青木宏諭, 大西智子, 辻井信之, 武山雅博, 田口真輝, 高塚英雄, 嶋緑倫
- Organizer
  第122回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] その症状、後天性血友病Aではないですか？～見逃さないためのポイント～2019
- Author(s)
  武山雅博
- Organizer
  CareNet Web講演会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 市販後エミシズマブを導入した血友病A小児13例の臨床的検討2019
- Author(s)
  水町邦義, 荻原建一, 古川晶子, 矢田弘史, 武山雅博, 野上恵嗣, 嶋緑倫
- Organizer
  第６１回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 血友病治療のUp to date2019
- Author(s)
  武山雅博
- Organizer
  第21回北海道ヘモフィリアケアセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 後天性血友病A患者の治療寛解後にみられる第VIII因子上昇に関する包括的凝固機能解析2019
- Author(s)
  柴崎史隆. 武山雅博, 野上恵嗣, 笹井香那, 嶋緑倫
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 血友病患者における定期補充療法中の破綻出血を踏まえた治療戦略2019
- Author(s)
  武山雅博
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 血友病周産期管理と新生児期・乳児期の頭蓋内出血の現状2019
- Author(s)
  武山雅博
- Organizer
  イデルビオン発売3周年記念講演会in札幌
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 第VIII因子補充の重要性とピークを見据えた止血管理2019
- Author(s)
  武山雅博
- Organizer
  ジビイ発売1周年記念講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 後天性血友病A診療の改善をめざして「止血治療の実際と最適化」2019
- Author(s)
  武山雅博
- Organizer
  第111回近畿血液学地方会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 学校において予防すべき感染症2019
- Author(s)
  武山雅博
- Organizer
  奈良市医師会学校医部会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 製品パート　rVIII-SingleChain（Afstyla）2019
- Author(s)
  武山雅博
- Organizer
  Hemophilia Expert Seminar West Japan
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] 血液凝固因子の構造解析と臨床応用への期待2019
- Author(s)
  武山雅博
- Organizer
  血友病セミナーin旭川
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] ヘムライブラを知る～その特性から検査時の注意点まで～2019
- Author(s)
  武山雅博
- Organizer
  第20回日本検査血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site2018
- Author(s)
  Masahiro Takeyama, Keiji Nogami, Kana Sasai, Midori Shima
- Organizer
  ６０thAmerican Society of Hematology　Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] R2159C 変異FVIII(FVIII-Ise)はC2 ドメインの構造機能変化をきたしている2018
- Author(s)
  越智　聡史，武山　雅博，野上　恵嗣，嶋　　緑倫
- Organizer
  第40回日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第VIII因子A3ドメイン上の新規第IXa因子結合部位の同定2018
- Author(s)
  武山　雅博, 野上　恵嗣, 笹井　香那, 嶋　　緑倫
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第VIII 因子A3 残基1663-1666 にArg1689開裂を制御するトロンビン結合領域が存在する2018
- Author(s)
  南　　博明，野上　恵嗣，笹井　香那，古川　晶子，武山　雅博，嶋　　緑倫
- Organizer
  第40回日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017
- Author(s)
  南　　博明, 野上　恵嗣, 笹井　香那, 古川　晶子, 武山　雅博, 嶋　　緑倫
- Organizer
  第79回　日本血液学会
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] Factor VIII A1 Residues 346-349 is a Novel Thrombin-binding Site Responsible for cleavage at Arg372 in the Heavy Chain2017
- Author(s)
  Minami H, Nogami K, Sasai K, Furukawa S, Takeyama M, Shima M
- Organizer
  the ISTH 2017 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04231
[Presentation] 小児血友病患者のnormalizationを目指して2017
- Author(s)
  武山雅博
- Organizer
  第59回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-17K10125
[Presentation] Identification of a protein S-interactive site on the factor VIII light chain2016
- Author(s)
  Shoko Furukawa, Masahiro Takeyama, Keiji Nogami, and Midori Shima
- Organizer
  第78回日本血液学会
- Place of Presentation
  パシフィコ横浜（横浜市西区みなとみらい）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] Identification of a protein S-interactive site on the factor VIII light chain2016
- Author(s)
  Shoko Furukawa, Masahiro Takeyama, Keiji Nogami, and Midori Shima
- Organizer
  The 58th American Society of Hematology
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 血流下血栓形成能は2N型von Willebrand病の臨床的重症度を反映する2015
- Author(s)
  薮本仁美、矢田弘史、志田泰明、武山雅博、野上恵嗣、細川和也、嶋　緑倫
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] Anti-Factor IXa/FX antibody (ACE910) improves the coagulation function in acquired hemophilia A ex vivo.2015
- Author(s)
  Masahiro Takeyama, Keiji Nogami, Tomoko Matsumoto, Takehisa Kitazawa, Kunihiro Hattori and Midori Shima
- Organizer
  The 57th American Society of Hematology
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 学術推進委員会(SPC)シンポジウム2 「Cell-based coagulationの立場からの抗凝固療法」 Anticoagulant therapy from the view of cell-based coagulation2015
- Author(s)
  武山雅博
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] A microchip flow-chamber system reflects the clinical phenotype in type 1 von Willebrand disease2015
- Author(s)
  野上恵嗣、矢田弘史、志田泰明、武山雅博、矢追博章、南　博明、古川晶子、嶋　緑倫
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 軽症血友病Ｂ患者の急性大動脈解離に対して、遺伝子組換え第IX因子製剤により人工血管置換術の周術期管理を行った１例2015
- Author(s)
  武山雅博、志田泰明、矢田弘史、野上恵嗣、嶋　緑倫
- Organizer
  第1回西日本血友病B研究会
- Place of Presentation
  大阪
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] Enhanced Global Hemostatic Potentials with a Bispecific Antibody to Factors IXa and X (ACE910) in the Whole Blood By Rotation Thromboelastometry (ROTEM).2015
- Author(s)
  Koji Yada, Keiji Nogami, Yasuaki Shida, Masahiro Takeyama, Ryu Kasai, and Midori Shima
- Organizer
  The 57th American Society of Hematology
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] The usefulness of desmopressin loading test for the diagnosis of severe type 1 von Willebrand disease2015
- Author(s)
  武山雅博, 大仲雅之, 矢田弘史, 志田泰明, 松本智子, 早川正樹, 松本雅則, 野上恵嗣, 嶋　緑倫
- Organizer
  第57回日本小児血液がん学会
- Place of Presentation
  山梨
- Year and Date
  2015-11-29
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 軽症・中等症血友病A患者におけるインヒビター発生機序とその克服に関する研究2015
- Author(s)
  武山雅博
- Organizer
  日本医療研究開発機構エイズ対策実用化研究事業血友病とその治療に伴う種々の合併症克服に関する研究平成２７年度第２回班会議
- Place of Presentation
  東京
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] ACE910 improves the coagulation activities in acquired hemophilia A2015
- Author(s)
  武山雅博，野上恵嗣，矢田弘史，松本智子，北沢剛久，服部有宏，嶋　緑倫
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 血流下血栓形成能は1型及び2型von Willebrand病に対するデスモプレシン投与効果を反映する2015
- Author(s)
  矢田弘史、野上恵嗣、志田泰明、武山雅博、細川和也、嶋　緑倫
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] Christian Medical College, Indiaにおける血友病関節症の診断及び治療2015
- Author(s)
  武山雅博
- Organizer
  関西血友病治療研究会
- Place of Presentation
  大阪
- Year and Date
  2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] Seven cases of acquired hemophilia A2015
- Author(s)
  Nozomi Okahashi, Ei Hoshino, Atsushi Hasegawa, Haruyuki Tanaka, Itsuto Amano, Hiroshi Kimura, Koji Yada, Yasuaki Shida, Masahiro Takeyama, Keiji Nogami, and Midori Shima
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 第VIII因子重鎖A2ドメイン上における第X(a)因子結合部位の同定2015
- Author(s)
  武山雅博、野上恵嗣、嶋　緑倫
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] 「Cell-based coagulationの立場からの抗凝固療法」 Anticoagulant therapy from the view of cell-based coagulation
- Author(s)
  武山雅博
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-21 – 2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-26461592
[Presentation] Factor VIII A2 domain contains a binding site for factor X
- Author(s)
  Masahiro Takeyama, Keiji Nogami, Tomoko Matsumoto, Midori Shima
- Organizer
  The 56th American Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26461592

1. 野上恵嗣 (50326328)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
2. Midori Shima (30162663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 矢田弘史 (30635785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 松本智子 (80642678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 志田泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Takeyama Masahiro 武山 雅博

TAKEYAMA MASAHIRO 武山 雅博

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活性化プロテインCおよびプロテインS制御による安定化第VIII因子製剤の開発Principal Investigator

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Regulation of factor VIII by activated protein C and protein SPrincipal Investigator

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Studies on molecular pathology of hemophilia A and gain-of-function of FVIII

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Research for the regulation of factor VIII by activated protein C and protein SPrincipal Investigator

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[Book] 血液病の外来診療2015

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[Journal Article] An anti-factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A.2020

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[Journal Article] valuation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system.2020

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[Journal Article] lasma-derived factors VIIa and X mixtures (Byclot) significantly improve impairment of coagulant potential ex vivo in plasmas from acquired hemophilia A patients.2020

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[Journal Article] Global coagulation function assessed by rotational thromboelastometrypredicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis.2019

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[Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor2018

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[Journal Article] A case of moderate haemophilia A with inhibitor, carrying the p.R1800H mutation, complicated with juvenile idiopathic arthritis2018

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[Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogenic but not autologous factor VIII activity.2015

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[Journal Article] プロテインCおよびプロテインSによる凝固第VIII因子の制御機構の解明および新規血友病治療製剤への応用2015

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[Journal Article] 第VIII因子 ― Factor VIIIと活性型プロテインC/プロテインSを軸とした新規凝固制御メカニズム ―2014

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NAID

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[Presentation] 後天性血友病Aの課題の克服～止血モニタリングとリハビリ～2019

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Takeyama Masahiro 武山雅博

TAKEYAMA MASAHIRO 武山雅博

[Presentation] 製品パート　rVIII-SingleChain（Afstyla）2019