Amano Masayuki 天野将之

… Alternative Names

AMANO Masayuki 天野将之

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Researcher Number	30575080
Other IDs	https://orcid.org/0000-0003-0516-9502
Affiliation (Current)	2024: 熊本大学, 大学院生命科学研究部(医), 特定研究員
Affiliation (based on the past Project Information) *help	2024: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任助教 2022: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2019 – 2020: 熊本大学, 病院, 特別研究員 2018: 熊本大学, 医学部附属病院, 特任助教 … More 2016 – 2017: 熊本大学, 医学部附属病院, 研究員 2015: 熊本大学, 大学院生命科学研究部, 研究員 2012: 熊本大学, エイズ学研究センター, 研究員 2012: 熊本大学, エイズ学研究センター・gCOEリサーチ, アソシエイト 2011: 熊本大学, エイズ学研究センター, ｇＣＯＥリサーチ・アソシエイト Less
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine
Keywords	Principal Investigator HIV-1 / 蛋白自己崩壊 / 脱殻 / キャプシド蛋白 / 創薬 / キャプシド構造蛋白 / HIV-1 キャプシド蛋白 / 薬剤開発 / 蛋白自壊 / CA蛋白 … More / 新規 HIV CA 阻害剤 / CA 自己崩壊 / HIV-1構造蛋白阻害 / 新規薬剤開発 / HIV-1 Capsid 蛋白 (CA) / 蛋白崩壊 / 新規抗HIV-1剤開発 / capsid蛋白 / Gag蛋白自壊 / Gag蛋白 / Capsid阻害剤 / HIV-1　Gag蛋白 / Capsid自壊 / Gag 自壊 / アミノ酸挿入変異 / Gag 蛋白 Less

Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoatingPrincipal Investigator
- Principal Investigator
  
  天野将之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Investigation of novel mechanism(s) regarding HIV-1 capsid protein degradation and uncoatingPrincipal Investigator
- Principal Investigator
  
  Amano Masayuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Development of novel anti-HIV-1 agents which induce significant degradation of HIV-1 capsid protein.Principal Investigator
- Principal Investigator
  
  Amano Masayuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Mechanism of spontaneous degradation observed in the insertioncontaining HIV-1 Capsid proteinsPrincipal Investigator
- Principal Investigator
  
  AMANO Masayuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University

All 2023 2022 2020 2019 2018 2017 2016 2015 2013 2012 2011

All Journal Article Presentation Book Patent

[Book] 化学療法の領域2016
- Author(s)
  天野将之
- Total Pages
  9
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K09574
[Journal Article] Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies2023
- Author(s)
  Ghosh Arun K.、Shahabi Dana、Kipfmiller Maya、Ghosh Ajay K.、Johnson Megan、Wang Yuan-Fang、Agniswamy Johnson、Amano Masayuki、Weber Irene T.、Mitsuya Hiroaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 83 Pages: 129168-129168
- DOI
  10.1016/j.bmcl.2023.129168
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24379
[Journal Article] Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine.2023
- Author(s)
  Amano M, Otsu S, Ichikawa Y, Higashi-Kuwata N, Matsushita S, Shimada S, Mitsuya H.
- Journal Title
  
  J Infect Dis.
  
  Volume: 227 Issue: 1 Pages: 161-163
- DOI
  10.1093/infdis/jiac393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24379
[Journal Article] Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variants2022
- Author(s)
  Amano Masayuki、Otsu Sachiko、Maeda Kenji、Uemura Yukari、Shimizu Yosuke、Omata Kazumi、Matsuoka Masao、Shimada Shinya、Mitsuya Hiroaki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 13524-13524
- DOI
  10.1038/s41598-022-17071-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24379
[Journal Article] Synthesis of Selenoesters via Aldol Condensation and/or Conjugate Reduction and Their Antiviral Activities2022
- Author(s)
  Boateng Alex、Amano Masayuki、Sugiura Masaharu
- Journal Title
  
  ACS Omega
  
  Volume: 8 Issue: 1 Pages: 1369-1374
- DOI
  10.1021/acsomega.2c06784
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24379
[Journal Article] Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands2022
- Author(s)
  Ghosh Arun K.、Kovela Satish、Sharma Ashish、Shahabi Dana、Ghosh Ajay K.、Hopkins Denver R.、Yadav Monika、Johnson Megan E.、Agniswamy Johnson、Wang Yuan‐Fang、Hattori Shin‐Ichiro、Higashi‐Kuwata Nobuyo、Aoki Manabu、Amano Masayuki、Weber Irene T.、Mitsuya Hiroaki
- Journal Title
  
  ChemMedChem
  
  Volume: 17 Issue: 9
- DOI
  10.1002/cmdc.202200058
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24379
[Journal Article] Third-Dose BNT162b2 Vaccination Elicits Markedly High-Level SARS-CoV-2 Neutralizing Antibodies in Vaccinees Who Responded Poorly to a Second Dose in Japan2022
- Author(s)
  Amano Masayuki、Maeda Kenji、Tsuchiya Kiyoto、Shimada Shinya、Mitsuya Hiroaki
- Journal Title
  
  The Journal of Infectious Diseases
  
  Volume: 226 Issue: 11 Pages: 2038-2039
- DOI
  10.1093/infdis/jiac209
- Open Access
- Data Source
  KAKENHI-PROJECT-23K24379
[Journal Article] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies2020
- Author(s)
  Ghosh Arun K.、Kovela Satish、Osswald Heather L.、Amano Masayuki、Aoki Manabu、Agniswamy Johnson、Wang Yuan-Fang、Weber Irene T.、Mitsuya Hiroaki
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 63 Issue: 9 Pages: 4867-4879
- DOI
  10.1021/acs.jmedchem.0c00202
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435
[Journal Article] A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor2020
- Author(s)
  Nakamura Tomofumi、Nakamura Teruya、Amano Masayuki、Miyakawa Toshikazu、Yamagata Yuriko、Matsuoka Masao、Nakata Hirotomo
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 19 Pages: 1-20
- DOI
  10.1128/jvi.00486-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06600, KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-18K08436, KAKENHI-PROJECT-18K16180
[Journal Article] Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance2019
- Author(s)
  Yuki Takamatsu, Manabu Aoki, Haydar Bulut, Debananda Das, Masayuki Amano, Venkata Reddy Sheri, Ladislau C. Kovari, Hironori Hayashi, Nicole S. Delino, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 63 Issue: 8 Pages: 1-1
- DOI
  10.1128/aac.00372-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications2019
- Author(s)
  Masayuki Amano, Pedro Miguel Salcedo-Gomez, Ravikiran S. Yedidi, Rui Zhao, Hironori Hayashi, Kazuya Hasegawa, Tomofumi Nakamura, Cuthbert D. Martyr, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 63 Issue: 7 Pages: 1-1
- DOI
  10.1128/aac.00466-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-19K17921, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-19H03701
[Journal Article] Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition.2019
- Author(s)
  Masayuki Amano, Haydar Bulut, Sadahiro Tamiya, Tomofumi Nakamura, Yasuhiro Koh, Hiroaki Mitsuya.
- Journal Title
  
  Scientific Reports.
  
  Volume: 9 Issue: 1 Pages: 9806-9806
- DOI
  10.1038/s41598-019-46082-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-17H04222
[Journal Article] Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.2018
- Author(s)
  2.Arun K. Ghosh, Prasanth R. Nyalapatla, Satish Kovela, Kalapala Venkateswara Rao, Margherita Brindisi, Heather L. Osswald, Masayuki Amano, Manabu Aoki, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  Journal of Medicinal Chemistry.
  
  Volume: 61(10) Issue: 10 Pages: 4561-4577
- DOI
  10.1021/acs.jmedchem.8b00298
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-15K09574
[Journal Article] Synthesis of 4’‐Substituted Purine 2’‐Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus.2018
- Author(s)
  3.Satoru Kohgo, Shuhei Imoto, Ryoh Tokuda, Yuki Takamatsu, Nobuyo Higashi-Kuwata, Manabu Aoki, Masayuki Amano, Hisao Kansui, Kengo Onitsuka, Kenji Maeda, Hiroaki Mitsuya.
- Journal Title
  
  ChemistrySelect.
  
  Volume: 3(11) Issue: 11 Pages: 3313-3317
- DOI
  10.1002/slct.201800527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-15K09574
[Journal Article] Synthesis, Anti-HBV, and Anti-HIV Activities of 3’-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines.2018
- Author(s)
  1.Hiroki Kumamoto, Shuhei Imoto, Masayuki Amano, Nobuyo Kuwata-Higashi, Masanori Baba, Hiroaki Mitsuya, Yuki Odanaka, Satoko Shimbara Matsubayashi, Hiromichi Tanaka, Kazuhiro Haraguchi.
- Journal Title
  
  ACS Medicinal Chemistry Letters.
  
  Volume: 9(12) Issue: 12 Pages: 1211-1216
- DOI
  10.1021/acsmedchemlett.8b00374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-15K09574
[Journal Article] A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.2017
- Author(s)
  Hiroki Kumamoto, Misato Fukano, Shuhei Imoto, Satoru Kohgo, Yuki Odanaka, Masayuki Amano, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya, Kazuhiro Haraguchi & Kiyoshi Fukuhara.
- Journal Title
  
  Nucleosides, nucleotides & nucleic acids
  
  Volume: 36 Issue: 7 Pages: 463-473
- DOI
  10.1080/15257770.2017.1322209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-26460153
[Journal Article] GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.2017
- Author(s)
  Masayuki Amano, Pedro Miguel Salcedo-Gomez, Ravikiran S. Yedidi, Nicole S. Delino, Hirotomo Nakata, Kalapala Venkateswara Rao, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12235-12235
- DOI
  10.1038/s41598-017-12052-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Design, synthesis, biological evaluation, and X-ray studies of HIV-1 protease inhibitors with modified P2'-ligands of Darunavir.2017
- Author(s)
  Arun K Ghosh, W. Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  ChemMedChem
  
  Volume: 12 Issue: 23 Pages: 1942-1952
- DOI
  10.1002/cmdc.201700614
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands2017
- Author(s)
  Arun K. Ghosh, W. Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 21 Pages: 4925-4931
- DOI
  10.1016/j.bmcl.2017.09.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.2017
- Author(s)
  Arun K. Ghosh , Margherita Brindisi, Prasanth R. Nyalapatla, Jun Takayama, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 19 Pages: 5114-5127
- DOI
  10.1016/j.bmc.2017.04.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222
[Journal Article] Diastereoselective Synthesis of 6" (Z)- and 6" (E) Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers2016
- Author(s)
  Hiroki Kumamoto, Misato Fukano, Tomohiko Nakano, Keito Iwagami, Chiaki Takeyama, Satoru Kohgo, Shuhei Imoto, Masayuki Amano, Nobuyo Kuwata-Higashi, Manabu Aoki, Hiroshi Abe, Hiroaki Mitsuya, Kiyoshi Fukuhara, Kazuhiro Haraguchi
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 81 Issue: 7 Pages: 2827-2836
- DOI
  10.1021/acs.joc.6b00105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12751, KAKENHI-PROJECT-15K09574
[Journal Article] A Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.2016
- Author(s)
  2.Masayuki Amano, Pedro Salcedo-Gómez, Rui Zhao, Ravikiran Yedidi, Debananda Das, Haydar Bulut, Nicole Delino, Sheri Reddy, Arun Ghosh, and Hiroaki Mitsuya
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 60 Issue: 12 Pages: 7046-7059
- DOI
  10.1128/aac.01428-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Journal Article] Design, Synthesis and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and its Monophosphate Derivatives.2015
- Author(s)
  Shuhei Imoto, Satoru Kohgo, Ryoh Tokuda, Hiroki Kumamoto, Manabu Aoki, Masayuki Amano, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya, Kazuhiro Haraguchi.
- Journal Title
  
  Nucleosides, nucleotides & Nucleic Acids
  
  Volume: 34 Issue: 8 Pages: 590-602
- DOI
  10.1080/15257770.2015.1037456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09574
[Journal Article] 4’-Modified Nucleoside Analogs: Potent Inhibitors Active against Entecavir-resistant HBV.2015
- Author(s)
  Yuki Takamatsu, Yasuhito Tanaka, Satoru Kohgo, Shuko Murakami, Kamlendra Singh, Debananda Das, David J. Venzon, Masayuki Amano, Nobuyo Kuwata, Manabu Aoki, Nicole S. Delino, Sanae Hayashi, Satoru Takahashi, Yoshikazu Sukenaga, Kazuhiro Haraguchi, Stefan G. Sarafianos, Kenji Maeda, Hiroaki Mitsuya.
- Journal Title
  
  Hepatology
  
  Volume: 62 Issue: 4 Pages: 1024-1036
- DOI
  10.1002/hep.27962
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Journal Article] Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.2015
- Author(s)
  Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 469 Issue: 2 Pages: 236-242
- DOI
  10.1016/j.bbrc.2015.11.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-26461427, KAKENHI-PROJECT-25461499
[Journal Article] Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.2015
- Author(s)
  Arun K. Ghosh, Jun Takayama, Luke A. Kassekert, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 25 Issue: 21 Pages: 4903-4909
- DOI
  10.1016/j.bmcl.2015.05.052
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-15K15382, KAKENHI-PROJECT-26293239
[Journal Article] Design of gem-Difluoro-bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation.2015
- Author(s)
  Arun K. Ghosh, Sofiya Yashchuk, Akira Mizuno, Nilanjana Chakraborty, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Pedro Miguel Salcedo Gomez, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  ChemMedChem
  
  Volume: 10 Issue: 1 Pages: 107-115
- DOI
  10.1002/cmdc.201402358
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-15K15382, KAKENHI-PROJECT-26293239
[Journal Article] Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.2015
- Author(s)
  Arun K. Ghosh, Cuthbert D. Martyr, Luke A. Kassekert, Prasanth R. Nyalapatla, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Masayuki Amano, Hiroaki Mitsuya.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 48 Pages: 11607-11621
- DOI
  10.1039/c5ob01930c
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Journal Article] Structure-Based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-Inhibitor X-ray Structural Studies.2015
- Author(s)
  Arun K. Ghosh, Xufen Yu, Heather L. Osswald, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  J Med Chem.
  
  Volume: 58 Issue: 13 Pages: 5334-5343
- DOI
  10.1021/acs.jmedchem.5b00676
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Journal Article] A NOVEL TRICYCLIC LIGAND-CONTAINING NONPEPTIDIC HIV-1 PROTEASE INHIBITOR, GRL-0739, EFFECTIVELY INHIBITS THE REPLICATION OF MULTI-DRUG-RESISTANT HIV-1 VARIANTS AND HAS A DESIRABLE CENTRAL NERVOUS SYSTEM (CNS) PENETRATION PROPERTY IN VITRO2015
- Author(s)
  Masayuki Amano, Yasushi Tojo, Pedro Miguel Salcedo-Gómez, Garth L. Parham, Prasanth R. Nyalapatla, Debananda Das, Arun K. Ghosh and Hiroaki Mitsuya
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 59 Issue: 5 Pages: 2625-2635
- DOI
  10.1128/aac.04757-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293239, KAKENHI-PROJECT-15K09574, KAKENHI-PROJECT-15K15382
[Journal Article] GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro, Antimicrob2013
- Author(s)
  Amano M, Tojo Y, Gomez PMS, Campbell JR, Das D, Aoki M, Xu CX, Rao KV, Ghosh AK, and Mitsuya H
- Journal Title
  
  Agents Chemother
  
  Volume: 57 Issue: 5 Pages: 2036-2046
- DOI
  10.1128/aac.02189-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484, KAKENHI-PROJECT-24791031
[Journal Article] Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes : Design, synthesis, and X- ray studies of potent HIV- 1 protease inhibitors2012
- Author(s)
  Ghosh AK, Chapsal BD, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H
- Journal Title
  
  Bioorganic &Medicinal Chemistry Letters
  
  Volume: 22 Issue: 6 Pages: 2308-2311
- DOI
  10.1016/j.bmcl.2012.01.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484
[Journal Article] Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV- 12012
- Author(s)
  Manabu Aoki, Matthew L. Danish, Hiromi Aoki- Ogata, Masayuki Amano, Kazuhiko Ide, Debananda Das, Yasuhiro Koh, and Hiroaki Mitsuya
- Journal Title
  
  Journal of Virology
  
  Volume: 86 Issue: 24 Pages: 13384-13396
- DOI
  10.1128/jvi.07234-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-23791140, KAKENHI-PROJECT-24659484, KAKENHI-PROJECT-24791031
[Journal Article] Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.2012
- Author(s)
  Arun K. Ghosh, Bruno D. Chapsal, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters.
  
  Volume: 22 Pages: 2308-2311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791140
[Journal Article] Loss of Protease Dimerization Inhibition Activity of Durunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1.2011
- Author(s)
  Yasuhiro Koh, Manabu Aoki, Matthew L. Danish, Hiromi Aoki-Ogata, Masayuki Amano, Debananda Das, Robert W. Shafer, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Journal of Virology.
  
  Volume: 85 Pages: 10079-10089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791140
[Journal Article] Design of Substituted Bis-tetrahydrofuran (Bis-THF)- Derived Potent HIV-1 Protease Inhibitors, Protein-Ligand X-ray Structure, and Convenient Syntheses of Bis-THF and Substituted Bis-THF Ligands.2011
- Author(s)
  Arun K. Ghosh, Cuthbert D. Martyr, Melinda Steffey, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  ACS Medicinal Chemistry Letters.
  
  Volume: 2 Pages: 298-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791140
[Journal Article] Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.2011
- Author(s)
  Kazuhiko Ide, Manabu Aoki, Masayuki Amano, Yasuhiro Koh, Ravikiran S. Yedidi, Debananda Das, Sofiya Leschenko, Bruno Chapsal, Arun K. Ghosh, Hiroaki Mitsuya.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy.
  
  Volume: 55 Pages: 1717-1727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791140
[Journal Article] 多剤耐性株に高い抗ウイルス活性を発揮する新規抗HIVプロテアーゼ阻害剤の同定・開発とGag capsid蛋白挿入変異とCA自壊の分子機構の研究(第11回ECC山口メモリアルエイズ研究奨励賞受賞研究)2011
- Author(s)
  天野将之
- Journal Title
  
  日本エイズ学会誌
  
  Volume: 13 Pages: 70-75
- Data Source
  KAKENHI-PROJECT-23791140
[Journal Article] Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligands: Synthesis, Biological Evaluations, and Protein-Ligand X-ray Crystal Structure.2011
- Author(s)
  Arun K. Ghosh, Bruno D. Chapsal, Garth L. Parham, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.
- Journal Title
  
  Journal of Medicinal Chemistry.
  
  Volume: 54 Pages: 5890-5901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791140
[Journal Article] Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol -Derived High Affinity P2 Ligands: Structure-Activity Studies and Biological Evaluation.2011
- Author(s)
  Arun K. Ghosh, Bruno D. Chapsal, Abigail Baldridge, Melinda P. Steffey, D. Eric Walters, Yasuhiro Koh, Masayuki Amano, Hiroaki Mitsuya.
- Journal Title
  
  Journal of Medicinal Chemistry.
  
  Volume: 54 Pages: 622-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791140
[Patent] 抗ウイルス剤2022
- Inventor(s)
  天野将之、杉浦正晴、ボアテング・アレックス
- Industrial Property Rights Holder
  天野将之、杉浦正晴、ボアテング・アレックス
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24379
[Patent] 抗HIV医薬組成物2019
- Inventor(s)
  天野将之、中村朋文
- Industrial Property Rights Holder
  天野将之、中村朋文
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-102088
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K08435
[Patent] 抗HIV医薬組成物2018
- Inventor(s)
  天野将之、中村朋文、杉浦正晴
- Industrial Property Rights Holder
  天野将之、中村朋文、杉浦正晴
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-15K09574
[Patent] 抗HIV医薬組成物2017
- Inventor(s)
  天野将之、中村朋文
- Industrial Property Rights Holder
  天野将之、中村朋文
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-244763
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] アルドール縮合や還元反応による抗ウイルス活性有機セレン化合物の合成2023
- Author(s)
  ボアテングアレックス、天野将之、杉浦正晴
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24379
[Presentation] Synthesis of Selenoesters by Aldol Condensation and/or Conjugate Reduction and Their Antiviral Activities2022
- Author(s)
  Boateng Alex、天野将之、杉浦正晴
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24379
[Presentation] Determining the Mechanism of a Possible HIV-1 Capsid Inhibitor: ACAi-0282020
- Author(s)
  Travis Chia、Masayuki Amano、Tomofumi Nakamura、Hirotomo Nakata、Masao Matsuoka.
- Organizer
  第34回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] 感染効率を上昇させるHIV-1ヌクレオカプシド内に認められた薬剤耐性変異2020
- Author(s)
  中村朋文、天野将之、Travis Chia、松岡雅雄、中田浩智
- Organizer
  第34回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] 高い中枢神経系移行性と強力な抗HIV活性を有する新規HIV関連神経認知障害（HAND）予防/治療薬の開発2019
- Author(s)
  天野将之、Pedro Miguel Salcedo-Gomez、Ravikiran S. Yedidi、趙睿、林宏典、長谷川和也、Cuthbert D. Martyr、Arun K. Ghosh、満屋裕明
- Organizer
  第29回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] HIV-1の必須構造蛋白であるキャプシドに対する新規阻害剤の開発2019
- Author(s)
  天野将之、中村朋文、杉浦正晴、高宗暢暁、松岡雅雄、満屋裕明
- Organizer
  第47回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] HIV-1 capsid (CA) 構造蛋白に作用し、その過剰安定化を誘導する事でHIV-1増殖阻害活性を発揮する化合物群の同定2019
- Author(s)
  天野将之、中村朋文、Pedro Miguel Salcedo-Gomez、趙睿、中田浩智、宮川寿一、Travis Chia Ren Teen、松岡雅雄、満屋裕明
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] HIV-1 capsid (CA) 構造蛋白において、C 末端アミノ酸が寄与する CA 蛋白不安定性に関するウイルス学的考察2018
- Author(s)
  55.天野将之、趙睿、中村朋文、中田浩智、宮川寿一、松岡雅雄、満屋裕明
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 capsid構造蛋白（CA）の安定性を変化させる事で抗ウイルス作用を発揮する、CA自己崩壊誘導化合物（CA decomposers）及びCA安定化過剰促進化合物（CA hyper-stabilizers）の開発2018
- Author(s)
  53.天野将之、中村朋文、Salcedo Gomez Pedro Miguel、趙睿、中田浩智、宮川寿一、松岡雅雄、満屋裕明
- Organizer
  第20回白馬シンポジウム
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 capsid構造蛋白（CA）の安定性を変化させる事で抗ウイルス作用を発揮する、CA自己崩壊誘導化合物（CA decomposers）及びCA安定化過剰促進化合物（CA hyper-stabilizers）の開発2018
- Author(s)
  53.天野将之、中村朋文、Salcedo Gomez Pedro Miguel、趙睿、中田浩智、宮川寿一、松岡雅雄、満屋裕明
- Organizer
  第20回白馬シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] Identification and Development of Novel Anti-HIV-1 Compounds which Induce Hyper-stabilization of HIV-1’s Capsid Structural Protein (CA)/ HIV-1 キャプシド構造蛋白の過剰安定化を促進させる事でウイルス増殖を抑制する、新規抗HIV-1化合物の開発2018
- Author(s)
  天野将之
- Organizer
  BioJapan 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] Identification and Development of Novel Anti-HIV-1 Compounds which Induce Hyper-stabilization of HIV-1’s Capsid Structural Protein (CA)/ HIV-1 キャプシド構造蛋白の過剰安定化を促進させる事でウイルス増殖を抑制する、新規抗HIV-1化合物の開発2018
- Author(s)
  天野将之
- Organizer
  BioJapan 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] HIV-1 capsid (CA) 構造蛋白において、C末端アミノ酸が寄与するCA蛋白不安定性に関するウイルス学的考察2018
- Author(s)
  天野将之、趙睿、中村朋文、中田浩智、宮川寿一、松岡雅雄、満屋裕明
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08435
[Presentation] HIV-1 Capsid (CA) 構造蛋白において、C 末端 9 アミノ酸が寄与する CA 蛋白不安定性に関するウイルス学的考察2017
- Author(s)
  天野将之、趙睿、中村朋文、中田浩智、宮川寿一、松岡雅雄、満屋裕明
- Organizer
  第19回白馬シンポジウム
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] The fragment of 9 amino acids at the C-terminal domain of HIV-1 Capsid protein (CA) induces structural fragility of CA, and is possibly essential for the uncoating/replication of HIV-12017
- Author(s)
  Masayuki Amano, Rui Zhao, Tomofumi Nakamura, Hirotomo Nakata, Toshikazu Miyakawa, Masao Matsuoka, and Hiroaki Mitsuya
- Organizer
  18th Kumamoto AIDS Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 Capsid 蛋白質不安定性の脱殻/ウイルス複製における意義2017
- Author(s)
  天野将之、趙睿、中村朋文、中田浩智、宮川寿一、田宮貞宏、松岡雅雄、満屋裕明
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 構造蛋白を過剰に安定化させる事で、CD4 陽性免疫細胞へのウイルスの感染および増殖を抑制する、新規 HIV-1 感染症治療薬の開発2017
- Author(s)
  天野将之、Salcedo Gomez Pedro Miguel、中村朋文、趙睿、松岡雅雄、満屋裕明
- Organizer
  日本医療研究開発機構・革新的医療技術創出拠点プロジェクト・第5回TR推進合同フォーラム・ライフサイエンス技術交流会
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 Capsid (CA) 構造蛋白において、C 末端 9 アミノ酸（CA223 - CA231）が寄与する CA 蛋白不安定性に関する分子学・ウイルス学的考察2017
- Author(s)
  天野将之、趙睿、中村朋文、中田浩智、宮川寿一、松岡雅雄、満屋裕明
- Organizer
  第27回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 Capsid 蛋白の自己崩壊誘導作用を有する低分子化合物（HIV-1 CA decomposer）の同定・検討2016
- Author(s)
  47.天野将之、Pedro Miguel Salcedo-Gomez、中村朋文、趙睿、満屋裕明
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋東急ホテル
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1 Capsid 蛋白の自己崩壊誘導作用を有する低分子化合物（HIV-1 CA decomposer）の同定・検討2016
- Author(s)
  天野将之、Pedro Miguel Salcedo-Gomez、中村朋文、趙睿、満屋裕明
- Organizer
  抗ウイルス療法学会
- Place of Presentation
  名古屋市立大学医学部
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] 高い中枢神経系移行性と強力な抗HIV-1活性を有する新規HIV関連神経認知障害（HAND）予防/治療薬の開発2015
- Author(s)
  天野将之、Pedro Miguel Salcedo-Gomez、林宏典、Arun K. Ghosh、満屋裕明
- Organizer
  抗ウイルス療法学会
- Place of Presentation
  国立感染症研究所
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] 高い中枢神経系移行性と強力な抗HIV-1活性を有し、HIVの耐性獲得に抵抗する新規HIV関連神経認知障害（HAND）予防/治療薬の開発2015
- Author(s)
  天野将之、Pedro Miguel Salcedo-Gomez、趙睿、林宏典、Ravikiran S. Yedidi、Arun K. Ghosh、満屋裕明
- Organizer
  白馬シンポジウム
- Place of Presentation
  鳥取大学医学部
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] Modified P1-Moiety Enhances Antiviral Activity against Drug-Resistant HIV-1 Variants and Central Nervous System (CNS) Penetration Effectiveness of Newly-Generated HIV-1 Protease Inhibitors In Vitro.2015
- Author(s)
  Masayuki Amano, Pedro Miguel Salcedo-Gomez, Zhao Rui, Ravikiran S. Yedidi, Nicole S. Delino, Arun K. Ghosh, and Hiroaki Mitsuya
- Organizer
  Kumamoto AIDS seminar
- Place of Presentation
  熊本・阿蘇グランヴィリオホテル
- Year and Date
  2015-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09574
[Presentation] HIV-1capsid 蛋白(CA)の挿入変異がもたらすCA 自壊の分子機構の解明および CA 阻害活性を有する化合物の検索2012
- Author(s)
  天野将之Pedro ,Miguel Salcedo-Gomez,Amber R Moore-Arthur, 満屋裕明
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  慶応義塾大学日吉キャンパス
- Year and Date
  2012-11-04
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] Mechanism ofspontaneous degradation observed in theinsertion-containing HIV-1 Capsidproteins, and a new attempt to discoversmall compound which induce HIV-1Capsid protein degradation2012
- Author(s)
  Masayuki Amano, Pedro Miguel SalcedoGomez, Amber R Moore-Arthur, andHiroaki Mitsuya
- Organizer
  13thKmamoto AIDS Seminar-GCOE JointInternational Symposium
- Place of Presentation
  Aso-GranvirioHotel, Kumamoto, Japan
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] HIV-1 capsid蛋白（CA）の挿入変異がもたらすCA自壊の分子機構の解明およびCA阻害活性を有する化合物の検索2012
- Author(s)
  天野将之、満屋裕明, et al.
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  神奈川　慶應義塾大学日吉キャンパス
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] A Novel OxatricyclicLigand-Containing NonpeptidicProtease Inhibitor (PI) GRL-0519APotent Against Multi-PI-Resistant HIVIn Vitro2012
- Author(s)
  Masayuki Amano, Y Tojo, M Aoki, S G.Pedro-Miguel, J R. Campbell, A K. Ghosh,H Mitsuya
- Organizer
  25thInternational Conferenceon Antiviral Research (ICAR)
- Place of Presentation
  Royton Hotel, Sapporo,Japan
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] Mechanism of spontaneous degradation observed in the insertion-containing HIV-1 Capsid proteins, and a new attempt to discover small compound which induce HIV-1 Capsid protein degradation2012
- Author(s)
  Masayuki Amano, Hiroaki Mitsuya, et al.
- Organizer
  13th Kmamoto AIDS Seminar-GCOE Joint International Symposium.
- Place of Presentation
  熊本　阿蘇リゾートグランヴィリオホテル
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] Novel HIV-1 protease inhibitors with potent antiviral activity and favorable blood brain barrier penetration.2012
- Author(s)
  Pedro Miguel Salcedo-Gomez, Masayuki Amano, Hiroaki Mitsuya, et al.
- Organizer
  13th Kmamoto AIDS Seminar-GCOE Joint International Symposium.
- Place of Presentation
  熊本　阿蘇リゾートグランヴィリオホテル
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] Novel HIV-1 proteaseinhibitors with potent antiviralactivity and favorable blood brainbarrier penetration2012
- Author(s)
  Pedro Miguel Salcedo-Gomez, MasayukiAmano, Arun K. Ghosh, and HiroakiMitsuya
- Organizer
  13th Kmamoto AIDSSeminar-GCOE Joint InternationalSymposium
- Place of Presentation
  Aso-Granvirio Hotel,Kumamoto, Japan
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] A Novel Oxatricyclic-Ligand- Containing Nonpeptidic Protease Inhibitor (PI) GRL-0519A Potent Against Multi-PI-Resistant HIV In Vitro.2012
- Author(s)
  Masayuki Amano, Hiroaki Mitsuya, et al.
- Organizer
  25th International Conference on Antiviral Research (ICAR).
- Place of Presentation
  北海道　ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] A Novel Oxatricyclic-Ligand-Containing Nonpeptidic Protease Inhibitor (PI) GRL-0519A Potent Against Multi-PI-Resistant HIV In Vitro.2012
- Author(s)
  Masayuki Amano
- Organizer
  25th International Conference on Antiviral Research (ICAR)
- Place of Presentation
  札幌、ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] Oxatricyclic (tris-tetrahydrofuranylurethane: tris-THF) 構造を有する新規のHIVプロテアーゼ阻害剤 (PI)，GRL-0519の抗ウイルス活性の検討2011
- Author(s)
  天野将之、満屋裕明
- Organizer
  第21回抗ウイルス療法研究会
- Place of Presentation
  金沢、金沢市文化センター
- Data Source
  KAKENHI-PROJECT-23791140
[Presentation] HIV-1 capsid蛋白 (CA) の挿入変異がもたらすCA自壊の分子機構の解明2011
- Author(s)
  天野将之
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  東京、ハイアットリージェンシー東京
- Data Source
  KAKENHI-PROJECT-23791140

1. 杉浦正晴 (00376592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 中村朋文 (00772526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岡田誠治 (50282455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高宗暢暁 (60322749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 刈谷龍昇 (40757663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAMURA Teruya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 阿部洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 満屋裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
9. GHOSH Arun K.

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 松下修三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Amano Masayuki 天野 将之

AMANO Masayuki 天野 将之

Research Projects

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Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoatingPrincipal Investigator

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Investigation of novel mechanism(s) regarding HIV-1 capsid protein degradation and uncoatingPrincipal Investigator

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Development of novel anti-HIV-1 agents which induce significant degradation of HIV-1 capsid protein.Principal Investigator

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Mechanism of spontaneous degradation observed in the insertioncontaining HIV-1 Capsid proteinsPrincipal Investigator

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[Book] 化学療法の領域2016

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[Journal Article] Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies2023

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[Journal Article] Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine.2023

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[Journal Article] Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variants2022

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[Journal Article] Synthesis of Selenoesters via Aldol Condensation and/or Conjugate Reduction and Their Antiviral Activities2022

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[Journal Article] Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands2022

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[Journal Article] Third-Dose BNT162b2 Vaccination Elicits Markedly High-Level SARS-CoV-2 Neutralizing Antibodies in Vaccinees Who Responded Poorly to a Second Dose in Japan2022

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[Journal Article] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies2020

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[Journal Article] A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor2020

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[Journal Article] Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance2019

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[Journal Article] Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications2019

Amano Masayuki 天野将之

AMANO Masayuki 天野将之