OBITA TAKAYUKI 帯田孝之

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OBITA Takayuki 帯田孝之

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Researcher Number	30578696
Other IDs
Affiliation (Current)	2025: 富山大学, 学術研究部薬学・和漢系, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 富山大学, 学術研究部薬学・和漢系, 准教授 2012 – 2018: 富山大学, 大学院医学薬学研究部(薬学), 准教授 2011: 富山大学, 大学院・医学薬学研究部(薬学), 准教授 2010: 富山大学, 大学院・医学薬学研究部(薬), 准教授
Review Section/Research Field	Principal Investigator Structural biochemistry / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 43030:Functional biochemistry-related / Biological pharmacy Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy
Keywords	Principal Investigator Ｘ線結晶構造解析 / ESCRT / 構造生物学 / 古細菌 / 細胞分裂 / 天然保湿因子 / 酵素活性機構 / プロフィラグリン / 酵素 / 酵素活性 … More / filaggrin / HPLC / Filaggrin / 酵素反応 / SASPase / Ｘ線結晶解析 / ITC / TFIIE / 基本転写因子 / 細胞質分裂 / タンパク質 / NMR / X線結晶構造解析 … More Except Principal Investigator タンパク質 / 天然変性蛋白質 / 立体構造 / DNA結合 / cGAS / NMR / 相互作用 / 天然変性タンパク質 / DNA結合タンパク質 / ゲルシフトアッセイ / 自然免疫 / ZCCHC3 / X線結晶構造解析 / DNA / PQBP1 / アロステリック機構 / SPR / アロステリック効果 / 表面プラズモン共鳴 / 解離定数 Less

Molecular and structural basis of natural moisturizing factor production mechanisms by profilaggrin-degrading enzymes.Principal Investigator
- Principal Investigator
  
  帯田孝之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Toyama
自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
- Principal Investigator
  
  水口峰之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Toyama
Structural study of pro-filaggrin recognition by SASPasePrincipal Investigator
- Principal Investigator
  
  Obita Takayuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  University of Toyama
How does PQBP1 suppress the induction of type I interferon expression by cGAS?
- Principal Investigator
  
  Mizuguchi Mineyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Toyama
Structural Study of basal transcription factor TFIIEPrincipal Investigator
- Principal Investigator
  
  Obita Takayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Toyama
Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
- Principal Investigator
  
  Mineyuki Mizuguchi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Toyama
Structural basis of Archaeal ESCRT complexPrincipal Investigator
- Principal Investigator
  
  OBITA TAKAYUKI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Toyama
Verification of the connector function of the transcription and splicing factor PQBP1
- Principal Investigator
  
  MIZUGUCHI Mineyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Toyama
Structural basis of the filament formation of ESCRT-III proteinsPrincipal Investigator
- Principal Investigator
  
  OBITA TAKAYUKI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Toyama
A structural study towards the understanding of the roles of Archaeal ESCRT in cell division.Principal Investigator
- Principal Investigator
  
  OBITA Takayuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Toyama

All 2024 2023 2022 2021 2017 2016 2014 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 生化学2014
- Author(s)
  帯田孝之
- Total Pages
  4
- Publisher
  公益社団法人日本生化学会
- Data Source
  KAKENHI-PROJECT-24770094
[Journal Article] Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA2024
- Author(s)
  Mizuguchi Mineyuki、Kyan Niko、Nishimata Suzuka、Nabeshima Yuko、Obita Takayuki
- Journal Title
  
  Bioscience Reports
  
  Volume: 44 Issue: 4
- DOI
  10.1042/bsr20240269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06546
[Journal Article] Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin‐inducing activity2023
- Author(s)
  Mizuguchi Mineyuki、Yokoyama Takeshi、Otani Takahito、Kuribara Shiori、Nabeshima Yuko、Obita Takayuki、Hirata Masato、Kawano Keiichi
- Journal Title
  
  FEBS Letters
  
  Volume: - Issue: 11 Pages: 1479-1488
- DOI
  10.1002/1873-3468.14618
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06540, KAKENHI-PROJECT-20H03854
[Journal Article] Design, synthesis, structure?activity relationship studies, and evaluation of novel GLS1 inhibitors2023
- Author(s)
  Jo Michiko、Koizumi Keiichi、Suzuki Mizuho、Kanayama Daisuke、Watanabe Yurie、Gouda Hiroaki、Mori Hisashi、Mizuguchi Mineyuki、Obita Takayuki、Nabeshima Yuko、Toyooka Naoki、Okada Takuya
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 87 Pages: 129266-129266
- DOI
  10.1016/j.bmcl.2023.129266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06540
[Journal Article] d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate <i>Ciona</i>2022
- Author(s)
  Krasovec Gabriel、Hozumi Akiko、Yoshida Tomoyuki、Obita Takayuki、Hamada Mayuko、Shiraishi Akira、Satake Honoo、Horie Takeo、Mori Hisashi、Sasakura Yasunori
- Journal Title
  
  Science Advances
  
  Volume: 8 Issue: 10 Pages: 1-22
- DOI
  10.1126/sciadv.abn3264
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06752, KAKENHI-PLANNED-21H05239, KAKENHI-PROJECT-19H03204, KAKENHI-PROJECT-19H03262, KAKENHI-PROJECT-20H03350, KAKENHI-PROJECT-20K06540, KAKENHI-PROJECT-21K19249, KAKENHI-ORGANIZER-21H05238, KAKENHI-PROJECT-23K23921
[Journal Article] Structural Study of Archaeal Basal Transcription Factor TFE2022
- Author(s)
  帯田孝之、三輪康平、水口峰之
- Journal Title
  
  SPring-8/SACLA Research Report
  
  Volume: 10 Issue: 2 Pages: 143-146
- DOI
  10.18957/rr.10.2.143
- ISSN
  2187-6886
- Year and Date
  2022-04-28
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K06540
[Journal Article] Crystal structure of the PX domain of Vps17p from <i>Saccharomyces cerevisiae</i>2022
- Author(s)
  Obita Takayuki、Inaka Koji、Kohda Daisuke、Maita Nobuo
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 78 Issue: 5 Pages: 210-216
- DOI
  10.1107/s2053230x22004472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06540, KAKENHI-PROJECT-23K21298, KAKENHI-PROJECT-19K05696
[Journal Article] The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin2022
- Author(s)
  Nakagawa Mei、Obita Takayuki、Mizuguchi Mineyuki
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 18 Pages: 1999-2011
- DOI
  10.1042/bcj20220203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06540
[Journal Article] Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation2021
- Author(s)
  Jin Meihua、Shiwaku Hiroki、Tanaka Hikari、Obita Takayuki、Ohuchi Sakurako、Yoshioka Yuki、Jin Xiaocen、Kondo Kanoh、Fujita Kyota、Homma Hidenori、Nakajima Kazuyuki、Mizuguchi Mineyuki、Okazawa Hitoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6565-6565
- DOI
  10.1038/s41467-021-26851-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J13728, KAKENHI-PROJECT-19K08011, KAKENHI-PROJECT-20K06540
[Journal Article] Structural fine-tuning of MIT interacting motif 2 (MIM2) and allosteric regulation of ESCRT-III by Vps4 in yeast.2016
- Author(s)
  Kojima R, Obita T, Onoue K, Mizuguchi M.
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26840018
[Journal Article] Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast2016
- Author(s)
  Kojima, R., Obita, T., Onoue, K., Mizuguchi., M.
- Journal Title
  
  J Mol Biol.
  
  Volume: 428(11) Issue: 11 Pages: 2392-2404
- DOI
  10.1016/j.jmb.2016.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J00404, KAKENHI-PROJECT-16K07265, KAKENHI-PROJECT-16K18534
[Journal Article] Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD2016
- Author(s)
  Mizuguchi, M., Obita, T., Kajiyama, A., Kozakai, Y., Nakai, T., Nabeshima, Y., Okazawa, H.
- Journal Title
  
  FEBS Letters
  
  Volume: 590 Issue: 14 Pages: 2221-31
- DOI
  10.1002/1873-3468.12256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-15K07886, KAKENHI-PROJECT-16K07265
[Journal Article] Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution2016
- Author(s)
  Miwa, K., Kojima, R., Obita, T., Ohkuma, Y., Tamura, Y., and Mizuguchi, M.
- Journal Title
  
  JOURNAL OF MOLECULAR BIOLOGY
  
  Volume: 428 Issue: 21 Pages: 4258-4266
- DOI
  10.1016/j.jmb.2016.09.008
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24118003, KAKENHI-PROJECT-15H05595, KAKENHI-PROJECT-14J00404, KAKENHI-PROJECT-15K14507, KAKENHI-PROJECT-16K07265, KAKENHI-PROJECT-16K18534, KAKENHI-PROJECT-15H05705
[Journal Article] Characterization of the interaction between Trypanosoma brucei Pex5p and its receptor Pex14p.2016
- Author(s)
  Watanabe Y, Kawaguchi K, Okuyama N, Sugawara Y, Obita T, Mizuguchi M, Morita M, Imanaka T.
- Journal Title
  
  FEBS letters
  
  Volume: 590 Issue: 2 Pages: 242-250
- DOI
  10.1002/1873-3468.12044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26840018
[Journal Article] Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1.2014
- Author(s)
  Mizuguchi M, Fuju T, Obita T, Ishikawa M, Tsuda M, Tabuchi A.
- Journal Title
  
  Sci Rep.
  
  Volume: 4 Issue: 1 Pages: 5224-5224
- DOI
  10.1038/srep05224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460064, KAKENHI-PROJECT-26840018
[Journal Article] A role for crenarchaeal ESCRT system in cell division2014
- Author(s)
  Obita T
- Journal Title
  
  Seikagaku
  
  Volume: 86(1) (Review. Japanese) Pages: 59-62
- NAID
  40020011073
- Data Source
  KAKENHI-PROJECT-24770094
[Journal Article] Mutations in the gene PQBP1 prevent its interaction with the spliceosomal protein U5-15kD2014
- Author(s)
  Mizuguchi, M., Obita, T., Serita, T., Kojima, R., Nabeshima, Y., and Okazawa, H.
- Journal Title
  
  Nat Commun.
  
  Volume: 5 Issue: 1 Pages: 3822-3822
- DOI
  10.1038/ncomms4822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J00404, KAKENHI-PLANNED-21113003, KAKENHI-PLANNED-22110002, KAKENHI-PROJECT-24590049, KAKENHI-PROJECT-26640037, KAKENHI-PROJECT-26840018
[Journal Article] In silico and pharmacological screenings identify novel serine racemase inhibitors.2014
- Author(s)
  Hisashi Mori, Ryogo Wada, Jie Li, Tetsuya Ishimoto, Mineyuki Mizuguchi, Takayuki Obita, Hiroaki Gouda, Shuichi Hirono, Naoki Toyooka.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 24 Issue: 16 Pages: 3732-3735
- DOI
  10.1016/j.bmcl.2014.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-25293059, KAKENHI-PROJECT-26840018
[Journal Article]2012
- Author(s)
  Hadders MA, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, Lamers MH, Williams RL, Martin-Serrano J
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109(43) Pages: 17424-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770094
[Journal Article] Shaw MK, Chong PL, Williams RL, Bell SD.2011
- Author(s)
  Samson RY, Obita T, Hodgson B
- Journal Title
  
  Molecular Cell
  
  Volume: 41-2 Pages: 186-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890071
[Journal Article] Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division2011
- Author(s)
  Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD
- Journal Title
  
  Molecular Cell
  
  Volume: 41(2) Pages: 186-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890071
[Journal Article] Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.2011
- Author(s)
  Samson RY, Obita T, et al
- Journal Title
  
  Molecular Cell
  
  Volume: 41(2) Pages: 186-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890071
[Presentation] 古細菌由来基本転写因子TFE のX線結晶構造解析2017
- Author(s)
  三輪康平、帯田孝之、大熊芳明、水口峰之
- Organizer
  日本薬学会北陸支部第129回例会
- Data Source
  KAKENHI-PROJECT-16K07265
[Presentation] 基本転写因子TFIIEの構造生物学的研究2017
- Author(s)
  帯田孝之、三輪康平、小島理恵子、大熊芳明、田村康、水口峰之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K07265
[Presentation] ヒト基本転写因子TFIIE複合体のX線結晶構造解析．2016
- Author(s)
  三輪康平，小島理恵子，帯田孝之，大熊芳明，田村康，水口峰之．
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K07265
[Presentation] 酵母Vps4によるESCRT-III認識モチーフの精密化．2016
- Author(s)
  帯田孝之，小島理恵子，水口峰之．
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K07265
[Presentation] Interaction of spliceosomal proteins PQBP1, U5-15kD, and WBP11.2016
- Author(s)
  Mizuguchi M, Nabeshima Y, Obita T, Okazawa H.
- Organizer
  The XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Kyoto
- Year and Date
  2016-08-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07886
[Presentation] ヒト基本転写因子TFIIEヘテロ二量体の構造基盤研究2016
- Author(s)
  三輪康平，小島理恵子，帯田孝之，大熊芳明，田村康，水口峰之
- Organizer
  日本薬学会北陸支部第128回例会
- Place of Presentation
  金沢
- Year and Date
  2016-11-27
- Data Source
  KAKENHI-PROJECT-16K07265
[Presentation] 古細菌の細胞分裂を担うESCRTタンパク質CdvAの構造基盤研究2014
- Author(s)
  帯田孝之
- Organizer
  第1回生命分子科学研究会
- Place of Presentation
  北海道ホテルニセコ甘露の森
- Year and Date
  2014-03-17
- Data Source
  KAKENHI-PROJECT-24770094
[Presentation] 古細菌の細胞分裂におけるESCRTの役割の構造基盤研究2011
- Author(s)
  帯田孝之
- Organizer
  大阪大学蛋白研セミナー
- Place of Presentation
  大阪大学
- Year and Date
  2011-01-13
- Data Source
  KAKENHI-PROJECT-22890071
[Presentation] 古細菌の細胞分裂におけるESCRTの役割の構造基盤研究2011
- Author(s)
  帯田孝之
- Organizer
  蛋白研セミナー
- Place of Presentation
  大阪大学蛋白質研究所
- Year and Date
  2011-01-12
- Data Source
  KAKENHI-PROJECT-22890071
[Presentation] Structural studies of the interaction between Vps4 and ESCRT-III2010
- Author(s)
  帯田孝之
- Organizer
  神戸大学GCOEセミナー
- Place of Presentation
  神戸大学
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-22890071
[Presentation] Vps4によるESCRT-IIIタンパク質の認識に関する研究
- Author(s)
  帯田孝之
- Organizer
  第二回生命分子科学研究会
- Place of Presentation
  北海道・小樽朝里クラッセホテル
- Year and Date
  2015-03-14 – 2015-03-16
- Data Source
  KAKENHI-PROJECT-26840018

1. MIZUGUCHI Mineyuki (30332662)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 田渕明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 佐竹炎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 岡澤均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 大熊芳明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 合田浩明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 広野修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OBITA TAKAYUKI 帯田 孝之

OBITA Takayuki 帯田 孝之

Research Projects

Research Products

Co-Researchers

Molecular and structural basis of natural moisturizing factor production mechanisms by profilaggrin-degrading enzymes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of pro-filaggrin recognition by SASPasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

How does PQBP1 suppress the induction of type I interferon expression by cGAS?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural Study of basal transcription factor TFIIEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural basis of Archaeal ESCRT complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Verification of the connector function of the transcription and splicing factor PQBP1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural basis of the filament formation of ESCRT-III proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A structural study towards the understanding of the roles of Archaeal ESCRT in cell division.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生化学2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin‐inducing activity2023

Author(s)

Journal Title

DOI

Data Source

OBITA TAKAYUKI 帯田孝之

OBITA Takayuki 帯田孝之