Yagishita Sosuke 柳下聡介

… Alternative Names

柳下聡介ヤギシタソウスケ

YAGISHITA Sosuke 柳下聡介

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Researcher Number	30585592
Other IDs
Affiliation (Current)	2025: 木更津工業高等専門学校, 基礎学系, 准教授
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第五部, 室長 2016 – 2021: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第五部, 室長 2012 – 2015: 埼玉医科大学, 医学部, 助教 2011: 独立行政法人理化学研究所, アルツハイマー病研究チーム, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51020:Cognitive and brain science-related / Basic Section 51030:Pathophysiologic neuroscience-related / Environmental physiology(including physical medicine and nutritional physiology) / Nerve anatomy/Neuropathology Except Principal Investigator General pharmacology
Keywords	Principal Investigator タウ / アルツハイマー病 / 神経活動 / 神経原線維変化 / 加齢 / 新規遺伝子発現 / PICK1 / 間欠的低酸素 / タウオパチー / 間欠的低酸素負荷 … More / 睡眠時無呼吸症候群 / アミロイドベータタンパク質 / ストレス / モデルマウス / 神経病理学 / 生化学 / グルタミン酸受容体 / シナプス / 新規モデル / 長期抑制 … More Except Principal Investigator アルツハイマー病 / アルツハイマー / 天然資源由来抽出物 / Aβタンパク質 / クリアランス / Aβ42 / アミロイドβタンパク / 天然由来成分 / 生活習慣病 / 野生型マウス / 天然化合物 / タウ / タウタンパク質 / アミロイドβタンパク質 Less

Analyses of the relationship between neuronal activity-dependent protein synthesis and neurofibrillary tangles formationPrincipal Investigator
- Principal Investigator
  
  柳下聡介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51020:Cognitive and brain science-related
- Research Institution
  National Center of Neurology and Psychiatry
The mechanisms of neurofibrillary tangle formation during ageing and the progression of Alzheimer diseasePrincipal Investigator
- Principal Investigator
  
  Yagishita Sosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center of Neurology and Psychiatry
Mechanisms of memory impairment caused by the increase in phosphorylated tauPrincipal Investigator
- Principal Investigator
  
  Yagishita Sosuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  National Center of Neurology and Psychiatry
A novel therapeutic strategy for Alzheimer's disease based on the promotion of clearance mechanism of amyloid beta protein
- Principal Investigator
  
  Iwasa Kensuke
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Saitama Medical University
Readjustment of "amyloid hypothesis" for developing methods to treat Alzheimer disease
- Principal Investigator
  
  Maruyama Kei
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Saitama Medical University
Molecular mechanism of memory impairment in Alzheimer's disease mice modelPrincipal Investigator
- Principal Investigator
  
  YAGISHITA Sosuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Saitama Medical University
  The Institute of Physical and Chemical Research

All 2024 2023 2021 2020 2019 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] THE LUNG perspectives2020
- Author(s)
  柳下聡介
- Total Pages
  80
- Publisher
  メディカルレビュー社
- ISBN
  9784779223808
- Data Source
  KAKENHI-PROJECT-19K07835
[Journal Article] Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation2024
- Author(s)
  Nagayama Takeru、Yagishita Sosuke、Shibata Megumi、Furuno Akiko、Saito Takashi、Saido Takaomi C.、Wakatsuki Shuji、Araki Toshiyuki
- Journal Title
  
  Neuroscience Research
  
  Volume: - Pages: 40-46
- DOI
  10.1016/j.neures.2024.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06801
[Journal Article] Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-b burden and memory impairment2023
- Author(s)
  Iwasa K, Yagishita S, Yagishita-Kyo N, Yamagishi A, Yamamoto S, Yamashina K, Haruta C, Asai M, Maruyama K, Shimizu K, Yoshikawa K
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 16770-16770
- DOI
  10.1038/s41598-023-44098-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06807, KAKENHI-PROJECT-23K06801, KAKENHI-PROJECT-19K07070
[Journal Article] Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus2021
- Author(s)
  Yagishita-Kyo Nan、Ikai Yuki、Uekita Tomoko、Shinohara Akio、Koshimoto Chihiro、Yoshikawa Keisuke、Maruyama Kei、Yagishita Sosuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 551 Pages: 54-62
- DOI
  10.1016/j.bbrc.2021.03.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06899, KAKENHI-PROJECT-18K07354, KAKENHI-PROJECT-19K07835, KAKENHI-PROJECT-18K15349
[Journal Article] Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease2017
- Author(s)
  Yamamoto S, Yamashina K, Ishikawa M, Gotoh M, Iwasa K, Yagishita S, Maruyama K, Murakami-Murofushi K, Yoshikawa K
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 14 Issue: 1 Pages: 142-142
- DOI
  10.1186/s12974-017-0923-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15777, KAKENHI-PROJECT-16K21328, KAKENHI-PROJECT-26860144
[Journal Article] Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging.2017
- Author(s)
  Yagishita S, Suzuki S, Yoshikawa K, Iida K, Hirata A, Suzuki M, Takashima A, Maruyama K, Hirasawa A, Awaji T.
- Journal Title
  
  Mol Brain
  
  Volume: 10 Issue: 1 Pages: 2-2
- DOI
  10.1186/s13041-016-0282-7
- NAID
  120005971848
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PROJECT-25870677, KAKENHI-PROJECT-16K15777, KAKENHI-PROJECT-16K21328, KAKENHI-PLANNED-26117004
[Journal Article] Intermittent hypoxia produces Alzheimer disease?2017
- Author(s)
  Yagishita S, Hirasawa A
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 26 Pages: 41786-41787
- DOI
  10.18632/oncotarget.18214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21328
[Journal Article] Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death.2017
- Author(s)
  Iwasa K, Yamamoto S, Yagishita S, Maruyama K, Yoshikawa K.
- Journal Title
  
  J Lipid Res.
  
  Volume: 58 Issue: 4 Pages: 649-655
- DOI
  10.1194/jlr.m070532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PROJECT-25870677, KAKENHI-PROJECT-16K15777, KAKENHI-PROJECT-16K21328
[Journal Article] Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease.2016
- Author(s)
  Asai M, Kinjo A, Kimura S, Mori R, Kawakubo T, Shirotani K, Yagishita S, Maruyama K, Iwata N.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 39 Pages: 1646-1652
- NAID
  130005598494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460341
[Journal Article] Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease.2016
- Author(s)
  Asai M, Kinjo A, Kimura S, Mori R, Kawakubo T, Shirotani K, Yagishita S, Maruyama K, Iwata N.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 39 Pages: 1646-1652
- NAID
  130005598494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21328
[Journal Article] Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.2016
- Author(s)
  YOnemura, Y., Futai, E., Yagishita, S., Aether, C., and Ishiura, S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 478 Issue: 4 Pages: 1751-1757
- DOI
  10.1016/j.bbrc.2016.09.018
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07290, KAKENHI-PROJECT-16K21328
[Journal Article] Glycogen Synthase Kinase 3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA22015
- Author(s)
  Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Issue: 49 Pages: 29438-48
- DOI
  10.1074/jbc.m114.619668
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PLANNED-26117004
[Journal Article] Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model2014
- Author(s)
  Iwasa K, Yamamoto S, Takahashi M, Suzuki S, Yagishita S, Awaji T, Maruyama K, Yoshikawa K
- Journal Title
  
  Prostaglandins, Leukotrienes and Essential Fatty Acids
  
  Volume: 91 Issue: 5 Pages: 175-182
- DOI
  10.1016/j.plefa.2014.08.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PROJECT-25670781, KAKENHI-PROJECT-25870677, KAKENHI-PROJECT-26670126
[Journal Article] Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice2014
- Author(s)
  Yamamoto S, Gotoh M, Kawamura Y, Yamashina K, Yagishita S, Awaji T, Tanaka M, Maruyama K, Murakami-Murofushi K, Yoshikawa K.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 741 Pages: 17-24
- DOI
  10.1016/j.ejphar.2014.07.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PROJECT-25670781, KAKENHI-PROJECT-25870677, KAKENHI-PROJECT-26860144
[Journal Article] Localization of mature neprilysin in lipid rafts.2012
- Author(s)
  Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, Ebina M, Suo S, Futai E, Murata M, Ishiura S.
- Journal Title
  
  J. Neurosci. Res.
  
  Volume: 90 Issue: 4 Pages: 870-877
- DOI
  10.1002/jnr.22796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082, KAKENHI-PROJECT-23700425, KAKENHI-PROJECT-23700429
[Journal Article] CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.2012
- Author(s)
  Watahiki H, Yagishita S, Futai E, Ishiura S.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 526 Issue: 2 Pages: 96-99
- DOI
  10.1016/j.neulet.2012.08.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082, KAKENHI-PROJECT-23700429
[Journal Article] An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model2011
- Author(s)
  Masashi Asai, Sosuke Yagishita, Nobuhisa Iwata, Takaomi C. Saido, Shoichi Ishiura, Kei Maruyama
- Journal Title
  
  FASEB J.
  
  Volume: 25(10) Issue: 10 Pages: 3720-30
- DOI
  10.1096/fj.11-182154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700429
[Journal Article] Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System2011
- Author(s)
  Yoji Yonemura, Eugene Futai, Sosuke Yagishita, Satoshi Suo, Taisuke Tomita, Takeshi Iwatsubo, Shoichi Ishiura
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286(52) Issue: 52 Pages: 44569-75
- DOI
  10.1074/jbc.m111.270108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] 微小管との結合に影響を与えるタウのリン酸化部位について2023
- Author(s)
  柳下聡介
- Organizer
  タウ研究会2023
- Data Source
  KAKENHI-PROJECT-23K06801
[Presentation] Microbiota depletion by vancomycin affects neuronal activity-dependent increase in the level of c-fos protein2021
- Author(s)
  Sosuke Yagishita, Toshiyuki Araki
- Organizer
  第44回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07835
[Presentation] 抗生物質投与による腸内細菌の除去が神経活動に与える影響2021
- Author(s)
  柳下聡介，荒木敏之
- Organizer
  第25回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07835
[Presentation] 神経活動に伴うリン酸化タウの変動およびタウ蓄積のメカニズム解明2019
- Author(s)
  柳下聡介，橋本翔子，斉藤貴志，西道隆臣，荒木敏之
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K07835
[Presentation] 「神経活動依存的なリン酸化タウの変動」から考えるタウ蓄積のメカニズム2019
- Author(s)
  柳下聡介
- Organizer
  タウ研究ミーティング2019
- Data Source
  KAKENHI-PROJECT-19K07835
[Presentation] 社会性に関わるシナプス接着分子に対する性ホルモンの影響2019
- Author(s)
  柳下-姜楠、原田美海、上北朋子、丸山敬、伊海結貴、越本知大、柳下聡介
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K21328
[Presentation] 間欠的低酸素負荷モデルを用いたリン酸化タウの増加・蓄積のメカニズム解明2019
- Author(s)
  柳下聡介，橋本翔子，斉藤貴志，西道隆臣，荒木敏之
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19K07835
[Presentation] INTERMITTENT HYPOXIA INCREASES TAU PHOSPHORYLATION VIA BIOLOGICAL PROCESSES COMMON TO AGING: POTENTIAL LINK BETWEEN SLEEP-DISORDERED BREATHING AND ALZHEIMER DISEASE,2017
- Author(s)
  Sosuke Yagishita
- Organizer
  6th Mediterranean Neuroscience Society Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21328
[Presentation] GSK-3βが関与するPICK1のリン酸化は，GluA2との結合を制御する2016
- Author(s)
  柳下聡介，村山美由紀，海老原朋江，丸山敬，高島明彦
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16K21328
[Presentation] GSK-3β-mediated phosphorylation of PICK1 regulates the GluA2-PICK1 interaction2016
- Author(s)
  Sosuke Yagishita, Miyuki Murayama, Tomoe Ebihara, Kei Maruyama, Akihiko Takashima
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21328
[Presentation] GSK-3β-mediated phosphorylation of PICK1 regulates the GluA2-PICK1 interaction, Society for Neuroscience2016
- Author(s)
  Sosuke Yagishita, Miyuki Murayama, Tomoe Ebihara, Kei Maruyama, Akihiko Takashima
- Organizer
  Society for Neuroscience
- Place of Presentation
  U.S.A., San Diego
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] GSK-3βが関与するPICK1のリン酸化は，GluA2との結合を制御する2016
- Author(s)
  柳下聡介，村山美由紀，海老原朋江，丸山敬，高島明彦
- Organizer
  第39回　日本神経科学大会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] 内在性タウのリン酸化亢進モデルマウスのマイクロアレイ解析2016
- Author(s)
  柳下聡介，淡路健雄，鈴木星也，飯田桂子，平田理子，鈴木正彦，丸山敬，平澤明
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] プロスタグランジンF2α FPレセプター阻害は多発性硬化症モデルマウスの神経脱髄と運動障害を改善する2015
- Author(s)
  岩佐健介、山本梓司、高橋茉莉香、鈴木星也、柳下聡介、淡路健雄、丸山敬、吉川圭介
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  東京都千代田区(一橋大学)
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26670126
[Presentation] Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction2015
- Author(s)
  Yamamoto S, Gotoh M, Kawamura Y, Yagishita S, Awaji T, Tanaka M, Maruyama K, Murakami-Murofushi K, Yoshikawa K
- Organizer
  ECTRIMS (European committee for treatment and research in Multiple Sclerosis)
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] プロスタグランジンF2α　FPレセプター阻害は多発性硬化症モデルマウスの神経脱髄と運動障害を改善する2015
- Author(s)
  岩佐健介、山本梓司、高橋茉莉香、鈴木星也、柳下聡介、淡路健雄、丸山敬、吉川圭介
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  東京都（一橋大学）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model2015
- Author(s)
  岩佐健介、山本梓司、高橋茉莉香、鈴木星也、柳下聡介、淡路健雄、丸山敬、吉川圭介
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] 内在性タウのリン酸化亢進モデルマウスはアルツハイマー病様の表現型を呈する2015
- Author(s)
  柳下聡介，鈴木星也，鈴木正彦，丸山敬，平澤明，淡路健雄
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] Prostaglandin F2α FP receptor inhibitor reduce demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model2015
- Author(s)
  岩佐　健介、山本梓司、高橋　茉莉香、鈴木　星也、柳下　聡介、淡路　健雄、丸山　敬、吉川　圭介
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-26670126
[Presentation] Establishment of a new mouse model with accelerated phosphorylation of endogenous tau2014
- Author(s)
  Seiya Suzuki, Sosuke Yagishita, Ayaka Sorimachi, Maya Moriizumi, Takeo Awaji, Masahiko Suzuki, Kei Maruyama
- Organizer
  日本薬理学会
- Place of Presentation
  仙台
- Year and Date
  2014-03-19
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] Establishment of a new mouse model with accelerated phosphorylation of endogenous tau2014
- Author(s)
  Seiya Suzuki, Sosuke Yagishita, Ayaka Sorimachi, Maya Moriizumi, Takeo Awaji, Masahiko Suzuki, Kei Maruyama
- Organizer
  日本薬理学会
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] Establishment of a new mouse model with accelerated phosphorylation of endogenous tau2014
- Author(s)
  Seiya Suzuki, Sosuke Yagishita, Ayaka Sorimachi, Maya Moriizumi, Takeo Awaji, Masahiko Suzuki, Kei Maruyama
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県　仙台市
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] 内在性タウのリン酸化亢進マウスモデルの作製2013
- Author(s)
  鈴木星也,柳下聡介,淡路健雄,鈴木正彦,丸山敬
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] 野生型マウスを用いた内在性タウのリン酸化亢進モデルの作製2013
- Author(s)
  鈴木星也,柳下聡介,淡路健雄,鈴木正彦,丸山敬
- Organizer
  日本認知症学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] 野生型マウスを用いた内在性タウのリン酸化亢進モデルの作製2013
- Author(s)
  鈴木星也，柳下聡介，淡路健雄，鈴木正彦，丸山敬
- Organizer
  日本認知症学会
- Place of Presentation
  長野県松本市
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] 間歇的低酸素負荷による内在性タウのリン酸化亢進モデルマウスの作製2013
- Author(s)
  鈴木星也，柳下聡介，淡路健雄，鈴木正彦，丸山敬
- Organizer
  第129回　日本薬理学会関東部会
- Place of Presentation
  順天堂大学（本郷キャンパス）
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] 野生型マウスを用いた内在性タウのリン酸化亢進モデルマウスの作製2013
- Author(s)
  鈴木星也，柳下聡介，淡路健雄，鈴木正彦，丸山敬
- Organizer
  日本認知症学会
- Place of Presentation
  長野県　松本市
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] 内在性タウのリン酸化亢進マウスモデルの作製2013
- Author(s)
  鈴木星也，柳下聡介，淡路健雄，鈴木正彦，丸山敬
- Organizer
  日本生化学会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] 内在性タウのリン酸化亢進マウスモデルの作製2013
- Author(s)
  鈴木星也，柳下聡介，淡路健雄，鈴木正彦，丸山敬
- Organizer
  日本生化学会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] in vitroおよびin vivoにおける低分子化合物によるtau凝集抑制作用の検討2011
- Author(s)
  添田義行,吉池裕二,前田純宏,木村哲也,村山美由紀,溝呂木達也,山下俊治,柳下聡介,斎藤臣雄,長田裕之,高島明彦
- Organizer
  日本認知症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] in vitroおよびin vivoにおける低分子化合物によるtau凝集抑制作用の検討2011
- Author(s)
  添田義行、吉池裕二、前田純宏、木村哲也、村山美由紀、溝呂木達也、山下俊治、柳下聡介、斎藤臣雄、長田裕之、高島明彦
- Organizer
  日本認知症学会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23700429
[Presentation] Establishment of a non-transgenic mouse model of neurodegenerative diseases with accelerated phosphorylation of endogenous tau
- Author(s)
  Sosuke Yagishita, Seiya Suzuki, Takeo Awaji, Keisuke Yoshikawa, Masahiko Suzuki, Akira Hirasawa, Kei Maruyama
- Organizer
  第12回 RCGM フロンティア国際シンポジウム
- Place of Presentation
  埼玉医科大学日高キャンパス（埼玉県日高市）
- Year and Date
  2014-10-31 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction
- Author(s)
  Yamamoto S, Gotoh M, Kawamura Y, Yamashina K, Yagishita S, Awaji T, Tanaka M, Maruyama K, Murakami-Murofushi K, Yoshikawa K
- Organizer
  PLM2015 (Phospholipase and other lipid mediators)
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-25460341
[Presentation] Prostaglandin F2α FP receptor inhibitor reduce demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model
- Author(s)
  Iwasa K, Yamamoto S, Takahashi M, Suzuki S, Yagishita S, Awaji T, Maruyama K, Yoshikawa K
- Organizer
  PLM2015 (Phospholipase and other lipid mediators)
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-25460341

1. Kondo Ryuichiro (80091370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Kuniyoshi Shimizu (20346836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 吉川圭介 (10435860)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. Maruyama Kei (30211577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
5. Iwasa Kensuke (00623703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 淡路健雄 (60297546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
7. YAMAMOTO shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. FUTAI Eugene

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Yagishita Sosuke 柳下 聡介

柳下 聡介 ヤギシタ ソウスケ

YAGISHITA Sosuke 柳下 聡介

Research Projects

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Co-Researchers

Analyses of the relationship between neuronal activity-dependent protein synthesis and neurofibrillary tangles formationPrincipal Investigator

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The mechanisms of neurofibrillary tangle formation during ageing and the progression of Alzheimer diseasePrincipal Investigator

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Mechanisms of memory impairment caused by the increase in phosphorylated tauPrincipal Investigator

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A novel therapeutic strategy for Alzheimer's disease based on the promotion of clearance mechanism of amyloid beta protein

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Readjustment of "amyloid hypothesis" for developing methods to treat Alzheimer disease

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Molecular mechanism of memory impairment in Alzheimer's disease mice modelPrincipal Investigator

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[Book] THE LUNG perspectives2020

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[Journal Article] Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation2024

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[Journal Article] Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-b burden and memory impairment2023

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[Journal Article] Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus2021

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[Journal Article] Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease2017

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[Journal Article] Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging.2017

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NAID

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[Journal Article] Intermittent hypoxia produces Alzheimer disease?2017

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[Journal Article] Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death.2017

Yagishita Sosuke 柳下聡介

柳下聡介ヤギシタソウスケ

YAGISHITA Sosuke 柳下聡介