Horike Nanao 堀家なな緒

… Alternative Names

堀家なな緒ホリケナナオ

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Researcher Number	30589221
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院生命機能研究科, 助教 2021: 大阪大学, 生命機能研究科, 助教 2020: 京都大学, iPS細胞研究所, 特別研究員(RPD) 2011: National Institute of Biomedical Innovation, 研究員 2010 – 2011: 独立行政法人医薬基盤研究所, 難病・疾患資源研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Pathological medical chemistry / Metabolomics
Keywords	Principal Investigator エネルギー代謝 / 質量分析 / 血漿プロテオーム解析 / 生理活性物質 / 軟骨 / 骨 / SCIDマウス / アディポサイトカイン / 褐色脂肪組織 / インスリンシグナル / 糖脂質代謝

The elucidation of the metabolic regulation mechanism by novel secreted factors derived from cartilage or bonePrincipal Investigator
- Principal Investigator
  
  堀家なな緒
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Osaka University
Identification of biological factors derived from bone tissue by plasma proteome analysis and their systemic metabolic control mechanismsPrincipal Investigator
- Principal Investigator
  
  Horike Nanao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Osaka University
  Kyoto University
ヒト組織移植ＳＣＩＤマウスを用いたヒト褐色脂肪由来アディポサイトカインの機能解明Principal Investigator
- Principal Investigator
  
  堀家なな緒
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  独立行政法人医薬基盤研究所
SCIDマウスに移植したヒト褐色脂肪組織由来新規アディポサイトカインの同定と創薬Principal Investigator
- Principal Investigator
  
  堀家なな緒
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  National Institute of Biomedical Innovation

All 2023 2021 2011 2010

All Journal Article Presentation Patent

[Journal Article] Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect2023
- Author(s)
  Abe Kengo、Yamashita Akihiro、Morioka Miho、Horike Nanao、Takei Yoshiaki、Koyamatsu Saeko、Okita Keisuke、Matsuda Shuichi、Tsumaki Noriyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 804-804
- DOI
  10.1038/s41467-023-36408-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02923, KAKENHI-PROJECT-20K09432, KAKENHI-PROJECT-23K21466, KAKENHI-PROJECT-23K18327, KAKENHI-PROJECT-23K27720
[Journal Article] SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB.2011
- Author(s)
  Sasaki T, Takemori H, Yagita Y, Terasaki Y, Uebi T, Horike N, Takagi H, Susumu T, Teraoka H, Kusano K, Hatano O, Oyama N, Sugiyama Y, Sakoda S, Kitagawa K.
- Journal Title
  
  Neuron
  
  Volume: 69 Pages: 106-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890256
[Journal Article] Phosphorylation of the CREB-specific coactivator TORC2 at Ser307 regulates its intracellular localization in COS-7 cells and in the mouse liver.2010
- Author(s)
  Uebi T, Tamura M, Horike N, Hashimoto YK, Takemori H
- Journal Title
  
  American Journal Physiology Endocrinology and Metabolism
  
  Volume: 299 Pages: 413-425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890256
[Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.2010
- Author(s)
  Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H
- Journal Title
  
  Journal Clinical Investigation
  
  Volume: 120 Pages: 2817-2828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890256
[Journal Article] Pinl associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010
- Author(s)
  Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T
- Journal Title
  
  Journal Biological Chemistry
  
  Volume: 285 Pages: 33018-33027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890256
[Journal Article] Downregulation of SIK2 expression promotes the melanogenic program in mice2010
- Author(s)
  Horike N, Kumagai A, Shimono Y, Onishi T, Itoh Y, Sasaki T, Kitagawa K, Hatano O, Takagi H, Susumu T, Teraoka T, Kusano K, Nagaoka Y, Kawahara H, Takemori H
- Journal Title
  
  Pigment Cell & Melanoma Research
  
  Volume: 23 Pages: 809-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890256
[Patent] メラニン産生促進剤2010
- Inventor(s)
  長岡康夫、熊谷彩子、堀家なな緒、竹森洋、堀部一平、小畑勝義
- Industrial Property Rights Holder
  学校法人関西大学
- Acquisition Date
  2010
- Data Source
  KAKENHI-PROJECT-22890256
[Presentation] 塩誘導性キナーゼ 3(SIK3)は関節軟骨表層へのせん断力負荷により不活性化され、ルブリシン発現を促進する2021
- Author(s)
  〇武井義明、小林与人、堀家なな緒、森岡美帆、高才東、釜谷崇志、山下晃弘、竹森洋、妻木範行
- Organizer
  第 33 回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K09432
[Presentation] Sirt3 protects in vitro fertilized mouse preimplantation embryos against oxidative stress induced p53-mediataed developmental arrest.2010
- Author(s)
  河村悠美子、内島泰信、堀家なな緒、砥波一夫、西山功一、浅野知一郎、栗原由紀子、栗原裕基
- Organizer
  第83回日本生化学会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22890256

1. 妻木範行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horike Nanao 堀家 なな緒

堀家 なな緒 ホリケ ナナオ

Research Projects

Research Products

Co-Researchers

The elucidation of the metabolic regulation mechanism by novel secreted factors derived from cartilage or bonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of biological factors derived from bone tissue by plasma proteome analysis and their systemic metabolic control mechanismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト組織移植ＳＣＩＤマウスを用いたヒト褐色脂肪由来アディポサイトカインの機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SCIDマウスに移植したヒト褐色脂肪組織由来新規アディポサイトカインの同定と創薬Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB.2011

Author(s)

Journal Title

Data Source

[Journal Article] Phosphorylation of the CREB-specific coactivator TORC2 at Ser307 regulates its intracellular localization in COS-7 cells and in the mouse liver.2010

Author(s)

Journal Title

Data Source

[Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.2010

Author(s)

Journal Title

Data Source

[Journal Article] Pinl associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010

Author(s)

Journal Title

Data Source

[Journal Article] Downregulation of SIK2 expression promotes the melanogenic program in mice2010

Author(s)

Journal Title

Data Source

[Patent] メラニン産生促進剤2010

Inventor(s)

Industrial Property Rights Holder

Acquisition Date

Data Source

[Presentation] 塩誘導性キナーゼ 3(SIK3)は関節軟骨表層へのせん断力負荷により不活性化され、ルブリ シン発現を促進する2021

Author(s)

Organizer

Data Source

[Presentation] Sirt3 protects in vitro fertilized mouse preimplantation embryos against oxidative stress induced p53-mediataed developmental arrest.2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Horike Nanao 堀家なな緒

堀家なな緒ホリケナナオ

[Presentation] 塩誘導性キナーゼ 3(SIK3)は関節軟骨表層へのせん断力負荷により不活性化され、ルブリシン発現を促進する2021