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Hayano Motoshi  早野 元詞

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HAYANO Motoshi  早野 元嗣

早野 元詞  ハヤノ モトシ

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Researcher Number 30593644
Other IDs
Affiliation (Current) 2025: 東京理科大学, 研究推進機構総合研究院, 准教授
2025: 順天堂大学, 医学部, 非常勤講師
2025: 慶應義塾大学, 医学部(信濃町), 特任講師
Affiliation (based on the past Project Information) *help 2017 – 2024: 慶應義塾大学, 医学部(信濃町), 特任講師
2014: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
2013: 公益財団法人東京都医学総合研究所, その他部局等, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 43050:Genome biology-related / Medium-sized Section 13:Condensed matter physics and related fields / Basic Section 49030:Experimental pathology-related / Biological Sciences / Applied health science / Molecular biology
Except Principal Investigator
Medium-sized Section 48:Biomedical structure and function and related fields / Molecular biology
Keywords
Principal Investigator
老化 / エピゲノム / 筋肉 / DNA損傷 / CTCF / FOXO1 / サルコペニア / オリゴデンドロサイト / 組織弾性モダリティ / 数理モデル … More / 原子間力顕微鏡 / 弾性 / Ero1 / ジスフィルド結合 / パルスフォースAFM法 / レオロジーマッピング / サテライト細胞 / SETD1B / Myc / HNF4A / RCM / ICE / スプライシング異常 / Ttn / Myh9 / Pax7 / ICEマウス / 記憶 / クロマチン編集 / 再生医療 / ヒストン修飾 / SETD8 / LSD1 / H4K20me1 / H3K4me1 … More
Except Principal Investigator
老化 / 脳 / タンパク / 構造解析 / 染色体ダイナミクス / リン酸化 / 複製起点 / 染色体DNA複製 / 脳発生 / 細胞分裂 / 乗り越えDNA合成 / 複製タイミング / 減数分裂期組換え / チェックポイント / Cdc7キナーゼ / 染色体DNA複製開始 Less
  • Research Projects

    (8 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (18 People)
  •  The changes in epigenetic information causes aging driven by DNA damagePrincipal Investigator

    • Principal Investigator
      早野 元詞
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43050:Genome biology-related
    • Research Institution
      Keio University
  •  The establishment of tissue elasticity modalities and aging controlPrincipal Investigator

    • Principal Investigator
      Hayano Motoshi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 13:Condensed matter physics and related fields
    • Research Institution
      Keio University
  •  Unraveling the role of peri-synaptic collagen in ageing with protein engineering

    • Principal Investigator
      長井 淳
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Aging speed regulated by epigenetic memory induced during environmental stressPrincipal Investigator

    • Principal Investigator
      早野 元詞
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  Regulation of aging by epigenetic memory in satellite stem cellPrincipal Investigator

    • Principal Investigator
      HAYANO Motoshi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Keio University
  •  A molecular mechanism of aging through epigenome and muscle regenerationPrincipal Investigator

    • Principal Investigator
      Hayano Motoshi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied health science
    • Research Institution
      Keio University
  •  複製プログラムにおける新規細胞内機能制御機構の解析Principal Investigator

    • Principal Investigator
      早野 元詞
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Molecular biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

All 2023 2019 2018 2017 2013 2012 2011 Other

All Journal Article Presentation Patent

  • [Journal Article] Loss of epigenetic information as a cause of mammalian aging2023

    • Author(s)
      Yang Jae-Hyun、Hayano Motoshi、....、Sinclair David A.
    • Journal Title

      Cell

      Volume: 186 Issue: 2 Pages: 305-326.e27

    • DOI

      10.1016/j.cell.2022.12.027

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21KK0134
  • [Journal Article] DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging2019

    • Author(s)
      Hayano Motoshi、Yang Jae-Hyun、Bonkowski Michael S.、et.,
    • Journal Title

      BioRxiv

      Volume: -

    • DOI

      10.1101/808659

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Journal Article] Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals2019

    • Author(s)
      Jae-Hyun Yang, Patrick T. Griffin, Daniel L. Vera, John K. Apostolides, Motoshi Hayano et a.,
    • Journal Title

      BioRxiv

      Volume: -

    • DOI

      10.1101/808642

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Journal Article] Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.2013

    • Author(s)
      Yamazaki, S. Hayano, M. and Masai, H.
    • Journal Title

      Trends in Genetics

      Volume: 29 Issue: 8 Pages: 449-460

    • DOI

      10.1016/j.tig.2013.05.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520, KAKENHI-PUBLICLY-25125724, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-25840081
  • [Journal Article] テロメア結合因子Rif1は、染色体複タイミングを決定する2012

    • Author(s)
      早野元詞、加納豊、松本清治、正井久雄
    • Journal Title

      細胞工学

      Volume: 31 Pages: 460-462

    • Data Source
      KAKENHI-PROJECT-23247031
  • [Journal Article] Rif1 is a global regulator of timing of replication origin firing in fission yeast2012

    • Author(s)
      Hayano M, Kanoh Y, Matsumoto S, Renard-Guillet C, Shirahige K, Masai H
    • Journal Title

      Genes & Dev

      Volume: 25 Issue: 2 Pages: 137-150

    • DOI

      10.1101/gad.178491.111

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22125001, KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520
  • [Journal Article] Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.2011

    • Author(s)
      Matsumoto, S., Hayano, M., Kanoh. Y. and Masai, H.
    • Journal Title

      J. Cell Biol.

      Volume: 195 Issue: 3 Pages: 387-401

    • DOI

      10.1083/jcb.201107025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
  • [Journal Article] Pre-firing binding of Mrc1 defines the early-firing origins which are selectively hyper-activated upon loss of fork stabilizing factors in fission yeast.2011

    • Author(s)
      Hayano, M., Kanoh, Y., Matsumoto, S., Kakusho, N. and Masai, H.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 31 Issue: 12 Pages: 2380-2389

    • DOI

      10.1128/mcb.01239-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
  • [Patent] 光刺激による脳波及び細胞活性制御装置及び方法2018

    • Inventor(s)
      早野元詞、坪田一男
    • Industrial Property Rights Holder
      早野元詞、坪田一男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-145270
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] エピゲノムおよび組織弾性による老化定量は可能か2019

    • Author(s)
      早野 元詞
    • Organizer
      定量生物学の会 第九回年会
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] Epigenetic identify driven by DNA damage induces aging2019

    • Author(s)
      Motoshi Hayano
    • Organizer
      19th HFSP Awardees Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Presentation] 老化を誘導する DNA 損傷によるエピゲノム自己同一性破綻2019

    • Author(s)
      早野 元詞
    • Organizer
      第19回日本抗加齢医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Presentation] Epigenetic changes driven by DNA damage induce aging2019

    • Author(s)
      Motoshi Hayano
    • Organizer
      The 10th APRU Population Aging Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Presentation] DNA損傷依存的エピゲノム変化による老化誘導と 身体機能低下の分子機構2019

    • Author(s)
      早野 元詞
    • Organizer
      第74回日本体力医学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Presentation] 超高齢社会における医療とヘルスケア2019

    • Author(s)
      早野 元詞
    • Organizer
      日米医療機器イノベーションフォーラム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16619
  • [Presentation] Evidence for an epigenetic cause of aging in mice2018

    • Author(s)
      Motoshi Hayano, Elias Levy Itshak Salfati, John Apostolides, Jae-Hyun Yang, Michael S. Bonkowski, Luis A. Rajman, Sachin Thakur, Neha Garg, Ana-Maria Balta, Sarah Mitchell, Yasuaki Mohri, Rafael deCabo, Emi Nishimura Andreas R. Pfenning, Philipp Oberdoerffer and David A. Sinclair.
    • Organizer
      The International Meeting on RECQ Helicases and Related Diseases 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] DNA損傷によるエピゲノム自己同一性の破綻と個体老化の分子機構2018

    • Author(s)
      早野元詞
    • Organizer
      第39回日本基礎老化学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] エピゲノム変動による老化モデル構築及び、 老化関連疾患誘導のメカニズム2018

    • Author(s)
      早野 元詞
    • Organizer
      第6回AAA (Academy of Aging and CArdiovascular-Diabetes Research)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] DO EPIGENETIC CHANGES CAUSE AGING IN MAMMALS?2018

    • Author(s)
      早野元詞
    • Organizer
      第6回若手による骨格筋細胞研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] エピゲノム変動による老化誘導マウスモデルと筋制御2018

    • Author(s)
      早野元詞
    • Organizer
      日本筋学会第4回学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] エピゲノム変動による老化モデルとその分子機構2017

    • Author(s)
      早野 元詞、Elias Salfati、Abhirup Das、John Apostolides、Luis Rajman、Michael Bonkowski、Sachin Thakur、Neha Garg、Sarah Mitchell、Andreas Pfenning、Jae-Hyun Yang、Rafael deCabo、Shelley Berger、Philipp Oberdoerffer、David Sinclair
    • Organizer
      Conbio2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] エピゲノム変動による老化モデル構築及び、 老化関連疾患誘導のメカニズム2017

    • Author(s)
      Motoshi Hayano, Luis A.Rajman ,Michael S. Bonkowski , Sachin Thakur , Neha Garg , John Apostolides , Sarah Mitchell , Andreas Pfenning, Jae-Hyun Yang, Rafael deCabo, Shelley L. Berger, Philipp Oberdoerffer5 and David A. Sinclair.
    • Organizer
      第10回 Symphony
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] Evidence for an epigenetic cause of aging in mice2017

    • Author(s)
      Motoshi Hayano, Luis A.Rajman ,Michael S. Bonkowski , Sachin Thakur , Neha Garg , John Apostolides , Sarah Mitchell , Andreas Pfenning, Jae-Hyun Yang, Rafael deCabo, Shelley L. Berger, Philipp Oberdoerffer5 and David A. Sinclair
    • Organizer
      Keystone Symposia, Aging and Mechanisms of Aging-Related Disease
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13228
  • [Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes

    • Author(s)
      Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
    • Organizer
      第86回日本生化学会大会事務局 インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-09-11 – 2013-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-23247031
  • 1.  MASAI Hisao (40229349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  YOSHIZAWA Naoko (30344071)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  TAKAI Yuko (90332270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MATSUMOTO Seiji (40190532)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  MORIYAMA Kenji (00250217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  SHINMOTO Michie (20216237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TANAKA Taku (80425686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KANO Yutaka (90450593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  ODA Masako (50399474)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ITO Sayuri (60462777)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MIYATAKE Shoichiro (30239420)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KAKUSHO Naoko (30599593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  岡嶋 孝治 (70280998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  長井 淳 (60892586)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  奥田 覚 (80707836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  ITOH Takehiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  須賀田 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  白髭 克彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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