Hayano Motoshi 早野元詞

… Alternative Names

HAYANO Motoshi 早野元嗣

早野元詞ハヤノモトシ

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Researcher Number	30593644
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 非常勤講師 2025: 慶應義塾大学, 医学部(信濃町), 特任講師
Affiliation (based on the past Project Information) *help	2017 – 2024: 慶應義塾大学, 医学部(信濃町), 特任講師 2014: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2013: 公益財団法人東京都医学総合研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Medium-sized Section 13:Condensed matter physics and related fields / Basic Section 49030:Experimental pathology-related / Biological Sciences / Applied health science / Molecular biology Except Principal Investigator Medium-sized Section 48:Biomedical structure and function and related fields / Molecular biology
Keywords	Principal Investigator 老化 / エピゲノム / 筋肉 / DNA損傷 / CTCF / FOXO1 / サルコペニア / オリゴデンドロサイト / 組織弾性モダリティ / 数理モデル … More / 原子間力顕微鏡 / 弾性 / Ero1 / ジスフィルド結合 / パルスフォースAFM法 / レオロジーマッピング / サテライト細胞 / SETD1B / Myc / HNF4A / RCM / ICE / スプライシング異常 / Ttn / Myh9 / Pax7 / ICEマウス / 記憶 / クロマチン編集 / 再生医療 / ヒストン修飾 / SETD8 / LSD1 / H4K20me1 / H3K4me1 … More Except Principal Investigator 老化 / 脳 / タンパク / 構造解析 / 染色体ダイナミクス / リン酸化 / 複製起点 / 染色体DNA複製 / 脳発生 / 細胞分裂 / 乗り越えDNA合成 / 複製タイミング / 減数分裂期組換え / チェックポイント / Cdc7キナーゼ / 染色体DNA複製開始 Less

The changes in epigenetic information causes aging driven by DNA damagePrincipal Investigator
- Principal Investigator
  
  早野元詞
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Keio University
The establishment of tissue elasticity modalities and aging controlPrincipal Investigator
- Principal Investigator
  
  Hayano Motoshi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 13:Condensed matter physics and related fields
- Research Institution
  Keio University
Unraveling the role of peri-synaptic collagen in ageing with protein engineering
- Principal Investigator
  
  長井淳
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Institute of Physical and Chemical Research
Aging speed regulated by epigenetic memory induced during environmental stressPrincipal Investigator
- Principal Investigator
  
  早野元詞
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Regulation of aging by epigenetic memory in satellite stem cellPrincipal Investigator
- Principal Investigator
  
  HAYANO Motoshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
A molecular mechanism of aging through epigenome and muscle regenerationPrincipal Investigator
- Principal Investigator
  
  Hayano Motoshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Keio University
複製プログラムにおける新規細胞内機能制御機構の解析Principal Investigator
- Principal Investigator
  
  早野元詞
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication
- Principal Investigator
  
  MASAI Hisao
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2023 2019 2018 2017 2013 2012 2011 Other

All Journal Article Presentation Patent

[Journal Article] Loss of epigenetic information as a cause of mammalian aging2023
- Author(s)
  Yang Jae-Hyun、Hayano Motoshi、....、Sinclair David A.
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 2 Pages: 305-326.e27
- DOI
  10.1016/j.cell.2022.12.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0134
[Journal Article] DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging2019
- Author(s)
  Hayano Motoshi、Yang Jae-Hyun、Bonkowski Michael S.、et.,
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/808659
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16619
[Journal Article] Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals2019
- Author(s)
  Jae-Hyun Yang, Patrick T. Griffin, Daniel L. Vera, John K. Apostolides, Motoshi Hayano et a.,
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/808642
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16619
[Journal Article] Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.2013
- Author(s)
  Yamazaki, S. Hayano, M. and Masai, H.
- Journal Title
  
  Trends in Genetics
  
  Volume: 29 Issue: 8 Pages: 449-460
- DOI
  10.1016/j.tig.2013.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520, KAKENHI-PUBLICLY-25125724, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-25840081
[Journal Article] テロメア結合因子Rif1は、染色体複タイミングを決定する2012
- Author(s)
  早野元詞、加納豊、松本清治、正井久雄
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 460-462
- Data Source
  KAKENHI-PROJECT-23247031
[Journal Article] Rif1 is a global regulator of timing of replication origin firing in fission yeast2012
- Author(s)
  Hayano M, Kanoh Y, Matsumoto S, Renard-Guillet C, Shirahige K, Masai H
- Journal Title
  
  Genes & Dev
  
  Volume: 25 Issue: 2 Pages: 137-150
- DOI
  10.1101/gad.178491.111
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22125001, KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520
[Journal Article] Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.2011
- Author(s)
  Matsumoto, S., Hayano, M., Kanoh. Y. and Masai, H.
- Journal Title
  
  J. Cell Biol.
  
  Volume: 195 Issue: 3 Pages: 387-401
- DOI
  10.1083/jcb.201107025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
[Journal Article] Pre-firing binding of Mrc1 defines the early-firing origins which are selectively hyper-activated upon loss of fork stabilizing factors in fission yeast.2011
- Author(s)
  Hayano, M., Kanoh, Y., Matsumoto, S., Kakusho, N. and Masai, H.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 31 Issue: 12 Pages: 2380-2389
- DOI
  10.1128/mcb.01239-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
[Patent] 光刺激による脳波及び細胞活性制御装置及び方法2018
- Inventor(s)
  早野元詞、坪田一男
- Industrial Property Rights Holder
  早野元詞、坪田一男
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-145270
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] エピゲノムおよび組織弾性による老化定量は可能か2019
- Author(s)
  早野　元詞
- Organizer
  定量生物学の会　第九回年会
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] Epigenetic identify driven by DNA damage induces aging2019
- Author(s)
  Motoshi Hayano
- Organizer
  19th HFSP Awardees Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16619
[Presentation] 老化を誘導する DNA 損傷によるエピゲノム自己同一性破綻2019
- Author(s)
  早野元詞
- Organizer
  第19回日本抗加齢医学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16619
[Presentation] Epigenetic changes driven by DNA damage induce aging2019
- Author(s)
  Motoshi Hayano
- Organizer
  The 10th APRU Population Aging Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16619
[Presentation] DNA損傷依存的エピゲノム変化による老化誘導と身体機能低下の分子機構2019
- Author(s)
  早野元詞
- Organizer
  第74回日本体力医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16619
[Presentation] 超高齢社会における医療とヘルスケア2019
- Author(s)
  早野元詞
- Organizer
  日米医療機器イノベーションフォーラム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16619
[Presentation] Evidence for an epigenetic cause of aging in mice2018
- Author(s)
  Motoshi Hayano, Elias Levy Itshak Salfati, John Apostolides, Jae-Hyun Yang, Michael S. Bonkowski, Luis A. Rajman, Sachin Thakur, Neha Garg, Ana-Maria Balta, Sarah Mitchell, Yasuaki Mohri, Rafael deCabo, Emi Nishimura Andreas R. Pfenning, Philipp Oberdoerffer and David A. Sinclair.
- Organizer
  The International Meeting on RECQ Helicases and Related Diseases 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] DNA損傷によるエピゲノム自己同一性の破綻と個体老化の分子機構2018
- Author(s)
  早野元詞
- Organizer
  第39回日本基礎老化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] エピゲノム変動による老化モデル構築及び、老化関連疾患誘導のメカニズム2018
- Author(s)
  早野元詞
- Organizer
  第6回AAA (Academy of Aging and CArdiovascular-Diabetes Research)
- Invited
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] DO EPIGENETIC CHANGES CAUSE AGING IN MAMMALS?2018
- Author(s)
  早野元詞
- Organizer
  第6回若手による骨格筋細胞研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] エピゲノム変動による老化誘導マウスモデルと筋制御2018
- Author(s)
  早野元詞
- Organizer
  日本筋学会第4回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] エピゲノム変動による老化モデルとその分子機構2017
- Author(s)
  早野元詞、Elias Salfati、Abhirup Das、John Apostolides、Luis Rajman、Michael Bonkowski、Sachin Thakur、Neha Garg、Sarah Mitchell、Andreas Pfenning、Jae-Hyun Yang、Rafael deCabo、Shelley Berger、Philipp Oberdoerffer、David Sinclair
- Organizer
  Conbio2017
- Invited
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] エピゲノム変動による老化モデル構築及び、老化関連疾患誘導のメカニズム2017
- Author(s)
  Motoshi Hayano, Luis A.Rajman ,Michael S. Bonkowski , Sachin Thakur , Neha Garg , John Apostolides , Sarah Mitchell , Andreas Pfenning, Jae-Hyun Yang, Rafael deCabo, Shelley L. Berger, Philipp Oberdoerffer5 and David A. Sinclair.
- Organizer
  第１０回 Symphony
- Invited
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] Evidence for an epigenetic cause of aging in mice2017
- Author(s)
  Motoshi Hayano, Luis A.Rajman ,Michael S. Bonkowski , Sachin Thakur , Neha Garg , John Apostolides , Sarah Mitchell , Andreas Pfenning, Jae-Hyun Yang, Rafael deCabo, Shelley L. Berger, Philipp Oberdoerffer5 and David A. Sinclair
- Organizer
  Keystone Symposia, Aging and Mechanisms of Aging-Related Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13228
[Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes
- Author(s)
  Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
- Organizer
  第86回日本生化学会大会事務局インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2013-09-11 – 2013-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-23247031

1. MASAI Hisao (40229349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. YOSHIZAWA Naoko (30344071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKAI Yuko (90332270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUMOTO Seiji (40190532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. MORIYAMA Kenji (00250217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SHINMOTO Michie (20216237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TANAKA Taku (80425686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KANO Yutaka (90450593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. ODA Masako (50399474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ITO Sayuri (60462777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIYATAKE Shoichiro (30239420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KAKUSHO Naoko (30599593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 岡嶋孝治 (70280998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 長井淳 (60892586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 奥田覚 (80707836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ITOH Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 須賀田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 白髭克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayano Motoshi 早野 元詞

HAYANO Motoshi 早野 元嗣

早野 元詞 ハヤノ モトシ

Research Projects

Research Products

Co-Researchers

The changes in epigenetic information causes aging driven by DNA damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The establishment of tissue elasticity modalities and aging controlPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling the role of peri-synaptic collagen in ageing with protein engineering

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Aging speed regulated by epigenetic memory induced during environmental stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of aging by epigenetic memory in satellite stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A molecular mechanism of aging through epigenome and muscle regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

複製プログラムにおける新規細胞内機能制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Loss of epigenetic information as a cause of mammalian aging2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] テロメア結合因子Rif1は、染色体複タイミングを決定する2012

Author(s)

Journal Title

Data Source

[Journal Article] Rif1 is a global regulator of timing of replication origin firing in fission yeast2012

Author(s)

Hayano Motoshi 早野元詞

HAYANO Motoshi 早野元嗣

早野元詞ハヤノモトシ

[Presentation] DNA損傷依存的エピゲノム変化による老化誘導と身体機能低下の分子機構2019

[Presentation] エピゲノム変動による老化モデル構築及び、老化関連疾患誘導のメカニズム2018

[Presentation] エピゲノム変動による老化モデル構築及び、老化関連疾患誘導のメカニズム2017