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kakusho naoko  覺正 直子

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KAKUSHO Naoko  覺正 直子

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Researcher Number 30599593
Other IDs
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help 2020 – 2021: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
2013 – 2017: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 43030:Functional biochemistry-related / Tumor biology
Except Principal Investigator
Structural biochemistry / Molecular biology
Keywords
Principal Investigator
核膜 / HEATドメイン / グアニン4重鎖 / 多量体形成 / 分裂酵母 / RNA-DNAハイブリッド / 複製タイミング / 高次構造 / クロマチンループ / Rif1タンパク質 … More / グアニン4重鎖DNA / DNA複製 / キナーゼ阻害剤 / がん細胞死 / M期 / S期 / 細胞周期 / Wee1キナーゼ / Cdc7キナーゼ … More
Except Principal Investigator
ゲノム不安定性 / DNA複製停止 / 複製複合体 / 染色体不安定性症候群 / DNA結合タンパク質 / 染色体脆弱部位 / チェックポイント応答 / RecGタンパク質 / 複製ストレス / 複製フォーク / PriAタンパク質 / 構造解析 / 染色体ダイナミクス / リン酸化 / 複製起点 / 染色体DNA複製 / 脳発生 / 細胞分裂 / 乗り越えDNA合成 / 複製タイミング / 減数分裂期組換え / チェックポイント / Cdc7キナーゼ / 染色体DNA複製開始 Less
  • Research Projects

    (4 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (15 People)
  •  Molecular Mechanisms of recognition of G-quadruplex by Rif1, a conserved nuclear factor regulating chromatin architecturePrincipal Investigator

    • Principal Investigator
      KAKUSHO Naoko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Development of new cancer therapy strategies by promoting aberrant cell division in the presence of replication inhibitorsPrincipal Investigator

    • Principal Investigator
      KAKUSHO Naoko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Stabilization of stalled replication forks by fork-binding proteins

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

All 2020 2019 2017 2015 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Detection of cellular G-quadruplex by using a loop structure as a structural determinant2020

    • Author(s)
      Masai Hisao、Kanoh Yutaka、Kakusho Naoko、Fukatsu Rino
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 531 Issue: 1 Pages: 75-83

    • DOI

      10.1016/j.bbrc.2020.05.191

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21410, KAKENHI-PROJECT-19K16082, KAKENHI-PROJECT-20KK0157, KAKENHI-PROJECT-17H01418, KAKENHI-PROJECT-18K06072, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-19H05277, KAKENHI-PUBLICLY-20H05399, KAKENHI-PROJECT-20H00463
  • [Journal Article] Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities2019

    • Author(s)
      Masai Hisao、Fukatsu Rino、Kakusho Naoko、Kanoh Yutaka、Moriyama Kenji、Ma Yue、Iida Keisuke、Nagasawa Kazuo
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8618-8618

    • DOI

      10.1038/s41598-019-44736-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05349, KAKENHI-PROJECT-18K06072, KAKENHI-PROJECT-18K06102, KAKENHI-PROJECT-19K16082, KAKENHI-PUBLICLY-19H05277, KAKENHI-PUBLICLY-18H04387, KAKENHI-PROJECT-17H01418
  • [Journal Article] Checkpoint-independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 kinase.2017

    • Author(s)
      Matsumoto, S., Kanoh, Y., Shimmoto, M., Hayano, M., Ueda, K., Fukatsu, R., Kakusho, N., and Masai, H.
    • Journal Title

      Mol. Cell. Biol.

      Volume: MCB.00355-16. Issue: 7

    • DOI

      10.1128/mcb.00355-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07456, KAKENHI-PROJECT-16K14675, KAKENHI-PROJECT-15K18423, KAKENHI-PROJECT-17H01418
  • [Journal Article] Rif1 binds to G-quadruplexes and suppresses replication over long distances.2015

    • Author(s)
      Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guillet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige, and *Hisao Masai
    • Journal Title

      Nature Struct. Mol. Biol.

      Volume: 22 Issue: 11 Pages: 889-897

    • DOI

      10.1038/nsmb.3102

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18423, KAKENHI-PLANNED-23105013, KAKENHI-PUBLICLY-26114723, KAKENHI-PROJECT-15H02369, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26560444, KAKENHI-PROJECT-26860077, KAKENHI-PROJECT-26282214, KAKENHI-PROJECT-26251004
  • [Journal Article] CDC28 phosphorylates Cac1p and regulates the association of Chromatin Assembly Factor I with chromatin.2015

    • Author(s)
      Jeffery, D., Kakusho, N., You, Z., Gharib, M., Wyse, B., Drury, E., Weinreich, M., Thibault, P. Verreault, A., Masai, H. and *Yankulov, K.
    • Journal Title

      Cell Cycle

      Volume: 14 Issue: 1 Pages: 74-85

    • DOI

      10.4161/15384101.2014.973745

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18423, KAKENHI-PUBLICLY-26114723, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004
  • [Journal Article] c-Jun N-terminal Kinase (JNK)-Mediated Rad18 Phosphorylation Facilitates Polη Recruitment to Stalled Replication Forks.2012

    • Author(s)
      Barkley, L.R., Palle, K., Durando, M., Day, T.A., Gurkar, A., Kakusho, N., Li, J., Masai, H., Vaziri, C.
    • Journal Title

      Mol. Biol. Cell.

      Volume: 23 Issue: 10 Pages: 1943-1954

    • DOI

      10.1091/mbc.e11-10-0829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520
  • [Journal Article] Mechanism of cancer cell death induced by depletion of an essential replication regulator2012

    • Author(s)
      Ito, S., Ishii, A., Kakusho, N., Taniyama, C., Yamazaki, S., Sakaue-Sawano, A., Miyawaki, A., and Masai, H
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Journal Article] Mechanism of cancer cell death induced by depletion of an essential replication regulator.2012

    • Author(s)
      Ito, S., Ishii, A., Kakusho, N., Taniyama, C., Yamazaki, S., Sakaue-Sawano, A., Miyawaki, A., and Masai, H.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36372-e36372

    • DOI

      10.1371/journal.pone.0036372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520
  • [Journal Article] Molecular mechanism of activation of human Cdc7 kinase: Bipartite interaction with Dbf4/ASK stimulates ATP binding and substrate recognition.2011

    • Author(s)
      Kitamura, R., Fukatsu, R., Kakusho, N., Cho, Y-S., Taniyama, C., Yamazaki, S., Toh, G-T., Yanagi, K., Arai, N., Chang, H-J. and Masai, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 26 Pages: 23031-23043

    • DOI

      10.1074/jbc.m111.243311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
  • [Journal Article] Pre-firing binding of Mrc1 defines the early-firing origins which are selectively hyper-activated upon loss of fork stabilizing factors in fission yeast.2011

    • Author(s)
      Hayano, M., Kanoh, Y., Matsumoto, S., Kakusho, N. and Masai, H.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 31 Issue: 12 Pages: 2380-2389

    • DOI

      10.1128/mcb.01239-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
  • [Presentation] Rif1が結合するグアニン4重鎖構造の細胞内存在と形成のメカニズムの解明2017

    • Author(s)
      加納 豊、松本 清治、深津 理乃、覺正 直子、正井 久雄
    • Organizer
      生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-15K18423
  • [Presentation] 細胞内におけるグアニン4重鎖DNA構造の存在を証明する新規技法の開発2017

    • Author(s)
      正井 久雄、加納 豊、覺正 直子
    • Organizer
      第24回DNA複製・組換え・修復ワークショップ
    • Data Source
      KAKENHI-PROJECT-15K18423
  • [Presentation] Rif1タンパク質の標的であるグアニン4重鎖DNA構造の分裂酵母細胞内での存在を証明するための新しい方法の開発2017

    • Author(s)
      正井 久雄、加納 豊、覺正 直子
    • Organizer
      第35回染色体ワークショップ・第16回核ダイナミクス研究会
    • Data Source
      KAKENHI-PROJECT-15K18423
  • [Presentation] Renard-Guillet Claire "Rif1 : a potential global regulator of DNA replication, DNA repair, and recombination"2013

    • Author(s)
      正井 久雄, 山崎 聡志, Lai Mongsing, Foiani Marco, 吉沢 直子, 加納 豊, 松本 清治, 森山賢治, 覺正 直子, 深津 理乃, 松嶋 夢叶, 河野 暢明
    • Organizer
      第36回(2013年)日本分子生物学会年会, ワークショップ 『DNA 二重鎖切断のend-resection と修復機構の選択・制御』
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] "Rif1: a potential global regulator of DNA replication, DNA repair, and recombination."2013

    • Author(s)
      正井 久雄、山崎 聡志、Lai Mongsing、Foiani Marco、吉沢 直子、加納 豊、松本 清治、森山賢治、覺正 直子、深津 理乃、松嶋 夢叶、河野 暢明、Renard-Guillet Claire
    • Organizer
      第36回(2013年)日本分子生物学会年会,ワークショップ 「DNA二重鎖切断のend-resectionと修復機構の選択・制御」
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes2013

    • Author(s)
      Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
    • Organizer
      第86回日本生化学会大会事務局 インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] “Chromatin architecture that regulates replication timing of eukaryotic chromosomes.“2013

    • Author(s)
      Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, and Rino Fukatsu
    • Organizer
      第86回日本生化学会大会事務局 インターナショナルセッション「Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome」
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] Cell cycle regulation of mouse embryonic stem cells : E2F- and Emi1-mediated positive feedback regulation2012

    • Author(s)
      Hisao Masai, Hiroko Fujii, Naoko Kakusho, Sayuri Ito, Satoshi Yamazaki, and Naoko Yoshizawa
    • Organizer
      4th Southeast Stem Cell Consortium Workshop at Florida State University
    • Place of Presentation
      Tallahassee, Florida
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] Regulation of replication program in fission yeast and human cells2012

    • Author(s)
      Hisao Masai, Satoshi Yamazaki, Yutaka Kanoh, Motoshi Hayano, Seiji Matsumoto, Naoko Yoshizawa, Rino Fukatsu, Naoko Kakusho, and Michie Shimmoto
    • Organizer
      8th 3R meeting
    • Place of Presentation
      Awajishima
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] Regulation of replication program in fission yeast and human cells2011

    • Author(s)
      Hisao Masai, Satoshi Yamazaki, Yutaka Kanoh, Motoshi Hayano, Seiji Matsumoto, Naoko Kakusho
    • Organizer
      Cold Spring Harbor Laboratory Meeting Eukaryotic DNA Replication & Genome Maintenance
    • Place of Presentation
      New York, USA
    • Year and Date
      2011-09-06
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] Regulation of replication program in fission yeast2011

    • Author(s)
      Hisao Masai, Seiji Matsumoto, Motoshi Hayano, Yutaka Kanoh, Michie Shimmoto, Naoko Kakusho, and Satomi Kudo
    • Organizer
      The 6th International Fission Yeast Meeting
    • Place of Presentation
      Boston, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] "Regulation of replication program in fission yeast and human cells."2011

    • Author(s)
      Hisao Masai, Satoshi Yamazaki, Yutaka Kanoh, Motoshi Hayano, Seiji Matsumoto, Masako Oda, Naoko Kakusho, Rino Fukatsu, Michie Shimmoto and Naoko Yoshizawa
    • Organizer
      日本分子生物学会総会 シンポジウム(招待講演)
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23657081
  • [Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes

    • Author(s)
      Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
    • Organizer
      第86回日本生化学会大会事務局 インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-09-11 – 2013-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-23247031
  • [Presentation] Rif1: a potential global regulator of DNA replication, DNA repair, and recombination

    • Author(s)
      正井 久雄、山崎 聡志、Lai Mongsing、Foiani Marco、吉沢 直子、加納 豊、松本 清治、森山賢治、覺正 直子、深津 理乃、松嶋 夢叶、河野 暢明、Renard-Guillet Claire
    • Organizer
      第36回(2013年)日本分子生物学会年会,ワークショップ 『DNA二重鎖切断のend-resectionと修復機構の選択・制御』
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2013-12-03 – 2013-12-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-23247031
  • 1.  MATSUMOTO Seiji (40190532)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 2.  KANO Yutaka (90450593)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 3.  MASAI Hisao (40229349)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 4.  TANAKA Taku (80425686)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIZAWA Naoko (30344071)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TAKAI Yuko (90332270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MORIYAMA Kenji (00250217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  SHINMOTO Michie (20216237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  ODA Masako (50399474)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ITO Sayuri (60462777)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  MIYATAKE Shoichiro (30239420)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HAYANO Motoshi (30593644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  須賀田 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 14.  飯田 圭介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  深津 理乃
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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