kakusho naoko 覺正直子

… Alternative Names

KAKUSHO Naoko 覺正直子

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Researcher Number	30599593
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2021: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2013 – 2017: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Tumor biology Except Principal Investigator Structural biochemistry / Molecular biology
Keywords	Principal Investigator 核膜 / HEATドメイン / グアニン４重鎖 / 多量体形成 / 分裂酵母 / RNA-DNAハイブリッド / 複製タイミング / 高次構造 / クロマチンループ / Rif1タンパク質 … More / グアニン４重鎖DNA / DNA複製 / キナーゼ阻害剤 / がん細胞死 / M期 / S期 / 細胞周期 / Wee1キナーゼ / Cdc7キナーゼ … More Except Principal Investigator ゲノム不安定性 / DNA複製停止 / 複製複合体 / 染色体不安定性症候群 / DNA結合タンパク質 / 染色体脆弱部位 / チェックポイント応答 / RecGタンパク質 / 複製ストレス / 複製フォーク / PriAタンパク質 / 構造解析 / 染色体ダイナミクス / リン酸化 / 複製起点 / 染色体DNA複製 / 脳発生 / 細胞分裂 / 乗り越えDNA合成 / 複製タイミング / 減数分裂期組換え / チェックポイント / Cdc7キナーゼ / 染色体DNA複製開始 Less

Molecular Mechanisms of recognition of G-quadruplex by Rif1, a conserved nuclear factor regulating chromatin architecturePrincipal Investigator
- Principal Investigator
  
  KAKUSHO Naoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of new cancer therapy strategies by promoting aberrant cell division in the presence of replication inhibitorsPrincipal Investigator
- Principal Investigator
  
  KAKUSHO Naoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication
- Principal Investigator
  
  MASAI Hisao
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Stabilization of stalled replication forks by fork-binding proteins
- Principal Investigator
  
  MASAI Hisao
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2020 2019 2017 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Detection of cellular G-quadruplex by using a loop structure as a structural determinant2020
- Author(s)
  Masai Hisao、Kanoh Yutaka、Kakusho Naoko、Fukatsu Rino
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 1 Pages: 75-83
- DOI
  10.1016/j.bbrc.2020.05.191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21410, KAKENHI-PROJECT-19K16082, KAKENHI-PROJECT-20KK0157, KAKENHI-PROJECT-17H01418, KAKENHI-PROJECT-18K06072, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-19H05277, KAKENHI-PUBLICLY-20H05399, KAKENHI-PROJECT-20H00463
[Journal Article] Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities2019
- Author(s)
  Masai Hisao、Fukatsu Rino、Kakusho Naoko、Kanoh Yutaka、Moriyama Kenji、Ma Yue、Iida Keisuke、Nagasawa Kazuo
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 8618-8618
- DOI
  10.1038/s41598-019-44736-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05349, KAKENHI-PROJECT-18K06072, KAKENHI-PROJECT-18K06102, KAKENHI-PROJECT-19K16082, KAKENHI-PUBLICLY-19H05277, KAKENHI-PUBLICLY-18H04387, KAKENHI-PROJECT-17H01418
[Journal Article] Checkpoint-independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 kinase.2017
- Author(s)
  Matsumoto, S., Kanoh, Y., Shimmoto, M., Hayano, M., Ueda, K., Fukatsu, R., Kakusho, N., and Masai, H.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: MCB.00355-16. Issue: 7
- DOI
  10.1128/mcb.00355-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K07456, KAKENHI-PROJECT-16K14675, KAKENHI-PROJECT-15K18423, KAKENHI-PROJECT-17H01418
[Journal Article] Rif1 binds to G-quadruplexes and suppresses replication over long distances.2015
- Author(s)
  Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guillet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige, and *Hisao Masai
- Journal Title
  
  Nature Struct. Mol. Biol.
  
  Volume: 22 Issue: 11 Pages: 889-897
- DOI
  10.1038/nsmb.3102
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18423, KAKENHI-PLANNED-23105013, KAKENHI-PUBLICLY-26114723, KAKENHI-PROJECT-15H02369, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26560444, KAKENHI-PROJECT-26860077, KAKENHI-PROJECT-26282214, KAKENHI-PROJECT-26251004
[Journal Article] CDC28 phosphorylates Cac1p and regulates the association of Chromatin Assembly Factor I with chromatin.2015
- Author(s)
  Jeffery, D., Kakusho, N., You, Z., Gharib, M., Wyse, B., Drury, E., Weinreich, M., Thibault, P. Verreault, A., Masai, H. and *Yankulov, K.
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Issue: 1 Pages: 74-85
- DOI
  10.4161/15384101.2014.973745
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18423, KAKENHI-PUBLICLY-26114723, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004
[Journal Article] c-Jun N-terminal Kinase (JNK)-Mediated Rad18 Phosphorylation Facilitates Polη Recruitment to Stalled Replication Forks.2012
- Author(s)
  Barkley, L.R., Palle, K., Durando, M., Day, T.A., Gurkar, A., Kakusho, N., Li, J., Masai, H., Vaziri, C.
- Journal Title
  
  Mol. Biol. Cell.
  
  Volume: 23 Issue: 10 Pages: 1943-1954
- DOI
  10.1091/mbc.e11-10-0829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520
[Journal Article] Mechanism of cancer cell death induced by depletion of an essential replication regulator2012
- Author(s)
  Ito, S., Ishii, A., Kakusho, N., Taniyama, C., Yamazaki, S., Sakaue-Sawano, A., Miyawaki, A., and Masai, H
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657081
[Journal Article] Mechanism of cancer cell death induced by depletion of an essential replication regulator.2012
- Author(s)
  Ito, S., Ishii, A., Kakusho, N., Taniyama, C., Yamazaki, S., Sakaue-Sawano, A., Miyawaki, A., and Masai, H.
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 5 Pages: e36372-e36372
- DOI
  10.1371/journal.pone.0036372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081, KAKENHI-PUBLICLY-24114520
[Journal Article] Molecular mechanism of activation of human Cdc7 kinase: Bipartite interaction with Dbf4/ASK stimulates ATP binding and substrate recognition.2011
- Author(s)
  Kitamura, R., Fukatsu, R., Kakusho, N., Cho, Y-S., Taniyama, C., Yamazaki, S., Toh, G-T., Yanagi, K., Arai, N., Chang, H-J. and Masai, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Issue: 26 Pages: 23031-23043
- DOI
  10.1074/jbc.m111.243311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
[Journal Article] Pre-firing binding of Mrc1 defines the early-firing origins which are selectively hyper-activated upon loss of fork stabilizing factors in fission yeast.2011
- Author(s)
  Hayano, M., Kanoh, Y., Matsumoto, S., Kakusho, N. and Masai, H.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 31 Issue: 12 Pages: 2380-2389
- DOI
  10.1128/mcb.01239-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247031, KAKENHI-PROJECT-23657081
[Presentation] Rif1が結合するグアニン４重鎖構造の細胞内存在と形成のメカニズムの解明2017
- Author(s)
  加納豊、松本清治、深津理乃、覺正直子、正井久雄
- Organizer
  生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15K18423
[Presentation] 細胞内におけるグアニン４重鎖DNA構造の存在を証明する新規技法の開発2017
- Author(s)
  正井久雄、加納豊、覺正直子
- Organizer
  第24回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-15K18423
[Presentation] Rif1タンパク質の標的であるグアニン４重鎖DNA構造の分裂酵母細胞内での存在を証明するための新しい方法の開発2017
- Author(s)
  正井久雄、加納豊、覺正直子
- Organizer
  第35回染色体ワークショップ・第16回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-15K18423
[Presentation] Renard-Guillet Claire "Rif1 : a potential global regulator of DNA replication, DNA repair, and recombination"2013
- Author(s)
  正井久雄, 山崎聡志, Lai Mongsing, Foiani Marco, 吉沢直子, 加納豊, 松本清治, 森山賢治, 覺正直子, 深津理乃, 松嶋夢叶, 河野暢明
- Organizer
  第36回(2013年)日本分子生物学会年会, ワークショップ『DNA 二重鎖切断のend-resection と修復機構の選択・制御』
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] "Rif1: a potential global regulator of DNA replication, DNA repair, and recombination."2013
- Author(s)
  正井久雄、山崎聡志、Lai Mongsing、Foiani Marco、吉沢直子、加納豊、松本清治、森山賢治、覺正直子、深津理乃、松嶋夢叶、河野暢明、Renard-Guillet Claire
- Organizer
  第36回（2013年）日本分子生物学会年会，ワークショップ「DNA二重鎖切断のend-resectionと修復機構の選択・制御」
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes2013
- Author(s)
  Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
- Organizer
  第86回日本生化学会大会事務局インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] “Chromatin architecture that regulates replication timing of eukaryotic chromosomes.“2013
- Author(s)
  Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, and Rino Fukatsu
- Organizer
  第86回日本生化学会大会事務局インターナショナルセッション「Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome」
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] Cell cycle regulation of mouse embryonic stem cells : E2F- and Emi1-mediated positive feedback regulation2012
- Author(s)
  Hisao Masai, Hiroko Fujii, Naoko Kakusho, Sayuri Ito, Satoshi Yamazaki, and Naoko Yoshizawa
- Organizer
  4th Southeast Stem Cell Consortium Workshop at Florida State University
- Place of Presentation
  Tallahassee, Florida
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] Regulation of replication program in fission yeast and human cells2012
- Author(s)
  Hisao Masai, Satoshi Yamazaki, Yutaka Kanoh, Motoshi Hayano, Seiji Matsumoto, Naoko Yoshizawa, Rino Fukatsu, Naoko Kakusho, and Michie Shimmoto
- Organizer
  8th 3R meeting
- Place of Presentation
  Awajishima
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] Regulation of replication program in fission yeast and human cells2011
- Author(s)
  Hisao Masai, Satoshi Yamazaki, Yutaka Kanoh, Motoshi Hayano, Seiji Matsumoto, Naoko Kakusho
- Organizer
  Cold Spring Harbor Laboratory Meeting Eukaryotic DNA Replication & Genome Maintenance
- Place of Presentation
  New York, USA
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] Regulation of replication program in fission yeast2011
- Author(s)
  Hisao Masai, Seiji Matsumoto, Motoshi Hayano, Yutaka Kanoh, Michie Shimmoto, Naoko Kakusho, and Satomi Kudo
- Organizer
  The 6th International Fission Yeast Meeting
- Place of Presentation
  Boston, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] "Regulation of replication program in fission yeast and human cells."2011
- Author(s)
  Hisao Masai, Satoshi Yamazaki, Yutaka Kanoh, Motoshi Hayano, Seiji Matsumoto, Masako Oda, Naoko Kakusho, Rino Fukatsu, Michie Shimmoto and Naoko Yoshizawa
- Organizer
  日本分子生物学会総会　シンポジウム(招待講演)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23657081
[Presentation] Chromatin architecture that regulates replication timing of eukaryotic chromosomes
- Author(s)
  Hisao Masai, Yutaka Kanoh, Satoshi Yamazaki, Motoshi Hayano, Naoko Yoshizawa, Kenji Moriyama, Yumeka Matsushima, Naoko Kakusho, Rino Fukatsu
- Organizer
  第86回日本生化学会大会事務局インターナショナルセッション『Assembly and architecture of protein complexes regulating inheritance and stable maintenance of genome』
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2013-09-11 – 2013-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-23247031
[Presentation] Rif1: a potential global regulator of DNA replication, DNA repair, and recombination
- Author(s)
  正井久雄、山崎聡志、Lai Mongsing、Foiani Marco、吉沢直子、加納豊、松本清治、森山賢治、覺正直子、深津理乃、松嶋夢叶、河野暢明、Renard-Guillet Claire
- Organizer
  第36回（2013年）日本分子生物学会年会，ワークショップ『DNA二重鎖切断のend-resectionと修復機構の選択・制御』
- Place of Presentation
  神戸ポートアイランド（兵庫）
- Year and Date
  2013-12-03 – 2013-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-23247031

1. MATSUMOTO Seiji (40190532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. KANO Yutaka (90450593)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. MASAI Hisao (40229349)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
4. TANAKA Taku (80425686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIZAWA Naoko (30344071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAI Yuko (90332270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MORIYAMA Kenji (00250217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. SHINMOTO Michie (20216237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ODA Masako (50399474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ITO Sayuri (60462777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. MIYATAKE Shoichiro (30239420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HAYANO Motoshi (30593644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 須賀田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 飯田圭介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 深津理乃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

kakusho naoko 覺正 直子

KAKUSHO Naoko 覺正 直子

Research Projects

Research Products

Co-Researchers

Molecular Mechanisms of recognition of G-quadruplex by Rif1, a conserved nuclear factor regulating chromatin architecturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new cancer therapy strategies by promoting aberrant cell division in the presence of replication inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the functions and structures of Cdc7 kinase, essential for initiation of DNA replication

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Stabilization of stalled replication forks by fork-binding proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Detection of cellular G-quadruplex by using a loop structure as a structural determinant2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Checkpoint-independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 kinase.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rif1 binds to G-quadruplexes and suppresses replication over long distances.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CDC28 phosphorylates Cac1p and regulates the association of Chromatin Assembly Factor I with chromatin.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] c-Jun N-terminal Kinase (JNK)-Mediated Rad18 Phosphorylation Facilitates Polη Recruitment to Stalled Replication Forks.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanism of cancer cell death induced by depletion of an essential replication regulator2012

Author(s)

Journal Title

Data Source

[Journal Article] Mechanism of cancer cell death induced by depletion of an essential replication regulator.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanism of activation of human Cdc7 kinase: Bipartite interaction with Dbf4/ASK stimulates ATP binding and substrate recognition.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pre-firing binding of Mrc1 defines the early-firing origins which are selectively hyper-activated upon loss of fork stabilizing factors in fission yeast.2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] Rif1が結合するグアニン４重鎖構造の細胞内存在と形成のメカニズムの解明2017

Author(s)

kakusho naoko 覺正直子

KAKUSHO Naoko 覺正直子