OGAWARA Yoko 小川原陽子

Researcher Number	30599626
Affiliation (based on the past Project Information) *help	2017 – 2019: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2013 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Tumor biology
Keywords	Principal Investigator AML / IDH / NPM / Hoxa9 / HOXA9 / IDH2 / YB-1 / 低酸素 / 5hmC / 2HG

NPM変異体とIDH変異体による協調的な急性骨髄性白血病発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  小川原陽子
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Analysis of NPM mutant-mediated acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  OGAWARA Yoko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan

All 2018 2017 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma2018
- Author(s)
  Nakagawa Makoto、Fujita Shuhei、Katsumoto Takuo、Yamagata Kazutsune、Ogawara Yoko、Hattori Ayuna、Kagiyama Yuki、Honma Daisuke、Araki Kazushi、Inoue Tatsuya、Kato Ayako、Inaki Koichiro、Wada Chisa、Ono Yoshimasa、Yamamoto Masahide、Miura Osamu、Nakashima Yasuharu、Kitabayashi Issay
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 194-208
- DOI
  10.1111/cas.13840
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07188, KAKENHI-PROJECT-18K16101
[Journal Article] IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia2015
- Author(s)
  Ogawara Y, Katsumoto T, Aikawa Y, Shima Y, Kagiyama Y, Soga T, Matsunaga H, Seki T, Araki K, Kitabayashi I.
- Journal Title
  
  Cancer Res.
  
  Volume: 75 Issue: 10 Pages: 2005-2016
- DOI
  10.1158/0008-5472.can-14-2200
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22130006, KAKENHI-PROJECT-25871159
[Journal Article] AMLにおけるエピゲノム変化　IDH標的研究2014
- Author(s)
  小川原陽子、　北林一生
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 1977-1981
- Data Source
  KAKENHI-PROJECT-25871159
[Journal Article] IDH 変異を標的とした新たながん治療戦略2014
- Author(s)
  小川原陽子、　北林一生
- Journal Title
  
  細胞工学
  
  Volume: Vol. 33 No. 2 Pages: 145-150
- Data Source
  KAKENHI-PROJECT-25871159
[Journal Article] 変異型IDHを標的とした治療法開発の現状と展望2014
- Author(s)
  小川原陽子、　北林一生
- Journal Title
  
  細胞
  
  Volume: Vol. 46 No. 3 Pages: 20-24
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] the molecular mechanisms of NPMc and IDH2 mutant-mediated upregulation of Hoxa genes2017
- Author(s)
  Yoko Ogawara, Issay Kitabayashi
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07188
[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2014
- Author(s)
  Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
- Organizer
  2014 Keystone Symposia Conference, X6: Tumor Metabolism
- Place of Presentation
  Whistler, Canaa
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] NPMc cooperates with IDH2 mutant to induce AML2013
- Author(s)
  Yoko Ogawara, Takuo Katsumoto and Issay Kitabayashi
- Organizer
  第75回日本血液学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] NPMc cooperates with IDH2 mutant to induce AML」English oral presentation.2013
- Author(s)
  Yoko Ogawara, Takuo Katsumoto and Issay Kitabayashi
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2013
- Author(s)
  Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Hironori Matsunaga, Takahiko Seki and Issay Kitabayashi
- Organizer
  55th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia
- Author(s)
  Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
- Organizer
  第12回幹細胞シンポジウム
- Place of Presentation
  九州大学医学部
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] IDH mutants are promising therapeutic targets for acute myeloid leukemia
- Author(s)
  Yoko Ogawara, Hironori Matsunaga, Takahiko Seki, Yukino Machida, Kazushi Araki, Issay Kitabayashi
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] IDH変異体の急性骨髄性白血病における機能
- Author(s)
  小川原　陽子、　北林　一生
- Organizer
  第19回造血器腫瘍研究会
- Place of Presentation
  佐賀
- Year and Date
  2015-01-23 – 2015-01-24
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] 変異型IDHの急性骨髄性白血病における機能
- Author(s)
  小川原　陽子、町田　雪乃、北林　一生
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08 – 2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] IDH mutant regulates metabolism and hypoxia pathway in AML
- Author(s)
  Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
- Organizer
  第７６回血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Invited
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] 変異型IDHの急性骨髄性白血病における機能
- Author(s)
  Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
- Organizer
  第８７回日本生化学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25871159
[Presentation] IDH mutant and cancer
- Author(s)
  Yoko Ogawara, Takuo Katsumoto, Yutaka Shima, Tomoyoshi Soga, Issay Kitabayashi
- Organizer
  第７３回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-25871159

1. 北林一生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OGAWARA Yoko 小川原 陽子

Research Projects

Research Products

Co-Researchers

NPM変異体とIDH変異体による協調的な急性骨髄性白血病発症メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of NPM mutant-mediated acute myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AMLにおけるエピゲノム変化 IDH標的研究2014

Author(s)

Journal Title

Data Source

[Journal Article] IDH 変異を標的とした新たながん治療戦略2014

Author(s)

Journal Title

Data Source

[Journal Article] 変異型IDHを標的とした治療法開発の現状と展望2014

Author(s)

Journal Title

Data Source

[Presentation] the molecular mechanisms of NPMc and IDH2 mutant-mediated upregulation of Hoxa genes2017

Author(s)

Organizer

Data Source

[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] NPMc cooperates with IDH2 mutant to induce AML2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] NPMc cooperates with IDH2 mutant to induce AML」English oral presentation.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] IDH mutants are promising therapeutic targets for acute myeloid leukemia

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] IDH変異体の急性骨髄性白血病における機能

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OGAWARA Yoko 小川原陽子

[Journal Article] AMLにおけるエピゲノム変化　IDH標的研究2014