Hosokawa Tomohisa 細川智永

Researcher Number	30602883
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2023: 京都大学, 医学研究科, 講師 2020 – 2022: 名古屋大学, 理学研究科, 講師 2017 – 2019: 京都大学, 医学研究科, 特定研究員 2018: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Neurophysiology / General neuroscience / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Basic Section 46030:Function of nervous system-related
Keywords	Principal Investigator シナプス可塑性 / 液液相分離 / 液-液相分離 / 長期増強 / 記憶 / 受容体 / 液－液相分離 / シナプス / synaptic structure / learning and memory / synaptic plasticity … More Except Principal Investigator … More 相互作用 / 長期増強現象 / 光操作 / ポストシナプス / 相分離 / 液-液相分離 / 記憶・学習 / 液ー液相分離 / LTP / スパイン / シナプス可塑性 / 長期増強 / コフィリン / アクチン細胞骨格 / リン酸化 / 液－液相分離 / CaMKII / 記憶 / シナプス Less

Regulatory mechanisms of synaptic protein accumulation and maintenance during memory formation.
- Principal Investigator
  
  Saneyoshi Takeo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Kyoto University
Structural role of CaMKII in PSD and the induction of LTP by optpgenetics.Principal Investigator
- Principal Investigator
  
  HOSOKAWA TOMOHISA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Nagoya University
  Kyoto University
Reconstitution of synaptic plasticity in vitroPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA TOMOHISA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Nagoya University
  Kyoto University
CaMKII acts as a protein hub to accumulate and activate synaptic proteinsPrincipal Investigator
- Principal Investigator
  
  Hosokawa Tomohisa
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Kyoto University

All 2021 2020 2018 2017

All Journal Article Presentation

[Journal Article] Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation2021
- Author(s)
  Hosokawa Tomohisa、Liu Pin-Wu
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 12 Pages: 795757-795757
- DOI
  10.3389/fphys.2021.795757
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-21K15188, KAKENHI-PROJECT-18KK0421, KAKENHI-PROJECT-22KF0163
[Journal Article] Novel mechanism of synaptic plasticity mediated by CaMKII2021
- Author(s)
  林康紀、細川智永、劉品吾、實吉岳郎
- Journal Title
  
  生化学
  
  Volume: 93 Issue: 2 Pages: 191-202
- DOI
  10.14952/SEIKAGAKU.2021.930191
- ISSN
  0037-1017
- Year and Date
  2021-04-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-PROJECT-20K21462
[Journal Article] Regulation of synaptic nanodomain by liquid?liquid phase separation: A novel mechanism of synaptic plasticity2021
- Author(s)
  Liu Pin-Wu、Hosokawa Tomohisa、Hayashi Yasunori
- Journal Title
  
  Current Opinion in Neurobiology
  
  Volume: 69 Pages: 84-92
- DOI
  10.1016/j.conb.2021.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-20K21462, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434, KAKENHI-PROJECT-22KF0163
[Journal Article] CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation2021
- Author(s)
  Hosokawa Tomohisa、Liu Pin-Wu、Cai Qixu、Ferreira Joana S.、Levet Florian、Butler Corey、Sibarita Jean-Baptiste、Choquet Daniel、Groc Laurent、Hosy Eric、Zhang Mingjie、Hayashi Yasunori
- Journal Title
  
  Nature Neuroscience
  
  Volume: not yet Issue: 6 Pages: 777-785
- DOI
  10.1038/s41593-021-00843-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05428, KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-20K21462, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434, KAKENHI-PROJECT-22KF0163
[Journal Article] Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms2020
- Author(s)
  Cai Qixu、Hosokawa Tomohisa、Zeng Menglong、Hayashi Yasunori、Zhang Mingjie
- Journal Title
  
  Structure
  
  Volume: 28 Issue: 3 Pages: 290-300.e4
- DOI
  10.1016/j.str.2019.11.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434
[Journal Article] Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif2020
- Author(s)
  Eriksen MS, Nikolaienko O, Hallin EI, Grodem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuellar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR.
- Journal Title
  
  The FEBS Journal
  
  Volume: 288 Issue: 9 Pages: 2930-2955
- DOI
  10.1111/febs.15618
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434
[Presentation] Calcium-induced persistent formation of protein condensate on Post-Synaptic Density by liquid-liquid phase separation2021
- Author(s)
  Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita, Yasunori Hayashi
- Organizer
  第44回日本神経科学大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06885
[Presentation] Calcium-induced persistent formation of protein condensate on Post-Synaptic Density by liquid-liquid phase separation2021
- Author(s)
  Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita, Yasunori Hayashi
- Organizer
  第44回日本神経科学大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0421
[Presentation] Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation2021
- Author(s)
  Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita
- Organizer
  第44回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06885
[Presentation] Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation2021
- Author(s)
  Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita
- Organizer
  第44回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0421
[Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020
- Author(s)
  細川智永、劉品吾、林康紀
- Organizer
  Neuroscience2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06885
[Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020
- Author(s)
  Tomohisa Hosokawa
- Organizer
  Japan Neurochemistry
- Data Source
  KAKENHI-PROJECT-19K06885
[Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020
- Author(s)
  Tomohisa Hosokawa
- Organizer
  Neuroscience2020
- Data Source
  KAKENHI-PROJECT-19K06885
[Presentation] CaMKIIの液液相分離によるグルタミン酸受容体のシナプス内区画化2020
- Author(s)
  細川智永、劉品吾、林康紀
- Organizer
  第６３回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18KK0421
[Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020
- Author(s)
  細川智永、劉品吾、林康紀
- Organizer
  Neuroscience2020
- Data Source
  KAKENHI-PROJECT-18KK0421
[Presentation] CaMKIIの液液相分離によるグルタミン酸受容体のシナプス内区画化2020
- Author(s)
  細川智永、劉品吾、林康紀
- Organizer
  第６３回日本神経化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06885
[Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020
- Author(s)
  Tomohisa Hosokawa
- Organizer
  Neuroscience2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0421
[Presentation] シナプスの構造および構造可塑性におけるCaMKIIの構造的役割2018
- Author(s)
  細川智永
- Organizer
  日本神経科学会
- Data Source
  KAKENHI-PROJECT-17K14947
[Presentation] シナプスの構造および構造可塑性におけるCaMKIIの構造的役割2018
- Author(s)
  細川智永
- Organizer
  日本神経科学会大会
- Data Source
  KAKENHI-PROJECT-17K14947
[Presentation] シナプスタンパク質のリン酸化の化学量論およびシナプス構造の新しいモデル2017
- Author(s)
  細川智永
- Organizer
  日本神経科学会大会
- Data Source
  KAKENHI-PROJECT-17K14947

1. Saneyoshi Takeo (00556201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HAYASHI Yasunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 林朗子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosokawa Tomohisa 細川 智永

Research Projects

Research Products

Co-Researchers

Regulatory mechanisms of synaptic protein accumulation and maintenance during memory formation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural role of CaMKII in PSD and the induction of LTP by optpgenetics.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reconstitution of synaptic plasticity in vitroPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CaMKII acts as a protein hub to accumulate and activate synaptic proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel mechanism of synaptic plasticity mediated by CaMKII2021

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Regulation of synaptic nanodomain by liquid?liquid phase separation: A novel mechanism of synaptic plasticity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Calcium-induced persistent formation of protein condensate on Post-Synaptic Density by liquid-liquid phase separation2021

Author(s)

Organizer

Data Source

[Presentation] Calcium-induced persistent formation of protein condensate on Post-Synaptic Density by liquid-liquid phase separation2021

Author(s)

Organizer

Data Source

[Presentation] Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation2021

Author(s)

Organizer

Data Source

[Presentation] Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation2021

Author(s)

Organizer

Data Source

[Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020

Author(s)

Organizer

Hosokawa Tomohisa 細川智永