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Hosokawa Tomohisa  細川 智永

ORCIDConnect your ORCID iD *help
Researcher Number 30602883
Other IDs
Affiliation (Current) 2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2023: 京都大学, 医学研究科, 講師
2020 – 2022: 名古屋大学, 理学研究科, 講師
2017 – 2019: 京都大学, 医学研究科, 特定研究員
2018: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Neurophysiology / General neuroscience / Basic Section 46010:Neuroscience-general-related
Except Principal Investigator
Basic Section 46030:Function of nervous system-related
Keywords
Principal Investigator
シナプス可塑性 / 液液相分離 / 液-液相分離 / 長期増強 / 記憶 / 受容体 / 液-液相分離 / シナプス / synaptic structure / learning and memory / synaptic plasticity … More
Except Principal Investigator
… More 相互作用 / 長期増強現象 / 光操作 / ポストシナプス / 相分離 / 液-液相分離 / 記憶・学習 / 液ー液相分離 / LTP / スパイン / シナプス可塑性 / 長期増強 / コフィリン / アクチン細胞骨格 / リン酸化 / 液-液相分離 / CaMKII / 記憶 / シナプス Less
  • Research Projects

    (4 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (3 People)
  •  Regulatory mechanisms of synaptic protein accumulation and maintenance during memory formation.

    • Principal Investigator
      Saneyoshi Takeo
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 46030:Function of nervous system-related
    • Research Institution
      Kyoto University
  •  Structural role of CaMKII in PSD and the induction of LTP by optpgenetics.Principal Investigator

    • Principal Investigator
      HOSOKAWA TOMOHISA
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      Nagoya University
      Kyoto University
  •  Reconstitution of synaptic plasticity in vitroPrincipal Investigator

    • Principal Investigator
      HOSOKAWA TOMOHISA
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Nagoya University
      Kyoto University
  •  CaMKII acts as a protein hub to accumulate and activate synaptic proteinsPrincipal Investigator

    • Principal Investigator
      Hosokawa Tomohisa
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurophysiology / General neuroscience
    • Research Institution
      Kyoto University

All 2021 2020 2018 2017

All Journal Article Presentation

  • [Journal Article] Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation2021

    • Author(s)
      Hosokawa Tomohisa、Liu Pin-Wu
    • Journal Title

      Frontiers in Physiology

      Volume: 12 Pages: 795757-795757

    • DOI

      10.3389/fphys.2021.795757

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-21K15188, KAKENHI-PROJECT-18KK0421, KAKENHI-PROJECT-22KF0163
  • [Journal Article] Novel mechanism of synaptic plasticity mediated by CaMKII2021

    • Author(s)
      林 康紀、細川 智永、劉 品吾、實吉 岳郎
    • Journal Title

      生化学

      Volume: 93 Issue: 2 Pages: 191-202

    • DOI

      10.14952/SEIKAGAKU.2021.930191

    • ISSN
      0037-1017
    • Year and Date
      2021-04-25
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-PROJECT-20K21462
  • [Journal Article] Regulation of synaptic nanodomain by liquid?liquid phase separation: A novel mechanism of synaptic plasticity2021

    • Author(s)
      Liu Pin-Wu、Hosokawa Tomohisa、Hayashi Yasunori
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 69 Pages: 84-92

    • DOI

      10.1016/j.conb.2021.02.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-20K21462, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434, KAKENHI-PROJECT-22KF0163
  • [Journal Article] CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation2021

    • Author(s)
      Hosokawa Tomohisa、Liu Pin-Wu、Cai Qixu、Ferreira Joana S.、Levet Florian、Butler Corey、Sibarita Jean-Baptiste、Choquet Daniel、Groc Laurent、Hosy Eric、Zhang Mingjie、Hayashi Yasunori
    • Journal Title

      Nature Neuroscience

      Volume: not yet Issue: 6 Pages: 777-785

    • DOI

      10.1038/s41593-021-00843-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05428, KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-20K21462, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434, KAKENHI-PROJECT-22KF0163
  • [Journal Article] Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms2020

    • Author(s)
      Cai Qixu、Hosokawa Tomohisa、Zeng Menglong、Hayashi Yasunori、Zhang Mingjie
    • Journal Title

      Structure

      Volume: 28 Issue: 3 Pages: 290-300.e4

    • DOI

      10.1016/j.str.2019.11.018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434
  • [Journal Article] Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif2020

    • Author(s)
      Eriksen MS, Nikolaienko O, Hallin EI, Grodem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuellar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR.
    • Journal Title

      The FEBS Journal

      Volume: 288 Issue: 9 Pages: 2930-2955

    • DOI

      10.1111/febs.15618

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885, KAKENHI-PROJECT-18KK0421, KAKENHI-PLANNED-18H05434
  • [Presentation] Calcium-induced persistent formation of protein condensate on Post-Synaptic Density by liquid-liquid phase separation2021

    • Author(s)
      Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita, Yasunori Hayashi
    • Organizer
      第44回日本神経科学大会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] Calcium-induced persistent formation of protein condensate on Post-Synaptic Density by liquid-liquid phase separation2021

    • Author(s)
      Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita, Yasunori Hayashi
    • Organizer
      第44回日本神経科学大会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation2021

    • Author(s)
      Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita
    • Organizer
      第44回日本分子生物学会年会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation2021

    • Author(s)
      Tomohisa Hosokawa, Pin-Wu Liu, Makoto Kinoshita
    • Organizer
      第44回日本分子生物学会年会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      Neuroscience2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020

    • Author(s)
      Tomohisa Hosokawa
    • Organizer
      Japan Neurochemistry
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020

    • Author(s)
      Tomohisa Hosokawa
    • Organizer
      Neuroscience2020
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] CaMKIIの液液相分離によるグルタミン酸受容体のシナプス内区画化2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      第63回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] CaMKIIの液-液相分離によるグルタミン酸受容体のシナプス内分離2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      Neuroscience2020
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] CaMKIIの液液相分離によるグルタミン酸受容体のシナプス内区画化2020

    • Author(s)
      細川 智永、劉 品吾、林 康紀
    • Organizer
      第63回日本神経化学会大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06885
  • [Presentation] Subsynaptic segregation of glutamate receptors by CaMKII-mediated liquid-liquid phase separation2020

    • Author(s)
      Tomohisa Hosokawa
    • Organizer
      Neuroscience2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0421
  • [Presentation] シナプスの構造および構造可塑性におけるCaMKIIの構造的役割2018

    • Author(s)
      細川智永
    • Organizer
      日本神経科学会
    • Data Source
      KAKENHI-PROJECT-17K14947
  • [Presentation] シナプスの構造および構造可塑性におけるCaMKIIの構造的役割2018

    • Author(s)
      細川智永
    • Organizer
      日本神経科学会大会
    • Data Source
      KAKENHI-PROJECT-17K14947
  • [Presentation] シナプスタンパク質のリン酸化の化学量論およびシナプス構造の新しいモデル2017

    • Author(s)
      細川智永
    • Organizer
      日本神経科学会大会
    • Data Source
      KAKENHI-PROJECT-17K14947
  • 1.  Saneyoshi Takeo (00556201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  HAYASHI Yasunori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  林 朗子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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