Fujiwara Daisuke 藤原大佑

… Alternative Names

藤原大佑フジワラダイスケ

FUJIWARA Daisuke 藤原大佑

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Researcher Number	30611420
Other IDs	https://orcid.org/0000-0002-6230-5534
Affiliation (Current)	2025: 大阪公立大学, 大学院理学研究科 , 講師
Affiliation (based on the past Project Information) *help	2022: 大阪公立大学, 大学院理学研究科, 講師 2019: 大阪府立大学, 理学(系)研究科(研究院), 講師 2013 – 2018: 大阪府立大学, 理学(系)研究科(研究院), 助教 2015: 大阪府立大学, 大学院理学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Chemical biology Except Principal Investigator Biomolecular chemistry / Integrative animal science
Keywords	Principal Investigator ペプチド / 阻害剤 / 医薬品 / 翻訳後修飾 / タンパク質-タンパク質相互作用 / オーロラキナーぜ / 細胞膜透過性 / オーロラキナーゼ / ファージディスプレイ / ライブラリー / プロテインキナーゼ … More Except Principal Investigator … More 有機化学 / 蛋白質 / ナノバイオ / 生体分子 / 進化分子工学 / ペプチド / 分子標的阻害剤 / 免疫増強剤 / 免疫学 / 生物分子化学 / 生体関連高分子化学 / がん抗原特異的免疫増強剤 / 抑制性T細胞 / 抑制分子標的阻害剤 / 樹状細胞 / 免疫抑制分子標的阻害剤 / がん特異的免疫増強剤 / トランスレーショナルリサーチ / 免疫抑制分子阻害剤 / 抗原特異的免疫増強剤 / がん免疫治療 / 医療・福祉 / ポスト抗体医薬 / 分子標的医薬 / 分子標的ペプチド / 医療・福祉福祉 / ヘリックス構造 / ファージ表層提示法 / 分子標的医薬品 Less

Drug Design: Helix-Loop-Helix peptide inhibitors of intracellular PTM-dependent PPIsPrincipal Investigator
- Principal Investigator
  
  藤原大佑
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Osaka Metropolitan University
A molecular design of molecular-targeting peptides (mid-size medicines) with cell membrane permeability.
- Principal Investigator
  
  Fujii Ikuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka Prefecture University
Development of the augmenting agent of cancer-specific immune responses and the inhibiter against the immune suppressive molecule for promoting cancer immunotherapy
- Principal Investigator
  
  Sugiura Kikuya
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Osaka Prefecture University
A method for generating molecular-targeting tools: Protein kinase-oriented library based on conformationally constrained peptidePrincipal Investigator
- Principal Investigator
  
  Fujiwara Daisuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Osaka Prefecture University
A novel methodology for generation of molecular-targeting drugs via directed evolution in combinatorial libraries of conformationally constrained peptides
- Principal Investigator
  
  Fujii Ikuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka Prefecture University

All 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] An immune-stimulatory helix-loop-helix peptide: selective inhibition of CTLA-4/B7 interaction.2020
- Author(s)
  Ramanayake Mudiyanselage TMR, Michigami M, Ye Z, Uyeda A, Inoue N, Sugiura K, Fujii I, Fujiwara D
- Journal Title
  
  ACS Chem Biol
  
  Volume: 15 Issue: 2 Pages: 360-368
- DOI
  10.1021/acschembio.9b00743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05044, KAKENHI-PROJECT-19H03529
[Journal Article] Identification and characterization of the first β-1,3- d -xylosidase from a gram-positive bacterium, Streptomyces sp. SWU102018
- Author(s)
  Phuengmaung Pornpimol、Fujiwara Daisuke、Sukhumsirichart Wasana、Sakamoto Tatsuji
- Journal Title
  
  Enzyme and Microbial Technology
  
  Volume: 112 Pages: 72-78
- DOI
  10.1016/j.enzmictec.2017.11.002
- NAID
  120006543800
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Journal Article] ポスト抗体医薬品：立体構造規制ペプチド「マイクロ抗体」を土台とした中分子創薬2018
- Author(s)
  藤原大佑、弓場英司、白石一乗、中瀬生彦、藤井郁雄
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 28 Pages: 83-87
- NAID
  130007826451
- Data Source
  KAKENHI-PROJECT-16H01882
[Journal Article] Generation of Molecular-Targeting Peptides for Protein Kinases: A Phage-Displayed Library of Helix-Loop-Helix Peptides conjugated with Adenosine2017
- Author(s)
  Daisuke Fujiwara, Kousuke Mihara, Yusuke Nakamura, Takeshi Tsumuraya, and Ikuo Fujii
- Journal Title
  
  Peptide Science
  
  Volume: 2016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870503
[Journal Article] Macrocyclization and labeling of helix-loop-helix peptide with intramolecular bis-thioether linkage.2016
- Author(s)
  Nishihara, T., Kitada, H., Fujiwara, D., Fujii, I.
- Journal Title
  
  Biopolymers
  
  Volume: 106 Pages: 415-421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01882
[Journal Article] ポスト抗体医薬品：高機能化分子標的ペプチドの設計と創出2016
- Author(s)
  藤原大佑，藤井郁雄
- Journal Title
  
  化学工業
  
  Volume: 67 Pages: 861-867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H01882
[Journal Article] Poly-arginine conjugated helix-loop-helix peptide as an inhibitor for p53-HDM2 Interaction2015
- Author(s)
  Shunsuke Inaura, Hidekazu Kitada, Masataka Michigami, Daisuke Fujiwara, Ikuhiko Nakase, Ikuo Fujii
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 259-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] The cyclized helix-loop-helix peptide as a molecular scaffold for the design of intracellular protein-protein interaction inhibitors2015
- Author(s)
  Daisuke Fujiwara, Hidekazu Kitada, Masahiro Oguri, Toshio Nishihara, Masataka Michigami, Kazunori Shiraishi, Eiji Yuba, Ikuhiko Nakase, Seiji Kodama, Kenji Kono, Sihyun Ham, Ikuo Fujii
- Journal Title
  
  Peptide Science
  
  Volume: 2015 Pages: 85-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] Design of helix-loop-helix peptide inhibitor for p53-HDM2 interaction2014
- Author(s)
  H. Kitada, M. Oguri, D. Fujiwara, I. Fujii
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 271-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] Molecular Design of Protein Kinase Inhibitors: Conjugation of ATP-Competitive Molecules with Kinase Surface-Targeted Peptides2014
- Author(s)
  R. Takayama, D. Fujiwara, and I. Fujii
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 313-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] Peptide-based immunoadsorbents: Molecular grafting of Ig/Fc-binding epitopes of Protein A onto a de novo-designedhelix-loop-helix peptide2014
- Author(s)
  K. Kawabata , H. Nagai , N. Konishi , D. Fujiwara, R. Sasaki, T. Ichikawa, I. Fujii
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 6 Pages: 1845-1849
- DOI
  10.1016/j.bmc.2014.01.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] Chemically Modified Phage-displayed Peptide Libraries: Tethering Biotin to the Displayed Peptides2013
- Author(s)
  Y. Nakamura, D. Fujiwara, and I. Fujii
- Journal Title
  
  Peptide Science
  
  Volume: 2013 Pages: 353-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] Phage Selection of Peptide “Microantibodies2013
- Author(s)
  D. Fujiwara and I. Fujii
- Journal Title
  
  Protocols in Chemical Biology
  
  Volume: 5 Issue: 3 Pages: 171-194
- DOI
  10.1002/9780470559277.ch130039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] Chemical Synthesis and Modification of Cyclic Helix-Loop-Helix Peptides by Click Chemistry and Intramolecular Bis-Thioether Linkage2013
- Author(s)
  T. Nishihara, H. Kitada, D. Fujiwara, and I. Fuji
- Journal Title
  
  Peptide Science
  
  Volume: 2013 Pages: 135-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242068
[Journal Article] The crystal structure of multidrug-resistance regulator RamR with multiple drugs2013
- Author(s)
  Yamasaki S, Nikaido E, Nakashima R, Sakurai K, Fujiwara D, Fujii I, Nishino K
- Journal Title
  
  Nature Comunications
  
  Volume: 4 Issue: 1 Pages: 1-7
- DOI
  10.1038/ncomms3078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370045, KAKENHI-PROJECT-25242068
[Patent] プロテインキナーゼ阻害剤2016
- Inventor(s)
  藤原大佑、藤井郁雄
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-01-19
- Data Source
  KAKENHI-PROJECT-26870503
[Presentation] Efficient intracellular delivery of cyclized helix-loop-helix peptide by conjugation of cell-penetrating peptides2018
- Author(s)
  Shunsuke Inaura, Hidekazu Kitada, Kazunori Zikihara, Masataka Michigami, Daisuke Fujiwara, Ikuhiko Nakase, Ikuo Fujii
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Fluorescent PPI-visualization of cyclized helix-loop-helix peptide "MicroAntibody" inhibiting intracellular HDM2-p53 interaction2018
- Author(s)
  Daisuke Fujiwara, Kazunori Zikihara, Shunsuke Inaura, Masataka Michigami, Eiji Yuba, Ikuhiko Nakase, Ikuo Fujii
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Conjugation of CPPs to cyclized helix-loop-helix peptides enhances the intracellulary inhibitory activity of p53-HDM2 interaction2018
- Author(s)
  Shunsuke Inaura, Hidekazu Kitada, Kazunori Zikihara, Masataka Michigami, Daisuke Fujiwara, Ikuhiko Nakase, Ikuo Fujii
- Organizer
  2018 6th TKU-OPU-HCMUT-DLU-TNU Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] cysteine-mediated introduction of methyllysine and acetyllysine analogues to helix-loop-helix peptide2018
- Author(s)
  Sojiro Higashi, Daisuke Fujiwara, Ikuo Fujii
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] プロテインキナーゼ指向型ファージ表層提示ペプチドライブラリーの構築2018
- Author(s)
  Daisuke Fujiwara, Kosuke Mihara, Yusuke Nakamura, Ikuo Fujii
- Organizer
  36th メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Cyclized Helix-Loop-Helix Peptide “Microantibody” as a Molecular Scaffold for Inhibitors against Protein-Protein Interactions2018
- Author(s)
  Daisuke Fujiwara
- Organizer
  E.T. Kaiser Memorial Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Generation of helix-loop-helix peptide inhibitor of the interaction between human CTLA-4 and B72018
- Author(s)
  Tharanga Madhushani Ramanayake, Daisuke Fujiwara, Masataka Michigami, Kikuya Sugiura, Ikuo Fujii
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Generation of Helix-Loop-Helix peptide inhibitor of the interaction between human -CTLA-4 and B72018
- Author(s)
  R.M.T.M. Ramanayake, D. Fujiwara, M. Michigam, K. Sugiura, I. Fujii
- Organizer
  第10回国際ペプチドシンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05044
[Presentation] ポスト抗体医薬品：立体構造規制ペプチド「マイクロ抗体」を土台とした中分子創薬2017
- Author(s)
  藤原大佑，道上雅孝，弓場英司，白石一乗，児玉靖司，中瀬生彦，Sihyun Ham，藤井郁雄
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Rational Design of KRAS-SOS1 Interaction Inhibitor Using Helix-Loop-Helix Peptide Scaffold2017
- Author(s)
  Kousuke Mihara, Daisuke Fujiwara, and Ikuo Fujii
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] A Helix-Loop-Helix Peptide Inhibiting Intracellular p53-HDM2 Interaction: A Role of Poly ARG in Non-Interacting Surface of the N-Terminal Helix2017
- Author(s)
  Shunsuke Inaura, Hidekazu Kitada, Kazunori Zikihara, Daisuke Fujiwara, Ikuo Fujii
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16H01882
[Presentation] Generation of Molecular-Targeting Peptides for Protein Kinases: A Phage-Displayed Library of Helix-Loop-Helix Peptides conjugated with Adenosine2016
- Author(s)
  Daisuke Fujiwara, Kousuke Mihara, Yusuke Nakamura, Takeshi Tsumuraya, and Ikuo Fujii
- Organizer
  第53回ペプチド討論会（日本ペプチド学会主催）
- Place of Presentation
  京都テルサ（京都府）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26870503
[Presentation] CYCLIZED HELIX-LOOP-HELIX PEPTIDE AS A MOLECULAR SCAFFOLD FOR THE DESIGN OF INTRACELLULAR PROTEIN-PROTEIN INTERACTION INHIBITORS2015
- Author(s)
  Daisuke Fujiwara, Hidekazu Kitada, Masahiro Oguri, Toshio Nishihara, Masataka Michigami, Kazunori Shiraishi, Eiji Yub, Ikuhiko Nakase, Seiji Kodama, Kenji Kono, Sihyun Ham, and Ikuo Fujii
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市中央公民館, 神奈川県
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-25242068
[Presentation] POLY-ARGININE CONJUGATED HELIX-LOOP-HELIX PEPTIDE AS A INHIBITOR FOR P53-HDM2 INTERACTION2015
- Author(s)
  Shunsuke Inaura1, Hidekazu Kitada, Masataka Michigami, Daisuke Fujiwara, Ikuhiko Nakase, Ikuo Fujii
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市中央公民館, 神奈川県
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-25242068
[Presentation] Molecular Design of Protien Kinase Inhibitors: Conjugation of ATP-Competitive Molecules with Kinase Surface-Targeted Peptides.2014
- Author(s)
  Ryo Takayama, Daisuke Fujiwara, Ikuo Fujii
- Organizer
  第51回ペプチド討論会（日本ペプチド学会）
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26870503
[Presentation] Chemical Modification of Peptide Libraries: Tethering Small Organic Compounds to Peptides on Phage Surface2013
- Author(s)
  Yusuke Nakamura, Daisuke Fujiwara, and Ikuo Fujii
- Organizer
  APIPS 2013 4th Asia-Pacific International Peptide Symposium
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25242068
[Presentation] CHEMICAL SYNTHESIS AND MODIFICATION OF CYCLIC HELIX-LOOP-HELIX PEPTIDES BY CLICK CHEMISTRY AND INTRAMOLECULAR BIS-THIOETHER LINKAGE2013
- Author(s)
  Toshio Nishhara, Hidekazu Kitada, Daisuke Fujiwara, Ikuo Fujii
- Organizer
  APIPS 2013 4th Asia-Pacific International Peptide Symposium
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25242068
[Presentation] マイクロ抗体：酵母１分子１細胞スクリーニングによる分子標的ペプチドの創出
- Author(s)
  藤原太佑，藤井郁雄
- Organizer
  第 66 回日本生物工学会大会
- Place of Presentation
  札幌コンベンションセンター，札幌
- Year and Date
  2014-09-09 – 2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-25242068
[Presentation] “MicroAntibodes”: Generation of Molecular-targeting Peptides by Directed Evolution in Conformationally Constrained Peptide libraries
- Author(s)
  Daisuke Fujiwara, Ikuo Fujii
- Organizer
  The 3rd Asian Chemical Biology Conference
- Place of Presentation
  Ngee Ann Kongsi Auditorium, National University of Singapore，Singapore
- Year and Date
  2014-12-15 – 2014-12-17
- Invited
- Data Source
  KAKENHI-PROJECT-25242068

1. Fujii Ikuo (70189984)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
2. TSUMURAYA Takeshi (00372855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Sugiura Kikuya (30171143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 道上雅孝 (60802428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 鳩谷晋吾 (40453138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 赤澤隆 (80359299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 弓場英司 (80582296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 植田光洋 (60566298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKASHIMA Ryosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujiwara Daisuke 藤原 大佑

藤原 大佑 フジワラ ダイスケ

FUJIWARA Daisuke 藤原 大佑

Research Projects

Research Products

Co-Researchers

Drug Design: Helix-Loop-Helix peptide inhibitors of intracellular PTM-dependent PPIsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A molecular design of molecular-targeting peptides (mid-size medicines) with cell membrane permeability.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the augmenting agent of cancer-specific immune responses and the inhibiter against the immune suppressive molecule for promoting cancer immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A method for generating molecular-targeting tools: Protein kinase-oriented library based on conformationally constrained peptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel methodology for generation of molecular-targeting drugs via directed evolution in combinatorial libraries of conformationally constrained peptides

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An immune-stimulatory helix-loop-helix peptide: selective inhibition of CTLA-4/B7 interaction.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and characterization of the first β-1,3- d -xylosidase from a gram-positive bacterium, Streptomyces sp. SWU102018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] ポスト抗体医薬品：立体構造規制ペプチド「マイクロ抗体」を土台とした中分子創薬2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Generation of Molecular-Targeting Peptides for Protein Kinases: A Phage-Displayed Library of Helix-Loop-Helix Peptides conjugated with Adenosine2017

Author(s)

Journal Title

Data Source

[Journal Article] Macrocyclization and labeling of helix-loop-helix peptide with intramolecular bis-thioether linkage.2016

Author(s)

Journal Title

Data Source

[Journal Article] ポスト抗体医薬品：高機能化分子標的ペプチドの設計と創出2016

Author(s)

Journal Title

Data Source

[Journal Article] Poly-arginine conjugated helix-loop-helix peptide as an inhibitor for p53-HDM2 Interaction2015

Author(s)

Journal Title

Data Source

[Journal Article] The cyclized helix-loop-helix peptide as a molecular scaffold for the design of intracellular protein-protein interaction inhibitors2015

Author(s)

Journal Title

Data Source

[Journal Article] Design of helix-loop-helix peptide inhibitor for p53-HDM2 interaction2014

Author(s)

Journal Title

Data Source

[Journal Article] Molecular Design of Protein Kinase Inhibitors: Conjugation of ATP-Competitive Molecules with Kinase Surface-Targeted Peptides2014

Author(s)

Journal Title

Data Source

Fujiwara Daisuke 藤原大佑

藤原大佑フジワラダイスケ

FUJIWARA Daisuke 藤原大佑