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Maruyama Takeshi  丸山 剛

ORCIDConnect your ORCID iD *help
Researcher Number 30613872
Other IDs
Affiliation (Current) 2025: 東京薬科大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help 2023: 東京薬科大学, 生命科学部, 教授
2021 – 2022: 早稲田大学, 高等研究所, 准教授(任期付)
2018 – 2020: 早稲田大学, 高等研究所, 講師(任期付)
2015 – 2017: 北海道大学, 遺伝子病制御研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields / Functional biochemistry
Except Principal Investigator
Biomedical engineering and related fields
Keywords
Principal Investigator
細胞競合 / がん / 細胞死 / 上皮細胞抗原提示認識 / 上皮細胞の免疫細胞様機能 / 細胞間コミュニケーション / 上皮細胞のMHC-I認識 / 細胞膜損傷 / 発がん制御 / 貪食様取込 … More / ゲノム編集 / 同種細胞間認識 / 上皮細胞間相互作用 / がん変異細胞排除 / 抗原提示変化 / 抗原提示 / がんの予防的治療 / がん変異細胞 / 上皮細胞 / 哺乳類細胞競合 … More
Except Principal Investigator
電子デバイス・機器 / 先端機能デバイス / マイクロ・ナノデバイス / ナノバイオ / 生体材料 / ナノインク / 含フッ素高分子 / 発熱 / 発光 / 共振周波数 / アンテナコイル / オプトジェネティクス / 光線力学療法 / 無線給電 / グラフェン / 自己展開 / インジェクタブルデバイス / インクジェット印刷 / 高分子ナノ薄膜 Less
  • Research Projects

    (5 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (12 People)
  •  超早期がん状態を投影する脳波シグナルの特定Principal Investigator

    • Principal Investigator
      丸山 剛
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Waseda University
  •  Immune cell-like functions of epithelial cells induced by MHC-I signalPrincipal Investigator

    • Principal Investigator
      Maruyama Takeshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
      Waseda University
  •  Epithelial cells recognize antigen presentation of transformed cellsPrincipal Investigator

    • Principal Investigator
      Maruyama Takeshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Waseda University
  •  Injectable, Developable and Operatable Nanosheet-Antenna in a Living Body

    • Principal Investigator
      Fujie Toshinori
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Biomedical engineering and related fields
    • Research Institution
      Tokyo Institute of Technology
      Waseda University
  •  Identification of genes related to signals from transformed cellsPrincipal Investigator

    • Principal Investigator
      Maruyama Takeshi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Functional biochemistry
    • Research Institution
      Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

  • [Journal Article] Epithelial recognition and elimination against aberrant cells2024

    • Author(s)
      Ayukawa Shiyu、Kamoshita Nagisa、Maruyama Takeshi
    • Journal Title

      Seminars in Immunopathology

      Volume: Online ahead of print. Issue: 4-6 Pages: 521-532

    • DOI

      10.1007/s00281-024-01001-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07107, KAKENHI-PROJECT-21H02768
  • [Journal Article] 上皮細胞によるMHC-I認識を介した異常監視2023

    • Author(s)
      鮎川志優, 丸山剛
    • Journal Title

      炎症と免疫

      Volume: 31 (2): Pages: 106-110

    • Data Source
      KAKENHI-PROJECT-21H02768
  • [Journal Article] MHC-I受容体を媒介する細胞競合2023

    • Author(s)
      鮎川志優、丸山 剛
    • Journal Title

      炎症と免疫

      Volume: 31(2) Pages: 106-110

    • Data Source
      KAKENHI-PROJECT-21H02768
  • [Journal Article] Cell competition in vertebrates ? a key machinery for tissue homeostasis2022

    • Author(s)
      Maruyama Takeshi、Fujita Yasuyuki
    • Journal Title

      Current Opinion in Genetics & Development

      Volume: 72 Pages: 15-21

    • DOI

      10.1016/j.gde.2021.09.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-21H02768
  • [Journal Article] 上皮細胞によるMHC-I認識とがん変異細胞を排除する細胞競合2022

    • Author(s)
      鮎川志優、丸山 剛
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 78 (1) Pages: 104-110

    • Data Source
      KAKENHI-PROJECT-21H02768
  • [Journal Article] Epithelial cells remove precancerous cells by cell competition via MHC class I?LILRB3 interaction2021

    • Author(s)
      Ayukawa Shiyu、Kamoshita Nagisa、Nakayama Jun、Teramoto Ryohei、Pishesha Novalia、Ohba Kenji、Sato Nanami、Kozawa Kei、Abe Hikari、Semba Kentaro、Goda Nobuhito、Fujita Yasuyuki、Maruyama Takeshi
    • Journal Title

      Nature Immunology

      Volume: 22 Issue: 11 Pages: 1391-1402

    • DOI

      10.1038/s41590-021-01045-6

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07345, KAKENHI-PROJECT-21K07107, KAKENHI-PROJECT-21H02768
  • [Journal Article] ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes?2021

    • Author(s)
      Takayanagi Saki、Watanabe Kengo、Maruyama Takeshi、Ogawa Motoyuki、Morishita Kazuhiro、Soga Mayumi、Hatta Tomohisa、Natsume Tohru、Hirano Tomoya、Kagechika Hiroyuki、Hattori Kazuki、Naguro Isao、Ichijo Hidenori
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 22009-22009

    • DOI

      10.1038/s41598-021-01123-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H04760, KAKENHI-PROJECT-20J14731, KAKENHI-PROJECT-21K06464, KAKENHI-PROJECT-21H02768
  • [Journal Article] The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia2020

    • Author(s)
      Sato Nanami、Yako Yuta、Maruyama Takeshi、Ishikawa Susumu、Kuromiya Keisuke、Tokuoka Suzumi M.、Kita Yoshihiro、Fujita Yasuyuki
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 132-132

    • DOI

      10.1038/s42003-020-0847-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19J10318, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675
  • [Journal Article] ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition2020

    • Author(s)
      Maruyama Takeshi、Sasaki Ayana、Iijima Sayuri、Ayukawa Shiyu、Goda Nobuhito、Tazuru Keisuke、Hashimoto Norikazu、Hayashi Takashi、Kozawa Kei、Sato Nanami、Ishikawa Susumu、Morita Tomoko、Fujita Yasuyuki
    • Journal Title

      iScience

      Volume: 23 Issue: 7 Pages: 101327-101327

    • DOI

      10.1016/j.isci.2020.101327

    • NAID

      120006979756

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21411, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675, KAKENHI-PROJECT-19K23929
  • [Journal Article] Graphene/Au Hybrid Antenna Coil Exfoliated with Multi‐Stacked Graphene Flakes for Ultra‐Thin Biomedical Devices2019

    • Author(s)
      Tetsu Yuma、Kido Yusuke、Hao Meiting、Takeoka Shinji、Maruyama Takeshi、Fujie Toshinori
    • Journal Title

      Advanced Electronic Materials

      Volume: 6 Issue: 2 Pages: 1901143-1901143

    • DOI

      10.1002/aelm.201901143

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05469, KAKENHI-PROJECT-18H03539, KAKENHI-PROJECT-17K20116, KAKENHI-PROJECT-18H02675
  • [Journal Article] Accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cells2018

    • Author(s)
      Mikio Takagi, Masaya Ikegawa, Takashi Shimada, Susumu Ishikawa, Mihoko Kajita, Takeshi Maruyama, Tomoko Kamasaki, Yasuyuki Fujita
    • Journal Title

      Genes to Cells

      Volume: 23 (11) Issue: 11 Pages: 974-981

    • DOI

      10.1111/gtc.12643

    • NAID

      120006734160

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15589, KAKENHI-ORGANIZER-26114001, KAKENHI-PLANNED-26114008, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675
  • [Journal Article] The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation2018

    • Author(s)
      Kasai Nobuhiro、Kadeer Ailijiang、Kajita Mihoko、Saitoh Sayaka、Ishikawa Susumu、Maruyama Takeshi、Fujita Yasuyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2097-2097

    • DOI

      10.1038/s41598-018-20146-1

    • NAID

      120006456414

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-26114001, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-16K19571, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-18H02675
  • [Journal Article] Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells2017

    • Author(s)
      Maruyama T, Saitoh S, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M and Fujita Y
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 114 Issue: 12 Pages: 3157-3162

    • DOI

      10.1073/pnas.1701746114

    • NAID

      120006346108

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05990
  • [Patent] 細胞競合の促進のための医薬組成物2019

    • Inventor(s)
      丸山 剛
    • Industrial Property Rights Holder
      丸山 剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18H02675
  • [Patent] 細胞競合の抑制のための医薬組成物2019

    • Inventor(s)
      丸山 剛
    • Industrial Property Rights Holder
      丸山 剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18H02675
  • [Patent] 印刷式インジェクタブルデバイス2017

    • Inventor(s)
      藤枝俊宣, 鉄 祐磨, 小久保奈々, 武岡真司, 丸山 剛
    • Industrial Property Rights Holder
      早稲田大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-221880
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-17K20116
  • [Presentation] Epithelial surveillance and elimination of precancerous cells2023

    • Author(s)
      丸山 剛
    • Organizer
      東京工業大学 国際シンポジウム
    • Data Source
      KAKENHI-PROJECT-21H02768
  • [Presentation] 上皮細胞相互作用による非免疫系を介した異常細胞の排除促進制御2022

    • Author(s)
      丸山 剛
    • Organizer
      BioJapan2022
    • Data Source
      KAKENHI-PROJECT-21H02768
  • [Presentation] MHC-I認識による上皮細胞間コミュニケーション制御2020

    • Author(s)
      鮎川志優, 寺本龍平, 鴨下渚, 丸山剛
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02675
  • [Presentation] がん変異細胞排除のためのMHC-I/AltR相互作用を介した上皮細胞の偏向性移動2020

    • Author(s)
      寺本龍平,鮎川志優,鴨下渚,丸山剛
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02675
  • 1.  Fujie Toshinori (70538735)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  太田 宏之 (20535190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  関口 寛人 (00580599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  瀬戸川 将 (30760508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  大川 宜昭 (80416651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  大庭 賢二 (20759576)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  河野 恵子 (30632723)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  GODA Nobuhito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  釜崎 とも子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  一條 秀憲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  鴨下 渚
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  藤田 恭之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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