Maruyama Takeshi 丸山剛

Researcher Number	30613872
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2023: 東京薬科大学, 生命科学部, 教授 2021 – 2022: 早稲田大学, 高等研究所, 准教授(任期付) 2018 – 2020: 早稲田大学, 高等研究所, 講師(任期付) 2015 – 2017: 北海道大学, 遺伝子病制御研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields / Functional biochemistry Except Principal Investigator Biomedical engineering and related fields
Keywords	Principal Investigator 細胞競合 / がん / 細胞死 / 上皮細胞抗原提示認識 / 上皮細胞の免疫細胞様機能 / 細胞間コミュニケーション / 上皮細胞のMHC-I認識 / 細胞膜損傷 / 発がん制御 / 貪食様取込 … More / ゲノム編集 / 同種細胞間認識 / 上皮細胞間相互作用 / がん変異細胞排除 / 抗原提示変化 / 抗原提示 / がんの予防的治療 / がん変異細胞 / 上皮細胞 / 哺乳類細胞競合 … More Except Principal Investigator 電子デバイス・機器 / 先端機能デバイス / マイクロ・ナノデバイス / ナノバイオ / 生体材料 / ナノインク / 含フッ素高分子 / 発熱 / 発光 / 共振周波数 / アンテナコイル / オプトジェネティクス / 光線力学療法 / 無線給電 / グラフェン / 自己展開 / インジェクタブルデバイス / インクジェット印刷 / 高分子ナノ薄膜 Less

超早期がん状態を投影する脳波シグナルの特定Principal Investigator
- Principal Investigator
  
  丸山剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Waseda University
Immune cell-like functions of epithelial cells induced by MHC-I signalPrincipal Investigator
- Principal Investigator
  
  Maruyama Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Waseda University
Epithelial cells recognize antigen presentation of transformed cellsPrincipal Investigator
- Principal Investigator
  
  Maruyama Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Waseda University
Injectable, Developable and Operatable Nanosheet-Antenna in a Living Body
- Principal Investigator
  
  Fujie Toshinori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biomedical engineering and related fields
- Research Institution
  Tokyo Institute of Technology
  Waseda University
Identification of genes related to signals from transformed cellsPrincipal Investigator
- Principal Investigator
  
  Maruyama Takeshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Epithelial recognition and elimination against aberrant cells2024
- Author(s)
  Ayukawa Shiyu、Kamoshita Nagisa、Maruyama Takeshi
- Journal Title
  
  Seminars in Immunopathology
  
  Volume: Online ahead of print. Issue: 4-6 Pages: 521-532
- DOI
  10.1007/s00281-024-01001-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07107, KAKENHI-PROJECT-21H02768
[Journal Article] 上皮細胞によるMHC-I認識を介した異常監視2023
- Author(s)
  鮎川志優, 丸山剛
- Journal Title
  
  炎症と免疫
  
  Volume: 31 (2): Pages: 106-110
- Data Source
  KAKENHI-PROJECT-21H02768
[Journal Article] MHC-I受容体を媒介する細胞競合2023
- Author(s)
  鮎川志優、丸山剛
- Journal Title
  
  炎症と免疫
  
  Volume: 31(2) Pages: 106-110
- Data Source
  KAKENHI-PROJECT-21H02768
[Journal Article] Cell competition in vertebrates ? a key machinery for tissue homeostasis2022
- Author(s)
  Maruyama Takeshi、Fujita Yasuyuki
- Journal Title
  
  Current Opinion in Genetics & Development
  
  Volume: 72 Pages: 15-21
- DOI
  10.1016/j.gde.2021.09.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-21H02768
[Journal Article] 上皮細胞によるMHC-I認識とがん変異細胞を排除する細胞競合2022
- Author(s)
  鮎川志優、丸山剛
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 78 (1) Pages: 104-110
- Data Source
  KAKENHI-PROJECT-21H02768
[Journal Article] Epithelial cells remove precancerous cells by cell competition via MHC class I?LILRB3 interaction2021
- Author(s)
  Ayukawa Shiyu、Kamoshita Nagisa、Nakayama Jun、Teramoto Ryohei、Pishesha Novalia、Ohba Kenji、Sato Nanami、Kozawa Kei、Abe Hikari、Semba Kentaro、Goda Nobuhito、Fujita Yasuyuki、Maruyama Takeshi
- Journal Title
  
  Nature Immunology
  
  Volume: 22 Issue: 11 Pages: 1391-1402
- DOI
  10.1038/s41590-021-01045-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07345, KAKENHI-PROJECT-21K07107, KAKENHI-PROJECT-21H02768
[Journal Article] ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes?2021
- Author(s)
  Takayanagi Saki、Watanabe Kengo、Maruyama Takeshi、Ogawa Motoyuki、Morishita Kazuhiro、Soga Mayumi、Hatta Tomohisa、Natsume Tohru、Hirano Tomoya、Kagechika Hiroyuki、Hattori Kazuki、Naguro Isao、Ichijo Hidenori
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 22009-22009
- DOI
  10.1038/s41598-021-01123-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04760, KAKENHI-PROJECT-20J14731, KAKENHI-PROJECT-21K06464, KAKENHI-PROJECT-21H02768
[Journal Article] The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia2020
- Author(s)
  Sato Nanami、Yako Yuta、Maruyama Takeshi、Ishikawa Susumu、Kuromiya Keisuke、Tokuoka Suzumi M.、Kita Yoshihiro、Fujita Yasuyuki
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 132-132
- DOI
  10.1038/s42003-020-0847-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19J10318, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675
[Journal Article] ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition2020
- Author(s)
  Maruyama Takeshi、Sasaki Ayana、Iijima Sayuri、Ayukawa Shiyu、Goda Nobuhito、Tazuru Keisuke、Hashimoto Norikazu、Hayashi Takashi、Kozawa Kei、Sato Nanami、Ishikawa Susumu、Morita Tomoko、Fujita Yasuyuki
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 7 Pages: 101327-101327
- DOI
  10.1016/j.isci.2020.101327
- NAID
  120006979756
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21411, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675, KAKENHI-PROJECT-19K23929
[Journal Article] Graphene/Au Hybrid Antenna Coil Exfoliated with Multi‐Stacked Graphene Flakes for Ultra‐Thin Biomedical Devices2019
- Author(s)
  Tetsu Yuma、Kido Yusuke、Hao Meiting、Takeoka Shinji、Maruyama Takeshi、Fujie Toshinori
- Journal Title
  
  Advanced Electronic Materials
  
  Volume: 6 Issue: 2 Pages: 1901143-1901143
- DOI
  10.1002/aelm.201901143
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05469, KAKENHI-PROJECT-18H03539, KAKENHI-PROJECT-17K20116, KAKENHI-PROJECT-18H02675
[Journal Article] Accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cells2018
- Author(s)
  Mikio Takagi, Masaya Ikegawa, Takashi Shimada, Susumu Ishikawa, Mihoko Kajita, Takeshi Maruyama, Tomoko Kamasaki, Yasuyuki Fujita
- Journal Title
  
  Genes to Cells
  
  Volume: 23 (11) Issue: 11 Pages: 974-981
- DOI
  10.1111/gtc.12643
- NAID
  120006734160
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15589, KAKENHI-ORGANIZER-26114001, KAKENHI-PLANNED-26114008, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PROJECT-18H03994, KAKENHI-PROJECT-18H02675
[Journal Article] The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation2018
- Author(s)
  Kasai Nobuhiro、Kadeer Ailijiang、Kajita Mihoko、Saitoh Sayaka、Ishikawa Susumu、Maruyama Takeshi、Fujita Yasuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2097-2097
- DOI
  10.1038/s41598-018-20146-1
- NAID
  120006456414
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-26114001, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-16K19571, KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PROJECT-18H02675
[Journal Article] Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells2017
- Author(s)
  Maruyama T, Saitoh S, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M and Fujita Y
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 114 Issue: 12 Pages: 3157-3162
- DOI
  10.1073/pnas.1701746114
- NAID
  120006346108
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05990
[Patent] 細胞競合の促進のための医薬組成物2019
- Inventor(s)
  丸山　剛
- Industrial Property Rights Holder
  丸山　剛
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02675
[Patent] 細胞競合の抑制のための医薬組成物2019
- Inventor(s)
  丸山　剛
- Industrial Property Rights Holder
  丸山　剛
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02675
[Patent] 印刷式インジェクタブルデバイス2017
- Inventor(s)
  藤枝俊宣, 鉄祐磨, 小久保奈々, 武岡真司, 丸山剛
- Industrial Property Rights Holder
  早稲田大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-221880
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K20116
[Presentation] Epithelial surveillance and elimination of precancerous cells2023
- Author(s)
  丸山　剛
- Organizer
  東京工業大学国際シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02768
[Presentation] 上皮細胞相互作用による非免疫系を介した異常細胞の排除促進制御2022
- Author(s)
  丸山　剛
- Organizer
  BioJapan2022
- Data Source
  KAKENHI-PROJECT-21H02768
[Presentation] MHC-I認識による上皮細胞間コミュニケーション制御2020
- Author(s)
  鮎川志優, 寺本龍平, 鴨下渚, 丸山剛
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02675
[Presentation] がん変異細胞排除のためのMHC-I/AltR相互作用を介した上皮細胞の偏向性移動2020
- Author(s)
  寺本龍平,鮎川志優,鴨下渚,丸山剛
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02675

1. Fujie Toshinori (70538735)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 太田宏之 (20535190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 関口寛人 (00580599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 瀬戸川将 (30760508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大川宜昭 (80416651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大庭賢二 (20759576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 河野恵子 (30632723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. GODA Nobuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 釜崎とも子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 一條秀憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鴨下渚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 藤田恭之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Maruyama Takeshi 丸山 剛

Research Projects

Research Products

Co-Researchers

超早期がん状態を投影する脳波シグナルの特定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune cell-like functions of epithelial cells induced by MHC-I signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epithelial cells recognize antigen presentation of transformed cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Injectable, Developable and Operatable Nanosheet-Antenna in a Living Body

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of genes related to signals from transformed cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Epithelial recognition and elimination against aberrant cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 上皮細胞によるMHC-I認識を介した異常監視2023

Author(s)

Journal Title

Data Source

[Journal Article] MHC-I受容体を媒介する細胞競合2023

Author(s)

Journal Title

Data Source

[Journal Article] Cell competition in vertebrates ? a key machinery for tissue homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 上皮細胞によるMHC-I認識とがん変異細胞を排除する細胞競合2022

Author(s)

Journal Title

Data Source

[Journal Article] Epithelial cells remove precancerous cells by cell competition via MHC class I?LILRB3 interaction2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes?2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Graphene/Au Hybrid Antenna Coil Exfoliated with Multi‐Stacked Graphene Flakes for Ultra‐Thin Biomedical Devices2019

Author(s)

Journal Title

Maruyama Takeshi 丸山剛