OCHI Tsunehiro 越智経浩

Researcher Number	30617840
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系臨床医学部門, 助教
Affiliation (based on the past Project Information) *help	2016 – 2023: 高知大学, 教育研究部医療学系基礎医学部門, 助教 2013: 高知大学, 医学部附属病院, その他 2011 – 2013: 高知大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 肝臓学 / XBP-1 / PNPLA3 mutation / PNPLA3 / NASH Except Principal Investigator NAFLD / NASH / 肝臓学 / 肝線維化 / RAGE … More / アポトーシス / miRNA / P.gingivalis / ＴＬＲ４ / ＴＬＲ２ / 貪食 / サイトカイン / Kupffer細胞 / サブセット / 分化 / 貪食能 / kupffer細胞 / マイクロアレイ / 肝細胞癌 Less

Elucidation of the mechanism of increased expression of RAGE in the development of NASH and development of liver fibrosis markers
- Principal Investigator
  
  Hirose Akira
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kochi University
The study for the pathogenesis of NASH using three kinds of PNPLA3 gene-modified micePrincipal Investigator
- Principal Investigator
  
  OCHI Tsunehiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Investigation of the pathogenetic factors for the development of NASH
- Principal Investigator
  
  ONO Masafumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Mechanisms involved in spontaneous development of hepatocellular carcinoma in mouse model of non-alcoholic steatohepatitis
- Principal Investigator
  
  SAIBARA Toshiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University

All 2018 2017 2016 2013 2012 2011 2009 Other

All Journal Article Presentation Book

[Book] 消化器疾患最新の治療2017-20182017
- Author(s)
  越智経浩／西原利治
- Total Pages
  504
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-16K19351
[Book] Mebio2016
- Author(s)
  越智経浩／小野正文／西原利治
- Total Pages
  108
- Publisher
  メジカルレビュー社
- Data Source
  KAKENHI-PROJECT-16K19351
[Book] NAFLD/NASHの治療.先端医療シリーズ42消化器疾患の最新医療2012
- Author(s)
  小野正文,宗景玄祐,越智経浩,西原利治
- Publisher
  先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-23590979
[Book] 先端医療シリーズ42　消化器疾患の最新医療2012
- Author(s)
  小野正文，宗景玄祐，越智経浩，西原利治
- Publisher
  先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-23590979
[Journal Article] Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring2018
- Author(s)
  Oki Y, Ono M, Hyogo H, Ochi T, Munekage K, Nozaki Y, Hirose A, Masuda K, Mizuta H, Okamoto N, Saibara T
- Journal Title
  
  Eur J Gastroenterol Hepatol
  
  Volume: - Issue: 7 Pages: 797-805
- DOI
  10.1097/meg.0000000000001118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-16K19351
[Journal Article] Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS2017
- Author(s)
  Ochi T, Kawaguchi T, Nakahara T, Ono M, Noguchi S, Koshiyama Y, Munekage K, Murakami E, Hiramatsu A, Ogasawara M, Hirose A, Mizuta H, Masuda K, Okamoto N, Suganuma N, Chayama K, Yamaguchi M, Torimura T, Saibara T
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 10146-10146
- DOI
  10.1038/s41598-017-09256-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19351, KAKENHI-PUBLICLY-16H01266, KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-17K09429, KAKENHI-PROJECT-15H04256
[Journal Article] High fasting insulin concentrations may be a pivotal predictor for the severity of hepatic fibrosis beyond the glycemic status in non-alcoholic fatty liver disease patients before development of diabetes mellitus．2016
- Author(s)
  Masuda K，Noguchi S，Ono M，Ochi T，Munekage K，Okamoto N，Suganuma N，Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: - Issue: 10 Pages: 983-990
- DOI
  10.1111/hepr.12832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-16K19351, KAKENHI-PROJECT-17K09429
[Journal Article] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.2016
- Author(s)
  Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 6 Pages: 584-592
- DOI
  10.1111/hepr.12587
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-25460315, KAKENHI-PROJECT-25460371, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-16K19351
[Journal Article] 非アルコール性脂肪肝炎(NASH)の診療2013
- Author(s)
  越智経浩,小野正文,西原利治他
- Journal Title
  
  臨床と研究
  
  Volume: 90(2) Pages: 53-57
- Data Source
  KAKENHI-PROJECT-23590979
[Journal Article] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic Fatty liver disease.2013
- Author(s)
  Hashiba M,Ono M,Okamoto N,Saibara T et.al
- Journal Title
  
  PLoS One
  
  Volume: 8(11) Issue: 11 Pages: e76161-e76161
- DOI
  10.1371/journal.pone.0076161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-25670369
[Journal Article] Hepatocyte destruction with enhanced collagen synthesis: Characteristic feature of chronic hepatitis C patients on haemodialysis2013
- Author(s)
  Ue, M., Ikebe, N., Munekage, K., Ochi, T., Hirose, A., Kataoka, H., Fujimoto, S., Kikuchi, K., Okuhara, Y., Ono, M.a , Saibara, T.
- Journal Title
  
  Journal of Viral Hepatitis
  
  Volume: 20(6) Issue: 5 Pages: 350-357
- DOI
  10.1111/jvh.12031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590601, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999
[Journal Article] Usefulness of Technetium-99m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease2012
- Author(s)
  Masuda K, Ono M, Fukumoto M, Hirose A, Munekage K, Ochi T, Okamoto N, Akagi N, Ogawa Y, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Issue: 3 Pages: 273-279
- DOI
  10.1111/j.1872-034x.2011.00923.x
- NAID
  10031144236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790650, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981
[Journal Article] Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis2011
- Author(s)
  Ono M, Ochi T, Munekage K, Ogasawara M, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Issue: 12 Pages: 1223-1229
- DOI
  10.1111/j.1872-034x.2011.00883.x
- NAID
  10031144201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22790650, KAKENHI-PROJECT-23590979
[Journal Article] Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis.2011
- Author(s)
  Ono M, Ochi T, Munekage K, Ogasawara M, Hirose A, Nozaki Y, Takahashi M, Okamoto N, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 1223-1229
- NAID
  10031144201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] EVALUATION OF IMPAIRED FATTY ACID OXIDATION CAPACITY BY DYNAMIC LIVER SCINTIGRAPHY WITH 1231-BMIPP IS IMPORTANT IN THE DEVELOPMENT OF NONALCOHOLIC FATTY LIVER DISEASE IN NON-OBESE PATIENTS2018
- Author(s)
  Yamamoto S, Ono M, Masuda K, Nagano S, Yano Y, Kitagawa T, Hashiba M, Ochi T, Munekage K, Hirose A, Mizuta H, Saibara T
- Organizer
  DDW2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19351
[Presentation] Involvement of PNPLA3 function for hepatic lipids metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice2017
- Author(s)
  Nagano S，Ono M，Ochi T，Munekage K，Yano Y，Mizuta H，Ogasawara M，Hirose A，Nozalki Y，Okamoto N，Iwasaki S，Jude A ObenT，Saibara T
- Organizer
  APDW 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19351
[Presentation] Functional roles of AGE-RAGE system for the development of hepatic fibrosis of NASH2017
- Author(s)
  Ono M，Munekage K，Ochi T，Hirose A，Ogasawara M，Okamoto N，Saibara T
- Organizer
  AASLD　THE LIVER MEETING 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19351
[Presentation] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH2016
- Author(s)
  Munegage K，Ono M，Ochi T，Ogasawara M，Hirose A，Fujimura Y ，Iwasaki S，Saibara T
- Organizer
  uegweek2016（24th United European Gastroenterology Week）
- Place of Presentation
  Austria Vienna（Austria Center Vienna）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-16K19351
[Presentation] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE2016
- Author(s)
  Ono M，Ochi T，Munegage K，Ogasawara M，Hirose A，Nozaki-Fujimura Y，Okamoto N， Iwasaki S，Oben J，Saibara T
- Organizer
  EASL（51th Annual Meeting of The European Association For The Study of The Liver）
- Place of Presentation
  Spain Barcelona（Fira Barcelona Gran Via）
- Year and Date
  2016-04-13
- Data Source
  KAKENHI-PROJECT-16K19351
[Presentation] 耐糖能異常からみたNAFLDの組織学的,生化学的特徴についての検討2013
- Author(s)
  越智経浩,宗景玄祐,小野正文
- Organizer
  第40回日本肝臓学会西部会, ワークショップ「NAFLD/NASHの病態と治療」
- Place of Presentation
  (長良川国際会議場・岐阜都ホテル)岐阜
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Glycemic variability is an indepe ndent predictive factor for developm ent of hepatic fibrosis in nonalcoho lic fatty liver disease2013
- Author(s)
  Ochi T, Hashiba M, Ono M, Hyogo H, I keda Y, Munekage K, Okamoto N, Iwasa ki S, Chayama K, Eguchi Y, Saibara T
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Poster,Walter E. Washington convention center(Washington USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease．2013
- Author(s)
  Ochi T,Ono M,Okamoto N,Saibara T et.al
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases 2013
- Place of Presentation
  Walter E. Washington convention center(Washington USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] 耐糖能異常からみたNAFLDの組織学的，生化学的特徴についての検討2013
- Author(s)
  越智経浩,小野正文　他
- Organizer
  第40回日本肝臓学会西部会
- Place of Presentation
  長良川国際会議場・岐阜都ホテル(岐阜)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Alcohol intake is less important as predictive factors for development of fatty liver dise ase compared to obesity,impairment o f glucose metabolism and dyslipidemia2012
- Author(s)
  Ono M,Eguchi Y,Hyogo H,Takahashi H,Ochi T,Munekage K,Hirose A,Tak ahashi M,Okamoto N,Fujimoto K,Cha yama K,Saibara T
- Organizer
  The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Poster Sessions,Hynes Convention Center(Boston USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Alcohol intake is less important as predictive factors for development of fatty liver dise ase compared to obesity,impairment o f glucose metabolism and dyslipidemia2012
- Author(s)
  Ono M,Eguchi Y,Hyogo H,Takahashi H,Ochi T,Munekage K,Hirose A,Tak ahashi M,Okamoto N,Fujimoto K,Cha yama K,Saibara T
- Organizer
  The 63rd Annual Meeting of the Am erican Association for the Study of Liver Diseases
- Place of Presentation
  Poster,Hynes Convention Center(Boston USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] エストロゲンによる非アルコール性脂肪性肝疾患と高尿酸血症に対する影響について2011
- Author(s)
  宗景玄祐，小野正文，越智経浩，小笠原光成，廣瀬享，他
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京　(ホテルグランパシフィックLE DAIBA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Angiotensinogen gene haplotype associate with the pr evalence of Japanese NASH2011
- Author(s)
  Ono M,Ochi T,Munekage K,Ogasawara M,Hirose A,Nozaki Y,Takahashi M,I wasaki S,Saibara T
- Organizer
  The 62nd Annual Meeting Of The American Association For The Study Of Liver Disease
- Place of Presentation
  Poster,Moscone Center West(San Francisco USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Angiotensinogen gene haplotype associate with the prevalence of Japanese NASH．2011
- Author(s)
  Ono M，Ochi T，Munekage K，Ogasawara M，Hirose A，Nozaki Y，Takahashi M，Shinji I，Saibara T
- Organizer
  The 62nd Annual Meeting Of The American Association For The Study Of Liver Disease
- Place of Presentation
  San Francisco, America ( Moscone Convention Center)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] NASH発症におけるPNPLA3(adiponutrin)遺伝子のERストレスへの役割について2011
- Author(s)
  小野正文,越智経浩,宗景玄祐
- Organizer
  第15回日本肝臓学会大会(JDDW 2011)シンポジウム「NASH発症の分子機構と治療標的」
- Place of Presentation
  (福岡国際センター他)福岡
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Angiotensinogen gene haplotype associate with the prevalence of Japanese NASH2011
- Author(s)
  Ono M,Ochi T,Munekage K,Ogasawara M,Hirose A,Nozaki Y,Takahashi M,I wasaki S,Saibara T
- Organizer
  The 62nd Annual Meeting Of The American Association For The Study Of Liver Disease
- Place of Presentation
  Poster,Moscone Center West(San Francisco USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] NASH発症におけるPNPLA3（adiponutrin）遺伝子のERストレスへの役割について2011
- Author(s)
  小野正文，越智経浩，宗景玄祐
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡 (福岡国際センター）
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Three single nucleo tide polymorphisms haplootype of ang iotensinogen gene associated with th e prevalence of Japanese NASH2011
- Author(s)
  Ono M,Ochi T,Munekage K,Ogasawara M,Hirose A,Nozaki -Fujimura Y,Tak ahashi M,Okamoto N,Iwasaki S,Eguc hi Y,Saibara T
- Organizer
  46th annual meeting of the European Assoc iation for the Study of the Liver
- Place of Presentation
  Poster,Internationales Congress Centrum(Berlin Germany)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Glycemic variability is an independent predictive factor for developm ent of hepatic fibrosis in nonalcoho lic fatty liver disease2011
- Author(s)
  Ochi T, Hashiba M, Ono M, Hyogo H, I keda Y, Munekage K, Okamoto N, Iwasa ki S, Chayama K, Eguchi Y, Saibara T
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Poster,Walter E. Washington convention center(Washington USA)
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] メタボリックシンドロームにおけるNASH線維化進展への影響2009
- Author(s)
  越智経浩
- Organizer
  第13回日本肝臓学会大会パネルディスカッション7 ;消化器疾患と生活習慣病
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590849
[Presentation] 75OGTT糖負荷テストから見たNASH患者における耐糖能異常の特徴と治療への展望
- Author(s)
  小野正文，越智経浩，宗景玄祐
- Organizer
  第39回日本肝臓学会西部会
- Place of Presentation
  岡山　(岡山コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-23590979
[Presentation] Three single nucleotide polymorphisms haplootype of angiotensinogen gene associated with the prevalence of Japanese NASH．
- Author(s)
  Ono M，Ochi T，Munekage K，Ogasawara M，Hirose A，Nozaki -Fujimura Y，Takahashi M，Okamoto N，Iwasaki S，Eguchi Y，Saibara T
- Organizer
  46th annual meeting of the European Association for the Study of the Liver
- Place of Presentation
  Berlin, Germany (ICC Berlin)
- Data Source
  KAKENHI-PROJECT-23590979

1. SAIBARA Toshiji (60145125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. MUNEKAGE Kensuke (60617843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
3. ONO Masafumi (70304681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
4. TODA Katsumi (40197893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Hirose Akira (30457395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KATAOKA Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. OKUHARA Yoshiyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 水田洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OCHI Tsunehiro 越智 経浩

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of increased expression of RAGE in the development of NASH and development of liver fibrosis markers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study for the pathogenesis of NASH using three kinds of PNPLA3 gene-modified micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the pathogenetic factors for the development of NASH

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms involved in spontaneous development of hepatocellular carcinoma in mouse model of non-alcoholic steatohepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 消化器疾患最新の治療2017-20182017

Author(s)

Total Pages

Publisher

Data Source

[Book] Mebio2016

Author(s)

Total Pages

Publisher

Data Source

[Book] NAFLD/NASHの治療.先端医療シリーズ42消化器疾患の最新医療2012

Author(s)

Publisher

Data Source

[Book] 先端医療シリーズ42 消化器疾患の最新医療2012

Author(s)

Publisher

Data Source

[Journal Article] Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High fasting insulin concentrations may be a pivotal predictor for the severity of hepatic fibrosis beyond the glycemic status in non-alcoholic fatty liver disease patients before development of diabetes mellitus．2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 非アルコール性脂肪肝炎(NASH)の診療2013

Author(s)

Journal Title

Data Source

[Journal Article] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic Fatty liver disease.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatocyte destruction with enhanced collagen synthesis: Characteristic feature of chronic hepatitis C patients on haemodialysis2013

Author(s)

Journal Title

DOI

Data Source

OCHI Tsunehiro 越智経浩

[Book] 先端医療シリーズ42　消化器疾患の最新医療2012