NAGASAKA KAZUNORI 長阪一憲

Researcher Number	30624233
Other IDs	https://orcid.org/0000-0002-0696-5175
Affiliation (Current)	2025: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 帝京大学, 医学部, 教授 2019: 帝京大学, 医学部, 准教授 2017 – 2019: 帝京大学, 医学部, 講師 2012 – 2016: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related / Basic Section 90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related / Nanobioscience / Basic Section 28050:Nano/micro-systems-related / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator 進行卵巣癌 / がん幹細胞 / 腹膜播種 / 卵巣癌 / 子宮頸癌 / 血液循環がん細胞 / 循環がん細胞 / 循環腫瘍細胞 / 婦人科癌 / がん幹細胞ニッチ … More / 血管新生 / 共培養モデル / 3次元培養 / 一細胞解析 / 腫瘍微小環境 / 卵巣癌腹水 / 新規腹膜播種阻害剤 / 単一細胞解析 / マイクロ流体デバイス / 微小環境 / 癌幹細胞 / STAT3/IL6経路 / Par3蛋白質 / IL6/STAT3経路 / 細胞極性 / STAT3 / prognosis / metastasis / ovarian cancer / cell polarity / Par3 / 国際情報交換 / ノンコーディングRNA / 転写物 / 発癌メカニズム / ヒトパピローマウイルス / 網羅的転写産物解析 / リン酸化機構 / 細胞極性決定因子 / 脱リン酸化酵素 / 転写産物 / 網羅的解析 / バイオマーカー / 細胞極性制御機構 … More Except Principal Investigator マイクロ流体デバイス / １細胞解析 / 1細胞解析 / フローサイトメトリー / 細胞診 / トランスクリプートム解析 / 誘電泳動 / トランスクリプトーム解析 / 単一細胞解析 / ゲノム工学 / セルソーター / リキッドバイオプシー / シリコン集積回路チップ / ヘルスリテラシー / ソーシャルネットワークサービス / ワクチン / ヒトパピローマウイルス / 子宮頚がん / 介入試験 / 男性 / ヘルスビリーフモデル / 知識 / ワクチン接種の意向 / 行動変容 / キャッチアップ / 子宮頚がん予防 / 大学生 / ワクチン接種 / ランダム化比較試験 / 子宮頸がん / HPVワクチン Less

Two-dimensional flow cytometry for cervical cancer screening
- Principal Investigator
  
  Kim SooHyeon
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
  Basic Section 90140:Medical technology assessment-related
  Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related
- Research Institution
  The University of Tokyo
婦人科がん患者体液中クラスター細胞のプロファイリング作成と転移メカニズムの解明Principal Investigator
- Principal Investigator
  
  長阪一憲
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Teikyo University
Development of a novel therapy targeting cancer stem cell nichesPrincipal Investigator
- Principal Investigator
  
  Nagasaka Kazunori
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Teikyo University
Research on improving health literacy in cervical cancer prevention using information and communication technology
- Principal Investigator
  
  Nomura Kyoko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Akita University
Development of a novel liquid biopsy platform by combining microfluidics and integrated circuits
- Principal Investigator
  
  KIM SooHyeon
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28050:Nano/micro-systems-related
- Research Institution
  The University of Tokyo
Microfluidic approach to single cell transcriptome analysis and its applications
- Principal Investigator
  
  FUJII Teruo
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Nanobioscience
- Research Institution
  The University of Tokyo
Analysis of Par3 complex in advanced and metastatic ovarian cancer and application of establishing a novel EMT inhibitorPrincipal Investigator
- Principal Investigator
  
  Kazunori Nagasaka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Teikyo University
  The University of Tokyo
Development of a biomarker in gynecologic cancer to predict outcome with abnormal expression of cell polarity molecules.Principal Investigator
- Principal Investigator
  
  NAGASAKA KAZUNORI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  The University of Tokyo

All 2023 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Book Other

[Book] 臨床検査ガイド20152015
- Author(s)
  長阪一憲矢野哲
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-24592506
[Book] 臨床検査ガイド2013-2014 ヒトパピローマウイルスDNA検査2013
- Author(s)
  長阪一憲　矢野哲
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-24592506
[Journal Article] The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.2019
- Author(s)
  Fukui S, Nagasaka K, Miyagawa Y, Kikuchi-Koike R, Kawata Y, Kanda R, Ichinose T, Sugihara T, Hiraike H, Wada-Hiraike O, Sasajima Y, Ayabe T
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 57 Pages: 5932-5948
- DOI
  10.18632/oncotarget.27219
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08709, KAKENHI-PROJECT-18K09248, KAKENHI-PROJECT-19K09834
[Journal Article] Role of concurrent transcervical resection and curettage (TCR+C) for detecting endometrial cancer2018
- Author(s)
  K. Nagasaka, Y. Matsumoto, K. Oda, M. Maruyama, M. Ikemura, T. Arimoto, K. Kawana, M. Fukayama, Y. Osuga, T. Fujii, Gynecologic Oncology Group, Endoscopic Surgery Group
- Journal Title
  
  Eur J Gyneacol Oncol
  
  Volume: 2 Pages: 265-270
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10705
[Journal Article] Polycystic Ovarian Morphology may be a Positive Prognostic Factor in Patients with Endometrial Cancer who Achieved Complete Remission after Fertility-Sparing Therapy with Progestin.2017
- Author(s)
  Fukui Y, Taguchi A, Adachi K, Sato M, Kawata A, Tanikawa M, Sone K, Mori M, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Osuga Y, Fujii T.
- Journal Title
  
  Asian Pac J Cancer Prev
  
  Volume: 18 Pages: 3111-3116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10705
[Journal Article] 性感染症の現状と治療の問題点　8. HPVワクチン2012
- Author(s)
  長阪一憲、川名敬
- Journal Title
  
  化学療法の領域 5月号
  
  Volume: 7 Pages: 97-104
- Data Source
  KAKENHI-PROJECT-24592506
[Journal Article] ヒトパピローマウイルスワクチンの効果2012
- Author(s)
  長阪一憲、川名敬
- Journal Title
  
  バムサジャーナル
  
  Volume: 2 Pages: 3-9
- NAID
  40019386632
- Data Source
  KAKENHI-PROJECT-24592506
[Presentation] 胎盤におけるTGF-β/Smads/UCHL5 axisでの血管新生制御の差違(Differential regulation of angiogenesis in TGF-β/Smads/UCHL5 axis in placenta)2023
- Author(s)
  Hashimoto Kei, Miyagawa Yuko, Takasaki Kazuki, Nakagawa Ippei, Koike Ryoko, Takahashi Yuko, Nishida Haruka, Ichinose Takayuki, Kihira Chikara, Sasamori Yukifumi, Ryo Eiji, Nagasaka Kazunori
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K09834
[Presentation] The detection of circulating tumor cells in gynecologic malignancies at our hospital2023
- Author(s)
  Kazuki Takasaki, Takayuki Ichinose, Haruka Nishida, Yuko Takahashi, Mana Hirano, Saya Watanabe, Takako Onodera, Kohei Takehara, Kosuke Miyakawa, Hiroka Tomiya, Haruko Hiraike, Kazunori Nagasaka
- Organizer
  日本産婦人科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09554
[Presentation] 子宮頸癌スクリーニングのためのマイクロ流体デバイス技術を用いたオンチップp16/Ki67二重免疫染色システムの開発(Development of on-chip p16/Ki67 double immunostaining system using microfluidic device technology for cervical cancer screening)(英語)2023
- Author(s)
  Hashimoto Kei, Miyagawa Yuko, Kumagai Tomoo, Koike Ryoko, Takahashi Yuko, Nishida Haruka, Ichinose Takayuki, Kihira Chikara, Hiraike Haruko, Kim Soo Hyeon, Nagasaka Kazunori
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K09834
[Presentation] 血液循環腫瘍細胞の多様性を解析するための誘電泳動を用いたマイクロ流体デバイスの開発(Electroactive microwell array device for the investigation of the diversity of circulating tumor cells)(英語)2023
- Author(s)
  杉谷善信, 長阪一憲, 藤井輝夫, キム・スーヒョン
- Organizer
  日本癌学会総会記事(0546-0476)82回 Page1579(2023.09)
- Data Source
  KAKENHI-PROJECT-19K09834
[Presentation] Electroactive microwell array device for the investigation of the diversity of circulating tumor cells2023
- Author(s)
  Yoshinobu Sugitani, Kazunori Nagasaka, Teruo Fujii, Soo Hyeon Kim
- Organizer
  日本癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09554
[Presentation] Comparison of the angiogenetic properties of ALDH1-positive and CD44-positive ovarian cancer stem-like cells using the three-dimensional co-culture system.2020
- Author(s)
  Kazunori Nagasaka, Yuko Miyagawa, Kaoru Yamawaki, Shiho Fukui, Ryoko Koike, Yoshiko Kawata, Ranka Kanda, Takeru Sugihara, Haruko Hiraike, Koichiro Kido, Takuya Ayabe
- Organizer
  第72回日本産科婦人科学会学術講演会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09834
[Presentation] Highly Efficient Trapping and Analysis of Rare Cells using an Electroactive Microwell Array with Barriers2017
- Author(s)
  Makoto Takeuchi, Kazunori Nagasaka
- Organizer
  第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10705
[Presentation] Introduction of HPV testing to improve cervical screening in Japan - A comparison of Japanese and foreign studies -2017
- Author(s)
  Kazunori Nagasaka
- Organizer
  AOGIN 2017 Tokyo Meeting (Asia-Oceania Research Organisation in Genital Infection and Neoplasia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10705
[Presentation] HIGHLY EFFICIENT TRAPPING AND ANALYSIS OF RARE CELLS USING AN ELECTROACTIVE MICROWELL ARRAY WITH BARRIERS2017
- Author(s)
  Makoto Takeuchi, Kazunori Nagasaka
- Organizer
  The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10705
[Presentation] Usefulness of transcervical resection (TCR) for differential diagnosis of malignant endometrial diseases2017
- Author(s)
  Kazunori Nagasaka
- Organizer
  18th APAGE Annual Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10705
[Presentation] Highly Efficient Trapping and Analysis of Rare Cells using an Electroactive Microwell Array with Barriers2017
- Author(s)
  M. Takeuchi, S. H. Kim, K. Nagasaka, M. Yoshida, Y. Kawata, K. Oda, T. Fujii
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-16H06328
[Presentation] Highly efficient trapping and analysis of rare cells using an electroactive microwell array with barriers2017
- Author(s)
  M. Takeuchi, S. H. Kim, K. Nagasaka, M. Yoshida, Y. Kawata, K. Oda and T. Fujii
- Organizer
  Proceedings of International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06328
[Presentation] Antitumor activity of MDM2 inhibitor DS-3032b and mTOR inhibitor Everolimus in clear cell carcinomas2017
- Author(s)
  Yoshiko Kawata, Kazunori Nagasaka
- Organizer
  第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10705
[Presentation] MDM2 inhibitor DS-3032b and mTOR inhibitor Everolimus exerts antitumor effect in ovarian and renal cell clear cell carcinomas2017
- Author(s)
  Yoshiko Kawata, Kazunori Nagasaka
- Organizer
  ASGO 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10705
[Presentation] CINから子宮頸癌への癌進展制御に関わるHPV由来の新規non-coding RNAの同定とその機能解析2014
- Author(s)
  田口歩、川名敬、長阪一憲、橋本浩介、西田晴香、井上知子、松本陽子、有本貴英、平池修、織田克利、大須賀穣、藤井知行
- Organizer
  日本産婦人科学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592506
[Presentation] HPV16 E6 interferes with hScrib regulation of ERK through protein phosphatase 1γ2013
- Author(s)
  Kazunori Nagasaka
- Organizer
  DNA Tumour Virus Meeting 2013
- Place of Presentation
  Birmingham, UK
- Data Source
  KAKENHI-PROJECT-24592506
[Presentation] Analysis of HPV-induced transcriptional network by deep-CAGE sequencing in different HPV16-positive cell-lines and cervical cancer specimens2013
- Author(s)
  Kazunori Nagasaka
- Organizer
  DNA Tumour Virus Meeting 2013
- Place of Presentation
  Birmingham, UK
- Data Source
  KAKENHI-PROJECT-24592506
[Presentation] 細胞極性決定因子hScribは脱リン酸化蛋白Protein phosphatase-1 gammaとの結合を介してERK系路を制御する2012
- Author(s)
  長阪一憲、川名敬、田口歩、清木孝之、山下亜紀、宮本雄一郎、曾根献文、松本陽子、平池修、織田克利、中川俊介、矢野哲、武谷雄二
- Organizer
  日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24592506
[Presentation] HPV検査と細胞診の臨床的意義：HPV life cycleの視点から
- Author(s)
  長阪一憲
- Organizer
  日本臨床細胞学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2014-11-02 – 2014-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-24592506
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1. Kim SooHyeon (80709189)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
2. Nomura Kyoko (40365987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FUJII Teruo (30251474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 長島健悟 (20510712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 平池春子 (30771258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 石川ひろの (40384846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 竹内武昭 (60453700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鈴木明日香 (20722482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 寺田幸弘 (10260431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 南園佐知子 (60567840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. PLESSY Charles (60391984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIKUCHI Ryoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. AYABE Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGASAKA KAZUNORI 長阪 一憲

Research Projects

Research Products

Co-Researchers

Two-dimensional flow cytometry for cervical cancer screening

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

婦人科がん患者体液中クラスター細胞のプロファイリング作成と転移メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel therapy targeting cancer stem cell nichesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on improving health literacy in cervical cancer prevention using information and communication technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel liquid biopsy platform by combining microfluidics and integrated circuits

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Microfluidic approach to single cell transcriptome analysis and its applications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Par3 complex in advanced and metastatic ovarian cancer and application of establishing a novel EMT inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a biomarker in gynecologic cancer to predict outcome with abnormal expression of cell polarity molecules.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 臨床検査ガイド20152015

Author(s)

Publisher

Data Source

[Book] 臨床検査ガイド2013-2014 ヒトパピローマウイルスDNA検査2013

Author(s)

Publisher

Data Source

[Journal Article] The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of concurrent transcervical resection and curettage (TCR+C) for detecting endometrial cancer2018

Author(s)

Journal Title

Data Source

[Journal Article] Polycystic Ovarian Morphology may be a Positive Prognostic Factor in Patients with Endometrial Cancer who Achieved Complete Remission after Fertility-Sparing Therapy with Progestin.2017

Author(s)

Journal Title

Data Source

[Journal Article] 性感染症の現状と治療の問題点 8. HPVワクチン2012

Author(s)

Journal Title

Data Source

[Journal Article] ヒトパピローマウイルスワクチンの効果2012

Author(s)

Journal Title

NAGASAKA KAZUNORI 長阪一憲

[Journal Article] 性感染症の現状と治療の問題点　8. HPVワクチン2012