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SAKAVE Jun-ichi  坂部 純一

Researcher Number 30631494
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8237-0472
Affiliation (based on the past Project Information) *help 2013 – 2015: 浜松医科大学, 医学部, 特任助教
2012 – 2015: 浜松医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Dermatology
Except Principal Investigator
Dermatology
Keywords
Principal Investigator
蛋白発現 / プロセシング / タンパク精製 / フィラグリン / 表皮バリア機能 / 蛋白のプロセシング / C末端領域結合タンパク / C末端領域の機能
Except Principal Investigator
アトピー性皮膚炎 / 皮膚バリア … More / フィラグリン / 蛋白 / 細胞・組織 / 発現制御 / 免疫学 / 表皮バリア / 皮膚バリア機能 / 接触性皮膚炎 / 天然保湿因子 / プロフィラグリン / 角化細胞 / カリクレイン / バリア / 角層 / 皮膚生理学 Less
  • Research Projects

    (5 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (8 People)
  •  Proteome analysis of stratum corneum from atopic dermatitis patients using non-invasive tape-stripping method.

    • Principal Investigator
      Tokura Yoshiki
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine
  •  プロフィラグリンのプロセシングにおけるC末領域の機能解析とガレクチン7の共同作用Principal Investigator

    • Principal Investigator
      坂部 純一
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Evaluation of percutaneous immune responses and role of natural moisturizing factor in filaggrin monomer transgenic mice

    • Principal Investigator
      IKEYA Shigeki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Significance of kallikrein-5 in the formation of filaggrin monomer

    • Principal Investigator
      TOKURA Yoshiki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Functional analysis of human profilaggrin C-terminus region: Identification of molecular mechanism in profilaggrin processingPrincipal Investigator

    • Principal Investigator
      SAKABE Jun-ichi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine

All 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CCL17 in patients with atopic dermatitis2015

    • Author(s)
      Ito T, Tatsuno K, Fujiyama T, Sakabe J, Tokura Y.
    • Journal Title

      Allergol. Int.

      Volume: 64 Issue: 2 Pages: 200-202

    • DOI

      10.1016/j.alit.2014.10.008

    • NAID

      130005290340

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461689, KAKENHI-PROJECT-26670524
  • [Journal Article] Leukoderma in patients with atopic dermatitis.2015

    • Author(s)
      Kuriyama S, Kasuya A, Fujiyama T, Tatsuno K, Sakabe J, Yamaguchi H, Ito T, Tokura Y
    • Journal Title

      J Dermatol

      Volume: 42 Issue: 2 Pages: 215-218

    • DOI

      10.1111/1346-8138.12746

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461655, KAKENHI-PROJECT-26670524
  • [Journal Article] Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.2015

    • Author(s)
      Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y:
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0125082-e0125082

    • DOI

      10.1371/journal.pone.0125082

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Journal Article] Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis.2015

    • Author(s)
      Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y
    • Journal Title

      PLoS One

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation2014

    • Author(s)
      Nakazawa S, Moriki M, Ikeya S, Sakabe J-I, Tokura Y
    • Journal Title

      J Dermatol

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659525
  • [Journal Article] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異と手掌皺亢進・尋常性魚鱗癬との関連.2014

    • Author(s)
      坂部 純一、 山口 隼人、 福家 辰樹、 池谷 茂樹、 神谷 浩二、 龍野 一樹、 戸倉 新樹
    • Journal Title

      日本小児皮膚科学会雑誌

      Volume: 33 Pages: 127-131

    • Data Source
      KAKENHI-PROJECT-25860944
  • [Journal Article] アトピー性皮膚炎患者におけるフィラグリン遺伝子変異と手掌皺亢進・尋常性魚鱗癬との関連2014

    • Author(s)
      坂部純一,山口隼人,福家辰樹,池谷茂樹,神谷浩二,龍野一樹,戸倉新樹
    • Journal Title

      日小皮会誌

      Volume: 33 Pages: 27-31

    • Data Source
      KAKENHI-PROJECT-26670524
  • [Journal Article] Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer2014

    • Author(s)
      Jun-Ichi Sakabe, Koji Kamiya, Hayato Yamaguchi, Shigeki Ikeya, Takahiro Suzuki, Masahiro Aoshima, Kazuki Tatsuno, Toshiharu Fujiyama, Masako Suzuki, Tsuyoshi Yatagai, Taisuke Ito, Toshiyuki Ojima, Yoshiki Tokura
    • Journal Title

      J Allergy Clin Immunol

      Volume: 134 Issue: 4 Pages: 957-960

    • DOI

      10.1016/j.jaci.2014.07.054

    • NAID

      40020962750

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25860944, KAKENHI-PROJECT-26670524, KAKENHI-PROJECT-26860877
  • [Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.2013

    • Author(s)
      Sakabe J, Yamamoto M, Hirakawa S, Motoyama A, Ohta I, Tatsuno K, Ito T, Kabashima K, Hibino T, Tokura Y
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Pages: 17179-17189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890082
  • [Journal Article] Second report of FLG R501X mutation in Japanese patients with atopic dermatitis2013

    • Author(s)
      Yamaguchi H, Tatsuno K, Sakabe J, Tokura Y.
    • Journal Title

      J Dermatol

      Volume: 40 Pages: 498-499

    • Data Source
      KAKENHI-PROJECT-24659525
  • [Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes2013

    • Author(s)
      Sakabe J, Yamamoto M, Hirakawa S, Motoyama A, Ohta I, Tatsuno K, Ito T, Kabashima K, Hibino T, Tokura Y.
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 17179-17189

    • Data Source
      KAKENHI-PROJECT-24659525
  • [Journal Article] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes2013

    • Author(s)
      Sakabe J, Yamamoto M, Hirakawa S, Motoyama A, Ohta I, Tatsuno K, Ito T, Kabashima K, Hibino T, Tokura Y
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 17179-17189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890082
  • [Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation2013

    • Author(s)
      Shinsuke Nakazawa
    • Journal Title

      Journal of Dermatology

      Volume: 41 Issue: 3 Pages: 230-231

    • DOI

      10.1111/1346-8138.12339

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860944, KAKENHI-PROJECT-26670524
  • [Journal Article] High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis2013

    • Author(s)
      Yamaguchi H, Kabashima-Kubo R, Bito T, Sakabe JI, Shimauchi T, Ito T, Hirakawa S, Hirasawa N, Ogasawara K, Tokura Y.
    • Journal Title

      J Dermatol Sci

      Volume: 72(3) Pages: 240-245

    • Data Source
      KAKENHI-PROJECT-24659525
  • [Journal Article] High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis.2013

    • Author(s)
      Yamaguchi H, Kabashima-Kubo R, Bito T, Sakabe JI, Shimauchi T, Ito T, Hirakawa S, Hirasawa N, Ogasawara K, Tokura Y
    • Journal Title

      J Dermatol Sci

      Volume: 73 Issue: 3 Pages: 240-245

    • DOI

      10.1016/j.jdermsci.2013.07.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659525, KAKENHI-PROJECT-25293399
  • [Journal Article] Second report of FLG R501X mutation in Japanese patients with atopic dermatitis.2013

    • Author(s)
      Yamaguchi H, Tatsuno K, Sakabe J, Tokura Y
    • Journal Title

      J Dermatol

      Volume: in press Issue: 6 Pages: 498-499

    • DOI

      10.1111/1346-8138.12133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659525
  • [Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency : Possible immunological state of the intrinsic type2012

    • Author(s)
      Kabashima-Kubo R, Nakamura M, Sakabe JI, Sugita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
    • Journal Title

      J Dermatol Sci

      Volume: 67 Pages: 37-43

    • Data Source
      KAKENHI-PROJECT-24659525
  • [Journal Article] Connexin 26 (GJB2) mutations in keratitis-ichthyosisdeafness (KID) syndrome presenting with squamous cell carcinoma2012

    • Author(s)
      Sakabe J-I, Yoshiki R, Sugita K, Haruyama S, Sawada Y, Kabashima R, Bito T, Nakamura M, Tokura Y
    • Journal Title

      J Dermatol

      Volume: (in press) Issue: 9 Pages: 814-815

    • DOI

      10.1111/j.1346-8138.2011.01414.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390328, KAKENHI-PROJECT-22659208, KAKENHI-PROJECT-24890082
  • [Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type2012

    • Author(s)
      Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
    • Journal Title

      J Dermatol Sci

      Volume: 67 Issue: 1 Pages: 37-43

    • DOI

      10.1016/j.jdermsci.2012.04.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390370, KAKENHI-PROJECT-23591662, KAKENHI-PROJECT-23659546, KAKENHI-PROJECT-23791245, KAKENHI-PROJECT-24390152, KAKENHI-PROJECT-24659525, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-24890082
  • [Journal Article] Atopic dermatitis presenting as generalized poikiloderma with filaggrin gene mutation

    • Author(s)
      Nakazawa S, Moriki M, Ikeya S, Sakabe J-I, Tokura Y.
    • Journal Title

      J Dermatol

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-24659525
  • [Presentation] アトピー性皮膚炎における発汗低下の指標:GCDFP15発現量の利用.2015

    • Author(s)
      神谷浩二,坂部純一,山口隼人,鈴木健晋,矢田貝 剛,青島正浩,伊藤泰介,戸倉新樹:
    • Organizer
      第265回日本皮膚科学会岡山地方会.
    • Place of Presentation
      岡山市
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Presentation] アトピー性皮膚炎における発汗低下の指標と機序:角層中GCDFP15量の利用.2015

    • Author(s)
      神谷浩二,坂部純一,山口隼人,鈴木健晋,矢田貝剛,青島正浩,伊藤泰介,戸倉新樹:
    • Organizer
      第114回日本皮膚科学会総会.
    • Place of Presentation
      横浜市
    • Year and Date
      2015-05-30
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Presentation] Gross cystic disease fluid protein 15 as a potential marker for decreased sweating in atopic dermatitis.2015

    • Author(s)
      Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, Ito T, Tokura Y:
    • Organizer
      45th Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Rotterdam, the Netherlands
    • Year and Date
      2015-09-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Presentation] アトピー性皮膚炎における発汗低下の指標としての角層GCDFP15.2015

    • Author(s)
      神谷浩二,坂部純一,山口隼人,鈴木健晋,矢田貝剛,青島正浩,伊藤泰介,戸倉新樹:
    • Organizer
      第2回汗と皮膚疾患の研究会.
    • Place of Presentation
      東京
    • Year and Date
      2015-08-08
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Presentation] Proteome analysis of stratum corneum from atopic dermatitis patients and GCDFP15 as a typical fruitful indicator for the disease condition.2015

    • Author(s)
      Sakabe J, Kamiya K, Tokura Y:
    • Organizer
      The 6th Annual Congress of Pan Asian-Pacific Skin Barrier Research Society [PAPSBRS].
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2015-12-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Presentation] Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer.2014

    • Author(s)
      Sakabe J, Kamiya K, Tokura Y
    • Organizer
      The 39th Annual Meeting of the Japanese Society for Investigative Dermatology.
    • Place of Presentation
      Suita, Japan
    • Year and Date
      2014-12-13
    • Data Source
      KAKENHI-PROJECT-26670524
  • [Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing2013

    • Author(s)
      Sakabe J, Yamamoto M, Motoyama A, Ohta I, Hirakawa S, Hibino T, Tokura Y.
    • Organizer
      2013 International Investigative Dermatology Meeting
    • Place of Presentation
      Edinburgh, United Kingdom
    • Data Source
      KAKENHI-PROJECT-24659525
  • [Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing.2013

    • Author(s)
      Jun-ichi Sakabe, Mami Yamamoto, Akira Motoyama, Isao Ohta, Satoshi Hirakawa, Toshihiko Hibino, Yoshiki Tokura
    • Organizer
      International Investigative Dermatology (IID) 2013
    • Place of Presentation
      Edinburgh
    • Data Source
      KAKENHI-PROJECT-24890082
  • [Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing2013

    • Author(s)
      Sakabe J, Yamamoto M, Motoyama A, Ohta I, Hirakawa S, Hibino T, Tokura Y
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      英国 エディンバラ
    • Data Source
      KAKENHI-PROJECT-24659525
  • [Presentation] Involvement of kallikrein-related peptidase 5 in profilaggrin processing2013

    • Author(s)
      Sakabe J, Yamamoto M, Motoyama A, Ohta I, Hirakawa S, Hibino T, Tokura Y
    • Organizer
      International Investigative Dermatology (IID) 2013
    • Place of Presentation
      Edinburgh
    • Data Source
      KAKENHI-PROJECT-24890082
  • [Presentation] Mandatory role of kallikrein 5 in profilaggrin maturation and possible association of its impairment with atopic dermatitis.2012

    • Author(s)
      Sakabe Jun-ichi
    • Organizer
      The 12th Kyungpook-Hamamatsu Joint Medical Symposium Hamamatsu Meeting
    • Place of Presentation
      Hamamatsu
    • Data Source
      KAKENHI-PROJECT-24890082
  • [Presentation] Co-localization of kallikrein5 and profilaggrin in keratohyalin granules and reduction of filaggrin monomers by kallikrein5 downmodulation.2012

    • Author(s)
      Sakabe Jun-ichi
    • Organizer
      The 37th Annual Meeting of the Japan Society for Investigative Dermatology (JSID)
    • Place of Presentation
      Naha
    • Data Source
      KAKENHI-PROJECT-24890082
  • [Presentation] Co-localization of kallikrein5 and profilaggrin in keratohyalin granules and reduction of filaggrin monomers by kallikrein5 downmodulation2012

    • Author(s)
      Sakabe J, Ohta I, Hirakawa S, Tokura Y.
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Naha, Japan
    • Data Source
      KAKENHI-PROJECT-24659525
  • [Presentation] Co-localization of kallikrein5 and profilaggrin in keratohyalin granules and reduction of filaggrin monomers by kallikrein5 downmodulation.

    • Author(s)
      Sakabe J, Ohta I, Hirakawa S, Tokura Y
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology.
    • Place of Presentation
      沖縄
    • Data Source
      KAKENHI-PROJECT-24659525
  • 1.  TOKURA Yoshiki (00172156)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 24 results
  • 2.  HIRAKAWA Satoshi (50419511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 3.  IKEYA Shigeki (40436936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  高橋 慶人
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  行 卓男
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  糟谷 啓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  中村 元信
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  小笠原 康悦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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