HARAYA YUKI 原矢佑樹

… Alternative Names

Haraya Yuki 原矢佑樹

TAKECHI YUKI 武知佑樹

武知佑樹タケチユウキ

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Researcher Number	30634604
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生化学部, 室長
Affiliation (based on the past Project Information) *help	2020 – 2023: 国立医薬品食品衛生研究所, 薬品部, 主任研究官 2012 – 2015: 姫路獨協大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Physical chemistry
Keywords	Principal Investigator 原子間力顕微鏡法 / 膜摂動 / 脂質膜 / 膜障害 / 膜通過 / 分子内架橋 / コンフォメーション / 細胞膜通過 / 膜活性ペプチド / 膜摂動力 / ドラッグデリバリー / 膜透過 / 細胞膜透過ペプチド … More Except Principal Investigator … More 膜透過 / 膜輸送 / NMR / 超精密解析 / 界面・表面物性 / 生物物理 Less

Elucidation and methodology development to unify the mechanisms for membrane penetration and disruption of membrane-active peptidesPrincipal Investigator
- Principal Investigator
  
  原矢佑樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Health Sciences
Unraveling membrane perturbation mechanisms and developing novel evaluation methods for controlling the function of cell-penetrating peptidesPrincipal Investigator
- Principal Investigator
  
  Haraya Yuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Health Sciences
Multinuclear Dynamic NMR of Diffusion and Transport of Popypeptides by Membrane Thermal Fluctuation
- Principal Investigator
  
  Okamura Emiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical chemistry
- Research Institution
  Himeji Dokkyo University

All 2024 2023 2022 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability2023
- Author(s)
  Takechi-Haraya Yuki、Ohgita Takashi、Usui Akiko、Nishitsuji Kazuchika、Uchimura Kenji、Abe Yasuhiro、Kawano Ryuji、Konaklieva Monika I.、Reimund Mart、Remaley Alan T.、Sato Yoji、Izutsu Ken-ichi、Saito Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 19396-19396
- DOI
  10.1038/s41598-023-46754-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06556, KAKENHI-PROJECT-23K06092, KAKENHI-PROJECT-21K15245
[Journal Article] Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E‐derived arginine‐rich amphipathic α‐helical peptides2022
- Author(s)
  Yuki Takechi‐Haraya, Takashi Ohgita, Mana Kotani, Hiroki Kono, Chihiro Saito, Hiroko Tamagaki‐Asahina, Kazuchika Nishitsuji, Kenji Uchimura, Takeshi Sato, Ryuji Kawano, Kumiko Sakai‐Kato, Ken‐ichi Izutsu and Hiroyuki Saito
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 4959-4959
- DOI
  10.1038/s41598-022-08876-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14337, KAKENHI-PROJECT-20K15982, KAKENHI-PROJECT-20K09605
[Journal Article] Regulation of Phospholipid Protrusion in the Cell Sized Vesicle by Hydrophobic Bisphenol A2015
- Author(s)
  Y. Takechi, Y. Shintani, D. Kimoto, and E. Okamura
- Journal Title
  
  Membrane
  
  Volume: 40 Pages: 38-45
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24550035
[Journal Article] Uptake of Sevoflurane Limited by the Presence of Cholesterol in the Lipid Bilayer Membrane: A Multinuclear Nuclear Magnetic Resonance Study2014
- Author(s)
  E. Okamura, Y. Takechi, and K. Aki
- Journal Title
  
  J. Oleo Sci.
  
  Volume: 63 Issue: 11 Pages: 1149-1157
- DOI
  10.5650/jos.ess14120
- NAID
  130004693947
- ISSN
  1345-8957, 1347-3352
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24550035
[Journal Article] Slow Tumbling but Large Protrusion of Phospholipids in the Cell Sized Giant Vesicle.2013
- Author(s)
  Takechi, Y., Saito, H., and Okamura, E
- Journal Title
  
  Chem. Phys. Lett
  
  Volume: 570 Pages: 136-140
- DOI
  10.1016/j.cplett.2013.03.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590046, KAKENHI-PROJECT-24550035, KAKENHI-PROJECT-25293006
[Journal Article] Physicochemical Mechanism for the Lipid Membrane Binding of Polyarginine: the Favorable Enthalpy Change with Structural Transition from Random Coil to α-Helix2012
- Author(s)
  Takechi, Y., Mizuguchi, C., Tanaka, M., Kawakami, T., Aimoto, S., Okamura, E., and Saito, H
- Journal Title
  
  Chem. Lett
  
  Volume: 41(10) Issue: 10 Pages: 1374-1376
- DOI
  10.1246/cl.2012.1374
- NAID
  10031120691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590046, KAKENHI-PROJECT-24550035
[Presentation] アポリポタンパク質E由来両親媒性ペプチドの細胞膜通過へ及ぼすコンフォメーション制限の影響2024
- Author(s)
  原矢佑樹, 扇田隆司, 臼井明子, 西辻和親, 内村健治, 阿部康弘, 川野竜司, Konaklieva Monika, Reimund Mart, Remaley Alan, 佐藤陽治, 伊豆津健一, 斎藤博幸
- Organizer
  日本薬学会年会第144年会
- Data Source
  KAKENHI-PROJECT-23K06092
[Presentation] 原子間力顕微鏡によるリポソームの特性解析とその応用2023
- Author(s)
  原矢佑樹
- Organizer
  第20回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-23K06092
[Presentation] Role of glycosaminoglycan interaction on direct cell membrane penetration of arginine-rich peptides2022
- Author(s)
  Yuki Takechi-Haraya
- Organizer
  Wakayama Medical University International Symposium on Japan-France Glycopathophysiology 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15982
[Presentation] キネティクスに基づく細胞へのオクタアルギニンの物理的膜透過メカニズム2015
- Author(s)
  武知(原矢)佑樹, 安岐健三, 通山由美, 原野雄一, 川上徹, 斎藤博幸, 岡村恵美子
- Organizer
  日本膜学会第３７年会
- Place of Presentation
  早稲田大学　西早稲田キャンパス（東京）
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] オクタアルギニンの物理的膜透過に関するリアルタイムin cell NMR研究2014
- Author(s)
  武知佑樹
- Organizer
  日本膜学会第36年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] 細胞サイズベシクル膜の揺らぎにあたえる疎水性物質やイオンの影響2013
- Author(s)
  武知佑樹
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学本郷キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] NMR核オーバーハウザー効果から見た細胞サイズベシクル中におけるリン脂質分子のダイナミクス2013
- Author(s)
  武知　佑樹
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学びわこくさつキャンパス（滋賀）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] 曲率の小さな細胞モデル膜中のリン脂質分子のダイナミクス2013
- Author(s)
  武知　佑樹
- Organizer
  日本膜学会第35年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] 疎水性物質による細胞サイズベシクル膜の揺らぎの抑制2013
- Author(s)
  武知佑樹
- Organizer
  膜シンポジウム2013
- Place of Presentation
  京都府立医科大学（京都）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] Physicochemical Mechanism for the Enhanced Ability of Lipid Membrane Penetration of Polyarginine2012
- Author(s)
  Yuki Takechi
- Organizer
  14th International Association of Colloid and Interface Scientists Conference
- Place of Presentation
  Sendai International Center, Sendai, Japan
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] 細胞サイズベシクルの高濃度調製と溶液NMRによる物性解析2012
- Author(s)
  武知　佑樹
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学薬学部記念講堂（京都）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] 細胞サイズベシクルの構造と動態に関する溶液NMR研究2012
- Author(s)
  武知　佑樹
- Organizer
  第35回溶液化学シンポジウム
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] カチオン性ポリペプチドと酸性脂質膜の相互作用解析―ポリペプチド-膜間相互作用に与えるアルギニンとリジンの影響―2012
- Author(s)
  武知　佑樹
- Organizer
  第62回日本薬学会近畿支部大会
- Place of Presentation
  武庫川女子大学（西宮）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] 溶液NMRを用いた細胞サイズベシクルの評価2012
- Author(s)
  武知　佑樹
- Organizer
  膜シンポジウム2012
- Place of Presentation
  神戸大学百年記念館（神戸）
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] Molecular Fluctuation of Lipids in Cell Sized Vesicles as Studied by NMR2012
- Author(s)
  Yuki Takechi
- Organizer
  The 6th International Symposium on Molecular Science of Fluctuations toward Biological Functions
- Place of Presentation
  Kyoto Terrsa, Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] Real Time in-Cell 19F NMR Spectroscopy on the Cell Membrane Permeation of Octaarginine
- Author(s)
  Y. Takechi, K. Aki, Y. Tohyama, T. Kawakami, H. Saito, and E. Okamura
- Organizer
  XXVIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Hyatt Regency Hotel, Dallas, Texas, USA
- Year and Date
  2014-08-24 – 2014-08-29
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] コレステロールによる麻酔剤セボフレンの取り込み制御に関する動的多核NMR研究
- Author(s)
  岡村恵美子、武知佑樹、安岐健三
- Organizer
  膜シンポジウム2014
- Place of Presentation
  神戸大学百年記念館（神戸）
- Year and Date
  2014-11-26 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24550035
[Presentation] In cell NMRによるオクタアルギニンペプチドの細胞内輸送のリアルタイム計測と速度論
- Author(s)
  武知佑樹、安岐健三、通山由美、川上徹、斎藤博幸、岡村恵美子
- Organizer
  第65回コロイドおよび界面化学討論会
- Place of Presentation
  東京理科大学（東京）
- Year and Date
  2014-09-03 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24550035

1. Okamura Emiko (00160705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. AKI KENZO (50714945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 斎藤博幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 朝比奈裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 田中将史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARAYA YUKI 原矢 佑樹

Haraya Yuki 原矢 佑樹

TAKECHI YUKI 武知 佑樹

武知 佑樹 タケチ ユウキ

Research Projects

Research Products

Co-Researchers

Elucidation and methodology development to unify the mechanisms for membrane penetration and disruption of membrane-active peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling membrane perturbation mechanisms and developing novel evaluation methods for controlling the function of cell-penetrating peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multinuclear Dynamic NMR of Diffusion and Transport of Popypeptides by Membrane Thermal Fluctuation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E‐derived arginine‐rich amphipathic α‐helical peptides2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Phospholipid Protrusion in the Cell Sized Vesicle by Hydrophobic Bisphenol A2015

Author(s)

Journal Title

Data Source

[Journal Article] Uptake of Sevoflurane Limited by the Presence of Cholesterol in the Lipid Bilayer Membrane: A Multinuclear Nuclear Magnetic Resonance Study2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Slow Tumbling but Large Protrusion of Phospholipids in the Cell Sized Giant Vesicle.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physicochemical Mechanism for the Lipid Membrane Binding of Polyarginine: the Favorable Enthalpy Change with Structural Transition from Random Coil to α-Helix2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] アポリポタンパク質E由来両親媒性ペプチドの細胞膜通過へ及ぼすコンフォメーション制限の影響2024

Author(s)

Organizer

Data Source

[Presentation] 原子間力顕微鏡によるリポソームの特性解析とその応用2023

Author(s)

Organizer

Data Source

[Presentation] Role of glycosaminoglycan interaction on direct cell membrane penetration of arginine-rich peptides2022

Author(s)

Organizer

Data Source

[Presentation] キネティクスに基づく細胞へのオクタアルギニンの物理的膜透過メカニズム2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] オクタアルギニンの物理的膜透過に関するリアルタイムin cell NMR研究2014

Author(s)

Organizer

Place of Presentation

HARAYA YUKI 原矢佑樹

Haraya Yuki 原矢佑樹

TAKECHI YUKI 武知佑樹

武知佑樹タケチユウキ