Otsuka Hirotada 大塚裕忠

… Alternative Names

大塚裕忠オオツカヒロタダ

OTSUKA Hirotada 大塚裕忠

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Researcher Number	30634844
Other IDs
Affiliation (Current)	2025: 日本獣医生命科学大学, 獣医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 日本獣医生命科学大学, 獣医学部, 准教授 2017 – 2018: 日本獣医生命科学大学, 獣医学部, 講師 2016: 昭和大学, 歯学部, 講師 2015: 昭和大学, 歯学部, 助教 2012 – 2013: 昭和大学, 歯学部, 助教
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 髄外造血 / 窒素含有型ビスホスホネート / 重症貧血マウスモデル / GCSF / 新規造血構造体 / シェーグレン症候群 / Klotho / リンパ球浸潤 / ヒスタミン / 加齢性炎症 … More / 唾液腺 / 脂肪関連リンパ組織 / 大網 / Cxcl12（SDF－１） / Nカドヘリン / VCAM-1 / Hisitidine decarboxylase / 造血サイトカイン / 胚子型ヘモグロビン / 造血前駆細胞 / 赤血球造血 / G-CSF / 肝臓 / 転写制御因子ＫＬＦ / HIF1a / 血リンパ節様構造 / ヘモグロビン発現制御因子 / 重症貧血 / 胚子ヘモグロビン Less

ヒスタミンをターゲットとした加齢性唾液腺内リンパ球浸潤の病態解明Principal Investigator
- Principal Investigator
  
  大塚裕忠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nippon Veterinary and Life Science University
The morphological and functional study of the newly discovered hematopoietic structure induced in a severely anemic mouse model.Principal Investigator
- Principal Investigator
  
  Otsuka Hirotada
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nippon Veterinary and Life Science University
The morphological and functional study of the newly discovered hematopoietic structure induced in a severely anemic mouse model.Principal Investigator
- Principal Investigator
  
  Otsuka Hirotada
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
The study of embryonic hemoglobin re-expression in adult mice.Principal Investigator
- Principal Investigator
  
  OTSUKA Hirotada
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University

All 2024 2023 2019 2018 2017 2016 2015 2013 2012

All Journal Article Presentation Book

[Book] 伴侶動物解剖生理学2015
- Author(s)
  大石元治、大塚裕忠、佐々木悠、鈴木武人、塚本篤士、松井利康
- Total Pages
  255
- Publisher
  緑書房
- Data Source
  KAKENHI-PROJECT-15K20367
[Book] The functional diversity of Kupffer cells. Handbook of Macrophage2012
- Author(s)
  Masanori Nakamura, Hirotada Otsuka, Hideki Yagi, Yasuo Endo
- Publisher
  NOVA Science Publishers
- Data Source
  KAKENHI-PROJECT-24890237
[Book] Extramedullary erythropoiesis in anemia. The New Frontiers in Research for Oral Cancer2012
- Author(s)
  Masanori Nakamura, Hirotada Otsuka, Hideki Yagi, Yasuo Endo
- Publisher
  MARUZEN PLANET
- Data Source
  KAKENHI-PROJECT-24890237
[Journal Article] Histamine deficiency inhibits lymphocyte infiltration in the submandibular gland of aged mice via increased anti-aging factor Klotho2023
- Author(s)
  Otsuka Hirotada、Nonaka Naoko、Nakamura Masanori、Soeta Satoshi
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 65 Issue: 3 Pages: 243-252
- DOI
  10.1016/j.job.2023.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09933
[Journal Article] Expression of receptor-type tumour endothelial marker 8 in carcinoma cells showing luminal progenitor-like phenotypes in canine mammary gland carcinomas2023
- Author(s)
  Mami Araki , Syunya Noguchi , Yoshiaki Kubo , Akiko Yasuda , Miki Koh , Hirotada Otsuka , Makoto Yokosuka , Satoshi Soeta
- Journal Title
  
  Journal of Comparative Pathology
  
  Volume: 200 Pages: 35-45
- DOI
  10.1016/j.jcpa.2022.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09933, KAKENHI-PROJECT-20K22964
[Journal Article] Decisive differences in the bone repair processes of the metaphysis and diaphysis in young mice2018
- Author(s)
  Inoue Satoshi、Otsuka Hirotada、Takito Jiro、Nakamura Masanori
- Journal Title
  
  Bone Reports
  
  Volume: 8 Pages: 1-8
- DOI
  10.1016/j.bonr.2017.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17089, KAKENHI-PROJECT-15K11022
[Journal Article] Nitrogen-containing bisphosphonate induced a newly discovered hematopoietic structure in the omentum of an anemic mouse model by stimulating G-CSF production.2017
- Author(s)
  Hirotada Otsuka, Hideki Yagi, Yasuo Endo, Satoshi Soeta, Naoko Nonaka, Masanori Nakamura.
- Journal Title
  
  Cell & Tissue Res.
  
  Volume: 367 Issue: 2 Pages: 297-309
- DOI
  10.1007/s00441-016-2525-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-15K11022
[Journal Article] Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing2017
- Author(s)
  Yamaguchi T, Hosomichi K, Yano K, Kim Y, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I
- Journal Title
  
  Hum Genome Variation
  
  Volume: 印刷中 Issue: 1 Pages: 17005-17005
- DOI
  10.1038/hgv.2017.5
- NAID
  120006891152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-15H02373, KAKENHI-PROJECT-15H05016, KAKENHI-PROJECT-26430195, KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-15K11051, KAKENHI-PROJECT-16K15782, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K19804, KAKENHI-PROJECT-17K17089, KAKENHI-PROJECT-25251043, KAKENHI-PROJECT-16K15843
[Journal Article] Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion2017
- Author(s)
  Takito J, Otsuka H, Inoue S, Kawashima T, Nakamura M
- Journal Title
  
  Biol Open
  
  Volume: 6 Issue: 7 Pages: 1104-1114
- DOI
  10.1242/bio.025460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11022, KAKENHI-PROJECT-17K17089
[Journal Article] Pulmonary platelet accumulation induced by catecholamines: its nvolvement in lipopolysaccharide-induced anaphylaxis-like shock.2017
- Author(s)
  Zhiqian Yu, Hiroko Saito, Hirotada Otsuka, Yosuke Shikama, Hiromi Funayama, Mai Sakai, Shigeo Murai, Masanori Nakamura, Takashi Yokochi, Haruhiko Takada, Shunji Sugawara, Yasuo Endo.
- Journal Title
  
  International Immunopharmacol
  
  Volume: 43 Pages: 40-53
- DOI
  10.1016/j.intimp.2016.11.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-16K11672, KAKENHI-PROJECT-15K11022, KAKENHI-PROJECT-17K17089, KAKENHI-PROJECT-16H07017
[Journal Article] New Experimental Anemic Model by Using a Nitrogen- Containing Bisphosphonate2017
- Author(s)
  Otsuka Hirotada, Nakamura Masanaori
- Journal Title
  
  Annals of Nutritional Disorders & Therapy
  
  Volume: 4 Issue: 2 Pages: 1-3
- DOI
  10.26420/annnutrdisordther.2017.1043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17089, KAKENHI-PROJECT-15K11022
[Journal Article] he expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate2016
- Author(s)
  Otsuka H, Takito J, Endo Y, Yagi H, Soeta S, Nonaka N, Nakamura M
- Journal Title
  
  BMC Hematol
  
  Volume: 16 Issue: 1 Pages: 4-4
- DOI
  10.1186/s12878-016-0041-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11022, KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-24592777
[Journal Article] Effect of minodronate, a nitrogen-containing bisphosphonate, on collagen-induced arthritis in mice2016
- Author(s)
  Hiroshi Arai, Hirotada Otsuka, Jiro Takito, Hhideki Yagi, Satoshi Inoue, Nobuaki Yanagisawa, Nnaoko Nonaka, Yasuo Endo, Masanori Nakamura
- Journal Title
  
  Cellular Immunology & Immunotherapeutics
  
  Volume: 1 Pages: 1-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20367
[Journal Article] Analysis of periapical alveolar bone resorption after the removal of interdental wire ligation2015
- Author(s)
  Kubono Y, Mayahara M, Otsuka H, Kataoka R, Takagi Y, Asari J, Nonaka N, Inoue M, Nakamura M
- Journal Title
  
  Ped Dent J
  
  Volume: 25 Issue: 1 Pages: 1-7
- DOI
  10.1016/j.pdj.2014.12.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11022, KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-24592777
[Presentation] ヒスタミンの欠損は、加齢に伴う唾液腺及び涙腺へのリンパ球浸潤を抑制する2024
- Author(s)
  大塚裕忠、黄美貴、野中直子、中村雅典、添田聡
- Organizer
  第１２９回日本解剖学会全国学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K09933
[Presentation] Histidine decarboxylase欠損は、抗老化因子Klotho発現を維持して加齢マウス顎下腺内リンパ球浸潤を抑制する2023
- Author(s)
  大塚裕忠、遠藤康男、大津浩、野中直子、中村雅典、添田聡
- Organizer
  第１２８回日本解剖学会全国学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K09933
[Presentation] ヒスタミン欠損マウスにおける造血・リンパ性器官の形態学的研究2019
- Author(s)
  大塚裕忠，角山優輔，遠藤康男，大津浩，中村雅典，添田聡
- Organizer
  第１２４回日本解剖学会全国学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 窒素含有型ビスホスホネートを用いた重症貧血マウスモデルの確立及び同モデルにおける造血動態の解析2018
- Author(s)
  大塚裕忠
- Organizer
  第１３７回昭和学士会
- Invited
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 髄外造血誘導におけるHistidine decarboxylaseの役割に関する研究2018
- Author(s)
  大塚裕忠，添田聡，大津浩，中村雅典，尼崎肇
- Organizer
  第１２３回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] マウス創傷治癒過程における局所的マクロファージ除去の影響2018
- Author(s)
  藤川芳織、井上知、滝戸次郎、大塚裕忠、中村雅典
- Organizer
  第１２３回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 2つの異なる扁平骨における骨修復過程の解析2018
- Author(s)
  井上知、藤川芳織、大塚裕忠、中村雅典
- Organizer
  第１２３回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 新規造血構造体形成時における大網組織造血微小環境の解析2017
- Author(s)
  大塚裕忠，中村雅典
- Organizer
  日本比較免疫学会
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 重症貧血マウスモデルの大網組織における造血関連因子の解析2017
- Author(s)
  大塚裕忠、中村雅典
- Organizer
  第１２２回日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K20367
[Presentation] Difference between bone repair process in scapula and calvaria2017
- Author(s)
  S Inoue, H Otsuka, M Nakamura
- Organizer
  65th Annual Meeting of the Japanese Association for Dental Research
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 肩甲骨および頭蓋骨における骨修復過程の比較2017
- Author(s)
  井上知、大塚裕忠、中村雅典
- Organizer
  第105回日本解剖学会関東支部学術集会
- Data Source
  KAKENHI-PROJECT-17K17089
[Presentation] 長骨骨幹部および骨端部における骨修復機構の比較2016
- Author(s)
  井上知、大塚裕忠、滝戸次郎、栁澤伸彰、野中直子、中村雅典
- Organizer
  第121回日本解剖学会
- Place of Presentation
  福島ビッグパレット
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15K20367
[Presentation] ミノドロネート投与によるコラーゲン誘導型関節炎モデルマウスへの影響2016
- Author(s)
  新井宏、大塚裕忠、滝戸次郎、井上知、栁澤伸彰、野中直子、中村雅典
- Organizer
  第121回日本解剖学会
- Place of Presentation
  福島ビッグパレット
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15K20367
[Presentation] 窒素含有型ビスホスホネートを用いた重症貧血マウスモデルにおける新規造血構造誘導機構の解析2016
- Author(s)
  大塚裕忠、中村雅典
- Organizer
  第121回日本解剖学会
- Place of Presentation
  福島ビッグパレット
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K20367
[Presentation] マウスに形成誘導された血リンパ節様構造における形態学的解析2013
- Author(s)
  大塚裕忠、中村雅典
- Organizer
  医学生物学電子顕微鏡技術学会第29回学術講演会
- Place of Presentation
  神奈川歯科大学
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] 成体マウスにおける胚子ヘモグロビン再発現について2013
- Author(s)
  大塚裕忠、中村雅典
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] 重症貧血マウスにおける胚子ヘモグロビン再発現の解析2013
- Author(s)
  大塚裕忠、中村雅典
- Organizer
  日本比較免疫学会第25回学術集会
- Place of Presentation
  岡山理科大学
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] マウスに形成誘導された血リンパ節様構造における形態学的解析2013
- Author(s)
  大塚裕忠
- Organizer
  医学生物学電子顕微鏡技術学会第２９回学術講演会
- Place of Presentation
  神奈川歯科大学
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] 成体マウスにおける胚子ヘモグロビンの再発現について2013
- Author(s)
  大塚裕忠
- Organizer
  第118回日本解剖学会総会・全国学術集会
- Place of Presentation
  かがわ国際会議場
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] 重症貧血マウスにおける胚子ヘモグロビン再発現の解析2013
- Author(s)
  大塚裕忠
- Organizer
  日本比較免疫学会第２５回学術集会
- Place of Presentation
  岡山理科大学
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] Definitive and primitive erythropoiesis can simultaneously occur in the adult mice2012
- Author(s)
  大塚裕忠、中村雅典
- Organizer
  第41回日本免疫学会総会・全国学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24890237
[Presentation] Definitive and primitive erythropoiesis can simultaneously occur in the adult mice2012
- Author(s)
  大塚裕忠
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24890237

1. 野中直子 (20307052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. Nakamura Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
3. Yagi Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Endo Yasuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. HOSOMICHI Kazuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otsuka Hirotada 大塚 裕忠

大塚 裕忠 オオツカ ヒロタダ

OTSUKA Hirotada 大塚 裕忠

Research Projects

Research Products

Co-Researchers

ヒスタミンをターゲットとした加齢性唾液腺内リンパ球浸潤の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The morphological and functional study of the newly discovered hematopoietic structure induced in a severely anemic mouse model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The morphological and functional study of the newly discovered hematopoietic structure induced in a severely anemic mouse model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of embryonic hemoglobin re-expression in adult mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 伴侶動物解剖生理学2015

Author(s)

Total Pages

Publisher

Data Source

[Book] The functional diversity of Kupffer cells. Handbook of Macrophage2012

Author(s)

Publisher

Data Source

[Book] Extramedullary erythropoiesis in anemia. The New Frontiers in Research for Oral Cancer2012

Author(s)

Publisher

Data Source

[Journal Article] Histamine deficiency inhibits lymphocyte infiltration in the submandibular gland of aged mice via increased anti-aging factor Klotho2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of receptor-type tumour endothelial marker 8 in carcinoma cells showing luminal progenitor-like phenotypes in canine mammary gland carcinomas2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decisive differences in the bone repair processes of the metaphysis and diaphysis in young mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nitrogen-containing bisphosphonate induced a newly discovered hematopoietic structure in the omentum of an anemic mouse model by stimulating G-CSF production.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pulmonary platelet accumulation induced by catecholamines: its nvolvement in lipopolysaccharide-induced anaphylaxis-like shock.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Experimental Anemic Model by Using a Nitrogen- Containing Bisphosphonate2017

Otsuka Hirotada 大塚裕忠

大塚裕忠オオツカヒロタダ

OTSUKA Hirotada 大塚裕忠