KOBAYASHI KENICHI 小林健一

… Alternative Names

KOBAYASHI Kenichi 小林健一

小林健一コバヤシケンイチ

Kobayashi Kenichi 小林健一

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Researcher Number	30639282
Other IDs
Affiliation (Current)	2025: 北海道医療大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2024: 北海道医療大学, 薬学部, 教授 2020 – 2022: 北海道医療大学, 薬学部, 教授 2017: 明治薬科大学, 薬学部, 講師 2013 – 2015: 明治薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Chemical pharmacy Except Principal Investigator Chemical pharmacy
Keywords	Principal Investigator 天然物合成 / 構造活性相関 / 抗がん剤 / Phaeosphaeride A / ケミカルバイオロジー / STAT3阻害剤 / Aβ凝集阻害剤 / L-755,807 / Euvesperin B / Euvesperin A … More / Berkeleyamide D / Rubrobramide / Talaramide A / BACE1阻害剤 / アミロイドβ凝集阻害剤 / アルツハイマー病 / 天然物の全合成 … More Except Principal Investigator 天然物化学 / 有機化学 / 薬学 / 天然物合成 / エポキシ-γ-ラクタム環 / 立体選択的Darzens反応 / L-755,807 / アルツハイマー病 Less

Phaeosphaeride類縁天然物の生物有機化学研究Principal Investigator
- Principal Investigator
  
  小林健一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Health Sciences University of Hokkaido
Lead discovery for Alzheimer's disease through synthetic organic chemistryPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Kenichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Health Sciences University of Hokkaido
Study on the development of potential agents for Alzheimer's disease by using natural source
- Principal Investigator
  
  古源寛
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meiji Pharmaceutical University
Structure-anticancer activity relationship study of natural product and its derivatives with a novel mechanism of actionPrincipal Investigator
- Principal Investigator
  
  Kobayashi Kenichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meiji Pharmaceutical University

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

[Book] Advances in Chemistry Research. Volume 662020
- Author(s)
  Kogen Hiroshi、Kobayashi Kenichi
- Total Pages
  260
- Publisher
  Nova Science Publishers
- ISBN
  9781536188448
- Data Source
  KAKENHI-PROJECT-20K06951
[Journal Article] Synthesis and biological evaluation of coumarin derivatives as selective CYP2A6 inhibitors2023
- Author(s)
  Yamaguchi Yuki、Nishizono Naozumi、Kobayashi Daisuke、Yoshimura Teruki、Wada Keiji、Kobayashi Kenichi、Oda Kazuaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 86 Pages: 129206-129206
- DOI
  10.1016/j.bmcl.2023.129206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06951
[Journal Article] Total Synthesis of Phaeosphaerides with STAT3 Inhibitory Activity2022
- Author(s)
  Kobayashi Kenichi、Kogen Hiroshi、Tamura Osamu
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 8 Pages: 755-765
- DOI
  10.5059/yukigoseikyokaishi.80.755
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-08-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06951
[Journal Article] Concise synthesis of the major metabolite M8 from ticagrelor and simultaneous determination of ticagrelor and M8 by a novel LC/MS method2021
- Author(s)
  Suzuki Momoko、Ogawa Ryuichi、Echizen Hirotoshi、Kogen Hiroshi、Kobayashi Kenichi
- Journal Title
  
  Journal of Chemical Research
  
  Volume: - Issue: 7-8 Pages: 716-720
- DOI
  10.1177/1747519821991993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06951
[Journal Article] Enantioselective total synthesis of (+)-rubrobramide, (+)-talaramide A, and (-)-berkeleyamide D by a skeletal diversification strategy2021
- Author(s)
  Tanaka Kosaku、Kobayashi Kenichi、Kogen Hiroshi
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 76 Pages: 9780-9783
- DOI
  10.1039/d1cc04290d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06951
[Journal Article] Highly Oxidized γ-Lactam-containing Natural Products: Total Synthesis and Biological Evaluation2020
- Author(s)
  Tanaka Kosaku III、Kogen Hiroshi、Kobayashi Kenichi
- Journal Title
  
  Heterocycles
  
  Volume: - Issue: 7 Pages: 1235-1235
- DOI
  10.3987/rev-20-944
- NAID
  40022623399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06951
[Journal Article] Recent topics of the natural products synthesis by dHoner-Wodsworth-Emmons reaction2018
- Author(s)
  Kobayashi K, Tanaka K III, and Kogen H
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 59 Pages: 568-582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08227
[Journal Article] Efficient synthesis of syn-α-alkoxy epoxide via a diastereoselective Darzens reaction2017
- Author(s)
  Tanaka K III, Kobayashi K, Takatori K and Kogen H
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Pages: 2062-2067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08227
[Journal Article] Total synthesis of (-)-phaeosphaeride B by a biomimetic conversion from (-)-phaeosphaeride A2017
- Author(s)
  Kobayashi K, Kunimura R, Tanaka K III, Tamura O and Kogen H
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Pages: 2382-2388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08227
[Journal Article] Establishment of Relative and Absolute Configurations of Phaeosphaeride A: Total Synthesis of ent-Phaeosphaeride A2015
- Author(s)
  Kenichi Kobayashi, Yukiko Kobayashi, Misato Nakamura, Osamu Tamura, and Hiroshi Kogen
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 80 Issue: 2 Pages: 1243-1248
- DOI
  10.1021/jo5025046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460022, KAKENHI-PROJECT-25860015
[Journal Article] Studies toward the Second-Generation Synthesis of Epolactaene: Highly Stereoselective Construction of the Epoxy-γ-Lactam Moiety2014
- Author(s)
  Kouta Tajima, Yoshifumi Umehara, Kenichi Kobayashi, Hiroshi Kogen
- Journal Title
  
  Synlett
  
  Volume: 25 Issue: 16 Pages: 2337-2340
- DOI
  10.1055/s-0034-1378562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] 抗真菌活性物質natalamycin Aの全合成研究2023
- Author(s)
  鈴木桃子、小林健一
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-20K06951
[Presentation] STAT3阻害天然物phaeosphaeride類の構造活性相関とケミカルバイオロジー研究2023
- Author(s)
  平山裕一郎、松永柾宏、深尾文香、小林健一
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-20K06951
[Presentation] 抗真菌活性物質natalamycin Aの全合成研究2022
- Author(s)
  鈴木桃子、小林健一
- Organizer
  日本化学会北海道支部2022年夏季研究発表会
- Data Source
  KAKENHI-PROJECT-20K06951
[Presentation] アルベカシン耐性MRSAに対する耐性解除物質biverlactone類の合成研究2022
- Author(s)
  松村建治、倉林七海宏、古源寛、小林健一
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-20K06951
[Presentation] Natalamycin Aの全合成研究2022
- Author(s)
  鈴木桃子、小林健一
- Organizer
  日本薬学会北海道支部第149回例会
- Data Source
  KAKENHI-PROJECT-20K06951
[Presentation] クマリン誘導体のアロマターゼ阻害に関する構造活性相関研究2021
- Author(s)
  山口由基、長谷川凌平、水落潤、平山裕一郎、小林健一
- Organizer
  日本薬学会第141年会（広島）
- Data Source
  KAKENHI-PROJECT-20K06951
[Presentation] STAT3 阻害活性を有する Paraphaeosphaeride A の全合成研究2018
- Author(s)
  國村理紗子, 田中耕作三世, 小林健一, 古源寛
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] 高度に酸化されたビサボラン型セスキテルペンの全合成2018
- Author(s)
  小林健一, 國村理紗子, 古源寛, 黒田智明
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] アミロイドβ 凝集阻害活性を有するL-755,807 の構造活性相関研究2018
- Author(s)
  田中耕作三世, 本間祐介, 小林健一, 荒幡一博, 木下薫, 小山清隆, 古源寛
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] 微小管安定化物質エポチロンD の全合成研究2018
- Author(s)
  鈴木桃子, 橋本昭吾, 小林健一, 古源寛
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] ビサボラン型セスキテルペンの全合成及び立体構造決定2017
- Author(s)
  國村理紗子、相沢唯、小林健一、古源寛、平井美咲、高木広和、黒田智
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] Darzens縮合を鍵反応とした(+)-epolactaeneの全合成研究2017
- Author(s)
  内田美和、田中耕作三世、田島広大、小林健一、古源寛
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] ビサボラン型セスキテルペンの全合成による立体構造の解明2017
- Author(s)
  國村理紗子、相沢唯、小林健一、高取和彦、古源寛、平井美咲、高木広和、黒田智明
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] Total synthesis and structural determination of a highly oxygenated bisabolane sesquiterpene2017
- Author(s)
  Kobayashi K, Kunimura R, Kogen H and Kuroda C
- Organizer
  The 26th French-Japanese Symposium on Medicinal and Fine Chemistry, 2017/9, Strasbourg, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] 生合成経路を模倣したParaphaeosphaeride Aの全合成研究2017
- Author(s)
  國村理紗子、小林健一、古源寛
- Organizer
  第74回有機合成化学協会関東支部シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] Total synthesis of phaeosphaeride A and its biomimetic conversion to phaeosphaeride B2017
- Author(s)
  Kobayashi K, Kunimura R, Tanaka K III and Kogen H
- Organizer
  The 26th French-Japanese Symposium on Medicinal and Fine Chemistry, 2017/9, Strasbourg, France
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] 抗菌活性および抗腫瘍活性を有する天然物lissoclinolideの全合成研究2017
- Author(s)
  桑原佳祐、小林健一、古源寛
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17K08227
[Presentation] Darzens縮合を用いたepoxy-γ-lactam環の効率的合成法の開発2016
- Author(s)
  田中耕作三世、小林健一、古源寛
- Organizer
  日本薬学会第136年会（横浜）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] 光学活性な2α,2α-二置換インドールの新規合成法の開発2016
- Author(s)
  五江渕祐太、春田雄太郎、小林健一、古源寛
- Organizer
  日本薬学会第136年会（横浜）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] 抗菌活性物質biverlactone Cの全合成研究2016
- Author(s)
  桑原佳佑、小林健一、古源寛
- Organizer
  日本薬学会第136年会（横浜）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] DGAT-1阻害剤のデザイン、合成、及び活性評価2016
- Author(s)
  松下航平、平野遼太郎、森若菜、郡司幸恵、小林健一、古源寛、若杉昌輝、広野修一、白波瀬弘明
- Organizer
  日本薬学会第136年会（横浜）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] Phaeosphaeride Aの相対および絶対立体配置の決定2015
- Author(s)
  小林健一、小林夕貴子、中村美里、田村修、古源寛
- Organizer
  日本薬学会第135年会（神戸）
- Place of Presentation
  デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] sp2 C-Br/C-H型クロスカップリング反応を利用したBractelactoneの全合成研究2015
- Author(s)
  小林健一、中村美里、高橋恵美、古源寛
- Organizer
  日本薬学会第135年会（神戸）
- Place of Presentation
  デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] DGAT-1阻害に基づく糖尿病治療薬の合成研究2015
- Author(s)
  森若菜、平野遼太郎、郡司幸恵、小林健一、古源寛、若杉昌輝、広野修一、白波瀬弘明
- Organizer
  日本薬学会第135年会（神戸）
- Place of Presentation
  デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] Relative and Absolute Configurations of Phaeosphaeride A: Total Synthesis of ent-Phaeosphaeride A2015
- Author(s)
  Kenichi Kobayashi, Yukiko Kobayashi, Misato Nakamura, Osamu Tamura, Hiroshi Kogen
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] Synthetic Studies on L-755,807, a Non-Peptide Bradykinin Antagonist2014
- Author(s)
  Kosaku III Tanaka, Kenichi Kobayashi, Hiroshi Kogen
- Organizer
  24th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Lyon, France
- Year and Date
  2014-09-15
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] Phaeosphaeride Aの全合成研究2014
- Author(s)
  小林健一、田村修、古源寛
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] エポチロンDの全合成研究2014
- Author(s)
  鈴木詩織、橋本昭吾、小林健一、古源寛
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] 神経突起伸長誘導物質エポラクタエンの第二世代合成法の開発研究2014
- Author(s)
  田島広大、梅原義史、中田亜紀子、小林健一、古源寛
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] 2α,2α-二置換インドールの新規合成法の開発2014
- Author(s)
  春田雄太郎、北野翔大、小林健一、古源寛
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] ent-Phaeosphaeride Aの全合成2014
- Author(s)
  小林健一、小林夕貴子、田村修、古源寛
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] 糖尿病治療薬を指向したDGAT-1阻害剤のデザイン、合成及び活性評価2014
- Author(s)
  平野遼太郎、小林健一、古源寛、若杉昌輝、広野修一、國代一祥
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学工学部2号館
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] L-755,807の全合成研究2014
- Author(s)
  田中耕作三世、小林健一、古源寛
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学全学教育棟
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] First Total Synthesis of ent-Phaeosphaeride A2014
- Author(s)
  Kenichi Kobayashi, Yukiko Kobayashi, Osamu Tamura, Hiroshi Kogen
- Organizer
  24th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Lyon, France
- Year and Date
  2014-09-15
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] Total synthesis and biological evaluations of an aplyronine A-mycalolide B hybrid2013
- Author(s)
  K. Kobayashi, H. Kogen, I. Hayakawa, H. Kigoshi
- Organizer
  1st European Conference on Natural Products
- Place of Presentation
  DECHEMA-HAUS, Frankfurt, Germany
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] Studies toward the total synthesis of L-755,8072013
- Author(s)
  K. Tanaka, K. Kobayashi, H. Kogen
- Organizer
  The 23rd FRENCH-JAPANESE SYMPOSIUM on Medical and Fine Chemistry
- Place of Presentation
  ANA CROWNE PLAZA NAGASAKI GLOVERHILL
- Data Source
  KAKENHI-PROJECT-25860015
[Presentation] ジアシルグリセロールアシル基転位酵素-1阻害剤のLigand-Based Drug Design2013
- Author(s)
  若杉昌輝、合田浩明、平野遼太郎、小林健一、古源寛、広野修一
- Organizer
  第41回構造活性相関シンポジウム
- Place of Presentation
  関西学院会館
- Data Source
  KAKENHI-PROJECT-25860015

1. 古源寛 (00515968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 平山裕一郎 (30746938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 田村修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI KENICHI 小林 健一

KOBAYASHI Kenichi 小林 健一

小林 健一 コバヤシ ケンイチ

Kobayashi Kenichi 小林 健一

Research Projects

Research Products

Co-Researchers

Phaeosphaeride類縁天然物の生物有機化学研究Principal Investigator

Principal Investigator

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Lead discovery for Alzheimer's disease through synthetic organic chemistryPrincipal Investigator

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Study on the development of potential agents for Alzheimer's disease by using natural source

Principal Investigator

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Research Institution

Structure-anticancer activity relationship study of natural product and its derivatives with a novel mechanism of actionPrincipal Investigator

Principal Investigator

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[Book] Advances in Chemistry Research. Volume 662020

Author(s)

Total Pages

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ISBN

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[Journal Article] Synthesis and biological evaluation of coumarin derivatives as selective CYP2A6 inhibitors2023

Author(s)

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DOI

Data Source

[Journal Article] Total Synthesis of Phaeosphaerides with STAT3 Inhibitory Activity2022

Author(s)

Journal Title

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ISSN

Year and Date

Language

Data Source

[Journal Article] Concise synthesis of the major metabolite M8 from ticagrelor and simultaneous determination of ticagrelor and M8 by a novel LC/MS method2021

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Journal Title

DOI

Data Source

[Journal Article] Enantioselective total synthesis of (+)-rubrobramide, (+)-talaramide A, and (-)-berkeleyamide D by a skeletal diversification strategy2021

Author(s)

Journal Title

DOI

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[Journal Article] Highly Oxidized γ-Lactam-containing Natural Products: Total Synthesis and Biological Evaluation2020

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DOI

NAID

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[Journal Article] Recent topics of the natural products synthesis by dHoner-Wodsworth-Emmons reaction2018

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[Journal Article] Efficient synthesis of syn-α-alkoxy epoxide via a diastereoselective Darzens reaction2017

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[Journal Article] Total synthesis of (-)-phaeosphaeride B by a biomimetic conversion from (-)-phaeosphaeride A2017

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[Journal Article] Establishment of Relative and Absolute Configurations of Phaeosphaeride A: Total Synthesis of ent-Phaeosphaeride A2015

Author(s)

KOBAYASHI KENICHI 小林健一

KOBAYASHI Kenichi 小林健一

小林健一コバヤシケンイチ

Kobayashi Kenichi 小林健一