Kaise Asako 皆瀬麻子

Researcher Number	30710397
Other IDs
Affiliation (Current)	2025: 東北医科薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 東北医科薬科大学, 薬学部, 助教 2016 – 2018: 東北医科薬科大学, 薬学部, 助手 2015: 東北薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator アンドロゲン受容体 / 膜透過性 / P糖タンパク質 / 肝ミクロソーム / エストロゲン受容体 / 創薬化学 / P糖たんぱく質 / 代謝安定性 / 乳癌 / 抗腫瘍作用 … More / 薬物安定性 / 細胞膜透過性 / カルボラン / ホウ素クラスター … More Except Principal Investigator ラジカル補足作用 / 抗腫瘍活性 / ホウ素化学 / 創薬化学 / スクリーニング / ラジカル捕捉 / ホウ素クラスター / ラジカル捕捉作用 / 抗腫瘍作用 / カルボラン / ランダムスクリーニング / 化合物ライブラリー / ホウ素化合物 Less

Fundamental research for practical application of carborane as a pharmaceutical structurePrincipal Investigator
- Principal Investigator
  
  Kaise Asako
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Middle up and down type medicinal chemistry based upon boron compound library
- Principal Investigator
  
  Ohta Kiminori
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
  Tohoku Medical and Pharmaceutical University

All 2024 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Design and Synthesis of Novel Breast Cancer Therapeutic Drug Candidates Based upon the Hydrophobic Feedback Approach of Antiestrogens2019
- Author(s)
  Ohta Kiminori、Kaise Asako、Taguchi Fumi、Aoto Sayaka、Ogawa Takumi、Endo Yasuyuki
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 21 Pages: 3966-3977
- DOI
  10.3390/molecules24213966
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08029
[Journal Article] Anti-cancer activity of m-carborane-containing trimethoxyphenyl derivatives through tubulin polymerization inhibition2019
- Author(s)
  Kaise Asako、Endo Yasuyuki、Ohta Kiminori
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 6 Pages: 1139-1144
- DOI
  10.1016/j.bmc.2019.02.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08029
[Journal Article] Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p -carborane cages2018
- Author(s)
  Kaise Asako、Ohta Kiminori、Fujii Shinya、Oda Akifumi、Goto Tokuhito、Endo Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 13 Pages: 3805-3811
- DOI
  10.1016/j.bmc.2018.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08029, KAKENHI-PROJECT-17K08257, KAKENHI-PROJECT-17H03997
[Journal Article] Novel p -carborane-containing multitarget anticancer agents inspired by the metabolism of 17β-estradiol2017
- Author(s)
  Kaise Asako、Ohta Kiminori、Endo Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 24 Pages: 6371-6378
- DOI
  10.1016/j.bmc.2017.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08029, KAKENHI-PROJECT-26460151
[Journal Article] Design and synthesis of p -carborane-containing sulfamates as multitarget anti-breast cancer agents2017
- Author(s)
  Kaise Asako、Ohta Kiminori、Shirata Chinami、Endo Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 24 Pages: 6417-6426
- DOI
  10.1016/j.bmc.2017.10.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08029, KAKENHI-PROJECT-26460151
[Journal Article] Design, synthesis, and anti-proliferative activity of 1-(4-methoxyphenyl)-12-hydroxymethyl-p-carborane derivatives2016
- Author(s)
  Asako Kaise, Kiminori Ohta, Yasuyuki Endo
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 122 Pages: 257-263
- DOI
  10.1016/j.ejmech.2016.06.029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08029, KAKENHI-PROJECT-26460151
[Presentation] がん細胞内のROSにより活性化される新規エストロゲン受容体制御化合物の創製2024
- Author(s)
  太田公規、今井唯人、江原北斗、皆瀬麻子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-20K15961
[Presentation] Development of novel tubulin polymerization inhibitors based on m-carborane cage2021
- Author(s)
  Asako Kaise, Yuya Yamashita, Kiminori Ohta, Yasuyuki Endo
- Organizer
  AIMECS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15961
[Presentation] 抗腫瘍活性を示すm-カルボラン含有トリメトキシフェニル誘導体2020
- Author(s)
  皆瀬麻子、太田公規、遠藤泰之
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-15K08029
[Presentation] 球状ホウ素クラスターを基盤とする新規エストロゲン受容体リガンドの設計と合成2019
- Author(s)
  皆瀬麻子、大山美優、吉見友弘、太田公規、遠藤泰之
- Organizer
  第３７回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K08029
[Presentation] マルチターゲット型抗腫瘍活性を示す新規カルボラン誘導体の創製2018
- Author(s)
  皆瀬麻子、太田公規、白田智七美、遠藤泰之
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K08029

1. Ohta Kiminori (90347906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 遠藤泰之 (80126002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

Kaise Asako 皆瀬 麻子

Research Projects

Research Products

Co-Researchers

Fundamental research for practical application of carborane as a pharmaceutical structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Middle up and down type medicinal chemistry based upon boron compound library

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Design and Synthesis of Novel Breast Cancer Therapeutic Drug Candidates Based upon the Hydrophobic Feedback Approach of Antiestrogens2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-cancer activity of m-carborane-containing trimethoxyphenyl derivatives through tubulin polymerization inhibition2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p -carborane cages2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel p -carborane-containing multitarget anticancer agents inspired by the metabolism of 17β-estradiol2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and synthesis of p -carborane-containing sulfamates as multitarget anti-breast cancer agents2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, synthesis, and anti-proliferative activity of 1-(4-methoxyphenyl)-12-hydroxymethyl-p-carborane derivatives2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] がん細胞内のROSにより活性化される新規エストロゲン受容体制御化合物の創製2024

Author(s)

Organizer

Data Source

[Presentation] Development of novel tubulin polymerization inhibitors based on m-carborane cage2021

Author(s)

Organizer

Data Source

[Presentation] 抗腫瘍活性を示すm-カルボラン含有トリメトキシフェニル誘導体2020

Author(s)

Organizer

Data Source

[Presentation] 球状ホウ素クラスターを基盤とする新規エストロゲン受容体リガンドの設計と合成2019

Author(s)

Organizer

Data Source

[Presentation] マルチターゲット型抗腫瘍活性を示す新規カルボラン誘導体の創製2018

Author(s)

Organizer

Data Source

Kaise Asako 皆瀬麻子