maruyama keiko 丸山慶子

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Maruyama Keiko 丸山慶子

MARUYAMA Keiko 丸山慶子

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Researcher Number	30712624
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2020 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 2016 – 2018: 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 2014: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related Except Principal Investigator Hematology
Keywords	Principal Investigator 血栓性素因 / プロテインC / プロテインS / 血液凝固第Ⅴ因子 / プロテインＳ / プロテインＣ Except Principal Investigator 静脈血栓症 / 変異体 / 静脈血栓症、 / 血栓性素因 … More / 経口避妊薬 / 遺伝子変異 / 凝固制御因子 / プロテインS / 静脈血栓塞栓症 / ライブイメージング / Bac-TRAP / トランスクリプトーム解析 / トランスジェニックマウス / 血管内皮細胞プロテインC受容体 / プロテイン C 受容体 / トランスクリプトーム / マウス / プロテインC受容体 / トロンボモジュリン / 遺伝子発現 / 血管内皮細胞 Less

凝固第Ⅴ因子改変体を用いた新たなプロテインＳおよびプロテインＣ活性検査法の確立Principal Investigator
- Principal Investigator
  
  丸山慶子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of new Protein S and Protein C activity assaysPrincipal Investigator
- Principal Investigator
  
  Maruyama Keiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Cardiovascular Center Research Institute
Studies on thrombotic risk of protein S K196E mutation
- Principal Investigator
  
  Miyata Toshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Production and analysis of Bac-TRAP mice that express fluorescent proteins driven by thrombomodulin or endothelial cell protein C receptor promoter
- Principal Investigator
  
  MIYATA TOSHIYUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute

All 2023 2022 2021 2020 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Alpha‐HIT assay: A new assay for heparin‐induced thrombocytopenia antibody detection using FcγRIIa‐coated beads and Alpha technology2022
- Author(s)
  Maruyama Keiko、Miyata Shigeki、Kokame Koichi
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 6 Issue: 7 Pages: e12818-e12818
- DOI
  10.1002/rth2.12818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16568
[Journal Article] First report of inherited protein S deficiency caused by paternal <I>PROS1</I> mosaicism2021
- Author(s)
  Nagaya Satomi、Maruyama Keiko、Watanabe Atsushi、Meguro-Horike Makiko、Imai Yuta、Hiroshima Yuki、Horike Shin-Ichi、Kokame Koichi、Morishita Eriko
- Journal Title
  
  Haematologica
  
  Volume: 107 Issue: 1 Pages: 330-333
- DOI
  10.3324/haematol.2021.278527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07365, KAKENHI-PROJECT-20K22869, KAKENHI-PROJECT-20K07307, KAKENHI-PROJECT-20K16568
[Journal Article] A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder2021
- Author(s)
  Osada M, Maruyama K, Kokame K, Denda R, Yamazaki K, Kunieda H, Hirao M, Madoiwa S, Okumura N, Murata M, Ikeda Y, Watanabe K, Tsukada Y, Kikuchi T
- Journal Title
  
  Blood Advance
  
  Volume: 5 Issue: 19 Pages: 3830-3838
- DOI
  10.1182/bloodadvances.2020003814
- NAID
  120007180883
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-20K16568
[Journal Article] Estimating the frequencies of pathogenic variants of antithrombin, protein C, and protein S using a public database and expression experiments2021
- Author(s)
  MARUYAMA Keiko、KOKAME Koichi
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 32 Issue: 5 Pages: 635-637
- DOI
  10.2491/jjsth.32.635
- NAID
  130008106791
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16568
[Journal Article] Carrier frequencies of antithrombin, protein C, and protein S deficiency variants estimated using a public database and expression experiments2020
- Author(s)
  Maruyama Keiko、Kokame Koichi
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 5 Issue: 1 Pages: 179-186
- DOI
  10.1002/rth2.12456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16568
[Journal Article] Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI2018
- Author(s)
  Keiko Maruyama, Masashi Akiyama, Toshiyuki Miyata, Koichi Kokame
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 2 Issue: 4 Pages: 751-756
- DOI
  10.1002/rth2.12152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-17J11206, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K08515
[Journal Article] IV.　動脈・静脈疾患の臨床研究動向　４．血栓性素因の遺伝要因2017
- Author(s)
  丸山慶子、宮田敏行
- Journal Title
  
  動脈・静脈の疾患（上）　最新の診断・治療動向
  
  Volume: 75 Pages: 277-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09834
[Journal Article] Thrombophilia in East Asian countries: are there any genetic differences in these countries?2016
- Author(s)
  Miyata T, Maruyama K, Banno F, Neki R.
- Journal Title
  
  Thromb J.
  
  Volume: 14(Suppl 1):25 Issue: S1 Pages: 123-128
- DOI
  10.1186/s12959-016-0109-x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462507, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K09835
[Patent] 活性化血液凝固第Ｖ因子の改変体ポリペプチド及びそれを用いる血液凝固制御因子の活性測定方法2023
- Inventor(s)
  小亀浩市、丸山慶子
- Industrial Property Rights Holder
  国立研究開発法人国立循環器病研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K06900
[Presentation] プロテインＳ遺伝子のイントロン１にある転写調節領域による発現調節2023
- Author(s)
  丸山慶子、小亀浩市
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06900
[Presentation] プロテインＳ遺伝子のイントロン１による遺伝子発現調節2022
- Author(s)
  丸山慶子、小亀浩市
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16568
[Presentation] FcγRIIa固相化ビーズとAlphaLISA技術を用いたHIT抗体検出法の開発2021
- Author(s)
  丸山慶子、宮田茂樹、小亀浩市
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16568
[Presentation] 公開データベースから抽出したアンチトロンビンおよびプロテインC変異の機能解析2020
- Author(s)
  丸山慶子、小亀浩市
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16568
[Presentation] A hereditary bleeding disorder caused by a novel homozygous mutation of thrombomodulin gene2020
- Author(s)
  M. Osada, K. Maruyama, K. Kokame, R. Denda, K. Yamazaki, H. Kunieda, M. Hirao, S. Madoiwa, M. Murata, Y. Ikeda, Y. Tsukada, T. Kikuch.
- Organizer
  The 28th Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16568
[Presentation] Carrier frequencies of antithrombin-, protein C-, or protein S-deficient variants estimated using a public database and expression experiments2020
- Author(s)
  K. Maruyama, K. Kokame
- Organizer
  The 28th Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16568
[Presentation] 妊娠を契機に深部静脈血栓症を発症した先天性アンチトロンビン欠乏症症例の遺伝学的検査の検討2018
- Author(s)
  根木玲子、伊田和史、光黒真菜、岡本章、丸山慶子、小亀浩市、宮田敏行
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-16K09834

1. MIYATA TOSHIYUKI (90183970)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Akiyama Masashi (30298179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. BANNO Fumiaki (00373514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TASHIMA Yuko (10423104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉松淳 (20221674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小亀浩市 (40270730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HORIKE Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. OKUMURA Nobuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 根木玲子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

maruyama keiko 丸山 慶子

Maruyama Keiko 丸山 慶子

MARUYAMA Keiko 丸山 慶子

Research Projects

Research Products

Co-Researchers

凝固第Ⅴ因子改変体を用いた新たなプロテインＳおよびプロテインＣ活性検査法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new Protein S and Protein C activity assaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on thrombotic risk of protein S K196E mutation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production and analysis of Bac-TRAP mice that express fluorescent proteins driven by thrombomodulin or endothelial cell protein C receptor promoter

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Alpha‐HIT assay: A new assay for heparin‐induced thrombocytopenia antibody detection using FcγRIIa‐coated beads and Alpha technology2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First report of inherited protein S deficiency caused by paternal &lt;I&gt;PROS1&lt;/I&gt; mosaicism2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Estimating the frequencies of pathogenic variants of antithrombin, protein C, and protein S using a public database and expression experiments2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Carrier frequencies of antithrombin, protein C, and protein S deficiency variants estimated using a public database and expression experiments2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IV. 動脈・静脈疾患の臨床研究動向 ４．血栓性素因の遺伝要因2017

Author(s)

Journal Title

Data Source

[Journal Article] Thrombophilia in East Asian countries: are there any genetic differences in these countries?2016

Author(s)

Journal Title

DOI

Data Source

[Patent] 活性化血液凝固第Ｖ因子の改変体ポリペプチド及びそれを用いる血液凝固制御因子の活性測定方法2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] プロテインＳ遺伝子のイントロン１にある転写調節領域による発現調節2023

maruyama keiko 丸山慶子

Maruyama Keiko 丸山慶子

MARUYAMA Keiko 丸山慶子

[Journal Article] First report of inherited protein S deficiency caused by paternal <I>PROS1</I> mosaicism2021

[Journal Article] IV.　動脈・静脈疾患の臨床研究動向　４．血栓性素因の遺伝要因2017