Tsubokawa Daigo 坪川大悟

Researcher Number	30714901
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 北里大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49040:Parasitology-related
Keywords	Principal Investigator RAGE / 幼虫体内移行 / 宿主応答 / 蠕虫 / 模倣分子 / S100様分子 / 腸管免疫 / ES物質 / カルシウム結合蛋白 / 体内移行 … More / RNA干渉 / ベネスタチン / 糞線虫 / カルシウム結合タンパク質 Less

Regulation mechanism of host immune response by S100-like proteins from parasite helminthsPrincipal Investigator
- Principal Investigator
  
  坪川大悟
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Kitasato University
The host-parasite relationship mediated by Strongyloides venestatin/RAGE axisPrincipal Investigator
- Principal Investigator
  
  Tsubokawa Daigo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  Kitasato University

All 2024 2023 2022 2021 2019 2018

All Journal Article Presentation

[Journal Article] Structural Elucidation of Sialylated O-Glycan Alditols Obtained from Mucins by Mass Spectrometry2024
- Author(s)
  Tsubokawa Daigo、Kawashima Rei、Ichikawa Takafumi
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2763 Pages: 209-221
- DOI
  10.1007/978-1-0716-3670-1_18
- ISBN
  9781071636695, 9781071636701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06996
[Journal Article] Extraction and Fractionation of Human Gastric Mucins from Gastric Juice2024
- Author(s)
  Kawashima Rei、Tsubokawa Daigo、Iijima Katsunori、Ichikawa Takafumi
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2763 Pages: 61-69
- DOI
  10.1007/978-1-0716-3670-1_5
- ISBN
  9781071636695, 9781071636701
- Data Source
  KAKENHI-PROJECT-21K06996
[Journal Article] Immunomodulators secreted from parasitic helminths act on pattern recognition receptors2023
- Author(s)
  Tsubokawa Daigo
- Journal Title
  
  Frontiers in Parasitology
  
  Volume: 1 Pages: 1091596-1091596
- DOI
  10.3389/fpara.2022.1091596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06996
[Journal Article] Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria2023
- Author(s)
  Takamiya Shinzaburo、Nakamura Takeshi、Tsubokawa Daigo、Tsuji Naotoshi、Fukuda Koichi、Yamasaki Hiroshi、Fujimura Tsutomu、Taka Hikari、Kaga Naoko、Kobayashi-Tanabe Momoko、Matsuda Motoo、Mita Toshihiro
- Journal Title
  
  Parasitology International
  
  Volume: 92 Pages: 102695-102695
- DOI
  10.1016/j.parint.2022.102695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-21K06996, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-20K05880
[Journal Article] Strongyloides venezuelensis-derived venestatin ameliorates asthma pathogenesis by suppressing receptor for advanced glycation end-products-mediated signaling2022
- Author(s)
  Tsubokawa Daigo、Satoh Masashi
- Journal Title
  
  Pulmonary Pharmacology & Therapeutics
  
  Volume: 75 Pages: 102148-102148
- DOI
  10.1016/j.pupt.2022.102148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06996, KAKENHI-PROJECT-22K08679, KAKENHI-PROJECT-19K09011
[Journal Article] 寄生蠕虫分泌物質による炎症性疾患治療効果2022
- Author(s)
  坪川大悟
- Journal Title
  
  Precision Medicine
  
  Volume: 5 Pages: 959-962
- Data Source
  KAKENHI-PROJECT-21K06996
[Journal Article] 消化管寄生蠕虫が有するカルシウム結合タンパク質の抗炎症機能2022
- Author(s)
  坪川大悟
- Journal Title
  
  Medical Science Digest
  
  Volume: 48 Pages: 36-38
- Data Source
  KAKENHI-PROJECT-21K06996
[Journal Article] Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection2021
- Author(s)
  Talaam Keith Kiplangat、Inaoka Daniel Ken、Hatta Takeshi、Tsubokawa Daigo、Tsuji Naotoshi、Wada Minoru、Saimoto Hiroyuki、Kita Kiyoshi、Hamano Shinjiro
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 65 Issue: 10
- DOI
  10.1128/aac.00418-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07523, KAKENHI-PROJECT-19H03436, KAKENHI-PROJECT-21K06996, KAKENHI-PROJECT-17H01684, KAKENHI-PROJECT-21H04852
[Journal Article] Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration2021
- Author(s)
  Tsubokawa Daigo、Kikuchi Taisei、Lee Jae Man、Kusakabe Takahiro、Yamamoto Yasuhiko、Maruyama Haruhiko
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 6 Pages: e1009649-e1009649
- DOI
  10.1371/journal.ppat.1009649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15140, KAKENHI-PROJECT-21K06996, KAKENHI-PROJECT-21H02695
[Journal Article] 経皮侵入性線虫Strongyloides venezuelensisの宿主体内移行における終末糖化産物受容体の働き2019
- Author(s)
  坪田理央, 坪川大悟, 八田岳士, 辻尚利
- Journal Title
  
  北里医学
  
  Volume: 49 Pages: 111-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15140
[Journal Article] Characterization of the RAGE-binding protein, Strongyloides venestatin, produced by the silkworm-baculovirus expression system.2019
- Author(s)
  Tsubokawa D, Lee JM, Hatta T, Mikami F, Maruyama H, Arakawa T, Kusakabe T, Tsuji N
- Journal Title
  
  Infect Genet Evol
  
  Volume: 75 Pages: 103964-103964
- DOI
  10.1016/j.meegid.2019.103964
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15140, KAKENHI-PROJECT-17H03919
[Journal Article] Positive phototropism is accelerated in Biomphalaria glabrata snails by infection with Schistosoma mansoni.2018
- Author(s)
  H Maeda, T Hatta, D Tsubokawa, F Mikami, T Nishimaki, T Nakamura, Anisuzzaman, M Matsubayashi, M Ogawa, CP da Costa, N Tsuji
- Journal Title
  
  Parasitology International
  
  Volume: 67 Issue: 5 Pages: 609-611
- DOI
  10.1016/j.parint.2018.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15140, KAKENHI-PROJECT-17H04641
[Journal Article] Tapeworm-related cutaneous larva migrans is caused by a cysteine protease from the larvae themselves.2018
- Author(s)
  D Tsubokawa, T Hatta, N Tsuji
- Journal Title
  
  Atlas of Science
  
  Volume: 15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] 消化管寄生線虫感染における終末糖化産物受容体を介した腸管免疫制御機構の解析2023
- Author(s)
  坪川大悟, 佐藤雅, 川上文貴, 川島麗, 市川尊文
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-21K06996
[Presentation] Receptor for advanced glycation products (RAGE) contributes to negative regulation of type 2 mucosal immunity to the intestinal nematode Nippostrongylus brasiliensis.2022
- Author(s)
  D Tsubokawa, M Satoh, F Kawakami, R Kawashima, T Ichikawa
- Organizer
  15th International Congress of Parasitology (ICOPA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06996
[Presentation] Nippostrongylus brasiliensis感染感受性における終末糖化産物受容体の役割2022
- Author(s)
  坪川大悟, 佐藤雅, 川上文貴, 川島麗, 市川尊文
- Organizer
  第91回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-21K06996
[Presentation] 寄生蠕虫S100様分子の終末糖化産物受容体(RAGE)を介する炎症応答への作用2021
- Author(s)
  坪川大悟, 佐藤雅
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06996
[Presentation] 糞線虫の宿主体内移行における終末糖化産物受容体(RAGE)の役割.2019
- Author(s)
  坪川大悟、八田岳士、小泉頌歌、三上房子、山本靖彦、丸山治彦、辻尚利
- Organizer
  第88回日本寄生虫学会(長崎)
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] マンソン住血吸虫による肉芽腫形成への終末糖化産物受容体(RAGE)の関与2019
- Author(s)
  小泉頌歌、坪川大悟、八田岳士、三上房子、中村健、山本靖彦、辻尚利
- Organizer
  第79回日本寄生虫学会東日本支部大会
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] ベネズエラ糞線虫の成虫寄生における終末糖化産物受容体(RAGE)の役割2019
- Author(s)
  坪川大悟、八田岳士、小泉頌歌、関口智也、三上房子、山本靖彦、辻尚利
- Organizer
  第13回蠕虫研究会（宮崎）
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] 住血吸虫症における肉芽腫性炎症と終末糖化産物受容体（RAGE）との関連2019
- Author(s)
  小泉頌歌，坪川大悟，八田岳士，三上房子，中村健，山本靖彦，辻尚利
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] 終末糖化産物受容体(RAGE)欠損マウスをもちいた蠕虫感染実験2018
- Author(s)
  坪川大悟、小泉頌歌、八田岳士、三上房子、丸山治彦、辻尚利
- Organizer
  第12回蠕虫研究会(湯河原)
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] ベネスタチン遺伝子ノックダウンによる糞線虫の宿主体内移行への影響2018
- Author(s)
  坪川大悟、八田岳士、小泉頌歌、三上房子、辻尚利
- Organizer
  第31回北里大学バイオサイエンスフォーラム(相模原)
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] RNAi mediated suppression of venestatin in the subcutaneous migration of Strongyloides venezuelensis2018
- Author(s)
  Daigo Tsubokawa, Takeshi Hatta, Taisei Kikuchi, Fusako Mikami, Haruhiko Maruyama and Naotoshi Tsuji
- Organizer
  ICOPA 2018 (DAEGU, KOREA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15140
[Presentation] ベネスタチン遺伝子ノックダウン糞線虫を用いた感染実験の展開2018
- Author(s)
  坪川大悟、八田岳士、小泉頌歌、三上房子、辻尚利.
- Organizer
  第26回分子寄生虫ワークショップ/第16回分子寄生虫・マラリア研究フォーラム(松山)
- Data Source
  KAKENHI-PROJECT-18K15140

1. 市川尊文 (30245378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 佐藤雅 (40611843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 川上文貴 (50511896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 川島麗 (70392389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. TAKA Hikari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KAGA Naoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 稲岡健ダニエル

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsubokawa Daigo 坪川 大悟

Research Projects

Research Products

Co-Researchers

Regulation mechanism of host immune response by S100-like proteins from parasite helminthsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The host-parasite relationship mediated by Strongyloides venestatin/RAGE axisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Structural Elucidation of Sialylated O-Glycan Alditols Obtained from Mucins by Mass Spectrometry2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Extraction and Fractionation of Human Gastric Mucins from Gastric Juice2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Immunomodulators secreted from parasitic helminths act on pattern recognition receptors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strongyloides venezuelensis-derived venestatin ameliorates asthma pathogenesis by suppressing receptor for advanced glycation end-products-mediated signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 寄生蠕虫分泌物質による炎症性疾患治療効果2022

Author(s)

Journal Title

Data Source

[Journal Article] 消化管寄生蠕虫が有するカルシウム結合タンパク質の抗炎症機能2022

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 経皮侵入性線虫Strongyloides venezuelensisの宿主体内移行における終末糖化産物受容体の働き2019

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of the RAGE-binding protein, Strongyloides venestatin, produced by the silkworm-baculovirus expression system.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Positive phototropism is accelerated in Biomphalaria glabrata snails by infection with Schistosoma mansoni.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tapeworm-related cutaneous larva migrans is caused by a cysteine protease from the larvae themselves.2018

Author(s)

Journal Title

Data Source

[Presentation] 消化管寄生線虫感染における終末糖化産物受容体を介した腸管免疫制御機構の解析2023

Tsubokawa Daigo 坪川大悟