• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mizuguchi Takaaki  水口 貴章

… Alternative Names

水口 貴章  ミズグチ タカアキ

MIZUGUCHI Takaaki  水口 貴章

Less
Researcher Number 30732557
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9073-9591
Affiliation (Current) 2025: 北里大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help 2021 – 2023: 北里大学, 薬学部, 助教
2017: 北里大学, 薬学部, 助教
2014 – 2017: 東京医科歯科大学, 生体材料工学研究所, 助教
Review Section/Research Field
Principal Investigator
Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Except Principal Investigator
Drug development chemistry
Keywords
Principal Investigator
環状ペプチド / 細胞内薬物送達分子 / 抗がん活性ペプチド / 二量体化アーム / EGFレセプター / bitopic化合物 / 二価型化合物 / バイトピック化合物 / ポジティブアロステリック効果 / 鎮痛薬 … More / オピオイド受容体 / オキシトシン / 有機化学 / ペプチド / ケミカルバイオロジー / 創薬化学 / 薬学 / 中分子 / 抗がん剤 / フローサイトメトリー / 蛍光イメージング / ドラッグデリバリー / 細胞内送達 / 二量体化阻害 / EGF受容体 / 細胞内送達分子 / 環状ぺプチド / 二量化アーム / 創薬研究 / 抗がん薬 / アラニン置換 / EGFレセプター / 共焦点レーザー顕微鏡 / 抗がん薬リード / 細胞内輸送 / フルオレセイン標識 / フルオレセイン / 蛍光プローブ / 二量化阻害 … More
Except Principal Investigator
2価結合型GPCRリガンド / 高次構造模倣型 / 二量体 / 2価型 / 二次構造 / 中分子創薬 / 医薬品開発 / ヒト免疫不全ウイルス / GPCR / CXCR4 / ステープルペプチド / がん / HIV / 環状ペプチド / ペプチドミメティック / 中分子 / 側鎖改変 / 親和性増強 / 二量化阻害ペプチド / EGFレセプター / 質量分析 / キャピラリー電気泳動 / スクリーニング / レセプター創薬 / ループ構造模倣環状ペプチド / 二量化阻害 / EGFレセプター Less
  • Research Projects

    (5 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (11 People)
  •  Studies on the development of oxytocin derivatives as novel mu-opioid receptor-mediated analgesicsPrincipal Investigator

    • Principal Investigator
      水口 貴章
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Kitasato University
  •  Studies on the development of a new class of anticancer agents based on dimerization arm of the EGF receptorPrincipal Investigator

    • Principal Investigator
      MIZUGUCHI Takaaki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kitasato University
      Tokyo Medical and Dental University
  •  Development of mid-size drugs based on peptidomimetic

    • Principal Investigator
      TAMAMURA Hirokazu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Studies on new chemical probes development that assumed dimeric interface of the EGF receptor ectodomain a targetPrincipal Investigator

    • Principal Investigator
      Mizuguchi Takaaki
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Systematic structure optimization of the EGF receptor-inhibiting peptide through use of a screening technology

    • Principal Investigator
      SAITO Kazuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo

All 2024 2023 2021 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the μ opioid receptor2023

    • Author(s)
      Mizuguchi Takaaki、Miyano Kanako、Yamauchi Risa、Yoshida Yuki、Takahashi Hideki、Yamazaki Ami、Ono Haruka、Inagaki Miku、Nonaka Miki、Uezono Yasuhito、Fujii Hideaki
    • Journal Title

      Peptides

      Volume: 159 Pages: 170901-170901

    • DOI

      10.1016/j.peptides.2022.170901

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K06460, KAKENHI-PROJECT-21K06584, KAKENHI-PROJECT-22K06849
  • [Journal Article] Effects of replacement and addition of an amino acid contained in a cyclic peptide corresponding to a β-hairpin loop sequence of human EGF receptor2017

    • Author(s)
      Kobayashi K, Mizuguchi T, Hattori Y, Ohara N, Ninomiya R, Iida M, Ooe H, Yamazaki Y, Takata M, Tamamura H, Akaji K
    • Journal Title

      Journal of Peptide Science

      Volume: 印刷中 Issue: 7-8 Pages: 581-586

    • DOI

      10.1002/psc.3004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K18910, KAKENHI-PROJECT-16H05104
  • [Journal Article] Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.2016

    • Author(s)
      Nami Ohashi1, Shigeyoshi Harada, Takaaki Mizuguchi1, Yu Irahara1, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura.
    • Journal Title

      Chem Med Chem

      Volume: 19 Issue: 8 Pages: 940-946

    • DOI

      10.1002/cmdc.201500590

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16K01931, KAKENHI-PROJECT-16K15139
  • [Journal Article] A minimally cytotoxic CD4 mimic as an HIV entry inhibitor2016

    • Author(s)
      Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Issue: 2 Pages: 397-400

    • DOI

      10.1016/j.bmcl.2015.11.103

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26105721, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-16K01931
  • [Journal Article] Functional Evaluation of Fluorescent-Labeled Derivatives of an Inhibitory Peptide against EGF Receptor Dimerization2016

    • Author(s)
      Mizuguchi T., Toyama K., Ishida Y., Nomura W., Tamamura H.
    • Journal Title

      Peptide Science

      Volume: 2015 Pages: 41-42

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Journal Article] Studies on a Novel Delivery Peptide Derived from the Dimerization Arm of EGF Receptor2016

    • Author(s)
      Toyama K., Mizuguchi T., Ishida Y., Nomura W., Tamamura H.
    • Journal Title

      Peptide Science

      Volume: 2015 Pages: 249-250

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Journal Article] Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands.2016

    • Author(s)
      Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 21 Pages: 6967-6973

    • DOI

      10.1016/j.bmc.2015.09.040

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15J05835, KAKENHI-PROJECT-26670053
  • [Journal Article] Studies on Identification of Active Sites of an Inhibitory Cyclic Peptide against EGF Receptor Dimerization2015

    • Author(s)
      Mizuguchi T, Yamazaki Y, Kobayashi K, Ooe H, Iida M, Ninomiya R, Saito K, Akaji K, Tamamura H.
    • Journal Title

      Peptide Science

      Volume: 2014 Pages: 163-164

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Journal Article] Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.2015

    • Author(s)
      Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 15 Pages: 4423-4427

    • DOI

      10.1016/j.bmc.2015.06.020

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-26670053
  • [Journal Article] Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.2015

    • Author(s)
      Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
    • Journal Title

      Org. Biomol. Chem.

      Volume: 13 Issue: 32 Pages: 8734-8739

    • DOI

      10.1039/c5ob00891c

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-26670053
  • [Journal Article] Studies on identification of active sites of an inhibitory cyclic peptide against EGF receptor dimerization.2015

    • Author(s)
      Takaaki Mizuguchi, Yukako Yamazaki, Kazuya Kobayashi, Honami Ooe, Mika Iida, Ryunosuke Ninomiya, Kazuki Saito, Kenichi Akaji, Hirokazu Tamamura
    • Journal Title

      Peptide Science

      Volume: 2014 Pages: 163-164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Journal Article] Application of plug-plug technique to ACE experiments for discovery of peptides binding to a larger target protein: A model study of calmodulin-binding fragments selected from a digested mixture of reduced BSA.2014

    • Author(s)
      Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Hiroshi Kataoka, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
    • Journal Title

      Electrophoresis

      Volume: 35 Issue: 6 Pages: 846-854

    • DOI

      10.1002/elps.201300339

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Journal Article] Effect of ring size and side-chain orientation of cyclic peptides for the inhibition of EGF receptor dimerization.2013

    • Author(s)
      Takaaki Mizuguchi, Naho Ohara, Mika Iida, Ryunosuke Ninomiya, Shinji Wada, Yoshiaki Kiso, Kazuki Saito, Kenichi Akaji
    • Journal Title

      Peptide Science

      Volume: 2012 Pages: 19-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Journal Article] Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor2012

    • Author(s)
      Takaaki Mizuguchi, et al.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 20 Issue: 19 Pages: 5730-5737

    • DOI

      10.1016/j.bmc.2012.08.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J06748, KAKENHI-PROJECT-24590134
  • [Presentation] μオピオイド受容体に対する新奇バイトピックリガンドを指向した オキシトシンとエンドモルフィン-1から成る二価型化合物の合成研究2024

    • Author(s)
      千葉 洸,水口 貴章,藤井 秀明
    • Organizer
      日本薬学会第144年会(横浜)
    • Data Source
      KAKENHI-PROJECT-21K06460
  • [Presentation] SYNTHESIS OF OXYTOCIN ANALOGUES FOCUSED ON THE HYDROPHOBIC STRUCTURES AND THEIR POSITIVE ALLOSTERIC MODULATOR EFFECT ON μ OPIOID RECEPTOR2021

    • Author(s)
      Takaaki Mizuguchi, Risa Yamauchi, Haruka Ono, Miku Inagaki, Ami Yamazaki, Kennosuke Itoh, Kanako Miyano, Miki Nonaka, Yasuhito Uezono, and Hideaki Fujii
    • Organizer
      The 58th Japanese Peptide Symposium
    • Data Source
      KAKENHI-PROJECT-21K06460
  • [Presentation] Functional Evaluation of Fluorescein-Labeled Peptides Based on the EGF Receptor Dimerization Arm Sequences2016

    • Author(s)
      Toyama K, Mizuguchi T, Nomura W, Tamamura H.
    • Organizer
      34th European Peptide Symposium 2016 & 8th International Peptide Symposium
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2016-09-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18910
  • [Presentation] Studies on cyclic peptides for the development of potent dimerization inhibitors against the EGF receptor2016

    • Author(s)
      Takaaki Mizuguchi, Kei Toyama, Wataru Nomura, Kenichi Akaji, Hirokazu Tamamura
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Center for Learning and Innovation Takeda Pharmaceutical Company, Ltd.
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] Studies on new intracellular delivery peptides based on the dimerization arm sequence of the EGF receptor2016

    • Author(s)
      Kei Toyama, Takaaki Mizuguchi, Yusuke Ishida, Wataru Nomura, and Hirokazu Tamamura
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Center for Learning and Innovation Takeda Pharmaceutical Company, Ltd.
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] EGF受容体の二量体化アームを基盤とした新規細胞内輸送ペプチドに関する研究2016

    • Author(s)
      外山桂、水口貴章、野村渉、玉村啓和
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] Development of New Fluorescein-Labeled Peptides with Inhibitory Effect on the EGF Receptor Activation2016

    • Author(s)
      Toyama K, Mizuguchi T, Nomura W, Tamamura H.
    • Organizer
      The 20th Korean Peptide Protein Society Symposium.
    • Place of Presentation
      Yangyang, Korea
    • Year and Date
      2016-06-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18910
  • [Presentation] Studies on a Novel Delivery Peptide Derived from the Dimerization Arm of EGF Receptor2015

    • Author(s)
      Kei Toyama, Takaaki Mizuguchi, Yusuke Ishida, Wataru Nomura, and Hirokazu Tamamura
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚市民会館(平塚)
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] Functional Evaluation of Fluorescent-Labeled Derivatives of an Inhibitory Peptide against EGF Receptor Dimerization2015

    • Author(s)
      Takaaki Mizuguchi, Kei Toyama, Yusuke Ishida, Wataru Nomura, and Hirokazu Tamamura
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚市民会館(平塚)
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] 蛍光プローブを用いたEGFレセプター二量体化阻害ペプチドの機能評価2015

    • Author(s)
      外山桂、水口貴章、石田有佑、野村渉、玉村啓和
    • Organizer
      創薬懇話会2015
    • Place of Presentation
      徳島大学(鳴門)
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] EGFレセプター二量化阻害ペプチドの蛍光標識体の合成と機能評価2015

    • Author(s)
      水口貴章、外山桂、石田有佑、野村渉、玉村啓和
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] 上皮成長因子受容体の「二量体化アーム」を基盤とした新規抗がん薬開発に向けた環状ペプチドに関する研究2015

    • Author(s)
      水口貴章、外山桂、石田有佑、野村渉、玉村啓和
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター(幕張)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] EGFレセプター二量化阻害環状ペプチドの活性部位に関する研究2014

    • Author(s)
      水口貴章, 山﨑由香子, 小林数也, 大江保奈美, 飯田美佳, 二宮龍之介, 齋藤一樹, 赤路健一, 玉村啓和
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島大学蔵本キャンパス大塚講堂(徳島県徳島市)
    • Year and Date
      2014-10-23
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Presentation] 二量体化に着目した新規作用機序のEGFレセプター阻害薬研究2014

    • Author(s)
      水口貴章, 二宮龍之介, 飯田美佳, 大江保奈美, 山崎由香子, 小林数也, 齋藤一樹, 赤路健一, 玉村啓和
    • Organizer
      創薬懇話会2014
    • Place of Presentation
      長良川温泉ホテルパーク(岐阜県岐阜市)
    • Year and Date
      2014-07-10
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Presentation] EGFレセプター二量化阻害環状ペプチドの活性部位に関する研究

    • Author(s)
      水口貴章,他
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島大学蔵本キャンパス大塚講堂
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-26893061
  • [Presentation] EGFレセプターの二量化阻害を示す環状ペプチドの構造的特徴

    • Author(s)
      水口貴章, 大原菜穂, 二宮龍之介, 山崎由香子, 飯田美佳, 大江保奈美, 齋藤一樹, 赤路健一
    • Organizer
      日本薬学会 第133回年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Presentation] EGFレセプターの二量化阻害ペプチドをもとにしたアラニン置換ペプチドの細胞増殖抑制効果

    • Author(s)
      二宮龍之介, 水口貴章, 大原菜穂, 飯田美佳, 齋藤一樹, 赤路健一
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学浜甲子園キャンパス(西宮市)
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Presentation] EGFレセプターの二量化阻害に必要な環状ペプチドの環の大きさと側鎖配置の効果

    • Author(s)
      水口貴章, 大原菜穂, 飯田美佳, 二宮龍之介, 和田真治, 木曽良明, 齋藤一樹, 赤路健一
    • Organizer
      第49回ペプチド討論会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Data Source
      KAKENHI-PROJECT-24590134
  • [Presentation] EGFレセプターの二量化阻害活性を示す環状ペプチドの環サイズと側鎖配置の評価

    • Author(s)
      大原菜穂, 水口貴章, 二宮龍之介, 飯田美佳, 齋藤一樹, 赤路健一
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      武庫川女子大学浜甲子園キャンパス(西宮市)
    • Data Source
      KAKENHI-PROJECT-24590134
  • 1.  AKAJI Kenichi (60142296)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 2.  TAMAMURA Hirokazu (80217182)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 3.  NOMURA Wataru (80463909)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 4.  SAITO Kazuki (10192585)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  大橋 南美 (90707051)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  TOYAMA Kei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 7.  YOSHIMURA Kazuhisa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MURAKAMI Tsutomu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  HARADA Shigeyoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  NARUMI Tetsuo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  斎藤 一樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 9 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi