HIRAYAMA Yuri 平山友里

Researcher Number	30732804
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 助教
Affiliation (based on the past Project Information) *help	2025: 千葉大学, 大学院医学研究院, 助教 2024: 千葉大学, 医学(系)研究科(研究院), 助教 2022 – 2023: 千葉大学, 大学院医学研究院, 助教 2019: 千葉大学, 大学院医学研究院, 助教 2018: 千葉大学, 医学部附属病院, 薬剤師 2017: 山梨大学, 医学部附属病院, 薬剤師 2016: 山梨大学, 総合研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / Basic Section 46010:Neuroscience-general-related / General pharmacology Except Principal Investigator Neurosurgery
Keywords	Principal Investigator 虚血耐性 / 脳梗塞 / アストロサイト / グリア細胞 / 乳酸 / 脳虚血 / ATP / VNUT / ミクログリア / 脳・神経 … More / Preconditioning / HIF-1α / P2X7受容体 / 脳虚血耐性 / ATP受容体 … More Except Principal Investigator グリア細胞 / HIF1a / P2X7受容体 / 虚血耐性 / 脳卒中 / アストロサイト Less

脳虚血時におけるアストロサイト乳酸放出機序の解明Principal Investigator
- Principal Investigator
  
  平山友里
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Chiba University
脳虚血耐性における乳酸のプロスタグランジン輸送機能制御の影響Principal Investigator
- Principal Investigator
  
  平山友里
- Project Period (FY)
  2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Chiba University
脳虚血耐性におけるアストロサイト由来乳酸の役割の解明Principal Investigator
- Principal Investigator
  
  平山友里
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Chiba University
Neuroprotection against cerebral ischemic injury via microglial VNUT-mediated pathwayPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Yuri
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Chiba University
Mechanism of astrocyte-mediated ischemic tolerancePrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Yuri
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  University of Yamanashi
Mechanisms underlying glia-mediated ischemic tolerance
- Principal Investigator
  
  KOIZUMI Schuichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  University of Yamanashi

All 2023 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Central administered xenin induced Fos expression in nesfatin-1 neurons in rats2023
- Author(s)
  Shota Saito, Hirofumi Hashimoto, Hidefumi Wakashin, Misaki Ishibane, Sangjon Pae, Shinpei Saito, Yoshie Reien, Yuri Hirayama, Yoshiteru Seo, Takashi Mizushima, Naohiko Anzai
- Journal Title
  
  Brain Research Bulletin
  
  Volume: 204 Pages: 110788-110788
- DOI
  10.1016/j.brainresbull.2023.110788
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06840, KAKENHI-PROJECT-22K06853, KAKENHI-PROJECT-21H03065
[Journal Article] Astrocytes and ischemic tolerance2018
- Author(s)
  Hirayama Yuri、Koizumi Schuichi
- Journal Title
  
  Neuroscience Research
  
  Volume: 126 Pages: 53-59
- DOI
  10.1016/j.neures.2017.11.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19016
[Journal Article] New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia.2018
- Author(s)
  Koizumi, S., Hirayama, Y., Morizawa, YM
- Journal Title
  
  Neurochem Int
  
  Volume: in press Pages: 107-114
- DOI
  10.1016/j.neuint.2018.01.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25117003, KAKENHI-PROJECT-16H04669, KAKENHI-PROJECT-16K19016, KAKENHI-PUBLICLY-18H05121, KAKENHI-WRAPUP-18H05199
[Journal Article] Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.2017
- Author(s)
  5.Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KE, Nakao A, Takeda M, Koizumi S
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 1 Pages: e0168234-e0168234
- DOI
  10.1371/journal.pone.0168234
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04864, KAKENHI-PROJECT-15K15524, KAKENHI-PROJECT-26860380, KAKENHI-PROJECT-16K11042, KAKENHI-PROJECT-15H04972
[Journal Article] Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning.2017
- Author(s)
  Hirayama, Y., Koizumi, S.
- Journal Title
  
  Glia.
  
  Volume: 65 Issue: 3 Pages: 523-530
- DOI
  10.1002/glia.23109
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25117003, KAKENHI-PROJECT-16H04669, KAKENHI-PROJECT-15K15524, KAKENHI-PROJECT-16K19016
[Journal Article] Astrocyte-Mediated Ischemic Tolerance2015
- Author(s)
  Yuri Hirayama, Yuri Ikeda-Matsuo, Shoji Notomi, Hiroshi Enaida, Hiroyuki Kinouchi, Schuichi Koizumi
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 35(9) Issue: 9 Pages: 3794-3805
- DOI
  10.1523/jneurosci.4218-14.2015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670622, KAKENHI-PROJECT-15K15524
[Presentation] 脳虚血耐性におけるアストロサイト由来乳酸の役割の解明2023
- Author(s)
  平山友里、小泉修一、安西尚彦
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K06853
[Presentation] Neuroprotection against cerebral ischemic injury via VNUT-mediated pathway2020
- Author(s)
  Hirayama, Y., Ngoc, Le HP., Koizumi, S., Anzai, N.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K14815
[Presentation] Role of microglial VNUT in cerebral ischemic injury2019
- Author(s)
  Hirayama, Y., Ngoc, Le HP., Ishii, I., Anzai, N., Koizumi, S.
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-18K14815
[Presentation] Neuroprotection by VNUT-mediated microglial ATP exocytosis in the ischemic brain2018
- Author(s)
  Ha P. N Le, Yuri Hirayama, Schuichi Koizumi
- Organizer
  WCP2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14815
[Presentation] 脳虚血耐性現象におけるグリア細胞の役割2017
- Author(s)
  平山友里
- Organizer
  北陸大学グリアセミナー
- Place of Presentation
  北陸大学（石川県・金沢市）
- Year and Date
  2017-02-15
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] 低酸素に依存しないアストロサイトHIF-1α発現上昇メカニズムと虚血耐性2017
- Author(s)
  平山友里
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K19016
[Presentation] Mechanism underlying hypoxia-independent upregulation of astrocytic HIF-1α after ischemic preconditioning2017
- Author(s)
  Yuri Hirayama
- Organizer
  Society for Neuroscience Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19016
[Presentation] 低酸素に依存しないアストロサイトHIF-1α発現上昇メカニズムと虚血耐性2017
- Author(s)
  平山友里、Le Pham Ngoc Ha、小泉修一
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール(長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] Glia-mediated ischemic tolerance2017
- Author(s)
  Yuri Hirayama
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-16K19016
[Presentation] Mechanisms of the long-lasting astrocyte-mediated ischemic tolerance.2016
- Author(s)
  Hirayama, Y., Ikeda-Matsuo, Y., Koizumi, S.
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] 持続的なアストロサイト性脳虚血耐性の分子メカニズム解析2016
- Author(s)
  平山友里
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松研修交流センター（静岡県・浜松市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K19016
[Presentation] 持続的なアストロサイト性脳虚血耐性の分子メカニズム解析2016
- Author(s)
  平山友里、小泉修一
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松（静岡県・浜松市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] アストロサイトP2X7受容体を介する持続的な脳虚血耐性2016
- Author(s)
  平山友里、小泉修一
- Organizer
  第20回Japan　Purine　Club　Meeting
- Place of Presentation
  東京慈恵会医科大学（東京都・港区）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] Phagocytes astrocytes after brain ischemia.2015
- Author(s)
  Morizawa, Y., Hirayama, Y., Shibata, S., Koizumi, S.
- Organizer
  European Meeting on Glial Cells in Health and Disease
- Place of Presentation
  Euskalduna Conference Centre(Bilbao, Spain)
- Year and Date
  2015-07-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] Role of P2X7 receptor/HIF-1 α signal pathway in astrocyte-mediated ischemic tolerance.2015
- Author(s)
  Hirayama, Y., Ikeda-Matsuo, Y., Koizumi, S.
- Organizer
  Society for Neuroscience Annual Meeting 2015
- Place of Presentation
  McCormic Place(Chicago, U.S.A)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] Activation of P2X7 receptor/HIF-1α signal pathway in astrocytes induces ischemic tolerances.2015
- Author(s)
  Hirayama, Y., Ikeda-Matsuo, Y., Koizumi, S.
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] Mechanisms underlying astrocyte-mediated ischemic tolerance.2015
- Author(s)
  Hirayama, Y., Koizumi, S.
- Organizer
  第20回グリア研究会
- Place of Presentation
  名古屋市立大学（愛知県名古屋市）
- Year and Date
  2015-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] New insights into glia-mediated ischemic tolerance.2015
- Author(s)
  Hirayama, Y., Ikeda-Matsuo, Y., Koizumi, S.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K15524
[Presentation] Glial cells-triggered ischemic tolerance2015
- Author(s)
  Koizumi, S., Hirayama, Y.
- Organizer
  The 2015 Cold Spring Harbor Conferences Asia
- Place of Presentation
  Suzhou Dushu Lake Conference Center(Suzhou, China)
- Year and Date
  2015-06-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15524

1. KOIZUMI Schuichi (10280752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. KINOUCHI Hiroyuki (30241623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 安西尚彦 (70276054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. SHINOZAKI Youichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIGETOMI Eiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAMURA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中尾篤人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 橋本弘史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRAYAMA Yuri 平山 友里

Research Projects

Research Products

Co-Researchers

脳虚血時におけるアストロサイト乳酸放出機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳虚血耐性における乳酸のプロスタグランジン輸送機能制御の影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳虚血耐性におけるアストロサイト由来乳酸の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuroprotection against cerebral ischemic injury via microglial VNUT-mediated pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of astrocyte-mediated ischemic tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms underlying glia-mediated ischemic tolerance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Central administered xenin induced Fos expression in nesfatin-1 neurons in rats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Astrocytes and ischemic tolerance2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Astrocyte-Mediated Ischemic Tolerance2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脳虚血耐性におけるアストロサイト由来乳酸の役割の解明2023

Author(s)

Organizer

Data Source

[Presentation] Neuroprotection against cerebral ischemic injury via VNUT-mediated pathway2020

Author(s)

Organizer

Data Source

[Presentation] Role of microglial VNUT in cerebral ischemic injury2019

Author(s)

HIRAYAMA Yuri 平山友里