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Komatsu Naoki  小松 直貴

ORCIDConnect your ORCID iD *help
Researcher Number 30737440
Other IDs
Affiliation (Current) 2025: 徳島大学, 大学院医歯薬学研究部(医学域), 助教
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
2022 – 2023: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
2019 – 2021: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 基礎科学特別研究員
2018: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
2016 – 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員
2014 – 2015: 京都大学, 生命科学研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 44010:Cell biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Cell biology / Tumor biology
Except Principal Investigator
Biological Sciences
Keywords
Principal Investigator
生細胞イメージング / mTOR / 細胞周期 / 光遺伝学 / シグナル伝達 / 光操作 / 蛍光プローブ / mTORC1 / 細胞増殖 / FRETプローブ … More / リボソームプロファイリング / RNA-seq / 遺伝子発現解析 / ライブイメージング / タンパク質ビオチン化 / 1細胞解析 / リボソーム / 蛍光タンパク質 / ビオチン化 / 細胞内シグナル伝達 / 抗癌剤抵抗性 / MEK阻害剤 / 生物画像解析 / 蛍光ライブイメージング / MEK阻害剤抵抗性 / 発現誘導 / BRET … More
Except Principal Investigator
固体イメージング / 個体イメージング / 共鳴エネルギー移動 / 固定イメージング / レチノイン酸 / 細胞周期 / 共鳴エネルギ移動 / バイオイメージング Less
  • Research Projects

    (6 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (9 People)
  •  mTORC1活性操作による細胞内恒常性維持機構の解明Principal Investigator

    • Principal Investigator
      小松 直貴
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Unraveling mTORC1 activity dynamics and its information processing in cell proliferationPrincipal Investigator

    • Principal Investigator
      小松 直貴
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Platform for light-inducible, biochemical labeling of ribosomes in living single cells for the novel single-cell analytics based on seamlessly connected live cell imaging and transcriptomicsPrincipal Investigator

    • Principal Investigator
      Komatsu Naoki
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Unraveling the working principle of MEK inhibitor resistance in cancer cells by artificial control of cell growth signal dynamicsPrincipal Investigator

    • Principal Investigator
      Komatsu Naoki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Institute of Physical and Chemical Research
  •  The development of fundamental bioimaging technologies for comprehensive understanding

    • Principal Investigator
      Atsushi Miyawaki
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Institute of Physical and Chemical Research
  •  Quantitative analysis of MEK inhibitor resistance in cancer cells based on reconstitution of cell growth signalingPrincipal Investigator

    • Principal Investigator
      Komatsu Naoki
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Tumor biology
    • Research Institution
      Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2015 Other

All Journal Article Presentation

  • [Journal Article] Single-Cell Live Imaging2019

    • Author(s)
      Toru Hiratsuka and Naoki Komatsu
    • Journal Title

      Single Cell Methods

      Volume: - Pages: 409-421

    • DOI

      10.1007/978-1-4939-9240-9_24

    • ISBN
      9781493992393, 9781493992409
    • Data Source
      KAKENHI-PROJECT-18K19313, KAKENHI-PROJECT-16K21109
  • [Journal Article] A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging.2018

    • Author(s)
      Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8984-8984

    • DOI

      10.1038/s41598-018-27174-x

    • NAID

      120006523820

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08796, KAKENHI-PUBLICLY-17H05516, KAKENHI-PROJECT-16K21109, KAKENHI-PLANNED-15H05949, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18H02490
  • [Journal Article] Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle2017

    • Author(s)
      Sakaue-Sawano Asako、Yo Masahiro、Komatsu Naoki、Hiratsuka Toru、Kogure Takako、Hoshida Tetsushi、Goshima Naoki、Matsuda Michiyuki、Miyoshi Hiroyuki、Miyawaki Atsushi
    • Journal Title

      Molecular Cell

      Volume: 68 Issue: 3 Pages: 626-640

    • DOI

      10.1016/j.molcel.2017.10.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K06900, KAKENHI-PROJECT-16K21109, KAKENHI-PLANNED-15H05948, KAKENHI-PUBLICLY-16H01653, KAKENHI-ORGANIZER-15H05935
  • [Journal Article] Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Foerster resonance energy transfer2017

    • Author(s)
      Takuya Hiratsuka,Takeshi Sano,Hisashi Kato,Naoki Komatsu,Masamichi Imajo,Yuji Kamioka,Kenta Sumiyama,Fumiaki Banno,Toshiyuki Miyata,Michiyuki Matsuda
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 印刷中 Issue: 7 Pages: 1487-1499

    • DOI

      10.1111/jth.13723

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21109, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K09835, KAKENHI-PROJECT-16K21106
  • [Journal Article] A FRET Biosensor for ROCK Based on a Consensus Substrate Sequence Identified by KISS Technology2017

    • Author(s)
      Chunjie Li, Ayako Imanishi, Naoki Komatsu, Kenta Terai, Mutsuki Amano, Kozo Kaibuchi and Michiyuki Matsuda
    • Journal Title

      Cell Struct. Funct.

      Volume: 42 Issue: 1 Pages: 1-13

    • DOI

      10.1247/csf.16016

    • NAID

      130005308480

    • ISSN
      0386-7196, 1347-3700
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21109, KAKENHI-PROJECT-17H01380
  • [Journal Article] mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.2015

    • Author(s)
      Komatsu N, Fujita Y, Matsuda M, Aoki K
    • Journal Title

      Oncogene

      Volume: in press Issue: 45 Pages: 5607-5616

    • DOI

      10.1038/onc.2015.16

    • NAID

      120005712924

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23701052, KAKENHI-PROJECT-26890015, KAKENHI-PROJECT-26290053
  • [Journal Article] Ras/Rap2015

    • Author(s)
      小松直貴,松田道行
    • Journal Title

      生体の科学

      Volume: 66 Pages: 402-403

    • Data Source
      KAKENHI-PROJECT-26890015
  • [Presentation] Visualization of cell cycle-dependent mTORC1/S6K activation2023

    • Author(s)
      小松 直貴, 宮脇 敦史
    • Organizer
      第61回日本生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K06230
  • [Presentation] 細胞周期依存的なmTORC1活性化の可視化2022

    • Author(s)
      小松直貴、宮脇敦史
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K06230
  • [Presentation] mTORC1活性動態の細胞周期進行における生物学的意義の解明2021

    • Author(s)
      小松 直貴
    • Organizer
      第73回日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-18K19313
  • [Presentation] 細胞周期依存的なmTORC1活性波の可視化2021

    • Author(s)
      小松 直貴
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K19313
  • [Presentation] mTORC1活性動態の細胞周期進行における生物学的意義の解明2020

    • Author(s)
      小松 直貴
    • Organizer
      多次元細胞計測ワークショップ
    • Data Source
      KAKENHI-PROJECT-18K19313
  • [Presentation] 癌細胞増殖シグナルのライブイメージング2019

    • Author(s)
      小松 直貴
    • Organizer
      理研シンポジウム「細胞システムの動態と論理XI」
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K21109
  • [Presentation] Unraveling mTORC1 activity dynamics and its biological roles in cell cycle progression2019

    • Author(s)
      Naoki Komatsu, Sakaue-Sawano Asako, Atsushi Miyawaki
    • Organizer
      ASCB|EMBO 2019 Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19313
  • [Presentation] 癌細胞増殖シグナルのライブイメージング2019

    • Author(s)
      小松 直貴
    • Organizer
      理研シンポジウム「細胞システムの動態と論理XI」
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19313
  • [Presentation] Unraveling mTORC1 activity dynamics and its biological roles in cell cycle progression2019

    • Author(s)
      Naoki Komatsu, Sakaue-Sawano Asako, Atsushi Miyawaki
    • Organizer
      ResonanceBio International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19313
  • [Presentation] Unraveling mTORC1 activity dynamics and its biological roles in cell cycle progression2019

    • Author(s)
      Naoki Komatsu
    • Organizer
      Resonance Bio International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05948
  • [Presentation] KRas変異およびBRaf変異による癌細胞増殖促進はmTORC1活性化に収束する2015

    • Author(s)
      小松直貴、松田道行、青木一洋
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2015-06-30
    • Data Source
      KAKENHI-PROJECT-26890015
  • [Presentation] KRas変異細胞およびBRaf変異細胞におけるMEK阻害剤感受性のFRETイメージングを用いた定量解析

    • Author(s)
      小松直貴
    • Organizer
      第37回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26890015
  • 1.  Atsushi Miyawaki (80251445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  牧 昌次郎 (20266349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  下薗 哲 (40391982)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  阪上 朝子 (90462689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  濱 裕 (30261796)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  AOKI Kazuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  YO Masahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  三好 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  上岡 裕治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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