Watanabe Chie 渡辺知恵

… Alternative Names

WATANABE Chie 渡辺知恵

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Researcher Number	30737747
Affiliation (Current)	2025: 城西大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 城西大学, 薬学部, 教授 2018 – 2022: 城西大学, 薬学部, 准教授 2014 – 2015: 大阪大谷大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical pharmacy Except Principal Investigator Basic Section 90120:Biomaterials-related / Basic Section 90140:Medical technology assessment-related
Keywords	Principal Investigator DDS / 核酸製剤 / 白血病 / VHH / リンパ節 / リンパ経路 / リンパ液 / 核酸医薬 / 抗体医薬 / B細胞 … More / 悪性リンパ腫 / リンパ管 / 核酸 / 腸管粘膜再構築モデル … More Except Principal Investigator ヤヌス微粒子 / RNA-Seq / 膝関節液 / KLグレード / 再生医療 / OA / 変形性膝関節症 / 吸収モデル / 核酸 / 多孔性 / 格子ボルツマン法 / 一方向放出 / 粘膜付着 / 多孔質半球 / ヤヌス粒子 / 経口核酸送達システム / Caco-2 / 腸管粘膜付着性 / 多孔性マイクロスフェア / 核酸医薬品 / 経口送達システム / インスリン / 核酸分子 / ポーラスヤヌス微粒子 / 経口デリバリー / DDS / ドラッグデリバリーシステム / siRNA / 多孔性ヤヌス粒子 / 大腸デリバリー / 粘膜付着性 / 脂質ナノ粒子 / 核酸医薬 / 多孔性ヤヌス微粒子 / 薬物送達システム / 経口製剤 / バイオ医薬品 Less

多孔性ヤヌス微粒子による経口核酸デリバリーの最適化と吸収過程の局所モデル化の試み
- Principal Investigator
  
  松本昭博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka Ohtani University
変形性膝関節症における再生医療適応の判定基準および治療アルゴリズムの確立
- Principal Investigator
  
  松田芳和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Josai University
Tumor targeted oligonucleotide therapy via lymphatic route for achievement of complete cure from relapsed malignant lymphomaPrincipal Investigator
- Principal Investigator
  
  WATANABE Chie
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Josai University
Development of an oral nucleic acid delivery system accelerating the paradigm shift to nucleic acid pharmaceutical products
- Principal Investigator
  
  Murakami Masahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka Ohtani University
The construction of 3 dimensional intestinal tract and mucosa model and the basic examination using oligonucleotide medicine.Principal Investigator
- Principal Investigator
  
  WATANABE Chie
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka Ohtani University

All 2023 2022 2021 2020 2019 2016 2015 Other

All Journal Article Presentation Book

[Book] Precision Medicine2022
- Author(s)
  村上正裕、松本昭博、渡辺知恵
- Total Pages
  4
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-21K07224
[Journal Article] Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.2023
- Author(s)
  Yi Cheng, Chie Watanabe, Yusuke Ando, Satoshi Kitaoka, Yuya Egawa, Tomoya Takashima, Akihiro Matsumoto, Masahiro Murakami.
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 9 Pages: 2338-2338
- DOI
  10.3390/pharmaceutics15092338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12828, KAKENHI-PROJECT-21K07224
[Journal Article] Targeting cellular gaps using Janus nanoparticles containing cationic polymers and surfactant lipids2023
- Author(s)
  Akihiro Matsumoto, Takeo Kitazawa, Yuta Hatori, Masahiro Murakami, Hiroshi Nakanishi, Chie Watanabe, Tomoya Takashima, Masahiro Murakami
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 17 Issue: 2 Pages: 104-113
- DOI
  10.5582/ddt.2022.01118
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2023-04-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12828, KAKENHI-PROJECT-21K06090, KAKENHI-PROJECT-21K06383, KAKENHI-PROJECT-21K07224
[Journal Article] 経口核酸医薬品開発への技術戦略2022
- Author(s)
  村上正裕,松本昭博,渡辺知恵
- Journal Title
  
  経口核酸医薬品開発への技術戦略
  
  Volume: 5 Pages: 1302-1305
- Data Source
  KAKENHI-PROJECT-22K12828
[Journal Article] 経口核酸医薬開発へのアプローチ2021
- Author(s)
  村上正裕、渡辺知恵
- Journal Title
  
  BIO Clinica
  
  Volume: 36 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-21K07224
[Journal Article] 核酸医薬品へのパラダイムシフトを加速する経口核酸送達システムの開発戦略2020
- Author(s)
  村上正裕、渡辺知恵、松本昭博
- Journal Title
  
  月刊「細胞」
  
  Volume: 52 Pages: 53-59
- NAID
  40022320372
- Data Source
  KAKENHI-PROJECT-18H03541
[Journal Article] Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer2019
- Author(s)
  Akihiro Matsumoto, Chie Watanabe, Masahiro Murakami
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 13 Issue: 6 Pages: 343-353
- DOI
  10.5582/ddt.2019.01090
- NAID
  130007788595
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2019-12-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03541
[Journal Article] Fabrication of porous ethyl cellulose microspheres based on the acetone-glycerin-water ternary system: Controlling porosity via the solvent-removal mode2015
- Author(s)
  Masahiro Murakami, Akihiro Matsumoto, Chie Watanabe, Yu Kurumado, Masashi Takama
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 9 Issue: 4 Pages: 303-309
- DOI
  10.5582/ddt.2015.01053
- NAID
  130005098743
- Open Access
- Data Source
  KAKENHI-PROJECT-26893307
[Journal Article] Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route2015
- Author(s)
  Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa & Takanori Yokota
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 17035-17947
- DOI
  10.1038/srep17035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] 抗体のリンパ管系における動態の解析2023
- Author(s)
  石坂勝太、安藤祐介、徳山憲人、松田芳和、渡辺知恵
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] スギ花粉誘発過敏性鼻粘膜組織におけるサイトカイン受容体シグナルの亢進2023
- Author(s)
  加川るか、安藤祐介、渡辺知恵、酒井寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] スギ花粉誘発過敏性鼻粘膜組織におけるCC chemokinesおよびその受容体発現の変化2023
- Author(s)
  森田佳純1、山下道生2、安藤祐介3、竹ノ谷文子2、渡辺知恵3、塩田清二4、酒井寛泰5、花崎元彦6、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] 抗体のリンパ管系における動態の解析2023
- Author(s)
  石坂勝太、安藤祐介、徳山憲人、松田芳和、渡辺知恵
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-22K12893
[Presentation] スギ花粉反復暴露マウスの鼻粘膜における好酸球性炎症の評価2023
- Author(s)
  石毛希、山下道生、安藤祐介、竹ノ谷文子、渡辺知恵、塩田清二、酒井寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] スギ花粉誘発過敏性鼻粘膜組織におけるAvp発現の増加2023
- Author(s)
  阿部佳叶、山下道生、安藤祐介、竹ノ谷文子、渡辺知恵、塩田清二、酒井寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] スギ花粉誘発鼻粘膜過敏性形成におけるhemokinin-1の関与2023
- Author(s)
  瀧澤陸人、山下道生、安藤祐介、竹ノ谷文子、渡辺知恵、塩田清二、酒井寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] スギ花粉誘発過敏性鼻粘膜組織におけるH3受容体遺伝子Hrh3発現の増加2023
- Author(s)
  野田栞、山下道生、安藤祐介、竹ノ谷文子、渡辺知恵、塩田清二、酒田寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] 低酸素暴露細胞モデルを用いた気管支平滑筋過敏性形成メカニズムの解明2023
- Author(s)
  山﨑智貴、安藤祐介、渡辺知恵、松田芳和、酒井寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-22K12893
[Presentation] HT29-MTXの部分積層培養による腸管上皮薬物透過性のin vitro評価系としてのCaco-2単層膜の改良2023
- Author(s)
  津久井優希、橋本拓馬、安藤祐介、北岡諭、江川裕哉、Cheng Yi、高島智之、松本昭博、渡辺知恵、村上正裕
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] スギ花粉誘発過敏性鼻粘膜組織におけるneuropeptide Y遺伝子Npyの発現低下2023
- Author(s)
  佐藤礼佳、安藤祐介、渡辺知恵、酒井寛泰、花崎元彦、千葉義彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] Localization of Janus nanoparticles around adherens junction in Caco-2 monolayer2022
- Author(s)
  Akihiro Matsumoto, Takeo Kitazawa, Yuta Hatori, Chie Watanabe, Tomoya Takashima, Masahiro Murakami
- Organizer
  4th International symposium on BA/BE of oral dru products,2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12828
[Presentation] 免疫細胞特異的アクチン結合タンパク質Coronin-1の発現制御機構の解析2021
- Author(s)
  安藤祐介、金子豊、長谷川晋也、築地信、渡辺知恵、奥輝明
- Organizer
  日本薬学会　第142年会
- Data Source
  KAKENHI-PROJECT-21K07224
[Presentation] Improved hepatic delivery of siRNA by condensed drug loading in a dimpled suppository2021
- Author(s)
  Akihiro Matsumoto, Chie Watanabe, Masahiro Murakam
- Organizer
  Pharma R&D 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03541
[Presentation] Systemic liver-targeting delivery of a novel DNA/RNA heteroduplex oligonucleotide via an enteral route2019
- Author(s)
  Chie Watanabe, Masahiro Murakami
- Organizer
  3rd Edition of Global Conference on Pharmaceutics and Drug Delivery Systems (Paris, France)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03541
[Presentation] Use of porous microsphere-containing suppository in the hepatocyte-specific enteral delivery system for the delivery of siRNA.2019
- Author(s)
  Akihiro Matsumoto, Chie Watanabe, Masahiro Murakami
- Organizer
  46th Controlled Release Society Annual Meeting & Exposition (Valencia, Spain)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03541
[Presentation] ビタミンE修飾siRNAの肝特異的経腸デリバリーにおける各種吸収促進剤の効果2016
- Author(s)
  渡辺知恵、岡田泰樹、吉田規恵、仁科一隆、横田隆徳、村上正裕
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] Liver-specific delivery of a novel DNA/RNA heteroduplex oligonucleotide via enteral routes produced by the combination of alpha-tocopherol conjugation and permeation enhancers.2016
- Author(s)
  C. Watanabe, Y.Cheng, A. Watari, M.Kondoh, K. Yagi, Y. Matsumoto, K. Toh, K. Miyata, K. Kataoka, S. Obika, K.Yoshida-Tanaka, K. Nishina. T. Yokota, and M. Murakami
- Organizer
  Controlled Release Society Annual Meeting & Exposition
- Place of Presentation
  Washington State Convention Center (Seattle, Washington, USA)
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] ビタミンE修飾siRNA-脂質ナノ粒子の経腸的リンパ移行動態評価2016
- Author(s)
  渡辺　知恵,　松本　有、藤　加珠子、宮田　完二郎、片岡　一則、横田　隆徳,　村上　正裕
- Organizer
  遺伝子デリバリー研究会　第１６回シンポジウム
- Place of Presentation
  川崎生命科学・環境研究センター（神奈川県・川崎市）
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] ビタミンE結合siRNAの腸管上皮透過性のin vitro評価（１）2015
- Author(s)
  程緯、乾衿奈、渡辺知恵、仁科一隆、横田隆徳、村上正裕
- Organizer
  第６５回　日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学（大阪府・富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] 核酸分子の消化管における安定性のin vitro評価（2）2015
- Author(s)
  小林慎也、渡辺知恵、小比賀聡、村上正裕
- Organizer
  第６５回　日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学（大阪府・富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] 金属イオン内包C60フラーレンの線虫の寿命に与える影響2015
- Author(s)
  阿部早季、森友祐、高間雅志、渡辺知恵、村上正裕
- Organizer
  第６５回　日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学（大阪府・富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] 疎水修飾siRNAの腸管における安定性のin vitro評価
- Author(s)
  小林慎也, 渡辺知恵, 仁科一隆, 横田隆徳, 村上正裕
- Organizer
  日本薬学会
- Place of Presentation
  兵庫県・神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26893307
[Presentation] エチルセルロース多孔性マイクロスフィアの調製法:細孔形成機構に関する検討
- Author(s)
  渡辺知恵、堀田幸佑、車戸祐、村上正裕
- Organizer
  日本薬学会
- Place of Presentation
  兵庫県・神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26893307

1. Murakami Masahiro (50174280)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 松本昭博 (80824911)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 安藤祐介 (10805881)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. 松田芳和 (00895401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Watanabe Chie 渡辺 知恵

WATANABE Chie 渡辺 知恵

Research Projects

Research Products

Co-Researchers

多孔性ヤヌス微粒子による経口核酸デリバリーの最適化と吸収過程の局所モデル化の試み

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

変形性膝関節症における再生医療適応の判定基準および治療アルゴリズムの確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tumor targeted oligonucleotide therapy via lymphatic route for achievement of complete cure from relapsed malignant lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an oral nucleic acid delivery system accelerating the paradigm shift to nucleic acid pharmaceutical products

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The construction of 3 dimensional intestinal tract and mucosa model and the basic examination using oligonucleotide medicine.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Precision Medicine2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting cellular gaps using Janus nanoparticles containing cationic polymers and surfactant lipids2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] 経口核酸医薬品開発への技術戦略2022

Author(s)

Journal Title

Data Source

[Journal Article] 経口核酸医薬開発へのアプローチ2021

Author(s)

Journal Title

Data Source

[Journal Article] 核酸医薬品へのパラダイムシフトを加速する 経口核酸送達システムの開発戦略2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Fabrication of porous ethyl cellulose microspheres based on the acetone-glycerin-water ternary system: Controlling porosity via the solvent-removal mode2015

Author(s)

Journal Title

DOI

NAID

Watanabe Chie 渡辺知恵

WATANABE Chie 渡辺知恵

[Journal Article] 核酸医薬品へのパラダイムシフトを加速する経口核酸送達システムの開発戦略2020