Kessoku Takaomi 結束貴臣

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KESSOKU Takaomi 結束貴臣

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Researcher Number	30738620
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 国際医療福祉大学成田病院, 准教授 2025: 横浜市立大学, 医学部, 客員講師
Affiliation (based on the past Project Information) *help	2023: 横浜市立大学, 医学部, 客員講師 2022 – 2023: 横浜市立大学, 医学研究科, 客員講師 2022 – 2023: 横浜市立大学, 附属病院, 講師 2016 – 2021: 横浜市立大学, 附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 57080:Social dentistry-related / Gastroenterology
Keywords	Principal Investigator 腸管透過性 / 腸管バリア / フェカリバクテリウム / 非アルコール性脂肪肝炎 / 非アルコール性脂肪肝疾患 / 肝硬変 / 肝細胞癌 / 予防 / 肝がん / NAFLD / 腸内細菌 … More Except Principal Investigator … More リスク予測 / 臨床薬理学的アプローチ / Ａrtificial Intelligence / 臨床薬理 / 薬理学 / 臨床薬理学 / 予測システム / Artificial Intelligence / 全身疾患 / 口腔内フローラ / 非アルコール性脂肪性肝疾患 / 肝がん / 唾液中IgA分泌速度 / 口腔内細菌叢 / IgA / 唾液 / 腸内細菌叢 / 非アルコール性脂肪性肝炎由来肝がん / 腸内細菌 / 歯周病原細菌 / 非アルコール性肝炎由来肝がん / Fusobacterium nucleatum / Porphyromonas gingivalis / 歯周病 / 非アルコール性脂肪性肝炎由来肝細胞がん / 非アルコール性脂肪性肝炎 / 便メタゲノム解析 / Faecalibacterium / 腸管透過性 / 肝細胞癌 / 非アルコール性脂肪肝炎 / 非アルコール性脂肪肝炎由来肝細胞癌 / NASH由来肝細胞癌 Less

Development of a Novel Treatment for Non-Alcoholic Fatty Liver Disease Focusing on the Intestinal BarrierPrincipal Investigator
- Principal Investigator
  
  KESSOKU Takaomi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yokohama City University
Establishment of a method to prevent the development of metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma by focusing on periodontal disease and oral microflora.
- Principal Investigator
  
  Minabe Masato
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Kanagawa Dental College
Preventive effect of intestinal bacteria on non-B non-C liver carcinogenesis.Principal Investigator
- Principal Investigator
  
  KESSOKU Takaomi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yokohama City University
Development of a prediction system of systemic disease using AI technology based on oral flora.
- Principal Investigator
  
  WADA Koichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shimane University
Evaluation of the role of gut-microbiota in NASH-associated HCC pathogenesis
- Principal Investigator
  
  IMAJO KENTO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yokohama City University
NASH and gut microbiotaPrincipal Investigator
- Principal Investigator
  
  KESSOKU Takaomi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yokohama City University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 「歯周病と非アルコール性脂肪肝炎」　ヒト常在細菌叢と生理機能・全身疾患　（落合邦康　監修）III:　第十二章2020
- Author(s)
  和田孝一郎、結束貴臣、小川祐二、今城健人、米田正人、中島淳.
- Publisher
  シーエムシー出版
- ISBN
  9784781315195
- Data Source
  KAKENHI-PROJECT-19H04032
[Journal Article] Association between Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma and Periodontopathic Bacteria: A Cross-Sectional Pilot Study2023
- Author(s)
  Takuma Ryo、Morozumi Toshiya、Yamamoto Yuko、Kobayashi Takashi、Matsui Takaaki、Yoneda Masato、Kessoku Takaomi、Nogami Asako、Tamura Muneaki、Kamata Yohei、Sugihara Shuntaro、Nomura Yoshiaki、To Masahiro、Minabe Masato、Mitsudo Kenji、Nakajima Atsushi、Komaki Motohiro
- Journal Title
  
  Applied Sciences
  
  Volume: 13 Issue: 6 Pages: 3893-3893
- DOI
  10.3390/app13063893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10454, KAKENHI-PROJECT-21K10222, KAKENHI-PROJECT-22K10355, KAKENHI-PROJECT-17K11984, KAKENHI-PROJECT-20K18838, KAKENHI-PROJECT-22K10320, KAKENHI-PROJECT-21K10219
[Journal Article] Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study2022
- Author(s)
  Kasai Yuki, Kessoku Takaomi, Nakajima Atsushi
- Journal Title
  
  Clinical and Translational Gastroenterology
  
  Volume: 13 Issue: 7 Pages: e00503-e00503
- DOI
  10.14309/ctg.0000000000000503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07966, KAKENHI-PROJECT-21K08012
[Journal Article] Efficacy of <i>Bifidobacterium bifidum</i> G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study2021
- Author(s)
  Fuyuki A, Higurashi T, Kessoku T, Ashikari K, Yoshihara T, Misawa N, Iwaki M, Kobayashi T, Ohkubo H, Yoneda M, Usuda H, Wada K, Nakajima A.
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 40 Issue: 2 Pages: 105-114
- DOI
  10.12938/bmfh.2020-073
- NAID
  130008026131
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04032
[Journal Article] The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target.2021
- Author(s)
  Kessoku T, Kobayashi T, Tanaka K, Yamamoto A, Takahashi K, Iwaki M, Ozaki A, Kasai Y, Nogami A, Honda Y, Ogawa Y, Kato S, Imajo K, Higurashi T, Hosono K, Yoneda M, Usuda H, Wada K, Saito S, Nakajima A.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22 Issue: 15 Pages: 8161-8161
- DOI
  10.3390/ijms22158161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04032, KAKENHI-PROJECT-21K08012
[Journal Article] A prospective interventional trial on the effect of periodontal treatment on Fusobacterium nucleatum abundance in patients with colorectal tumours2021
- Author(s)
  Yoshihara Tsutomu、Kioi Mitomu、Baba Junichi、Usuda Haruki、Kessoku Takaomi、Iwaki Michihiro、Takatsu Tomohiro、Misawa Noboru、Ashikari Keiichi、Matsuura Tetsuya、Fuyuki Akiko、Ohkubo Hidenori、Matsumoto Mitsuharu、Wada Koichiro、Nakajima Atsushi、Higurashi Takuma
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 23719-23719
- DOI
  10.1038/s41598-021-03083-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10463, KAKENHI-PROJECT-19KK0412, KAKENHI-PROJECT-19H04032, KAKENHI-PROJECT-21K16003
[Journal Article] Endotoxins and Non-Alcoholic Fatty Liver Disease2021
- Author(s)
  Kessoku T, Kobayashi T, Imajo K, Tanaka K, Yamamoto A, Takahashi K, Kasai Y, Ozaki A, Iwaki M, Nogami A, Honda Y, Ogawa Y, Kato S, Higurashi T, Hosono K, Yoneda M, Okamoto T, Usuda H, Wada K, Kobayashi N, Saito S, Nakajima A
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 12 Pages: 770986-770986
- DOI
  10.3389/fendo.2021.770986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08583, KAKENHI-PROJECT-19H04032, KAKENHI-PROJECT-21K08012
[Journal Article] Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease.2020
- Author(s)
  Iwaki M, Kessoku T, Ozaki A, Kasai Y, Kobayashi T, Nogami A, Honda Y, Ogawa Y, Imajo K, Yoneda M, Maeda A, Tanaka Y, Nakajima S, Ohno H, Usuda H, Kawanaka M, Kawaguchi T, Torimura T, Kage M, Hyogo H, Takahashi H, Eguchi Y, Aishima S, Wada K, Kobayashi N, Sumida Y, Saito S, Nakajima A.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: － Issue: 8 Pages: 2275-2284
- DOI
  10.1111/jgh.15487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04032
[Journal Article] Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial2020
- Author(s)
  Kamata Yohei、Kessoku Takaomi、Shimizu Tomoko、Kobayashi Takashi、Kurihashi Takeo、Sato Satsuki、Kuraji Syotaro、Aoyama Norio、Iwasaki Tomoyuki、Takashiba Shogo、Hamada Nobushiro、Kodama Toshiro、Tamura Toshiyuki、Ino Satoshi、Higurashi Takuma、Taguri Masataka、Yamanaka Takeharu、Yoneda Masato、Minabe Masato
- Journal Title
  
  Trials
  
  Volume: 21 Issue: 1 Pages: 291-291
- DOI
  10.1186/s13063-020-4201-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07637, KAKENHI-PROJECT-19K10454, KAKENHI-PROJECT-19K10463, KAKENHI-PROJECT-18K17035, KAKENHI-PROJECT-19H04032, KAKENHI-PROJECT-18K15029
[Journal Article] The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton pump inhibitor and aspirin.2020
- Author(s)
  Yoshihara T, Oikawa Y, Kato T, Kessoku T, Kobayashi T, Kato S, Misawa N, Ashikari K, Fuyuki A, Ohkubo H, Higurashi T, Tateishi Y, Tanaka Y, Nakajima S, Ohno H, Wada K, Nakajima A.
- Journal Title
  
  Gut Microbes.
  
  Volume: 11 Issue: 5 Pages: 1385-1404
- DOI
  10.1080/19490976.2020.1758290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04032
[Journal Article] Rationale and design of a randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated phase 2a study to investigate the efficacy and safety of elobixibat in combination with cholestyramine for non-alcoholic fatty liver disease.2020
- Author(s)
  Kessoku T, Kobayashi T, Ozaki A, Iwaki M, Honda Y, Ogawa Y, Imajo K, Saigusa Y, Yamamoto K, Yamanaka T, Usuda H, Wada K, Yoneda M, Saito S, Nakajima A.
- Journal Title
  
  BMJ Open.
  
  Volume: 10 Issue: 9 Pages: e037961-e037961
- DOI
  10.1136/bmjopen-2020-037961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04032
[Journal Article] Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial.2020
- Author(s)
  Kessoku T, Imajo K, Kobayashi T, Yoneda M, Kirikoshi H, Kubota K, Taguri M, Yamanaka T, Usuda H, Wada K, Kobayashi N, Saito S, Nakajima A.
- Journal Title
  
  Lancet Gastroenterol Hepatol.
  
  Volume: 5 Issue: 11 Pages: 996-1007
- DOI
  10.1016/s2468-1253(20)30216-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04032
[Journal Article] The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota2020
- Author(s)
  Misawa N、Higurashi T、Takatsu T、Iwaki M、Kobayashi T、Yoshihara T、Ashikari K、Kessoku T、Fuyuki A、Matsuura T、Ohkubo H、Usuda H、Wada K、Naritaka N、Takei H、Nittono H、Matsumoto M、Honda A、Nakajima A、Camilleri M
- Journal Title
  
  Alimentary Pharmacology & Therapeutics
  
  Volume: 52 Issue: 5 Pages: 821-828
- DOI
  10.1111/apt.15950
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11509, KAKENHI-PROJECT-19H04032
[Journal Article] Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression2019
- Author(s)
  Murata Yuka、Yamashiro Takashi、Kessoku Takaomi、Jahan Israt、Usuda Haruki、Tanaka Tetsuya、Okamoto Takayuki、Nakajima Atsushi、Wada Koichiro
- Journal Title
  
  BioMed Research International
  
  Volume: 2019 Pages: 1-9
- DOI
  10.1155/2019/2916243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08583, KAKENHI-PROJECT-19H04032, KAKENHI-PROJECT-18K15029
[Journal Article] Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis.2017
- Author(s)
  Honda Y, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Takizawa T, Saito S, Nagashima Y, Nakajima A.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 42477-42477
- DOI
  10.1038/srep42477
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19340, KAKENHI-PROJECT-16K19357
[Journal Article] Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.2016
- Author(s)
  Kessoku T, Imajo K, Honda Y, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 25 Issue: 1 Pages: 22251-22251
- DOI
  10.1038/srep22251
- NAID
  120005749754
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19341, KAKENHI-PROJECT-15H04757, KAKENHI-PROJECT-26860516, KAKENHI-PROJECT-25293175, KAKENHI-PROJECT-26460456, KAKENHI-PROJECT-15K19340, KAKENHI-PROJECT-16K19357
[Journal Article] The characteristics of non-obese NAFLD: Effect of genetic and environmental factors.2016
- Author(s)
  Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A, Hotta K
- Journal Title
  
  Hepatol Res
  
  Volume: - Issue: 10 Pages: 636-636
- DOI
  10.1111/hepr.12648
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461343, KAKENHI-PROJECT-26860516, KAKENHI-PROJECT-15K19340, KAKENHI-PROJECT-16K09781, KAKENHI-PROJECT-16K19357
[Journal Article] The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice.2016
- Author(s)
  Honda Y, Imajo K, Kato T, et al.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 1 Pages: e0146337-e0146337
- DOI
  10.1371/journal.pone.0146337
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19341, KAKENHI-PROJECT-25293175, KAKENHI-PROJECT-16K19357
[Journal Article] Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.2016
- Author(s)
  Higurashi T, Hosono K, Takahashi H, Komiya Y, Umezawa S, Sakai E, Uchiyama T, Taniguchi L, Hata Y, Uchiyama S, Hattori A, Nagase H, Kessoku T, Arimoto J, Matsuhashi N, Inayama Y, Yamanaka S, Taguri M, Nakajima A.
- Journal Title
  
  Lancet Oncol.
  
  Volume: 17 Issue: 4 Pages: 475-783
- DOI
  10.1016/s1470-2045(15)00565-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860519, KAKENHI-PROJECT-16K19357
[Journal Article] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Nonalcoholic Fatty Liver Disease Than Transient Elastography.2016
- Author(s)
  Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T,Yamanaka T, Wada K, Saito S, Nakajima A
- Journal Title
  
  Gastroenterology
  
  Volume: 150 Issue: 3 Pages: 626-37
- DOI
  10.1053/j.gastro.2015.11.048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-15K19341, KAKENHI-PROJECT-15H04757, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-26860516, KAKENHI-PROJECT-25293175, KAKENHI-PROJECT-16K19357
[Presentation] 腸内細菌/腸管バリアを標的とした非アルコール性脂肪肝疾患に対する新規治療開発2023
- Author(s)
  結束貴臣
- Organizer
  日本臨床栄養学会
- Data Source
  KAKENHI-PROJECT-21K07966
[Presentation] 非アルコール性脂肪性肝炎由来幹細胞がんにおける歯周病の関与2022
- Author(s)
  琢磨遼, 両角俊哉, 松井嵩昌, 山本裕子, 結束貴臣, 米田正人, 野上麻子, 小林貴, 杉原俊太郎, 鎌田要平, 田村宗明, 光藤健司, 中島淳, 三邉正人, 小牧基浩
- Organizer
  歯周病の関与：第65回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10454
[Presentation] Gut microbiota and NASH/NAFLD2020
- Author(s)
  Takaomi Kessoku,Takashi Kobayashi, Atsushi Nakajima
- Organizer
  JDDW
- Data Source
  KAKENHI-PROJECT-19K17471
[Presentation] Elevated hepatic iron overload obtained by magnetic resonance imaging reflects hepatic inflammation and ballooning in patients with non-alcoholic fatty liver disease.2019
- Author(s)
  69.K. Imajo, K. Suzuki, Y. Honda, Y. Ogawa, M. Yoneda, T. Kessoku, S. Saito, A Nakajima.
- Organizer
  IBD and Liver: East Meets West Poster Session Liver, Kyoto,2018(Kyoto Hotel Okura), September 8.
- Invited
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] Increased levels of bile acid in feces plays an important role in pathophysiology of non-alcoholic steatohepatitis.2019
- Author(s)
  Kessoku T., Kobayashi T., Imajo K., Wada K., et al.
- Organizer
  International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04032
[Presentation] Increased levelsof bile acid in faces plays an important role in pathophysiology of nonalcoholic stestohepatitis.2019
- Author(s)
  18.Kessoku T, Kobayashi T, Imajo K, Honda Y, Ogawa Y, Kato S, Higurashi T, Yoneda M, Yousuke Oikawa, Yoshiki Tanaka, Shunji Nakajima, Usuda H, Wada K, Saito S, Nakajima A:
- Organizer
  The international liver congress 2019 Poster,Vienna(Austria), April 12 2019.
- Invited
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] A direct comparative study among magnetic resonance elastography, vibration controlled transient elastography and shear wave elastography in patients with nonalcoholic fatty liver disease.2019
- Author(s)
  19.Kento Imajo, Takaomi Kessoku, Takashi Kobayashi, Yasushi Honda, Yuji Ogawa, Masato Yoneda, Hiroyuki Kirikosho, Satoru Saito, Atsushi Nakajima :
- Organizer
  The international liver congress 2019 Poster,Vienna(Austria), April 13 2019.
- Invited
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] 「食事内容の変化がもたらすLeaky gut SyndromeやNASHに対するFaecalibacteriumu prausnitziiの治療効果」2019
- Author(s)
  小林貴、結束貴臣、今城、中島淳
- Organizer
  一般演題１　第9回肥満と消火器疾患研究会，石川(ホテル日航金沢)，2019年5月8日.
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] Faecalibacterium prausnitzii 経口投与によるLeaky gut syndrome改善とNASH治療の可能性2019
- Author(s)
  小林貴、結束貴臣、今城健人、中島淳
- Organizer
  第38回　アルコール医学生物学研究会学術集会　一般演題 5，2019年.
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] NASH における Faecalibacterium prausnitzii 減少の機序と菌体成分による治療の可能性.2019
- Author(s)
  小林貴、結束貴臣、今城、中島淳
- Organizer
  第105回日本消化器病学会総会　ワークショップ2(WS2-12)　消化器領域における腸内細菌研究と臨床応用，石川（ANA クラウンプラザホテル金沢）2019年5月9日．
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] Efficacy, safety, and tolerability of lubiprostone for the treatment of non-alcoholic fatty liver disease: The LUBIPRONE, double-blind, randomized, placebo-controlled, phase II study.2019
- Author(s)
  Kessoku T., Imajyo K., Ogawa Y., Wada K., et al.
- Organizer
  International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04032
[Presentation] 高果糖や高コレステロール食がもたらすLeaky gut syndromeに対するFaecalibacterium prausnitzii治療の検討2018
- Author(s)
  結束貴臣、今城健人、中島淳
- Organizer
  JDDW 2018
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] Faecalibacterium improves pathogenesis of nonalcoholic steatohepatitis via controlling Treg induced gut-permeability2018
- Author(s)
  Takaomi Kessoku, Kento Imajo
- Organizer
  European Association for the Study of the Liver 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] Faecalibacterium improves pathogenesis of nonalcoholic steatohepatitis via controlling Treg induced gut-permeability2018
- Author(s)
  結束貴臣、今城健人、中島淳
- Organizer
  EASL 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] 非アルコール性脂肪肝炎とその関連病態に対するFaecalibacterium prausnitziiの効果2018
- Author(s)
  結束貴臣、今城健人
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09434
[Presentation] The aggravation of nonalcoholic fatty liver disease is associated with endotoxemia via the increase of gut-permeability by faecalibacterium prausnittii in human and vivo study2016
- Author(s)
  Takaomi Kessoku
- Organizer
  Asian Pacific Digestive Week
- Place of Presentation
  Kobe Convention Center (兵庫県神戸市)
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-16K19357
[Presentation] 非アルコール性脂肪肝疾患患者の腸内細菌叢に関する検討.2016
- Author(s)
  結束貴臣
- Organizer
  第52回日本肝臓学会総会. WS5：NASH/NAFLD研究の新展開.
- Place of Presentation
  幕張メッセ（千葉県幕張市）
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-16K19357
[Presentation] 非アルコール性脂肪肝炎の線維化進展に寄与する腸内細菌叢の検討.2016
- Author(s)
  結束貴臣
- Organizer
  第102回日本消化器病学会総会. ワークショップ3
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K19357
[Presentation] CHARACTERISTICS OF FECAL MICROBIOTA IN NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) PATIENTS: A CONNECTION BETWEEN ENDOTOXIN AND NAFLD.2016
- Author(s)
  Takaomi Kessoku
- Organizer
  The International Liver Congress2016 - 51st annual meeting of the European Association for the Study of the Liver (EASL)
- Place of Presentation
  バルセロナ、スペイン
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19357

1. 中島淳 (30326037)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. IMAJO KENTO (30600192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
3. Minabe Masato (60148004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. WADA Koichiro (90263467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 斉藤聡 (00275041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 留野渉 (00644957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 本多靖 (00784844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 米田正人 (10423831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 小川祐二 (20644959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 両角俊哉 (20444151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 宮内睦美 (50169265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山本裕子 (60756568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 鎌田要平 (80385070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 梅村和夫 (40232912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 田中徹也 (10346380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 岡本貴行 (30378286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 臼田春樹 (30707667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
18. OGAWA Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
19. HOTTA Kikuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 兵庫秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 細野邦広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 小野正文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kessoku Takaomi 結束 貴臣

KESSOKU Takaomi 結束 貴臣

Research Projects

Research Products

Co-Researchers

Development of a Novel Treatment for Non-Alcoholic Fatty Liver Disease Focusing on the Intestinal BarrierPrincipal Investigator

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Establishment of a method to prevent the development of metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma by focusing on periodontal disease and oral microflora.

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Preventive effect of intestinal bacteria on non-B non-C liver carcinogenesis.Principal Investigator

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Development of a prediction system of systemic disease using AI technology based on oral flora.

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Evaluation of the role of gut-microbiota in NASH-associated HCC pathogenesis

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NASH and gut microbiotaPrincipal Investigator

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[Book] 「歯周病と非アルコール性脂肪肝炎」 ヒト常在細菌叢と生理機能・全身疾患 （落合邦康 監修）III: 第十二章2020

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[Journal Article] Association between Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma and Periodontopathic Bacteria: A Cross-Sectional Pilot Study2023

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[Journal Article] Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study2022

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[Journal Article] Efficacy of <i>Bifidobacterium bifidum</i> G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study2021

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[Journal Article] The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target.2021

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[Journal Article] A prospective interventional trial on the effect of periodontal treatment on Fusobacterium nucleatum abundance in patients with colorectal tumours2021

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[Journal Article] Endotoxins and Non-Alcoholic Fatty Liver Disease2021

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[Journal Article] Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease.2020

Kessoku Takaomi 結束貴臣

KESSOKU Takaomi 結束貴臣

[Book] 「歯周病と非アルコール性脂肪肝炎」　ヒト常在細菌叢と生理機能・全身疾患　（落合邦康　監修）III:　第十二章2020