Okita Yukari 沖田結花里

… Alternative Names

OKITA Yukari 沖田結花里

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Researcher Number	30743710
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help	2025: 筑波大学, 医学医療系, 助教 2017 – 2023: 筑波大学, 医学医療系, 助教 2015 – 2016: 筑波大学, 医学医療系, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Experimental pathology Except Principal Investigator Experimental pathology
Keywords	Principal Investigator 腫瘍形成 / GPNMB / がん幹細胞 / EMT / 細胞運動 / スフェア形成 / 環状ペプチド / 分子標的治療 / 転移形成 / MafK … More / TGF-β / 上皮間葉転換 / 幹細胞マーカー / 抗体 / 特殊環状ペプチド / 乳がん / Gpnmb … More Except Principal Investigator Gpnmb / 幹細胞 / 上皮間葉転換 / MAFK / 特殊環状ペプチド / GPNMB / MafK / TMEPAI / TGF-β / トランスフォーミング増殖因子β / がん幹細胞 / 足場非依存性増殖 / がん Less

GPNMBによるがん幹細胞性誘導と可塑性に関する研究Principal Investigator
- Principal Investigator
  
  沖田結花里
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Tsukuba
Role of glycoprotein NMB in cancer stemness inductionPrincipal Investigator
- Principal Investigator
  
  沖田結花里
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Tsukuba
Role of TGF-beta related molecules in tumorigenesis through cancer stemness inductionPrincipal Investigator
- Principal Investigator
  
  Okita Yukari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  University of Tsukuba
Roles of GPNMB in cancer stem cells and development of therapeutic agent targeting GPNMBPrincipal Investigator
- Principal Investigator
  
  Okita Yukari
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of Tsukuba
Roles of MafK-Gpnmb axis in malignant progression of cancer and molecular targeted therapyPrincipal Investigator
- Principal Investigator
  
  OKITA Yukari
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Tsukuba
Roles of TGF-beta target genes TMEPAI and MafK on cancer development
- Principal Investigator
  
  Kato Mitsuyasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Tsukuba

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Glycoprotein nonmetastatic melanoma protein B impacts the malignant potential of bladder cancer cells through its hem‐immunoreceptor tyrosine‐based activation motif2024
- Author(s)
  Kimura Tomokazu、Okita Yukari、Nagumo Yoshiyuki、Chin Jas Min、Fikry Muhammad Ali、Shiga Masanobu、Kandori Shuya、Kawahara Takashi、Suzuki Hiroyuki、Nishiyama Hiroyuki、Kato Mitsuyasu
- Journal Title
  
  Pathology International
  
  Volume: - Issue: 5 Pages: 262-273
- DOI
  10.1111/pin.13419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07184, KAKENHI-PROJECT-20K20597
[Journal Article] Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal squamous cell carcinoma2022
- Author(s)
  Manevich L, Okita Y, Okano Y, Sugasawa T, Kawanishi K, Poullikkas T, Dang Cao LTL, Zheng L, Nakayama M, Matsumoto S, Tabuchi K, Kato M
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 9 Pages: 3244-3254
- DOI
  10.1111/cas.15359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07658, KAKENHI-PROJECT-20K20597
[Journal Article] Polyvinyl alcohol scaffolds and supplementation support 3D and sphere culturing of human cancer cell lines by reducing apoptosis and promoting cellular proliferation2021
- Author(s)
  Okita Yukari、Zheng Ling、Kawanishi Kunio、Miyoshi Hirotoshi、Yanagihara Kazuyoshi、Kato Mitsuyasu
- Journal Title
  
  Genes to Cells
  
  Volume: 26(5) Issue: 5 Pages: 336-343
- DOI
  10.1111/gtc.12843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07658, KAKENHI-PROJECT-20K20597, KAKENHI-PROJECT-19K17730, KAKENHI-PROJECT-20K16434, KAKENHI-PROJECT-18H02676
[Journal Article] Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation2021
- Author(s)
  Wang Chen、Okita Yukari、Zheng Ling、Shinkai Yasuhiro、Manevich Lev、Chin Jas M.、Kimura Tomokazu、Suzuki Hiroyuki、Kumagai Yoshito、Kato Mitsuyasu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4187-4197
- DOI
  10.1111/cas.15090
- NAID
  120007178942
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07473, KAKENHI-PROJECT-19K07658, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K20597
[Journal Article] Role of the kringle-like domain in glycoprotein NMB for its tumorigenic potential.2019
- Author(s)
  Xie R, Okita Y, Ichikawa Y, Fikry MA, Huynh Dam KT, Tran STP, Kato M
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 7 Pages: 2237-2246
- DOI
  10.1111/cas.14076
- NAID
  120007133159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07658, KAKENHI-PROJECT-18H02676
[Journal Article] Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties2018
- Author(s)
  Chen Chen、Okita Yukari、Watanabe Yukihide、Abe Fumie、Fikry Muhammad Ali、Ichikawa Yumu、Suzuki Hiroyuki、Shibuya Akira、Kato Mitsuyasu
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 22 Pages: 6424-6435
- DOI
  10.1158/0008-5472.can-18-0599
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05022, KAKENHI-PROJECT-16H06387, KAKENHI-PROJECT-16K08706, KAKENHI-PROJECT-17K14981
[Journal Article] Cell-surface GPNMB and induction of stemness.2018
- Author(s)
  Okita Y, Chen C, Kato M.
- Journal Title
  
  Oncotarget
  
  Volume: 9(99) Issue: 99 Pages: 37289-37290
- DOI
  10.18632/oncotarget.26472
- Open Access
- Data Source
  KAKENHI-PROJECT-18H02676, KAKENHI-PROJECT-17K14981
[Journal Article] The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB2017
- Author(s)
  Yukari Okita, Minori Kimura, Rudy Xie, Chen Chen, Larina Tzu-Wei Shen, Yurika Kojima, Hiroyuki Suzuki, Masafumi Muratani, Masao Saitoh, Kentaro Semba, Carl-Henrik Heldin, Mitsuyasu Kato
- Journal Title
  
  Science Signaling
  
  Volume: 10 Issue: 474 Pages: 11-11
- DOI
  10.1126/scisignal.aak9397
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19070, KAKENHI-PROJECT-16K08706, KAKENHI-PUBLICLY-15H01343, KAKENHI-PROJECT-15H05576
[Journal Article] Transforming growth factor-&βinduces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.2013
- Author(s)
  Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Ogami T, Koinuma D, Kato M.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 28 Pages: 20658-20667
- DOI
  10.1074/jbc.m113.450478
- NAID
  120007136878
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25293092, KAKENHI-PROJECT-25460472, KAKENHI-PROJECT-25640059
[Presentation] 乳がんの進展におけるGPNMBの作用2024
- Author(s)
  沖田結花里、加藤光保
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K07184
[Presentation] 乳がんにおけるGPNMBとFGFRの相互作用2023
- Author(s)
  エルヒナウィ　マナール、沖田結花里、加藤光保
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07184
[Presentation] 細胞運動性獲得におけるGPNMBの作用2023
- Author(s)
  沖田結花里、加藤光保
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07184
[Presentation] 乳がんにおけるglycoprotein NMBの役割2022
- Author(s)
  沖田結花里、加藤光保
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07184
[Presentation] 薬剤耐性における転写因子MAFKの作用2021
- Author(s)
  八幡原礼音、沖田結花里、加藤光保
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07658
[Presentation] 乳がん細胞の幹細胞性獲得におけるGPNMBの作用2020
- Author(s)
  沖田結花里、加藤光保
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K07658
[Presentation] 幹細胞性誘導によるがんの持続的増殖機構2020
- Author(s)
  加藤光保、沖田結花里
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07658
[Presentation] GPNMBによる幹細胞性誘導機構の解明2019
- Author(s)
  沖田結花里、陳晨、加藤光保
- Organizer
  第3回がん三次元培養研究会
- Data Source
  KAKENHI-PROJECT-19K07658
[Presentation] 乳がんの発生・進展における転写因子MAFKとその標的遺伝子GPNMBの作用2018
- Author(s)
  沖田結花里
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 幹細胞性誘導による腫瘍形成機構2018
- Author(s)
  加藤光保、陳晨、沖田結花里
- Organizer
  第2回がん三次元培養研究会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 乳がん細胞におけるGPNMBの幹細胞性誘導作用2018
- Author(s)
  沖田結花里、鈴木裕之、加藤光保
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 幹細胞性誘導によるがん細胞の持続的増加機構2018
- Author(s)
  加藤光保、沖田結花里
- Organizer
  第107回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] Glycoprotein nmbとがん幹細胞性2018
- Author(s)
  沖田結花里、陳晨、加藤光保
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 乳がん細胞の運動におけるGPNMBとFGF-2の作用2018
- Author(s)
  市川優矛、沖田結花里、加藤光保
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] Kringle-like domain is essential in GPNMB-induced breast cancer formation2017
- Author(s)
  Rudy Xie, Yukari Okita, and Mitsuyasu Kato
- Organizer
  第40回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] Cell surface expression of GPNMB on dormant breast cancer stem cells2017
- Author(s)
  Chen Chen, Yukari Okita, and Mitsuyasu Kato
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] Mutual induction of GPNMB and LPAR1 in Breast Cancer2017
- Author(s)
  Xinzhu Hong, Minori Kimura,Yukari Okita, and Mitsuyasu Kato
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] Norvel therapeutic strategy targeting GPNMB expressing dormant cancer cells2017
- Author(s)
  Yukari Okita
- Organizer
  TGF-β meeting in Uppsala 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 乳がんの発生・進展におけるGPNMBの役割2017
- Author(s)
  沖田結花里、陳晨、加藤光保
- Organizer
  第1回がん三次元培養研究会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 乳がんの発生・進展におけるGPNMBの役割2017
- Author(s)
  沖田結花里、陳晨、鈴木裕之、加藤光保
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K14981
[Presentation] 転写因子MafKはTGF-βによって誘導され、腫瘍形成を促進する2016
- Author(s)
  加藤光保、沖田結花里
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県　横浜市
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] 乳がんにおけるGPNMBの役割2016
- Author(s)
  沖田結花里、陳晨、鈴木裕之、加藤光保
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  パシフィコ横浜　神奈川県　横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] Roles of GPNMB in breast cancer initiation and malignant progression2016
- Author(s)
  Yukari Okita, Ai Kato, Chen Chen, Hiroyuki Suzuki, and Mitsuyasu Kato
- Organizer
  the 41st Naito Conference
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ　北海道　札幌市
- Year and Date
  2016-07-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] Roles of GPNMB in breast cancer malignant formation and progression2016
- Author(s)
  Yukari Okita, Hiroyuki Suzuki, and Mitsuyasu Kato
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県　横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] 乳がんの発生・進展におけるGPNMBの役割2016
- Author(s)
  沖田結花里、鈴木裕之、加藤光保
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  宮城県仙台市、仙台国際交流センター
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] Roles of GPNMB in Breast Cancer Stem Cells2016
- Author(s)
  陳晨、沖田結花里、加藤光保
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  パシフィコ横浜　神奈川県　横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] 乳がんの発生・進展におけるGPNMBの役割2016
- Author(s)
  沖田結花里、鈴木裕之、加藤光保
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター　宮城県　仙台市
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] 乳がんにおける転写因子MafKの働き2015
- Author(s)
  沖田結花里、鈴木裕之、加藤光保
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293092
[Presentation] 乳がんにおける転写因子MafKの働き2015
- Author(s)
  沖田結花里、鈴木裕之、加藤光保
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市、名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] Transcription factor MafK induces epithelial-mesenchymal transition and malignant progression of breast cancer cells.2015
- Author(s)
  Yukari Okita, Hiroyuki Suzuki and Mitsuyasu Kato
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Snowmass, Colorado
- Year and Date
  2015-07-12
- Data Source
  KAKENHI-PROJECT-25293092
[Presentation] Transcription factor MafK induces epithelial-mesenchymal transition and malignant progression of breast cancer cells2015
- Author(s)
  Yukari Okita, Hiroyuki Suzuki, and Mitsuyasu Kato
- Organizer
  FASEB meeting The TGF-β Superfamily: Signaling in Development and Disease
- Place of Presentation
  アメリカ合衆国コロラド州
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19070
[Presentation] 乳腺細胞の上皮間葉転換と腫瘍形成における転写因子MafKの役割2013
- Author(s)
  沖田結花里
- Organizer
  第32回分子病理学研究会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25293092
[Presentation] 乳腺上皮細胞の上皮間葉転換と腫瘍形成における小Maf群転写因子の役割2013
- Author(s)
  沖田結花里
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25293092
[Presentation] 乳がんにおける転写因子MafKの役割
- Author(s)
  沖田結花里
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25293092

1. KATO Mitsuyasu (20194855)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. WATANABE Yukihide (40618534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鈴木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okita Yukari 沖田 結花里

OKITA Yukari 沖田 結花里

Research Projects

Research Products

Co-Researchers

GPNMBによるがん幹細胞性誘導と可塑性に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of glycoprotein NMB in cancer stemness inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of TGF-beta related molecules in tumorigenesis through cancer stemness inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of GPNMB in cancer stem cells and development of therapeutic agent targeting GPNMBPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of MafK-Gpnmb axis in malignant progression of cancer and molecular targeted therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of TGF-beta target genes TMEPAI and MafK on cancer development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glycoprotein nonmetastatic melanoma protein B impacts the malignant potential of bladder cancer cells through its hem‐immunoreceptor tyrosine‐based activation motif2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal squamous cell carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyvinyl alcohol scaffolds and supplementation support 3D and sphere culturing of human cancer cell lines by reducing apoptosis and promoting cellular proliferation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Role of the kringle-like domain in glycoprotein NMB for its tumorigenic potential.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-surface GPNMB and induction of stemness.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB2017

Author(s)

Okita Yukari 沖田結花里

OKITA Yukari 沖田結花里