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Yoon Jeong-Hwan  尹 晶煥

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… Alternative Names

尹 晶煥  ユン ジヨンフアン

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Researcher Number 30748885
Affiliation (Current) 2025: 東京医科大学, 医学部, 兼任助教
Affiliation (based on the past Project Information) *help 2016 – 2023: 東京医科大学, 医学部, 兼任助教
Review Section/Research Field
Principal Investigator
Basic Section 49070:Immunology-related / Immunology
Except Principal Investigator
Basic Section 53050:Dermatology-related / Basic Section 55040:Respiratory surgery-related / Collagenous pathology/Allergology
Keywords
Principal Investigator
lung mucosal immunity / lung cancer / STATs / SMADs / TGF-beta / T cell / Dendritic cell / Anti-tumor immunity / Lung cancer / 抗腫瘍免疫 … More / 信号伝達 / 炎症 / 形質転換増殖因子β(TGF-β) / Tリンパ球 / 樹状細胞 / STAT / SMAD / 肺癌 / 免疫監視・腫瘍免疫 / 免疫学 / anti-tumor immunity / differentiation / Smad / TGF-β / dendritic cell … More
Except Principal Investigator
SMAD / TGF-β / IL-6 / 生物学的治療薬 / ランゲルハンス細胞 / 樹状細胞 / TGF-βシグナル伝達機構 / 尋常性乾癬 / T細胞 / 乾癬 / EGFR-TKI耐性 / 肺癌 / リンカー / Smad2 / 上皮成長因子受容体-チロシンキナーゼ阻害薬抵抗性 / SMADリン酸化 / 非小細胞性肺癌 / SMADリン酸化 / リンカーリン酸化 / EGFR-TKI抵抗性 / 非小細胞肺癌 / 細胞・組織 / シグナル伝達 / 免疫学 / STAT / TGF-beta / Th17細胞 / STAT3 / Smad3/4 / Stat / Smad / Th17 / 関節リウマチ Less
  • Research Projects

    (5 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (12 People)
  •  乾癬の病態形成におけるTGF-βシグナルの役割

    • Principal Investigator
      大久保 ゆかり
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tokyo Medical University
  •  SMAD-STAT immune signaling network in lung cancer microenvironmentPrincipal Investigator

    • Principal Investigator
      Yoon Jeong-Hwan
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Tokyo Medical University
  •  Linker-phosphorylated SMAD2 induces resistance to tyrosine kinase inhibition in EGFR-mutated lung adenocarcinoma

    • Principal Investigator
      Makino Yojiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Tokyo Medical University
  •  The development of the efficacious anti-tumor DC therapies using TGF-beta antagonistsPrincipal Investigator

    • Principal Investigator
      Yoon Jeong-Hwan
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Medical University
  •  SMAD-STAT signaling network in the pathogenesis of rheumatoid arthritis

    • Principal Investigator
      Mamura Mizuko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Tokyo Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.2017

    • Author(s)
      Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 484 Issue: 2 Pages: 269-77

    • DOI

      10.1016/j.bbrc.2017.01.093

    • NAID

      120007134941

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-26462138, KAKENHI-PROJECT-17K15735, KAKENHI-PROJECT-17H04067
  • [Presentation] Canonical TGF-β signaling via SMAD3 and SMAD4 ameliorates psoriasis by suppressing Th1 and Th17 differentiation2023

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Jin Soo Han, In-Kyu Lee, Ji Hyeon Ju, Masahiko Kuroda, Yukari Okubo and Mizuko Mamura
    • Organizer
      第38回日本乾癬学会学術大会
    • Data Source
      KAKENHI-PROJECT-22K08415
  • [Presentation] Canonical TGF-β signaling via SMAD3 and SMAD4 suppresses Th1 and Th17 differentiation in the pathogenesis of psoriasis2022

    • Author(s)
      Mizuko Mamura, Jeong-Hwan Yoon, Eunjin Bae, Inkyu Lee, Jin Soo Han, Ji-Hyun Ju, Masahiko Kuroda, Yukari Okubo, Isao Matsumoto, Takayuki Sumida
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-22K08415
  • [Presentation] SMAD4 suppresses allergic contact dermatitis by inhibiting cytotoxic T lymphocyte-induced Th1 apoptosis2022

    • Author(s)
      YOON Jeong-Hwan
    • Organizer
      2022 Annual Meeting of the Korean Association for Laboratory Animal Sciences
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] CD4+ T cell-intrinsic SMAD4 is essential for Th2 differentiation in Th2-type allergic dermatitis2022

    • Author(s)
      Mizuko Mamura, Eunjin Bae, Jin Soo Han, In-Kyu Lee, Ji Hyeon Ju, Yukari Okubo, Jeong-Hwan Yoon
    • Organizer
      第71回日本アレルギー学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K08415
  • [Presentation] Canonical TGF-β signaling via SMAD3 and SMAD4 suppresses Th1 and Th17 differentiation in psoriasis2021

    • Author(s)
      YOON Jeong-Hwan
    • Organizer
      第70回日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] SMAD4 suppresses allergic contact dermatitis by inhibiting cytotoxic T lymphocyte-induced Th1 apoptosis2021

    • Author(s)
      YOON Jeong-Hwan
    • Organizer
      第50回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] Intense ALK5 inhibition facilitates progression and metastasis of mouse melanoma2021

    • Author(s)
      YOON Jeong-Hwan
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] Canonical TGF-β signaling via SMAD4 suppresses Th1 and Th17 differentiation in psoriasis2021

    • Author(s)
      YOON Jeong-Hwan
    • Organizer
      第85回日本インターフェロン・サイトカイン学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] SMAD4-mediated TGF-β signaling suppresses Th1 and Th17 differentiation in the pathogenesis of psoriasis2020

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Yukari Okubo and Mizuko Mamura
    • Organizer
      JSA/WAO Joint Congress 2020
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] SMAD3 Determines Conventional versus Plasmacytoid Dendritic Cell Fates2019

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Jin Soo Han, Seok Hee Park, Susumu Nakae, InKyu Lee, Ji Hyeon Ju, Isao Matsumoto, Takayuki Sumida and Mizuko Mamura
    • Organizer
      The 48th Annual Meeting of The Japanese Society for Immunology, Hamamatsu, Japan
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16699
  • [Presentation] Canonical TGF-β signaling via Smad3/4 suppresses Th17 differentiation2018

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Ji Hyeon Ju, In-Kyu Lee, Isao Matsumoto, Takayuki Sumida, Mizuko Mamura
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09908
  • [Presentation] Canonical TGF-β signaling via SMAD3 and SMAD4 suppresses STAT3-induced arthritogenic Th17 differentiation2018

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Ji Hyeon Ju, Masahiro Yokosawa, Yuya Kondo, Isao Matsumoto, Takayuki Sumida, Mizuko Mamura
    • Organizer
      第5回 日本リウマチ学会ベーシックリサーチカンファレンス
    • Data Source
      KAKENHI-PROJECT-16K09908
  • [Presentation] Selection of Smad2 for TGF-β to suppress dendritic cells by STAT3/c-Ski-induced repression of Smad32017

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Katsuko Sudo, Seok Hee Park, Michael Weinstein, Susumu Nakae, Jin Soo Han,InKyu Lee, Ji Hyeon Ju, Takayuki Sumida, Masahiko Kuroda, Keiji Miyazawa, Mitsyasu Kato, Mizuko Mamura
    • Organizer
      The American Association for Cancer Research Annual Meeting 2017, Washington DC, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15735
  • [Presentation] Repression of SMAD3 by STAT3 and c-Ski Is Essential for Conventional Dendritic Cell Differentiation2017

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Katsuko Sudo, Seok Hee Park, Michael Weinstein, Susumu Nakae, Jin Soo Han,InKyu Lee, Ji Hyeon Ju, Takayuki Sumida, Masahiko Kuroda, Keiji Miyazawa, Mitsyasu Kato, Mizuko Mamura
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology, Sendai, Japan
    • Data Source
      KAKENHI-PROJECT-17K15735
  • [Presentation] Repression of SMAD3 by STAT3 and c-Ski Is Essential for Conventional Dendritic Cell Differentiation2017

    • Author(s)
      Jeong-Hwan Yoon, Eunjin Bae, Katsuko Sudo, Seok Hee Park, Michael Weinstein, Susumu Nakae, Jin Soo Han,InKyu Lee, Ji Hyeon Ju, Takayuki Sumida, Masahiko Kuroda, Keiji Miyazawa, Mitsyasu Kato, Mizuko Mamura
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society, Kanazawa, Japan
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15735
  • [Presentation] Canonical TGF-β signaling via Smad3/4 regulates expression and function of SOCS3 to suppress Th17 differentiation2016

    • Author(s)
      Mizuko Mamura, Jeong-Hwan Yoon, Ji Hyeon Ju, Isao Matsumoto, Takayuki Sumida
    • Organizer
      The 60th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-04-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09908
  • 1.  Mamura Mizuko (60400686)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 9 results
  • 2.  裴 恩真 (40773388)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  Makino Yojiro (70421047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  住田 孝之 (00183054)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  大平 達夫 (40317847)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  池田 徳彦 (70246205)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  大久保 ゆかり (40233530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  神田 浩子 (00345208)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KATO Mitsuyasu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SUDO Katsuko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MIYAZAWA Keiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KURODA Masahiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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