Nishi Kiyoto 西清人

Researcher Number	30749362
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 滋賀医科大学, 医学部, 助教 2021 – 2023: 滋賀医科大学, 医学部, 助教 2016 – 2017: 京都大学, 医学研究科, 医員 2015: 京都大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / 0902:General internal medicine and related fields Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 臓器連関 / ナルディライジン / エネルギー代謝 / 糖代謝 / 肝細胞 / 褐色脂肪組織 / 糖尿病 / ミトコンドリア / BCAA / MPC … More / 糖新生 / ピルビン酸 / アミノ酸 / 脂質代謝 / マクロファージ / 白色脂肪 / 肝臓 / 転写調節 / インスリン … More Except Principal Investigator ナルディライジン / 制御性T細胞 / 抗体産生 / メタロプロテアーゼ / 自己免疫疾患 Less

Investigation of proteases with multiple functions as novel therapeutic targets for autoimmune diseases
- Principal Investigator
  
  西英一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shiga University of Medical Science
多機能ペプチダーゼによる新規エネルギー代謝制御機構の解明と治療応用への展開Principal Investigator
- Principal Investigator
  
  西清人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shiga University of Medical Science
Regulatory roles of amino acid metabolites in pyruvate metabolismPrincipal Investigator
- Principal Investigator
  
  Nishi Kiyoto
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Shiga University of Medical Science
エネルギー代謝における新規臓器連関の解明Principal Investigator
- Principal Investigator
  
  西清人
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Investigation of the role of a novel regulator of insulin secretionPrincipal Investigator
- Principal Investigator
  
  Nishi Kiyoto
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2017 2016 2015

All Journal Article Presentation

[Journal Article] Null mutation of exocyst complex component 3-like does not affect vascular development in mice2024
- Author(s)
  Takashima Satsuki、Okamura Eiichi、Ichiyama Yusuke、Nishi Kiyoto、Shimizu Akio、Watanabe Chisato、Muto Masanaga、Matsumoto Shoma、Tsukiyama-Fujii Setsuko、Tsukiyama Tomoyuki、Ogita Hisakazu、Nishi Eiichiro、Ohji Masahito、Sugiyama Fumihiro、Takahashi Satoru、Mizuno Seiya、Mizutani Ken-ichi、Ema Masatsugu
- Journal Title
  
  Exp. Anim.
  
  Volume: 73 Issue: 1 Pages: 93-100
- DOI
  10.1538/expanim.23-0105
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1146, KAKENHI-PROJECT-23K07966, KAKENHI-PROJECT-23K08732, KAKENHI-PROJECT-21K06854, KAKENHI-PROJECT-22K19246, KAKENHI-PROJECT-22K19428, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K23794
[Journal Article] Nardilysin determines hematopoietic stem cell fitness by regulating protein synthesis2024
- Author(s)
  Oshima Shinichiro、Sinha Rahul、Ohno Mikiko、Nishi Kiyoto、Eto Koji、Takaori-Kondo Akifumi、Nishi Eiichiro、Yamamoto Ryo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 693 Pages: 149355-149355
- DOI
  10.1016/j.bbrc.2023.149355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07550, KAKENHI-PROJECT-23K07966, KAKENHI-PROJECT-22K19428
[Journal Article] Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes2023
- Author(s)
  Nishi Kiyoto、Yoshii Akira、Abell Lauren、Zhou Bo、Frausto Ricardo、Ritterhoff Julia、McMillen Timothy S.、Sweet Ian、Wang Yibin、Gao Chen、Tian Rong
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112641-112641
- DOI
  10.1016/j.celrep.2023.112641
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07966
[Journal Article] Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis2022
- Author(s)
  Saijo S, Ohno M, Iwasaki H, Matsuda S, Nishi K, Hiraoka Y, Ide N, Kimura T, Nishi E.
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 3449-3449
- DOI
  10.1038/s41598-022-07379-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05958, KAKENHI-PROJECT-20K21523, KAKENHI-PROJECT-20H03449, KAKENHI-PROJECT-20K08445, KAKENHI-PROJECT-21K20867, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22H04922
[Journal Article] Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine2022
- Author(s)
  Nishimura Kimihiro、Fujita Yukihiro、Ida Shogo、Yanagimachi Tsuyoshi、Ohashi Natsuko、Nishi Kiyoto、Nishida Atsushi、Iwasaki Yasumasa、Morino Katsutaro、Ugi Satoshi、Nishi Eiichiro、Andoh Akira、Maegawa Hiroshi
- Journal Title
  
  Molecular Metabolism
  
  Volume: 59 Pages: 101458-101458
- DOI
  10.1016/j.molmet.2022.101458
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08998, KAKENHI-PROJECT-20K21523, KAKENHI-PROJECT-18H02862, KAKENHI-PROJECT-20H03449, KAKENHI-PROJECT-21K20867
[Journal Article] Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion2017
- Author(s)
  Fujii Takayuki、Nishi Eiichiro、Ito Hiromu、Yoshitomi Hiroyuki、Furu Moritoshi、Okabe Namiko、Ohno Mikiko、Nishi Kiyoto、Morita Yusuke、Morita Yugo、Azukizawa Masayuki、Okahata Akinori、Tomizawa Takuya、Kimura Takeshi、Matsuda Shuichi
- Journal Title
  
  RMD Open
  
  Volume: 3 Issue: 1 Pages: e000436-e000436
- DOI
  10.1136/rmdopen-2017-000436
- NAID
  120006325113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09575, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-16K15216, KAKENHI-PROJECT-17K16147
[Journal Article] Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 32017
- Author(s)
  Kasai Y, Toriguchi K, *Hatano E, Nishi K, Ohno M, Yoh T, Fukuyaman K, Nishio T, Okuno M, Iwaisako K, Seo S, Taura K, Kurokawa M, Kunichika M, Uemoto S, *Nishi E
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 5 Pages: 910-917
- DOI
  10.1111/cas.13204
- NAID
  120006333898
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293068, KAKENHI-PROJECT-26461909, KAKENHI-PROJECT-15K19513, KAKENHI-PROJECT-16K15216, KAKENHI-PROJECT-17K09575, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-17K16147
[Journal Article] Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome2017
- Author(s)
  Chen Po-Min、Ohno Mikiko、Hiwasa Takaki、Nishi Kiyoto、Saijo Sayaka、Sakamoto Jiro、Morita Yusuke、Matsuda Shintaro、Watanabe Shin、Kuwabara Yasuhide、Ono Koh、Imai Masao、Inoue Katsumi、Murai Tatsuya、Inada Tsukasa、Tanaka Masaru、Kita Toru、Kimura Takeshi、Nishi Eiichiro
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 243 Pages: 1-8
- DOI
  10.1016/j.ijcard.2017.04.047
- NAID
  130007900462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09575, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-17H04177, KAKENHI-PROJECT-16K15216, KAKENHI-PROJECT-17K16147
[Journal Article] Nardilysin is required for maintaining pancreatic β-Cell Function.2016
- Author(s)
  Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijo S, Sakamoto J, Chen P-M, Morita Y, Matsuda S, Iwasaki K, Sugizaki K, Harada N, Mukumoto Y, Kiyonari H, Furuyama K, Kawaguchi Y, Uemoto S, Kita T, Inagaki N, Kimura T and Nishi E
- Journal Title
  
  Diabetes
  
  Volume: 65 Issue: 10 Pages: 3015-3027
- DOI
  10.2337/db16-0178
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01557, KAKENHI-PROJECT-16H05297, KAKENHI-PROJECT-26293068, KAKENHI-PROJECT-15K19376, KAKENHI-PROJECT-15K19513, KAKENHI-PROJECT-16K09745, KAKENHI-PROJECT-16K15216
[Presentation] M16メタロエンドペプチダーゼによる洞機能制御機構2024
- Author(s)
  大野美紀子, 松浦博, 西清人,糀谷泰彦, 牧山武,池田真也, 西英一郎
- Organizer
  第33回日本循環薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] Nardilysin in vascular smooth muscle cells regulates vascular contraction and blood pressure2024
- Author(s)
  Batbaatar Mend Amar, Mikiko Ohno, Kiyoto Nishi, Shinya Ikeda, and Eiichiro Nishi
- Organizer
  第8回Neuro-Vascular研究会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] NRDC in vascular smooth muscle cells controls vascular contraction and blood pressure via the regulation of calcium mobilization2024
- Author(s)
  Mend Amar Batbaatar, Mikiko Ohno, Takeshi Kinoshita, Kiyoto Nishi, Shinya Ikeda, Eiichiro Nishi
- Organizer
  第33回日本循環薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] 分岐鎖アミノ酸代謝産物によるヒ? ルヒ? ン酸代謝制御機構の解明2024
- Author(s)
  西清人,大野美紀子,西英一郎, Rong Tian
- Organizer
  第33回日本循環薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] NRDC in vascular smooth muscle cells regulates vascular contraction and blood pressure2023
- Author(s)
  Mend Amar Batbaatar, Mikiko Ohno, Takeshi Kinoshita, Kiyoto Nishi, Eiichiro Nishi
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] Nardilysin in hepatocyte regulates brown adipose tissue activity2023
- Author(s)
  Kiyoto Nishi、Hirotaka Iwasaki、Mikiko Ohno、Eiichiro Nishi
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] ナルディライジンの酵素活性阻害薬のスクリーニング佐野芳珠季，西清人，大野美紀子，西英一郎大野美紀子西清人西英一郎2023
- Author(s)
  佐野芳珠季，西清人，大野美紀子，西英一郎大野美紀子西清人西英一郎
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] ナルディライジンは制御性T細胞を介して自己免疫性肝炎に関与する2023
- Author(s)
  吉田晋也、里岡大樹、西清人、大野美紀子、平田多佳子、安藤朗、西英一郎
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] Enzymatic activity of nardilysin plays significant roles in the regulation of central nervous system activity2023
- Author(s)
  Mikiko Ohno, Shigeyuki Esumi, Tetsuya Obayashi, Takayuki Fujii, Kiyoto Nishi, Shinya Ikeda, Eiichiro Nishi
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] 肝細胞のナルディライジンは褐色脂肪組織熱産生を制御する2023
- Author(s)
  西清人、岩﨑広高、大野美紀子、西英一郎
- Organizer
  第32回循環薬理学会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] ナルディライジンに着目した自己免疫性肝炎の病態解明2023
- Author(s)
  吉田晋也，西清人，里岡大樹，大野美紀子，平田多佳子，安藤朗，西英一郎西清人大野美紀子西英一郎
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] Nardilysin in hepatocyte regulates diet-induced thermogenesis via the modulation of brown adipose tissue activity2023
- Author(s)
  Kiyoto Nishi, Hirotaka Iwasaki, Mikiko Ohno and Eiichiro Nishi
- Organizer
  12th General Meeting of the International Proteolysis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] ナルディライジンによる循環動態制御機構2023
- Author(s)
  大野美紀子，西清人，西英一郎
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07966
[Presentation] The regulatory roles of branched-chain amino acid metabolites in pyruvate metabolism2022
- Author(s)
  Kiyoto Nishi、Eiichiro Nishi、Rong Tian
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] 肝細胞のナルディライジンは褐色脂肪組織を介して食事誘導性熱産生を制御する2022
- Author(s)
  西清人, 岩崎広高, 松田真太郎, 松田真太郎, 大野美紀子, 西英一郎
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] 分岐鎖アミノ酸代謝産物はピルビン酸輸送を介して糖新生を抑制する2022
- Author(s)
  西清人、西英一郎、Rong Tian
- Organizer
  第24回・第25回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] TおよびB細胞のナルディライジンによる抗体産生調節機構の解明2021
- Author(s)
  茶谷元晴, 藤井貴之, 藤堂景史, 大野美紀子, 西清人, 平田多佳子, 安藤朗, 西英一郎
- Organizer
  第26回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] 脂肪細胞のNardilysinは細胞における酸素需要および低酸素誘導因子（HIF1-α）シグナルを介してインスリン感受性を制御する2021
- Author(s)
  松田真太郎、岩﨑広高、西清人、大野美紀子、西英一郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] 肝細胞のナルディライジンによる褐色脂肪組織制御機構の解明2021
- Author(s)
  西清人, 岩崎広高, 松田真太郎, 松田真太郎, 大野美紀子, 西英一郎
- Organizer
  第53回日本動脈硬化学会学術集会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] 分岐鎖アミノ酸代謝産物によるピルビン酸代謝制御機構の解明2021
- Author(s)
  西清人、西英一郎、Rong Tian
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20867
[Presentation] Nardilysin Critically Regulates Insulin Secretion and Glucose Metabolism2017
- Author(s)
  Nishi K, Ohno M, Saijo S, Morita Y, Matsuda S, Sakamoto J, Chen P, Kimura T, Nishi E.
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K19513
[Presentation] Nardilysin Regulates Glucose Homeostasis via the Maintenance of Pancreatic β-Cell Function and Identity2016
- Author(s)
  西清人、佐藤雄一、大野美紀子、平岡義範、西城さやか、坂本二郎、陳博敏、森田雄介、松田真太郎、北徹、稲垣暢也、木村剛、西英一郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K19513
[Presentation] ナルディライジンによる膵β細胞機能・分化制御機構の解明2016
- Author(s)
  西清人、大野美紀子、西城さやか、森田雄介、松田真太郎、稲垣暢也、西英一郎
- Organizer
  第37日本肥満学会
- Place of Presentation
  東京
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K19513
[Presentation] Nardylisin regulates glucose metabolism through insulin secretion2016
- Author(s)
  西清人、稲垣暢也、西英一郎
- Organizer
  第21回アディポサイエンス・シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2016-08-20
- Data Source
  KAKENHI-PROJECT-15K19513
[Presentation] Nardilysin is essential for the maintenance of pancreatic β-Cell function and identity2015
- Author(s)
  Kiyoto Nishi
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸、日本
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K19513
[Presentation] Nardilysin is Required for Maintaining Function and Identity of Pancreatic β-Cells2015
- Author(s)
  Kiyoto Nishi
- Organizer
  Keystone symposia “Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies (T2)”
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19513
[Presentation] Nardilysin is a Critical Regulator of Pancreatic β-Cell Function2015
- Author(s)
  Kiyoto Nishi
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪、日本
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K19513

1. 西英一郎 (30362528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 大野美紀子 (10583198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 池田真也 (80985804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平岡義範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 卯木智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishi Kiyoto 西 清人

Research Projects

Research Products

Co-Researchers

Investigation of proteases with multiple functions as novel therapeutic targets for autoimmune diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多機能ペプチダーゼによる新規エネルギー代謝制御機構の解明と治療応用への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory roles of amino acid metabolites in pyruvate metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エネルギー代謝における新規臓器連関の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the role of a novel regulator of insulin secretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Null mutation of exocyst complex component 3-like does not affect vascular development in mice2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Nardilysin determines hematopoietic stem cell fitness by regulating protein synthesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 32017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nardilysin is required for maintaining pancreatic β-Cell Function.2016

Nishi Kiyoto 西清人

[Presentation] 分岐鎖アミノ酸代謝産物によるヒ? ルヒ? ン酸代謝制御機構の解明2024

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