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Mizoguchi Yoko  溝口 洋子

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… Alternative Names

溝口 洋子  ミゾグチ ヨウコ

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Researcher Number 30750533
Other IDs
Affiliation (Current) 2025: 広島大学, 医系科学研究科(医), 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 広島大学, 医系科学研究科(医), 助教
2015: 広島大学, 大学病院, 医科診療医
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
小胞体ストレス / 酸化ストレス / iPSC / 先天性好中球減少症 / 重症先天性好中球減少症 / 薬剤スクリーニング / SCN / ELANE異常症 / 好中球減少症 / プロテオーム / UPR / iPS細胞 … More
Except Principal Investigator
… More 遺伝子異常 / 自己抗体 / 中和抗体 / RelA / インターフェロン過剰 / 易感染性 / STAT1 / I型インターフェロン / ウイルス / 原発性免疫不全症 Less
  • Research Projects

    (4 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (7 People)
  •  重症先天性好中球減少症における酸化ストレスに着目した病態解明と新規治療薬探索Principal Investigator

    • Principal Investigator
      溝口 洋子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Hiroshima University
  •  Elucidating the etiopathogenesis of primary immunodeficiency with a focus on susceptibility to viruses

    • Principal Investigator
      岡田 賢
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Hiroshima University
  •  Elucidation of the pathogenesis of endoplasmic reticulum stress in congenital neutropenia based on proteome analysisPrincipal Investigator

    • Principal Investigator
      Mizoguchi Yoko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Hiroshima University
  •  疾患特異的iPS細胞を利用した先天性好中球減少の病態解明と新規治療薬探索Principal Investigator

    • Principal Investigator
      溝口 洋子
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University

All 2024 2023 2022 2021 2015

All Journal Article Presentation Book

  • [Book] 好中球機能 小児臨床検査ガイド2023

    • Author(s)
      溝口洋子、岡田賢
    • Total Pages
      4
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-23K07291
  • [Book] 顆粒球減少症(好中球減少症)小児内科55巻増刊号 エキスパートが教える小児の 薬物治療2023

    • Author(s)
      溝口洋子
    • Total Pages
      4
    • Publisher
      東京医学社
    • Data Source
      KAKENHI-PROJECT-23K07291
  • [Book] 顆粒球減少症(好中球減少症)小児内科55巻増刊号 エキスパートが教える小児の 薬物治療2023

    • Author(s)
      溝口洋子
    • Total Pages
      4
    • Publisher
      東京医学社
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Book] 重症先天性好中球減少症(SCN). 原発性免疫不全症候群 診療の手引き 改訂第2版 自己免疫不全・自 己炎症学会編集2023

    • Author(s)
      溝口洋子、岡田賢
    • Total Pages
      4
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-23K07291
  • [Book] 重症先天性好中球減少症(SCN). 原発性免疫不全症候群 診療の手引き  改訂第2版 自己免疫不全・自己炎症学会編集2023

    • Author(s)
      溝口洋子、岡田賢
    • Total Pages
      4
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Book] 好中球機能 小児臨床検査ガイド2023

    • Author(s)
      溝口洋子、岡田賢
    • Total Pages
      4
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Journal Article] Generation of complex bone marrow organoids from human induced pluripotent stem cells2024

    • Author(s)
      Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C.
    • Journal Title

      Nature Methods

      Volume: - Issue: 5 Pages: 868-881

    • DOI

      10.1038/s41592-024-02172-2

    • Data Source
      KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905
  • [Journal Article] Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research2023

    • Author(s)
      Asano Takaki、Noma Kosuke、Mizoguchi Yoko、Karakawa Shuhei、Okada Satoshi
    • Journal Title

      Immunological Reviews

      Volume: 322 Issue: 1 Pages: 81-97

    • DOI

      10.1111/imr.13300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-23K24302
  • [Journal Article] Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants2023

    • Author(s)
      Kiyomi Shitaoka, Akifumi Higashiura, Yohei Kawano, Akima Yamamoto, Yoko Mizoguchi, Takao Hashiguchi , Norihisa Nishimichi, Shiyu Huang, Ayano Ito, Shun Ohki, Miyuki Kanda, Tomohiro Taniguchi, Rin Yoshizato, Hitoshi Azuma, Yasuo Kitajima, Yasuyuki Yokosaki, Satoshi Okada, Takemasa Sakaguchi, Tomoharu Yasuda
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s42003-023-04782-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16372, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-23K07835, KAKENHI-PROJECT-21K19720, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-21H02751
  • [Journal Article] Isolated Chronic Mucocutaneous Candidiasis due to a Novel Duplication Variant of IL17RC2023

    • Author(s)
      Noma Kosuke、Tsumura Miyuki、Nguyen Tina、Asano Takaki、Sakura Fumiaki、Tamaura Moe、Imanaka Yusuke、Mizoguchi Yoko、Karakawa Shuhei、Hayakawa Seiichi、Shoji Takayo、Hosokawa Junichi、Izawa Kazushi、Ling Yun、Casanova Jean-Laurent、Puel Anne、Tangye Stuart G.、Ma Cindy S.、Ohara Osamu、Okada Satoshi
    • Journal Title

      Journal of Clinical Immunology

      Volume: 44 Issue: 1 Pages: 18-18

    • DOI

      10.1007/s10875-023-01601-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15921, KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-23K24302
  • [Journal Article] Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes2023

    • Author(s)
      Linder Monika I.、Mizoguchi Yoko、Hesse Sebastian、et al.
    • Journal Title

      Blood

      Volume: 141 Issue: 6 Pages: 645-658

    • DOI

      10.1182/blood.2022016783

    • Data Source
      KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905
  • [Journal Article] Analyzing mitochondrial respiration of human induced pluripotent stem cell-derived myeloid progenitors using Seahorse technology2023

    • Author(s)
      Fan Yanxin、Mizoguchi Yoko、Tatematsu Megumi、Linder Monika I.、Frenz Stephanie、Choi Jongsu、Klein Christoph
    • Journal Title

      STAR Protocols

      Volume: 4 Issue: 1 Pages: 102073-102073

    • DOI

      10.1016/j.xpro.2023.102073

    • Data Source
      KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905
  • [Journal Article] A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis2023

    • Author(s)
      Sakura F, Noma K, Asano T, Tanita K, Toyofuku E, Kato K, Tsumura M, Nihira H, Izawa K, Mitsui-Sekinaka K, Konno R, Kawashima Y, Mizoguchi Y, Karakawa S, Hayakawa S, Kawaguchi H, Imai K, Nonoyama S, Yasumi T, Ohnishi H, Kanegane H, Ohara O, Okada S
    • Journal Title

      PNAS Nexus

      Volume: 2 Issue: 4 Pages: 1-12

    • DOI

      10.1093/pnasnexus/pgad104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-22K15939, KAKENHI-PROJECT-23K24302
  • [Journal Article] Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity2023

    • Author(s)
      Moriya Kunihiko、Nakano Tomohiro、Honda Yoshitaka、Tsumura Miyuki、Ogishi Masato、、、Izawa Kazushi、Asano Takaki、Kakuta Fumihiko、Abukawa Daiki、、、Boisson Bertrand、Puel Anne、Casanova Jean-Laurent、Nishikomori Ryuta、Ohga Shouichi、Okada Satoshi、Sasahara Yoji、Kure Shigeo
    • Journal Title

      Journal of Experimental Medicine

      Volume: 220 Issue: 9

    • DOI

      10.1084/jem.20212276

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K14979, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07268, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K16924, KAKENHI-PROJECT-23K24302
  • [Journal Article] Age‐specific incidence of joint disease in paediatric patients with haemophilia: A single‐centre real‐world outcome based on consecutive US examination2023

    • Author(s)
      Mizoguchi Yoko、Tani Chihiro、Aizawa Mika、Tomioka Keita、Shimomura Maiko、Nishimura Shiho、Matsubara Yoshiko、Iwaki Daisuke、Tanaka Kiyoto、Kawaguchi Hiroshi、Nakashima Yuko、Mikami Yukio、Okada Satoshi、Kobayashi Masao
    • Journal Title

      Haemophilia

      Volume: 29 Issue: 5 Pages: 1359-1365

    • DOI

      10.1111/hae.14848

    • Data Source
      KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905
  • [Journal Article] Mendelian susceptibility to mycobacterial diseases: state-of-the-art2022

    • Author(s)
      Noma Kosuke、Mizoguchi Yoko、Tsumura Miyuki、Okada Satoshi
    • Journal Title

      Clinical Microbiology and Infection

      Volume: - Issue: 11 Pages: 00143-4

    • DOI

      10.1016/j.cmi.2022.03.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
  • [Journal Article] Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ2022

    • Author(s)
      Tsumura Miyuki、Miki Mizuka、Mizoguchi Yoko、Hirata Osamu、Nishimura Shiho、Tamaura Moe、Kagawa Reiko、Hayakawa Seiichi、Kobayashi Masao、Okada Satoshi
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 149 Issue: 1 Pages: 252-261

    • DOI

      10.1016/j.jaci.2021.05.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17301, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-21K15904, KAKENHI-PROJECT-22K15921, KAKENHI-PROJECT-20K22780
  • [Journal Article] Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-192022

    • Author(s)
      Eto S, Nukui Y, Tsumura M, Nakagama Y, Kashimada K, Mizoguchi Y, Utsumi T, Taniguchi M, Sakura F, Noma K, Yoshida Y, Ohshimo S, Nagashima S, Okamoto K, Endo A, Imai K, Kanegane H, Ohnishi H, Hirata S, Sugiyama E, Shime N, Ito M, Ohge H, Kido Y, Bastard P, Casanova JL, Ohara O, Tanaka J, Morio T, Okada S
    • Journal Title

      Journal of Clinical Immunology

      Volume: 42 Issue: 7 Pages: 1360-1370

    • DOI

      10.1007/s10875-022-01308-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-20K17460, KAKENHI-PROJECT-23K24302
  • [Journal Article] HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation2022

    • Author(s)
      Fan Yanxin、Murgia Marta、Linder Monika I.、Mizoguchi Yoko、Wang Cong、Lyszkiewicz Marcin、Zietara Natalia、Liu Yanshan、Frenz Stephanie、Sciuccati Gabriela、Partida-Gaytan Armando、Alizadeh Zahra、Rezaei Nima、Rehling Peter、Dennerlein Sven、Mann Matthias、Klein Christoph
    • Journal Title

      Journal of Clinical Investigation

      Volume: 132 Issue: 9 Pages: 1-18

    • DOI

      10.1172/jci153153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Journal Article] Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells2022

    • Author(s)
      Yang R, Avery DT, Jackson KJL, Ogishi M, Benhsaien I, Du L, Ye X, Han J, Rosain J, Peel JN, Alyanakian MA, Neven B, Winter S, Puel A, Boisson B, Payne KJ, Wong M, Russell AJ, Mizoguchi Y, . et al.
    • Journal Title

      Science Immunology

      Volume: 7 Issue: 73 Pages: 3277-3290

    • DOI

      10.1126/sciimmunol.abq3277

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K24302
  • [Journal Article] Inborn errors of STAT1 immunity2021

    • Author(s)
      Mizoguchi Yoko、Okada Satoshi
    • Journal Title

      Current Opinion in Immunology

      Volume: 72 Pages: 59-64

    • DOI

      10.1016/j.coi.2021.02.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-21K15905
  • [Journal Article] Inherited CARD9 Deficiency in a Child with Invasive Disease Due to Exophiala dermatitidis and Two Older but Asymptomatic Siblings2021

    • Author(s)
      Imanaka Yusuke、Taniguchi Maki、Doi Takehiko、Tsumura Miyuki、Nagaoka Rie、Shimomura Maiko、Asano Takaki、Kagawa Reiko、Mizoguchi Yoko、Karakawa Shuhei、Arihiro Koji、Imai Kohsuke、Morio Tomohiro、Casanova Jean-Laurent、Puel Anne、Ohara Osamu、Kamei Katsuhiko、Kobayashi Masao、Okada Satoshi
    • Journal Title

      Journal of Clinical Immunology

      Volume: - Issue: 5 Pages: 975-986

    • DOI

      10.1007/s10875-021-00988-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-19K17301, KAKENHI-PROJECT-21K15904, KAKENHI-PROJECT-21K15905
  • [Journal Article] Mammalian VPS45 orchestrates trafficking through the endosomal system2021

    • Author(s)
      Frey Laura、Zietara Natalia、Lyszkiewicz Marcin、Marquardt Benjamin、Mizoguchi Yoko、Linder Monika I.、Liu Yanshan、Giesert Florian、Wurst Wolfgang、Dahlhoff Maik、Schneider Marlon R.、Wolf Eckhard、Somech Raz、Klein Christoph
    • Journal Title

      Blood

      Volume: 137 Issue: 14 Pages: 1932-1944

    • DOI

      10.1182/blood.2020006871

    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] Successful donor marrow leukocyte infusion for cases with mixed chimerism following RIST from MRDs2024

    • Author(s)
      Yoko Mizoguchi
    • Organizer
      第46回日本造血・免疫細胞療法学会
    • Data Source
      KAKENHI-PROJECT-23K07291
  • [Presentation] Successful donor marrow leukocyte infusion for cases with mixed chimerism following RIST from MRDs2024

    • Author(s)
      Yoko Mizoguchi
    • Organizer
      第46回日本造血・免疫細胞療法学会
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] Sever congenital neutropenia2023

    • Author(s)
      Yoko Mizoguchi
    • Organizer
      Klaus Betke Symposium 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07291
  • [Presentation] Sever congenital neutropenia2023

    • Author(s)
      Yoko Mizoguchi
    • Organizer
      Klaus Betke Symposium 2023
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] 小児血友病患者における関節症予防のために定期的な関節超音波評価の重要性2022

    • Author(s)
      溝口洋子
    • Organizer
      日本小児血液・がん学会
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] 血友病診療の現在と未来2021

    • Author(s)
      溝口洋子
    • Organizer
      第73回 中国四国小児科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] 血友病個別化治療の実践に向けた当科の取り組み2021

    • Author(s)
      溝口洋子、小林正夫
    • Organizer
      第43回日本血栓止血学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] The efficacy of continuous US evaluation for joint health in pediatric patients with hemophilia.2021

    • Author(s)
      Yoko Mizoguchi, Chihiro Tani, Shiho Nishimura, Keiko Matsubara, Keita Tomioka, Maiko Shimomura, Yuko Nakashima, Hiroshi Kawaguchi, Satoshi Okada and Masao Kobayashi.
    • Organizer
      第83回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K15905
  • [Presentation] A comparison of cyclic neutropenia and severe congenital neutropenia with disease-specific iPS cells2015

    • Author(s)
      齋藤聡志、西村志帆、津村弥来、溝口洋子、古江綾、岡田賢、平本貴史、海老原康博、辻浩一郎、小林正夫
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K19618
  • 1.  岡田 賢 (80457241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  小原 收 (20370926)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  津村 弥来 (80646274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 4.  浅野 孝基
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  下岡 清美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  玉浦 萌
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  香川 礼子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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