Uekusa Yoshinori 植草義徳

Researcher Number	30753024
Other IDs	https://orcid.org/0000-0003-1654-5403
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 食品部, 協力研究員
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 薬学部(芝共立), 助教 2018 – 2023: 慶應義塾大学, 薬学部(芝共立), 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator 核磁気共鳴 / 生物活性強度 / 生物活性 / 細胞透過性 / 相互作用 / IAM / フラボノール / フラボン / フラボノイド / 構造活性相関 … More / リン脂質膜 / 分子間相互作用 / NMR / リン脂質膜親和性 / フラボノール類 / フラボン類 / フラボノイド類 … More Except Principal Investigator 単離・構造決定 / 天然有機化合物 / 熱帯病 / 海洋天然物 / 構造決定 / 全合成 / ペプチド / シアノバクテリア / PGE2 / 一酸化窒素 / 混合物 / リン脂質膜親和性 / ポリメトキシフラボン / PG産生 / NO産生抑制 / オウゴン / プロスタグランジン(PG)産生抑制 / 一酸化窒素(NO)産生抑制 / 抗炎症作用 / フラボノイド / リン脂質二重層 / テアフラビン / 脂質膜二重層 / 胆汁酸ミセル / 分子間相互作用 / リン脂質 / 脂質膜 / 柿ポリフェノール / カカオポリフェノール / NOE / AFM / ポリフェノール / リポソーム / 原子間力顕微鏡 / NMR / リン脂質膜 / テアフラビン類 / 紅茶ポリフェノール / 紅茶 Less

多成分系における化合物間相互作用の網羅的検出と機序解明Principal Investigator
- Principal Investigator
  
  植草義徳
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Keio University
Development of a platform for drug discovery by isolation and synthesis of novel natural products derived from unculturable marine cyanobacteria
- Principal Investigator
  
  吉田将人
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  University of Tsukuba
Analysis of the interaction between flavones and phospholipid membranes in the early stage of biological activity expressionPrincipal Investigator
- Principal Investigator
  
  Uekusa Yoshinori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Keio University
Molecular interaction of theaflavins with phospholipids
- Principal Investigator
  
  NAKAYAMA Tsutomu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tokyo University of Agriculture
Mechanistic study of anti-inflammatory activity of flavonoid mixtures and its application
- Principal Investigator
  
  Kiuchi Fumiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] The inhibitory effect of DIF-3 on polyinosinic?polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2024
- Author(s)
  Araya Ryusei、Men Shihu、Uekusa Yoshinori、Yu Zaiqiang、Kikuchi Haruhisa、Daitoku Kazuyuki、Minakawa Masahito、Kawaguchi Shogo、Furukawa Ken-Ichi、Oshima Yoshiteru、Imaizumi Tadaatsu、Seya Kazuhiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 157-165
- DOI
  10.1016/j.jphs.2024.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0099, KAKENHI-PROJECT-23K08064
[Journal Article] Oxidation of methylophiopogonanone A on the surface of TLC plate2022
- Author(s)
  Kiuchi, F., Uekusa, Y., Narukawa, Y.
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 76 Issue: 2 Pages: 504-508
- DOI
  10.1007/s11418-022-01604-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07138
[Journal Article] Anti-trypanosome screening of Salvadoran flora2022
- Author(s)
  Castillo, U. G., Komatsu, A., Martinez, M. L., Menjivar, J., Nunez, M. J., Uekusa, Y., Narukawa, Y., Kiuchi, F., Nakajima-Shimada, J.
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 76 Issue: 1 Pages: 259-267
- DOI
  10.1007/s11418-021-01562-6
- NAID
  40022799597
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07138
[Journal Article] Synthesis of Methylophiopogonanone A2020
- Author(s)
  Katagiri R, Uekusa Y, Narukawa Y, Kiuchi F
- Journal Title
  
  Heterocycles
  
  Volume: 100 Issue: 5 Pages: 803-808
- DOI
  10.3987/com-20-14231
- NAID
  40022257929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06721, KAKENHI-PROJECT-18K06734
[Presentation] Moorea producens PALが産生するhonuaiakeamide類の構造決定と生合成経路の解析2024
- Author(s)
  佐藤宙，植草義徳，小川慧人，Evgenia Glukhov，William H. Gerwick，菊地晴久
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21KK0099
[Presentation] 卵菌Saprolegnia terrestrisが産生する二次代謝産物探索2023
- Author(s)
  櫻井廣祐、西村壮央、植草義徳、菊地晴久
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21KK0099
[Presentation] ポリフェノール類はどのようにリン脂質膜と相互作用するのか2023
- Author(s)
  植草義徳
- Organizer
  第19回日本カテキン学会年次学術大会　特別講演連動シンポジウム
- Data Source
  KAKENHI-PROJECT-21KK0099
[Presentation] 分子ネットワーク解析を活用した海洋性シアノバクテリア由来新規化合物の効率的探索2022
- Author(s)
  小川慧人，植草義徳，木内文之，William H. Gerwick，菊地晴久
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21KK0099
[Presentation] Baicalinとberberine類縁体の間で生じる化合物間相互作用の解析2022
- Author(s)
  谷岡ちはる，植草義徳，遠周直人，木内文之，菊地晴久
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] 分子ネットワーク解析を活用した海洋性シアノバクテリア由来新規化合物の効率的探索2022
- Author(s)
  小川慧人，植草義徳，木内文之，William H. Gerwick，菊地晴久
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] 卵菌Saprolegnia terrestrisが産生する新規二次代謝産物の探索2022
- Author(s)
  櫻井廣祐、西村壮央、植草義徳、菊地晴久
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21KK0099
[Presentation] 分子ネットワークを用いたシアノバクテリア由来の新規化合物の単離2021
- Author(s)
  小川慧人，植草義徳，木内文之，William H. Gerwick，菊地晴久
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21KK0099
[Presentation] 分子ネットワークを用いたシアノバクテリア由来の新規化合物の単離2021
- Author(s)
  小川慧人，植草義徳，木内文之，William H. Gerwick，菊地晴久
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] 栄養源バクテリアの変化による細胞性粘菌由来新規二次代謝産物の探索2021
- Author(s)
  室谷拓冶，佐々木瞳，江口裕美，植草義徳，菊地晴久
- Organizer
  日本細胞性粘菌学会第11回例会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] Development of peptide alkaloid-type compound library based on brefeldin A by molecular skeleton recombination strategy2021
- Author(s)
  Sato, Y., Nishimura, T., Shiga, K., Sugawara, A., Uekusa, Y., Kikuchi, H.
- Organizer
  13th AFMC International Medicinal Chemistry Symposium (AIMECS 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] NMRを用いたテアフラビン類によるリポソーム凝集作用の解明2021
- Author(s)
  陳瀟逸，植草義徳，中山勉，木内文之，菊地晴久
- Organizer
  第17回日本カテキン学会年次学術大会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] NMRを用いたテアフラビン類とリン脂質膜との相互作用解析（第2報）2021
- Author(s)
  陳瀟逸、植草義徳、中山勉、木内文之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K05525
[Presentation] テアフラビン類とリン脂質膜との分子間相互作用解析2021
- Author(s)
  陳瀟逸，植草義徳，中山勉，木内文之，菊地晴久
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] NMRを用いたテアフラビン類とリン脂質膜との相互作用解析（第2報）2020
- Author(s)
  陳瀟逸，植草義徳，中山勉，木内文之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] Caco-2細胞を用いたフラボン類の細胞透過性とリン脂質膜親和性及び抗炎症作用の連関2020
- Author(s)
  遠周直人，植草義徳，木内文之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] NMRを用いたテアフラビン類とリン脂質膜との相互作用解析2020
- Author(s)
  陳瀟逸，植草義徳，中山勉，木内文之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K05525
[Presentation] NMRを用いたテアフラビン類とリン脂質膜との相互作用解析2020
- Author(s)
  陳瀟逸，植草義徳，中山勉，木内文之．
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] Structural analysis of the complex of baicalin and berberine in aqueous solution2019
- Author(s)
  Yoshinori Uekusa, Riina Tsutsumi, Kenjiro Nakamoto, and Fumiyuki Kiuchi
- Organizer
  American Society of Pharmacognosy 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06734
[Presentation] Structural analysis of the complex of baicalin and berberine in aqueous solution2019
- Author(s)
  Uekusa, Y., Tsutsumi, R., Nakamoto, K., and Kiuchi, F.
- Organizer
  American Society of Pharmacognosy 2019 Annual Meeting (ASP2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] テアフラビン類の抗炎症作用とリン脂質膜に対する親和性の評価2019
- Author(s)
  植草義徳，陳瀟逸，鰐口あおい，倉田幸一，中山勉，木内文之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K05525
[Presentation] Solubility-enhancement of berberine-baicalin complex by crocins”, American Society of Pharmacognosy 2019 Annual Meeting (ASP2019),2019
- Author(s)
  Okoshi, K., Uekusa, Y., Narukawa, Y., and Kiuchi, F.
- Organizer
  American Society of Pharmacognosy 2019 Annual Meeting (ASP2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07138
[Presentation] メタボローム解析を用いたチンピの品質評価に関する研究2018
- Author(s)
  八汐祥恵，鰐口あおい，二見萌，植草義徳，河野徳昭，渕野裕之，川原信夫，木内文之
- Organizer
  日本生薬学会第65回年会
- Data Source
  KAKENHI-PROJECT-18K06734

1. Kiuchi Fumiyuki (60161402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. NAKAYAMA Tsutomu (50150199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 奈良井朝子 (00339475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 飯嶋益巳 (40390728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉田将人 (80511906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岩崎有紘 (00754897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 成川佑次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uekusa Yoshinori 植草 義徳

Research Projects

Research Products

Co-Researchers

多成分系における化合物間相互作用の網羅的検出と機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a platform for drug discovery by isolation and synthesis of novel natural products derived from unculturable marine cyanobacteria

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the interaction between flavones and phospholipid membranes in the early stage of biological activity expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular interaction of theaflavins with phospholipids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic study of anti-inflammatory activity of flavonoid mixtures and its application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The inhibitory effect of DIF-3 on polyinosinic?polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidation of methylophiopogonanone A on the surface of TLC plate2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-trypanosome screening of Salvadoran flora2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthesis of Methylophiopogonanone A2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Moorea producens PALが産生するhonuaiakeamide類の構造決定と生合成経路の解析2024

Author(s)

Organizer

Data Source

[Presentation] 卵菌Saprolegnia terrestrisが産生する二次代謝産物探索2023

Author(s)

Organizer

Data Source

[Presentation] ポリフェノール類はどのようにリン脂質膜と相互作用するのか2023

Author(s)

Organizer

Data Source

[Presentation] 分子ネットワーク解析を活用した海洋性シアノバクテリア由来新規化合物の効率的探索2022

Author(s)

Organizer

Data Source

[Presentation] Baicalinとberberine類縁体の間で生じる化合物間相互作用の解析2022

Author(s)

Organizer

Data Source

[Presentation] 分子ネットワーク解析を活用した海洋性シアノバクテリア由来新規化合物の効率的探索2022

Author(s)

Organizer

Data Source

Uekusa Yoshinori 植草義徳