nogami ayako 野上彩子

… Alternative Names

野上彩子ノガミアヤコ

Nogami Ayako 野上彩子

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Researcher Number	30754890
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 講師(キャリアアップ)
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師(キャリアアップ) 2022: 東京医科歯科大学, 医歯学総合研究科, 助教 2019 – 2020: 東京医科歯科大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator エピトープ / CAR-T療法 / PNH / ネオエピトープ / 自己反応性T細胞 / 発作性夜間ヘモグロビン尿症 / 再生不良性貧血 / 血球減少 / 骨髄不全 / TKI … More / UPS / 急性骨髄性白血病 / Rsk / DUB / REDD1 / proteasome / ITD / AML / FLT3 Less

骨髄不全症における標的オトリ人工抗体開発に向けたネオエピトープ反応性T細胞の検出Principal Investigator
- Principal Investigator
  
  野上彩子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Specific ubiquitination and degradation through the proteasome system and development of the therapy resistance induced by mutated tyrosine kinase FLT3-ITD in AMLPrincipal Investigator
- Principal Investigator
  
  Nogami Ayako
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] A novel chimeric antigen receptor (CAR) system using an?exogenous protease, in which activation of T?cells is controlled by expression patterns of cell?surface proteins on target cells2022
- Author(s)
  Aoyama Satoru、Yasuda Shunichiro、Li Huixin、Watanabe Daisuke、Umezawa Yoshihiro、Okada Keigo、Nogami Ayako、Miura Osamu、Kawamata Norihiko
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 49 Issue: 4 Pages: 42-52
- DOI
  10.3892/ijmm.2022.5097
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15599, KAKENHI-PROJECT-20K17371
[Journal Article] Therapeutic Advances in Immunotherapies for Hematological Malignancies2022
- Author(s)
  Nogami Ayako、Sasaki Koji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11526-11526
- DOI
  10.3390/ijms231911526
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15599
[Journal Article] Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway2019
- Author(s)
  A. Nogami, K. Okada, S. Ishida, H. Akiyama, Y. Umezawa, O. Miura
- Journal Title
  
  Translational oncology
  
  Volume: 12 Issue: 2 Pages: 336-349
- DOI
  10.1016/j.tranon.2018.11.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08349, KAKENHI-PROJECT-19K17852
[Journal Article] Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress2019
- Author(s)
  H. Akiyama, Y. Umezawa, S. Ishida, K. Okada, A. Nogami, O. Miura
- Journal Title
  
  Cancer letters
  
  Volume: 453 Pages: 84-94
- DOI
  10.1016/j.canlet.2019.03.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08349, KAKENHI-PROJECT-19K17852
[Presentation] CAR-T細胞療法後の遷延性血球減少症における免疫学的機構の解明2023
- Author(s)
  野上　彩子、青山　慧、北浦　萌、山本　正英、東田　修二
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15599
[Presentation] FLT3-ITDはRSK1を活性化し，mTORC1とeIF4Bを強調，BADとBIMを抑制する2020
- Author(s)
  渡邉大介、野上彩子、岡田啓五、秋山弘樹、梅澤佳央、長尾俊景、三浦修
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17852
[Presentation] FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim2019
- Author(s)
  Ayako Nogami, Daisuke Watanabe, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Toshikage Nagao, Shuji Tohda and Osamu Miura
- Organizer
  60th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17852

1. 三浦修

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

nogami ayako 野上 彩子

野上 彩子 ノガミ アヤコ

Nogami Ayako 野上 彩子

Research Projects

Research Products

Co-Researchers

骨髄不全症における標的オトリ人工抗体開発に向けたネオエピトープ反応性T細胞の検出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Specific ubiquitination and degradation through the proteasome system and development of the therapy resistance induced by mutated tyrosine kinase FLT3-ITD in AMLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A novel chimeric antigen receptor (CAR) system using an?exogenous protease, in which activation of T?cells is controlled by expression patterns of cell?surface proteins on target cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic Advances in Immunotherapies for Hematological Malignancies2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] CAR-T細胞療法後の遷延性血球減少症における免疫学的機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] FLT3-ITDはRSK1を活性化し，mTORC1とeIF4Bを強調，BADとBIMを抑制する2020

Author(s)

Organizer

Data Source

[Presentation] FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim2019

Author(s)

Organizer

Data Source

nogami ayako 野上彩子

野上彩子ノガミアヤコ

Nogami Ayako 野上彩子