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Umemura Atsushi  楳村 敦詩

ORCIDConnect your ORCID iD *help
Researcher Number 30759585
Other IDs
Affiliation (Current) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help 2021: 京都府立医科大学, 医学(系)研究科(研究院), 教授
2020: 京都府立医科大学, 医学(系)研究科(研究院), 助教
2019: 京都府立医科大学, 医学(系)研究科(研究院), 学内講師
2015 – 2016: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Tumor biology
Keywords
Principal Investigator
肝癌 / HCC / 慢性肝障 / 肝発癌 / ホノキオール / NASH / MIG6 / ERRFI1 / Glucocorticoid receptor / 慢性肝障害 … More / EGFR / 肝細胞癌 / シグナル伝達 / 医療・福祉 / 癌 / mTOR / NRF2 / p62 Less
  • Research Projects

    (2 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (1 People)
  •  The development of NASH-HCC prevention targeting EGFRPrincipal Investigator

    • Principal Investigator
      Umemura Atsushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  The role of p62 in the HCC initiation and progressionPrincipal Investigator

    • Principal Investigator
      Umemura Atsushi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Tumor biology
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2021 2020 2019 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress.2021

    • Author(s)
      Okuda K, Umemura A, Kataoka S, Yano K, Takahashi A, Okishio S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Nakagawa H, Liu Y, Mitsumoto Y, Kanbara Y, Shima T, Okanoue T, Itoh Y.
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 758549-758549

    • DOI

      10.3389/fonc.2021.758549

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08377, KAKENHI-PROJECT-20K08337
  • [Journal Article] Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor?MIG6 Axis2021

    • Author(s)
      Okuda Keiichiro、Umemura Atsushi、Umemura Shiori、Kataoka Seita、Taketani Hiroyoshi、Seko Yuya、Nishikawa Taichiro、Yamaguchi Kanji、Moriguchi Michihisa、Kanbara Yoshihiro、Arbiser Jack L.、Shima Toshihide、Okanoue Takeshi、Karin Michael、Itoh Yoshito
    • Journal Title

      Cancers

      Volume: 13 Issue: 7 Pages: 1515-1515

    • DOI

      10.3390/cancers13071515

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08377, KAKENHI-PROJECT-20K08337
  • [Journal Article] Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells.2021

    • Author(s)
      Kataoka S, Umemura A, Okuda K, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, Shima T, Okanoue T, Itoh Y.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 24 Pages: 13354-13354

    • DOI

      10.3390/ijms222413354

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08377, KAKENHI-PROJECT-20K08337
  • [Journal Article] Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease.2017

    • Author(s)
      Mitsuyoshi H, Yasui K, Hara T, Taketani H, Ishiba H, Okajima A, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Minami M, Itoh Y.
    • Journal Title

      Hepatol Res

      Volume: - Issue: 13 Pages: 1459-1468

    • DOI

      10.1111/hepr.12883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-26461016, KAKENHI-PROJECT-15K09017
  • [Journal Article] 肝細胞癌とオートファジー2016

    • Author(s)
      楳村敦詩、山口寛二、Michael Karin、伊藤義人
    • Journal Title

      肝胆膵

      Volume: 73 Pages: 201-206

    • Data Source
      KAKENHI-PROJECT-15H06547
  • [Journal Article] p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.2016

    • Author(s)
      Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M.
    • Journal Title

      Cancer Cell

      Volume: 29 Pages: 935-948

    • DOI

      10.1016/j.canlet.2017.04.002

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-15K09017, KAKENHI-PROJECT-16K10512, KAKENHI-PROJECT-15K19040
  • [Journal Article] Current status and future prospects of chemotherapy for advanced hepatocellular carcinoma.2016

    • Author(s)
      Moriguchi M, Umemura A, Itoh Y.
    • Journal Title

      Clin J Gastroenterol

      Volume: 9 Issue: 4 Pages: 184-190

    • DOI

      10.1007/s12328-016-0670-7

    • Data Source
      KAKENHI-PROJECT-15H06547
  • [Journal Article] Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression.2016

    • Author(s)
      Seko Y, Sumida Y, Tanaka S, Mori K, Taketani H, Ishiba H, Hara T, Okajima A, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Kanemasa K, Yasui K, Imai S, Shimada K, Itoh Y.
    • Journal Title

      Hepatol Res

      Volume: - Issue: 11 Pages: 1083-1092

    • DOI

      10.1111/hepr.12840

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-15K09017
  • [Journal Article] NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.2016

    • Author(s)
      Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR,McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.
    • Journal Title

      Cell

      Volume: 164(5) Issue: 5 Pages: 896-910

    • DOI

      10.1016/j.cell.2015.12.057

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06547
  • [Journal Article] Genome-wide DNA methylation analysis in hepatocellular carcinoma.2016

    • Author(s)
      Yamada N, Yasui K, Dohi O, Gen Y, Tomie A, Kitaichi T, Iwai N, Mitsuyoshi H, Sumida Y, Moriguchi M, Yamaguchi K, Nishikawa T, Umemura A, Naito Y, Tanaka S, Arii S, Itoh Y.
    • Journal Title

      Oncol Rep.

      Volume: 35 Issue: 4 Pages: 2228-2236

    • DOI

      10.3892/or.2016.4619

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09017, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-15H06547
  • [Presentation] グルタミン代謝は肝線維化および肝癌の治療・予防標的になり得る2021

    • Author(s)
      楳村敦詩
    • Organizer
      第107回消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-19K08377
  • [Presentation] 治療・予防法の確立を目指したNASH背景肝における発癌機構の解明2020

    • Author(s)
      楳村 敦詩
    • Organizer
      第56回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-19K08377
  • [Presentation] EGFRをターゲットとしたNASH発癌予防法の探求2019

    • Author(s)
      楳村 敦詩
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-19K08377
  • [Presentation] The Effect of mTORC1 Inhibition on NAFLD and subsequent HCC Development2016

    • Author(s)
      Atsushi Umemura, Yoshito Itoh, Michael Karin.
    • Organizer
      The international congress 2016, European Association for the Study of the Liver (EASL)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-04-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06547
  • [Presentation] 肝発癌・進展における,mTORC1およびp62-Nrf2シグナルの役割2016

    • Author(s)
      楳村敦詩、山口寛二、伊藤義人
    • Organizer
      第52回日本肝臓学会総会(幕張)
    • Place of Presentation
      幕張
    • Year and Date
      2016-05-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06547
  • [Presentation] p62, a Key Regulator for Initiation and Development of HCC2015

    • Author(s)
      Atsushi Umemura, Yoshito Itoh, Maria T. Diaz-Meco, Jorge Moscat, and Michael Karin
    • Organizer
      AASLD Liver meeting 2015
    • Place of Presentation
      Moscone Center in San Francisco
    • Year and Date
      2015-11-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06547
  • [Presentation] 肝癌および慢性肝疾患の病態におけるmTORC1阻害の影響2015

    • Author(s)
      楳村敦詩、山口寛二、伊藤義人
    • Organizer
      第41回日本肝臓学会西部会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15H06547
  • 1.  安居 幸一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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