Ohgane Kenji 大金賢司

Researcher Number	30771092
Other IDs
Affiliation (Current)	2025: お茶の水女子大学, 基幹研究院, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: お茶の水女子大学, 基幹研究院, 講師 2020: 東京理科大学, 理工学部応用生物科学科, 助教 2018 – 2019: 東京大学, 定量生命科学研究所, 助教 2017: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator 構造活性相関 / オキシステロール / 医薬化学 / STING / 脂質 / ステロール誘導体 / 自然免疫 / STING経路 / スクアレンモノオキシゲナーゼ / コレステロール合成経路 … More / タンパク質の安定性 / タンパク質安定性 / コレステロール / オフターゲット標的 / ケミカルバイオロジー / ステロール / シャペロン / ニーマンピック病C型 / ケミカルプローブ / itraconazole / 光親和性標識 / ファーマコロジカルシャペロン / NPC1 / オフターゲット / イトラコナゾール … More Except Principal Investigator タンパク質ータンパク質相互作用阻害剤 / ファオルダマー / 大環状化合物 / らせん分子 / 環状構造 / らせん構造 / フォルダマー / 芳香族アミド Less

New molecular shapes from strained aromatic foldamer macrocycles and their application to development of PPI inhibitors
- Principal Investigator
  
  棚谷綾
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Ochanomizu University
内在性脂質に基づく新規自然免疫調節剤の創製と作用機序の解析Principal Investigator
- Principal Investigator
  
  大金賢司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Ochanomizu University
Development of novel cholesterol synthesis modulators that alter stability of cholesterol-biosynthetic enzymesPrincipal Investigator
- Principal Investigator
  
  Ohgane Kenji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Ochanomizu University
  Tokyo University of Science
Analysis of off-target activities of an anti-fungal drug ItraconazolePrincipal Investigator
- Principal Investigator
  
  Ohgane Kenji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 膜タンパク質工学ハンドブック2020
- Author(s)
  監修: 津本浩平、浜窪隆雄 (分担執筆者: 大金賢司他130名)
- Total Pages
  624
- Publisher
  エヌ・ティー・エス出版
- ISBN
  9784860435370
- Data Source
  KAKENHI-PROJECT-17K15487
[Journal Article] Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase2023
- Author(s)
  Kawamura Kota、Yoshioka Hiromasa、Sato Chikako、Yajima Tomoko、Furuyama Yuuki、Kuramochi Kouji、Ohgane Kenji
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 78 Pages: 117145-117145
- DOI
  10.1016/j.bmc.2022.117145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15949
[Journal Article] Allosteric stabilization of a key cholesterol biosynthetic enzyme squalene monooxygenase by its substrate2021
- Author(s)
  大金賢司、吉岡広大
- Journal Title
  
  生化学
  
  Volume: 93 Issue: 1 Pages: 147-151
- DOI
  10.14952/SEIKAGAKU.2021.930147
- ISSN
  0037-1017
- Year and Date
  2021-02-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K15949
[Journal Article] Epo-C12 inhibits peroxiredoxin 1 peroxidase activity2021
- Author(s)
  Yoda Tomoka、Furuta Masateru、Tsutsumi Tomohiko、Ikeda Seiki、Yukizawa Shunsuke、Arai Satoshi、Morita Akinori、Yamatoya Kenji、Nakata Kazuya、Tomoshige Shusuke、Ohgane Kenji、Furuyama Yuuki、Sakaguchi Kengo、Sugawara Fumio、Kobayashi Susumu、Ikekita Masahiko、Kuramochi Kouji
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 41 Pages: 116203-116203
- DOI
  10.1016/j.bmc.2021.116203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15949
[Journal Article] Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives2021
- Author(s)
  Nishiuchi Kota、Ohashi Hirofumi、Nishioka Kazane、Yamasaki Masako、Furuta Masateru、Mashiko Takumi、Tomoshige Shusuke、Ohgane Kenji、Kamisuki Shinji、Watashi Koichi、Kuramochi Kouji
- Journal Title
  
  Journal of Natural Products
  
  Volume: 85 Issue: 1 Pages: 284-291
- DOI
  10.1021/acs.jnatprod.1c01120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-21K05299, KAKENHI-PROJECT-20K15949, KAKENHI-PROJECT-20K16267
[Journal Article] Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile.2021
- Author(s)
  Yuichi Kato, Tomoka Inoue, Yuuki Furuyama, Kenji Ohgane, Mahito Sadaie, Kouji Kuramochi
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 86 Pages: 153519-153519
- DOI
  10.1016/j.tetlet.2021.153519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05868, KAKENHI-PROJECT-20K15949
[Journal Article] A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate2020
- Author(s)
  Hiromasa Yoshioka, Hudson W. Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J. Brown, Kenji Ohgane
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 117 Issue: 13 Pages: 7150-7158
- DOI
  10.1073/pnas.1915923117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
[Journal Article] Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols2020
- Author(s)
  Sagimori Ikuya、Yoshioka Hiromasa、Hashimoto Yuichi、Ohgane Kenji
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 3 Pages: 115298-115298
- DOI
  10.1016/j.bmc.2019.115298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
[Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020
- Author(s)
  Yamashita Hiroko、Tomoshige Shusuke、Nomura Sayaka、Ohgane Kenji、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 1 Pages: 115175-115175
- DOI
  10.1016/j.bmc.2019.115175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-17K15487
[Journal Article] Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation2020
- Author(s)
  Toyota Yosuke、Yoshioka Hiromasa、Sagimori Ikuya、Hashimoto Yuichi、Ohgane Kenji
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 14 Pages: 115576-115576
- DOI
  10.1016/j.bmc.2020.115576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15949
[Journal Article] Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs2020
- Author(s)
  Shioi Ryuta、Karaki Fumika、Yoshioka Hiromasa、Noguchi-Yachide Tomomi、Ishikawa Minoru、Dodo Kosuke、Hashimoto Yuichi、Sodeoka Mikiko、Ohgane Kenji
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 12 Pages: e0243746-e0243746
- DOI
  10.1371/journal.pone.0243746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15949, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] Multiplexing fluorogenic esterase-based viability assay with luciferase assays2019
- Author(s)
  Ohgane Kenji、Yoshioka Hiromasa、Hashimoto Yuichi
- Journal Title
  
  MethodsX
  
  Volume: 6 Pages: 2013-2020
- DOI
  10.1016/j.mex.2019.09.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
[Journal Article] Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton2019
- Author(s)
  Nanjyo Shun、Ohgane Kenji、Yoshioka Hiromasa、Makishima Makoto、Hashimoto Yuichi、Noguchi- Yachide Tomomi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 10 Pages: 1952-1961
- DOI
  10.1016/j.bmc.2019.03.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06570, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17K15487
[Journal Article] Unexpected Emergence of Luciferase-Inhibitory Activity During Structural Development Study of Phenyloxadiazole-based Ppar Ligands2018
- Author(s)
  Ryuta Shioi, Yosuke Toyota, Tomomi Noguchi-Yachide, Minoru Ishikawa, Takao Yamaguchi, Makoto Makishima, Yuichi Hashimoto, and Kenji Ohgane
- Journal Title
  
  HETEROCYCLES
  
  Volume: 97 Issue: 2 Pages: 854-864
- DOI
  10.3987/com-18-s(t)61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-18K06570
[Journal Article] Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole2018
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 28 Issue: 4 Pages: 707-710
- DOI
  10.1016/j.bmcl.2018.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Discovery of Small Molecules that Induce the Degradation of Huntingtin2017
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, and Minoru Ishikawa
- Journal Title
  
  Angew. Chem. Int. Ed. Engl.
  
  Volume: 56 Issue: 38 Pages: 11530-11533
- DOI
  10.1002/anie.201706529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027
[Journal Article] Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels-Alder Reactions.2017
- Author(s)
  Karaki, F.; Ohgane, K.; Imai, H.; Itoh, K.; Fujii, H.
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: 2017 Issue: 26 Pages: 3815-3829
- DOI
  10.1002/ejoc.201700411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18912, KAKENHI-PROJECT-17K15487
[Journal Article] Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein2017
- Author(s)
  Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 12 Pages: 2781-2787
- DOI
  10.1016/j.bmcl.2017.04.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015
[Presentation] STING経路の活性化を抑制するオキシステロール誘導体の構造活性相関2024
- Author(s)
  中里英礼奈, 髙橋花乃子, 露木理緒, 朽津芳彦, 石川稔, 向井康治朗, 田口友彦, 大金賢司
- Organizer
  日本薬学会第144会年会
- Data Source
  KAKENHI-PROJECT-23K06023
[Presentation] 3-アミノステロール誘導体の合成およびヒトSTING経路に対する薬理学的作用解析2024
- Author(s)
  露木理緒, 中里英礼奈, 高橋花乃子, 朽津芳彦, 石川稔, 向井康治朗, 田口友彦, 大金賢司
- Organizer
  日本薬学会第144会年会
- Data Source
  KAKENHI-PROJECT-23K06023
[Presentation] イトラコナゾールの新たな生物活性に着目したプローブ化2023
- Author(s)
  大金賢司, 川端彩希, 塩井隆太, 安藤勇輝, 相川京子
- Organizer
  第 96 回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06023
[Presentation] タンパク質を安定化・不安定化する低分子化合物2022
- Author(s)
  大金賢司
- Organizer
  東北大学生命科学研究科セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K15949
[Presentation] HMG-CoA 還元酵素を不安定化する新規低分子化合物の創製2022
- Author(s)
  河村幸汰, 吉岡広大, 倉持幸司, 古山祐貴, 大金賢司
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K15949
[Presentation] 生細胞中でのタンパク質安定性変化に着目したスクアレンモノオキシゲナーゼ阻害剤探索法の開発2021
- Author(s)
  井上朋香, 吉岡広大, 倉持幸司, 大金賢司
- Organizer
  日本薬学会第141年会 (広島)
- Data Source
  KAKENHI-PROJECT-20K15949
[Presentation] スクアレンモノオキシゲナーゼの分解を誘導するステロールの構造活性相関研究2021
- Author(s)
  勝田覚, 吉岡広大, 倉持幸司, 大金賢司
- Organizer
  日本薬学会第141年会 (広島)
- Data Source
  KAKENHI-PROJECT-20K15949
[Presentation] コレステロール輸送膜タンパク質NPC1/NPC1L1を標的とした、フォールディング・局在異常を制御する小分子の探索2019
- Author(s)
  大金賢司
- Organizer
  第14回トランスポーター研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] Squalene as a new feedback factor of squalene epoxidase stability2019
- Author(s)
  Hiromasa Yoshioka, Ngee Kiat Chua, Hudson W. Coates, Yuichi Hashimoto, Andrew J. Brown, Kenji Ohgane
- Organizer
  60th International Conference on the Bioscienceof Lipids (ICBL)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] Chemical biology approach to understand small molecule-mediated degradation of HMG-CoA reductase2019
- Author(s)
  Kenji Ohgane, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto
- Organizer
  60th International Conference on the Bioscienceof Lipids (ICBL)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] 銀アセチリドの化学に基づく直接的アルキン濃縮精製法の開発2019
- Author(s)
  大金賢司, 淺沼三和子, 中尾周平, 境太希, どど孝介, 袖岡幹子
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] ニーマンピック病C型に対する化学的アプローチ2018
- Author(s)
  大金賢司
- Organizer
  理研シンポジウム第13回有機合成化学のフロンティア
- Invited
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] ER downregulationの母核横断的な構造活性相関2018
- Author(s)
  南條舜, 谷内出友美, 吉岡広大, 槇島誠, 石川稔, 橋本祐一, 大金賢司
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] イトラコナゾールのNPC1に対するシャペロン作用に着目した構造活性相関研究2018
- Author(s)
  安藤有輝，塩井隆太, 吉岡広大，谷内出友美, 石川稔, 橋本祐一，大金賢司
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] identification of chaperone drugs for NPC through drug repurposing screening2018
- Author(s)
  Kenji Ohgane
- Organizer
  Michael, Marcia and Christa Parseghian Scientific Conference for Niemann-Pick Type C Research (Ara Parseghian Medical Research Fund at Notre Dame)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] ItraconazoleのNPC1シャペロンとしての構造活性相関研究2018
- Author(s)
  安藤有輝, 塩井隆太, 吉岡広大, 谷内出友美, 石川稔, 橋本祐一, 大金賢司
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K15487
[Presentation] ドラッグリポジショニングによるニーマンピック病C型に対するシャペロンドラッグの探索2017
- Author(s)
  大金賢司, 塩井隆太, 安藤有輝, 谷内出友美, 石川稔, どど孝介, 袖岡幹子, 橋本祐一
- Organizer
  第35会メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K15487

1. 棚谷綾 (40361654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 石田良典 (10937684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 影近弘之 (20177348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 桑原拓也 (60768654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田口友彦 (10300881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 向井康治朗 (90767633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. NOGUCHI Tomomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. KURAMOCHI Kouji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 橋本祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 唐木文霞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 友重秀介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohgane Kenji 大金 賢司

Research Projects

Research Products

Co-Researchers

New molecular shapes from strained aromatic foldamer macrocycles and their application to development of PPI inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

内在性脂質に基づく新規自然免疫調節剤の創製と作用機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel cholesterol synthesis modulators that alter stability of cholesterol-biosynthetic enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of off-target activities of an anti-fungal drug ItraconazolePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 膜タンパク質工学ハンドブック2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Allosteric stabilization of a key cholesterol biosynthetic enzyme squalene monooxygenase by its substrate2021

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Epo-C12 inhibits peroxiredoxin 1 peroxidase activity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation2020

Author(s)

Journal Title

Ohgane Kenji 大金賢司