SASAKI NOBUO 佐々木伸雄

… Alternative Names

Sasaki Nobuo 佐々木伸雄

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Researcher Number	30777769
Other IDs
Affiliation (Current)	2025: 群馬大学, 生体調節研究所, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 群馬大学, 生体調節研究所, 教授 2016 – 2020: 慶應義塾大学, 医学部(信濃町), 特任助教
Review Section/Research Field	Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Gastroenterology / Basic Section 49050:Bacteriology-related / Basic Section 49030:Experimental pathology-related Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator オルガノイド / 腸内細菌 / 共培養システム / 組織幹細胞 / 数理モデル / 大腸癌 / Reg4 / Lgr5 / 再生 / 炎症性腸疾患 … More / 幹細胞 / 組織再生 / ニッチ / 幹細胞ニッチ / 潰瘍性大腸炎 / 嫌気性培養 / 共培養システム開発 / 嫌気性腸内細菌 / プロバイオティクス / 嫌気性細菌 / 内科 / 幹細胞学 / 組織性幹細胞 / 細菌 / 腸管幹細胞 … More Except Principal Investigator 腸管 / 胆汁酸トランスポーター / 個別化医療 / バイオバンク / 腸内細菌 / オルガノイド / 大腸癌 Less

Establishment of personalized medicine and prevention methods for colorectal cancer considering the intestinal environment
- Principal Investigator
  
  岡田拓久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
次世代型オルガノイドライブラリー構築による腸内環境依存的な発癌機構の理解Principal Investigator
- Principal Investigator
  
  佐々木伸雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Gunma University
Predictive modeling of bacteria variation using in vitro reconstructions of the human gut ecosystemPrincipal Investigator
- Principal Investigator
  
  佐々木伸雄
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Gunma University
ヒト腸管における胆汁酸吸収実態の解明と新規トランスポーターの探索
- Principal Investigator
  
  小林彰子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  The University of Tokyo
Developing a scalable-coculturing system for gut anaerobes and intestinal epitheliumPrincipal Investigator
- Principal Investigator
  
  SASAKI Nobuo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Keio University
Molecular mechanism of the colonic stem cell niche during intestinal epithelial regeneration in inflammatory bowel disease.Principal Investigator
- Principal Investigator
  
  Sasaki Nobuo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Gunma University
  Keio University
A novel culture system of intestinal epithelium for study the interaction among microbiome-host epithelium-immune cellsPrincipal Investigator
- Principal Investigator
  
  Sasaki Nobuo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
腸内細菌と腸管上皮細胞の相互作用メカニズム解明のための新規培養法の確立Principal Investigator
- Principal Investigator
  
  佐々木伸雄
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] 腸内代謝物質を介した免疫系の修飾2023
- Author(s)
  宮内　栄治，佐々木　伸雄
- Total Pages
  153
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-23K27404
[Book] 腸内環境を自在にデザインする未来の創生を目指し2023
- Author(s)
  佐々木　伸雄
- Total Pages
  117
- Publisher
  北関東医学会
- Data Source
  KAKENHI-PROJECT-19H03455
[Book] 腸内代謝物質を介した免疫系の修飾2023
- Author(s)
  宮内　栄治，佐々木　伸雄
- Total Pages
  8
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-23K17415
[Book] 改訂版　もっとよくわかる！腸内細菌叢（福田真嗣/編）担当：オルガノイドを用いた解析2022
- Author(s)
  宣　旭，佐々木　伸雄
- Total Pages
  195
- Publisher
  羊土社
- ISBN
  9784758122115
- Data Source
  KAKENHI-PROJECT-19H03455
[Book] 決定版　オルガノイド実験スタンダード (佐藤，武部，永楽/編)2019
- Author(s)
  佐々木　伸雄，金井　隆典，佐藤　俊朗
- Total Pages
  372
- Publisher
  羊土社
- ISBN
  9784758122399
- Data Source
  KAKENHI-PROJECT-19H03455
[Book] 決定版　オルガノイド実験スタンダード (佐藤，武部，永楽/編)2019
- Author(s)
  佐々木　伸雄，金井　隆典，佐藤　俊朗
- Total Pages
  372
- Publisher
  羊土社
- ISBN
  9784758122399
- Data Source
  KAKENHI-PROJECT-19K22544
[Book] Biology and Engineering of Stem Cell Niches (Edit by Vishwakarma and Karp)2017
- Author(s)
  Sasaki N, Sato T, Clevers H
- Total Pages
  15
- Publisher
  Academic Press Elsevier
- Data Source
  KAKENHI-PROJECT-17K15968
[Book] 組織性肝細胞2016
- Author(s)
  佐々木　伸雄，佐藤　俊朗
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16H07176
[Book] 臨床免疫・アレルギー科2016
- Author(s)
  佐々木　伸雄
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16H07176
[Journal Article] D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease2023
- Author(s)
  Umeda Satoko、　Sujino Tomohisa、、、Shiomi Daisuke、Ashida Hiroshi、Kanai Takanori
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 16 Issue: 6 Pages: 1011-1031
- DOI
  10.1016/j.jcmgh.2023.08.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18272, KAKENHI-PROJECT-23K17415, KAKENHI-PROJECT-23KK0138, KAKENHI-PROJECT-23H00425, KAKENHI-PROJECT-21H02728, KAKENHI-PROJECT-21H02905, KAKENHI-PROJECT-23K24127, KAKENHI-PROJECT-23K27404, KAKENHI-PROJECT-23K27590
[Journal Article] DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation2023
- Author(s)
  Oda Tsukasa、Gotoh Nanami、Kasamatsu Tetsuhiro、Handa Hiroshi、Saitoh Takayuki、Sasaki Nobuo
- Journal Title
  
  Cell Proliferation
  
  Volume: Cell Peolif. 2023 Issue: 6
- DOI
  10.1111/cpr.13398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-23K17415, KAKENHI-PROJECT-23K27404
[Journal Article] Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression2023
- Author(s)
  Ishihara Rei、Oda Tsukasa、Murakami Yuki、Matsumura Ikuko、Watanabe Saki、Asao Yuta、Masuda Yuta、Gotoh Nanami、Kasamatsu Tetsuhiro、Takei Hisashi、Kobayashi Nobuhiko、Sasaki Nobuo、Saitoh Takayuki、Murakami Hirokazu、Handa Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 3 Pages: 2216-2216
- DOI
  10.3390/ijms24032216
- Data Source
  KAKENHI-PROJECT-19H03455
[Journal Article] Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut2022
- Author(s)
  Yoshimatsu Yusuke、Sujino Tomohisa、Hosoe Naoki、et al.
- Journal Title
  
  Cell Reports
  
  Volume: 39 Issue: 6 Pages: 110773-110773
- DOI
  10.1016/j.celrep.2022.110773
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07994, KAKENHI-PROJECT-21K18272, KAKENHI-PROJECT-20H00536, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-21H02905
[Journal Article] Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice2022
- Author(s)
  Yamazaki Kyoko、Miyauchi Eiji、Kato Tamotsu、Sato Keisuke、Suda Wataru、Tsuzuno Takahiro、Yamada-Hara Miki、Sasaki Nobuo、Ohno Hiroshi、Yamazaki Kazuhisa
- Journal Title
  
  Journal of Oral Microbiology
  
  Volume: 14 Issue: 1 Pages: 2110194-2110194
- DOI
  10.1080/20002297.2022.2110194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-19K05907
[Journal Article] 腸内細菌－宿主細胞の相互作用メカニズムを紐解く新規共培養系の開発2021
- Author(s)
  佐々木　伸雄
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75 Pages: 77-81
- NAID
  40022452487
- Data Source
  KAKENHI-PROJECT-19K22544
[Journal Article] 腸内細菌-宿主細胞の相互作用メカニズムを紐解く新規共培養系の開発2021
- Author(s)
  佐々木　伸雄
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75 Pages: 77-81
- NAID
  40022452487
- Data Source
  KAKENHI-PROJECT-19H03455
[Journal Article] 腸内細菌-宿主細胞の相互作用メカニズムを紐解く新規共培養系の開発2021
- Author(s)
  佐々木　伸雄，小田　司，佐藤　俊朗
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75(1) Pages: 77-81
- NAID
  40022452487
- Data Source
  KAKENHI-PROJECT-19H03455
[Journal Article] Development of a scalable co-culture system for gut anaerobes and human colon epithelium2020
- Author(s)
  Sasaki Nobuo、Miyamoto Kentaro、Maslowski Kendle M.、Ohno Hiroshi、Kanai Takanori、Sato Toshiro
- Journal Title
  
  Gastroenterology
  
  Volume: in Press Issue: 1 Pages: 388-390
- DOI
  10.1053/j.gastro.2020.03.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-18KK0246
[Journal Article] Somatic inflammatory gene mutations in human ulcerative colitis epithelium.2020
- Author(s)
  Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R, Yoshida K, Sasaki N, Hibi T, Ishihara S, Kanai T, Sato T.
- Journal Title
  
  Nature
  
  Volume: 7789 Issue: 7789 Pages: 254-259
- DOI
  10.1038/s41586-019-1844-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-17J04827, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-17K09395, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-19K22544
[Journal Article] Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids2019
- Author(s)
  Bolhaqueiro A.C.F., Ponsioen B., Bakker B., Klaasen S., Kucukkose E., van Jaarsveld R.H., Vivie J., Verlaan-Klink I., Hami N., Spierings D.C.J., Sasaki N., Dutta D., Boj S.F., Vries R.G.J., Lansdorp P.M., van de Wetering M. van Oudenaarden A., Clevers H., Kranenburg O., Foijer F., Snippert H.J.G., Kops G.J.P.
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 5 Pages: 824-834
- DOI
  10.1038/s41588-019-0399-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-19H03455
[Journal Article] Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion2019
- Author(s)
  van Es Johan H.、Wiebrands Kay、L?pez-Iglesias Carmen、van de Wetering Marc、Zeinstra Laura、van den Born Maaike、Korving Jeroen、Sasaki Nobuo、Peters Peter J.、van Oudenaarden Alexander、Clevers Hans
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 52 Pages: 26599-26605
- DOI
  10.1073/pnas.1801888117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-19H03455
[Journal Article] Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells2019
- Author(s)
  Han S, Fink J, Jorg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers　H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK
- Journal Title
  
  Cell Stem Cell
  
  Volume: 25 Issue: 3 Pages: 342-356.e7
- DOI
  10.1016/j.stem.2019.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-19H03455
[Journal Article] Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.2019
- Author(s)
  Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, Suzuki T, Koda Y, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Kamada N, Hattori M, Ashida H, Sakamoto M, Atarashi K, Narushima S, Yoshimura A, Honda K, Sato T, Kanai T.
- Journal Title
  
  Nat Microbiol.
  
  Volume: 4 Issue: 3 Pages: 492-503
- DOI
  10.1038/s41564-018-0333-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-18K15794, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-16K09374, KAKENHI-PROJECT-16K15293, KAKENHI-PROJECT-19K22544, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-16H05186, KAKENHI-PROJECT-16K08091
[Journal Article] Intra-tumour diversification in colorectal cancer at the single-cell level2018
- Author(s)
  Roerink Sophie F.#、Sasaki Nobuo#(#co-first author)、Lee-Six Henry、et al.,
- Journal Title
  
  Nature
  
  Volume: 556 Issue: 7702 Pages: 457-462
- DOI
  10.1038/s41586-018-0024-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15968
[Journal Article] Automated brightfield morphometry of 3D organoid populations by OrganoSeg2018
- Author(s)
  Borten Michael A.、Bajikar Sameer S.、Sasaki Nobuo、Clevers Hans、Janes Kevin A.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-017-18815-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15968
[Journal Article] Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology2018
- Author(s)
  Sasaki Nobuo、Clevers Hans
- Journal Title
  
  Current Opinion in Genetics & Development
  
  Volume: 52 Pages: 117-122
- DOI
  10.1016/j.gde.2018.09.001
- Data Source
  KAKENHI-PROJECT-17K15968
[Journal Article] Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.2017
- Author(s)
  Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H.
- Journal Title
  
  Science
  
  Volume: 358 Issue: 6360 Pages: 234-238
- DOI
  10.1126/science.aao3130
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15968
[Journal Article] Tissue-specific mutation accumulation in human adult stem cells during life2016
- Author(s)
  Blokzijl F,de Ligt J,Jager M,Sasselli V,Roerink S,Sasaki N,Huch M,Boymans S,Kuijk E,Prins P, Nijman I,Martincorena I,Mokry M,Wiegerinck CL,Middendorp S,Sato T,Schwank G, Nieuwenhuis EES,Verstegen MMA,van der Laan LJW,de Jonge J,IJzermans JNM, Vries RG,van de Wetering M,Stratton MR,Clevers H,Cuppen E,van Boxtel R
- Journal Title
  
  Nature
  
  Volume: 238 Issue: 7624 Pages: 260-264
- DOI
  10.1038/nature19768
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-16H07176, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K08974
[Journal Article] Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.2016
- Author(s)
  Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, Lpez-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 113 Issue: 37
- DOI
  10.1073/pnas.1607327113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07176
[Patent] 上皮細胞培養用培養容器及びその使用2020
- Inventor(s)
  佐藤俊朗，佐々木伸雄
- Industrial Property Rights Holder
  佐藤俊朗，佐々木伸雄
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] 消化管における胆汁酸輸送機作の解析2024
- Author(s)
  黒部（高島）優季、齋藤佑太、宮脇里奈、三坂巧、柳澤宏太、宮内栄治、佐々木伸雄、荻原琢男、小林彰子
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K18428
[Presentation] オルガノイドを用いた腸内細菌研究のホントのところ2023
- Author(s)
  佐々木　伸雄，内山　皓太，清水　俊輔，柳澤　宏太，宣　旭，宮内　栄治
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] オルガノイド技術が切り拓く腸内細菌・栄養学2023
- Author(s)
  佐々木　伸雄
- Organizer
  第77回日本栄養・食糧学会大会（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] ムチン動態に関与する機能性微生物の探索2023
- Author(s)
  内山　皓太, 　清水　俊輔，宮内　栄治, 佐々木　伸雄
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] ヒト回腸由来オルガノイドを利用した胆汁酸トランスポーターASBT発現解析2023
- Author(s)
  柳澤宏太, 宮内栄治, 齋藤貴之, 高島優季, 小林彰子, 佐々木伸雄
- Organizer
  第70回北関東医学会総会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] 消化器癌の個別化治療法の開発に向けた群馬大学オルガノイドバンク2023
- Author(s)
  内田　真太郎、今井　淳稀、宣　旭、山口　亜梨紗、塩井　生馬、柴崎　雄太、小峯　知佳、大曽根　勝也、岡田　拓久、白石　卓也、酒井　真、佐野　彰彦、横堀　武彦、小川　博臣、宗田　真、小田　司、宮内　栄治、調　憲、佐伯　浩司、佐々木　伸雄
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] 大腸上皮幹細胞ニッチであるDCS細胞の細胞系譜解析2023
- Author(s)
  青柳瑠南, 小田司, 宮内栄治, 相賀裕美子, 齋藤貴之, 佐々木伸雄
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] Comprehensive gene expression changes in multiple myeloma via HIF-1 stabilization by deferoxamine2023
- Author(s)
  Natsuki Shiraishi, Nanami Gotoh, Tsukasa Oda, Tetsuhiro Kasamatsu, Runa Aoyagi, Ayane Omori, Kota Yanagisawa, Yua Itoi, Miyami, Iida, Hikaru Negishi, Nobuo Sasaki, Akihiko Yokohama, Hiroshi Handa, Takayuki Saitoh
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] ヒト回腸由来オルガノイドを利用した胆汁酸トランスポーターASBT発現解析2023
- Author(s)
  柳澤宏太, 宮内栄治, 齋藤貴之, 高島優季, 小林彰子, 佐々木伸雄
- Organizer
  第9回生体調節研究所内分泌代謝シンポジウム
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] HIF-1αの安定化剤を用いた模擬低酸素環境下における多発性骨髄腫細胞の遺伝子発現解析2023
- Author(s)
  白石菜月、後藤七海、小田司、笠松哲光、青柳瑠南、大森綺音、柳澤宏太、糸井悠晏、飯田南、根岸光、佐々木伸雄、横濱章彦、半田寛、齋藤貴之
- Organizer
  第70回北関東医学会総会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] オルガノイド技術が切り拓く腸内細菌・栄養学2023
- Author(s)
  佐々木　伸雄
- Organizer
  第77回日本栄養・食糧学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] ヒト回腸由来オルガノイドを利用した胆汁酸トランスポーターASBT発現解析2023
- Author(s)
  柳澤宏太, 宮内栄治, 齋藤貴之, 高島優季, 小林彰子, 佐々木伸雄
- Organizer
  第9回生体調節研究所内分泌代謝シンポジウム
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] オルガノイドを用いた腸内細菌研究のホントのところ2023
- Author(s)
  佐々木　伸雄，内山　皓太，清水　俊輔，柳澤　宏太，宣　旭，宮内　栄治
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] 大腸上皮幹細胞ニッチであるDCS細胞の細胞系譜解析2023
- Author(s)
  青柳瑠南, 小田司, 宮内栄治, 相賀裕美子, 齋藤貴之, 佐々木伸雄
- Organizer
  第70回北関東医学会総会
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation2023
- Author(s)
  Tsukasa Oda, Nanami Gotoh, Tetsuhiro Kasamatsu, Hiroshi Handa, Takayuki Saitoh, Nobuo Sasaki
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27404
[Presentation] ヒト回腸由来オルガノイドを利用した胆汁酸トランスポーターASBT発現解析2023
- Author(s)
  柳澤宏太, 宮内栄治, 齋藤貴之, 高島優季, 小林彰子, 佐々木伸雄
- Organizer
  0回北関東医学会総会
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] ムチン動態に関与する機能性微生物の探索2023
- Author(s)
  内山　皓太, 　清水　俊輔，宮内　栄治, 佐々木　伸雄
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] 母体炎症が仔の1型糖尿病病態に与える影響2023
- Author(s)
  宮内栄治, 中西裕美子, 髙木若菜, 川住雅美, 大野博司, 佐々木伸雄
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K17415
[Presentation] オルガノイドが紐解く消化管の複雑性2022
- Author(s)
  佐々木　伸雄
- Organizer
  第26回腸内細菌学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓くHuman Biologyの新時代2022
- Author(s)
  佐々木　伸雄
- Organizer
  第45回セルセラピーセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] 生体調節研究所における癌研究2022
- Author(s)
  佐々木　伸雄，小田　司
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドを利用した内分泌学・腸内細菌研究のススメ2022
- Author(s)
  佐々木　伸雄
- Organizer
  第36回　日本糖尿病・肥満動物学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] 新技術が切り拓く今後の腸内細菌研究2022
- Author(s)
  佐々木　伸雄
- Organizer
  第2回腸内デザイン学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] 大腸上皮幹細胞ニッチであるDeep Crypt Sedretory細胞の細胞系譜解析2022
- Author(s)
  青柳　瑠南, 佐々木　伸雄
- Organizer
  第69回北関東医学会総会
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] Prediction of pancreatic cancer with salivary and fecal metabolomic profiles2022
- Author(s)
  E. Miyauchi, Z. Ito, T. Taida, N. Sasaki, K. Uchiyama, S. Koido, T. Ohkusa, N. Sato, H. Ohno
- Organizer
  International Human Microbiome Consortium 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] Cigarette smoking modulates colonic mucosal microbiota and immune responses in patients with inflammatory bowel diseases2022
- Author(s)
  Eiji Miyauchi, Nobuo Sasaki, Hiroshi Ohno
- Organizer
  The 8th IMCR Symposium on Endocrine and Metabolism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation2022
- Author(s)
  Tsukasa Oda, Nobuo Sasaki
- Organizer
  The 8th IMCR Symposium on Endocrine and Metabolism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] DNA損傷誘導性の細胞老化は液ー液相分離で形成される53BP1 nuclar fociにより制御される2022
- Author(s)
  小田司，後藤七海，笠松哲光，半田寛，齋藤貴之，佐々木伸雄
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓く腸内細菌研究2021
- Author(s)
  佐々木　伸雄
- Organizer
  2021年度第4回生活習慣病予防のための機能性食品開発に関する研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓く腸内細菌研究2021
- Author(s)
  佐々木　伸雄
- Organizer
  第一回腸内デザイン学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓く腸内細菌研究の新時代2021
- Author(s)
  佐々木　伸雄
- Organizer
  第7回内分泌・代謝シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓く腸内細菌研究2021
- Author(s)
  佐々木　伸雄
- Organizer
  第20回生体機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] Developing of the organoid system for applied researches in gut microbiota2020
- Author(s)
  佐々木　伸雄
- Organizer
  第43回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] The study of epithelial crosstalk at the host-microbes interface using organoid2020
- Author(s)
  Nobuo Sasaki
- Organizer
  8th Global Network Forum on Infection and Immunity: Microbiome
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] The study of epithelial crosstalk at the host-microbes interface using organoid2020
- Author(s)
  Nobuo Sasaki
- Organizer
  8th Global Network Forum on Infection and Immunity: Microbiome
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] 嫌気性腸内細菌とヒト正常大腸上皮細胞の共培養を可能にする新規培養系の開発2020
- Author(s)
  佐々木　伸雄
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] オルガノイドが切り拓く腸内細菌研究の新時代2019
- Author(s)
  佐々木　伸雄
- Organizer
  日本乳酸菌学会2019年度秋季セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] 大腸がんにおいて1細胞レベルで明らかにされた単一腫瘍内における不均一性の網羅的解析2019
- Author(s)
  佐々木　伸雄
- Organizer
  第46回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] オルガノイドが切り拓く次世代の腸内細菌研究2019
- Author(s)
  佐々木　伸雄，佐藤　俊朗
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] Organoid unravels the interaction mechanism between mucosal barrier and bacteria2019
- Author(s)
  Nobuo Sasaki
- Organizer
  Keio International Symposium, The Crossroads of Intestinal Microbiology, Mucosal Immunology and Epithelial Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓く次世代の腸内細菌研究2019
- Author(s)
  佐々木　伸雄，佐藤　俊朗
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] 大腸がんにおいて1細胞レベルで明らかにされた単一腫瘍内における不均一性の網羅的解析2019
- Author(s)
  佐々木　伸雄
- Organizer
  第46回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03455
[Presentation] オルガノイドが切り拓く腸内細菌研究の新時代2019
- Author(s)
  佐々木　伸雄
- Organizer
  日本乳酸菌学会2019年度秋季セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] Organoid unravels the interaction mechanism between mucosal barrier and bacteria2019
- Author(s)
  Nobuo Sasaki
- Organizer
  Keio International Symposium, The Crossroads of Intestinal Microbiology, Mucosal Immunology and Epithelial Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22544
[Presentation] Application of organoid for the study of interaction between host and microbes2018
- Author(s)
  佐々木　伸雄
- Organizer
  Looking to the future of Developmental Cell Biology
- Invited
- Data Source
  KAKENHI-PROJECT-17K15968
[Presentation] 大腸がんにおいて1細胞レベルで明らかにされた単一腫瘍内における不均一性の網羅的解析2018
- Author(s)
  佐々木　伸雄
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15968
[Presentation] オルガノイド研究の礎~応用~未来2018
- Author(s)
  佐々木　伸雄，佐藤　俊朗
- Organizer
  日本農芸化学会 2018
- Invited
- Data Source
  KAKENHI-PROJECT-17K15968
[Presentation] A high-resolution molecular history of intra-cancer diversification using patient-derived organoid2017
- Author(s)
  Nobuo Sasaki, Hans Clevers
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15968
[Presentation] Comparing clonal evolution at single cell level between normal crypts and colon cancer2017
- Author(s)
  Nobuo Sasaki
- Organizer
  Korean Society for Biochemistry and Molecular Biology international conference 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15968
[Presentation] The function of Notch signaling in intestinal stem cells2016
- Author(s)
  Nobuo Sasaki
- Organizer
  The 9th Notch Meeting
- Place of Presentation
  静岡県　国立遺伝学研究所
- Year and Date
  2016-10-05
- Invited
- Data Source
  KAKENHI-PROJECT-16H07176
[Presentation] Reg4+ Deep Crypt Secretory Cells Function as epithelial niche for Lgr5+ stem cells in colon2016
- Author(s)
  Nobuo Sasaki
- Organizer
  第89回　日本生化学学会大会
- Place of Presentation
  宮城県　仙台国際センター
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16H07176

1. 岡田拓久 (50851383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 横堀武彦 (60420098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 宮内栄治 (60634706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 佐伯浩司 (80325448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小林彰子 (90348144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SATO Toshiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 筋野智久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 細江直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 寺谷俊昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 金井隆典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 杉本真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAKI NOBUO 佐々木 伸雄

Sasaki Nobuo 佐々木 伸雄

Research Projects

Research Products

Co-Researchers

Establishment of personalized medicine and prevention methods for colorectal cancer considering the intestinal environment

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次世代型オルガノイドライブラリー構築による腸内環境依存的な発癌機構の理解Principal Investigator

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Predictive modeling of bacteria variation using in vitro reconstructions of the human gut ecosystemPrincipal Investigator

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ヒト腸管における胆汁酸吸収実態の解明と新規トランスポーターの探索

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Developing a scalable-coculturing system for gut anaerobes and intestinal epitheliumPrincipal Investigator

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Molecular mechanism of the colonic stem cell niche during intestinal epithelial regeneration in inflammatory bowel disease.Principal Investigator

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A novel culture system of intestinal epithelium for study the interaction among microbiome-host epithelium-immune cellsPrincipal Investigator

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腸内細菌と腸管上皮細胞の相互作用メカニズム解明のための新規培養法の確立Principal Investigator

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[Book] 腸内代謝物質を介した免疫系の修飾2023

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[Book] 腸内環境を自在にデザインする未来の創生を目指し2023

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[Book] 腸内代謝物質を介した免疫系の修飾2023

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[Book] 改訂版 もっとよくわかる！腸内細菌叢（福田真嗣/編） 担当：オルガノイドを用いた解析2022

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[Book] 決定版 オルガノイド実験スタンダード (佐藤，武部，永楽/編)2019

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SASAKI NOBUO 佐々木伸雄

Sasaki Nobuo 佐々木伸雄

[Book] 改訂版　もっとよくわかる！腸内細菌叢（福田真嗣/編）担当：オルガノイドを用いた解析2022

[Book] 決定版　オルガノイド実験スタンダード (佐藤，武部，永楽/編)2019

[Book] 決定版　オルガノイド実験スタンダード (佐藤，武部，永楽/編)2019