Sakaguchi Hideya 坂口秀哉

Researcher Number	30779153
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2025: 京都大学, iPS細胞研究所, 特別研究員(PD)
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2017 – 2019: 京都大学, iPS細胞研究所, 特別研究員(PD) 2016 – 2017: 京都大学, iPS細胞研究所, 特定研究員
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / General medical chemistry / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 48040:Medical biochemistry-related / General medical chemistry Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator オルガノイド / ヒト多能性幹細胞 / 大脳オルガノイド / 神経オルガノイド / 大脳皮質 / 神経分化誘導 / 疾患モデリング / 神経機能創発 / 海馬 / 内側側頭葉てんかん … More / カルシウムイメージング / 海馬オルガノイド / 皮質脊髄路 / ハイコンテントアナリシス / 神経機能評価 / 分化誘導 / 脊髄オルガノイド / 脊髄 / 大脳皮質オルガノイド / 神経再生 / 再生医学 / 神経発生 … More Except Principal Investigator PEG / 体軸形成 / 尾頭軸 / 背腹軸 / 濃度勾配 / 脊髄オルガノイド / ミクログリア / 神経オルガノイド / 血液脳関門 / Organ-on-a-Chip Less

神経オルガノイドにおける脳機能創発の再構成と神経精神疾患モデリングPrincipal Investigator
- Principal Investigator
  
  坂口秀哉
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
Development of an In Vitro Disease Model Incorporating Organ-Organ Interaction
- Principal Investigator
  
  萩原将也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Physical and Chemical Research
Development of Spinal Cord Organoids using Body Axis Formation Platform
- Principal Investigator
  
  萩原将也
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Physical and Chemical Research
Modeling mesial temporal lobe epilepsy using hippocampal organoidsPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Hideya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Institute of Physical and Chemical Research
in vitro generation of cortico-spinal tract using human pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Hideya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
ヒト多能性幹細胞由来の大脳新皮質組織を用いた霊長類に於ける神経回路の再構築Principal Investigator
- Principal Investigator
  
  坂口秀哉
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
ヒト多能性幹細胞から6層構造を持つ成熟した大脳新皮質の分化誘導Principal Investigator
- Principal Investigator
  
  坂口秀哉
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University

All 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] Organ Regeneration 3D Stem Cell Culture & Manipulation2017
- Author(s)
  Taisuke Kadoshima, Hideya Sakaguchi, and Mototsugu Eiraku
- Total Pages
  16
- Publisher
  Springer New York
- Data Source
  KAKENHI-PROJECT-16H06897
[Journal Article] The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness2019
- Author(s)
  Sawai Tsutomu、Sakaguchi Hideya、Thomas Elizabeth、Takahashi Jun、Fujita Misao
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 3 Pages: 440-447
- DOI
  10.1016/j.stemcr.2019.08.003
- NAID
  120006734877
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13843, KAKENHI-PROJECT-17H04302, KAKENHI-PROJECT-17J10294, KAKENHI-PROJECT-18K15046
[Journal Article] Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids2019
- Author(s)
  Sakaguchi Hideya、Ozaki Yuki、Ashida Tomoka、Matsubara Takayoshi、Oishi Naotaka、Kihara Shunsuke、Takahashi Jun
- Journal Title
  
  Stem Cell Reports
  
  Volume: 印刷中
- NAID
  120006888502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15046
[Journal Article] Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids.2019
- Author(s)
  Sakaguchi H, Ozaki Y, Ashida T, Matsubara T, Oishi N, Kihara S, Takahashi J.
- Journal Title
  
  Stem Cell Rep.
  
  Volume: 13 Issue: 3 Pages: 458-473
- DOI
  10.1016/j.stemcr.2019.05.029
- NAID
  120006888502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04302, KAKENHI-PROJECT-17J10294, KAKENHI-PROJECT-18K15046
[Journal Article] Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells2018
- Author(s)
  Ogura Takenori、Sakaguchi Hideya、Miyamoto Susumu、Takahashi Jun
- Journal Title
  
  Development
  
  Volume: 145 Issue: 16 Pages: 162214-162214
- DOI
  10.1242/dev.162214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15046
[Journal Article] Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1.2017
- Author(s)
  Noritaka Sano, Takafumi Shimogawa, Hideya Sakaguchi, Yoshihiko Ioroi, Yoshifumi Miyawaki, Asuka Morizane, Susumu Miyamoto, and Jun Takahashi.
- Journal Title
  
  Frontiers in Cellular Neuroscience.
  
  Volume: 11
- DOI
  10.3389/fncel.2017.00123
- NAID
  120006318875
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J10294
[Journal Article] 大脳皮質オルガノイド ―発生学的観点からの解説とその将来的展望2016
- Author(s)
  坂口秀哉、永樂元次
- Journal Title
  
  実験医学
  
  Volume: 34 Pages: 116-122
- Data Source
  KAKENHI-PROJECT-16H06897
[Presentation] Self-Organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids2019
- Author(s)
  Hideya Sakaguchi, Jun Takahashi
- Organizer
  ISSCR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の海馬、脊髄、大脳皮質組織とその神経活動へのアプローチ2019
- Author(s)
  坂口秀哉
- Organizer
  奈良先端科学技術大学院大学　研究科セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] Self-Organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids2019
- Author(s)
  Hideya Sakaguchi, Jun Takahashi
- Organizer
  ISSCR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J10294
[Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の３次元大脳組織とそれに由来する神経ネットワークにおける神経活動の評価2019
- Author(s)
  坂口秀哉
- Organizer
  第2回横河電機ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] Self-organized synchronization in human neuronal network activity derived from cerebral organoids.2018
- Author(s)
  Sakaguchi Hideya and Takahashi Jun
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の海馬、大脳皮質、および脊髄組織2018
- Author(s)
  坂口秀哉
- Organizer
  金沢大学　脳神経医学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] Self-organized synchronization in human neuronal network activity derived from cerebral organoid.2018
- Author(s)
  Sakaguchi Hideya and Takahashi Jun
- Organizer
  International Society for Stem Cell Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の大脳オルガノイド ~イメージングによる多面的評価と新しいアプローチ~2018
- Author(s)
  坂口秀哉
- Organizer
  Sartoriusフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18K15046
[Presentation] 細胞の自己組織化能によって形成されるヒト多能性幹細胞由来の大脳組織～再生医療へ向けた課題と展望～2017
- Author(s)
  坂口秀哉
- Organizer
  日本再生医療学会
- Place of Presentation
  仙台国際センター(宮城県・仙台市)
- Year and Date
  2017-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-16H06897
[Presentation] Three-dimensional evaluation of human embryonic stem cell-derived cerebral organoid.2017
- Author(s)
  Hideya Sakaguchi and Jun Takahashi.
- Organizer
  International Society of Stem Cell Research.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J10294

1. 萩原将也 (00705056)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Koh IsabelSiewYin (90868415)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SAWAI Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高橋淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakaguchi Hideya 坂口 秀哉

Research Projects

Research Products

Co-Researchers

神経オルガノイドにおける脳機能創発の再構成と神経精神疾患モデリングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an In Vitro Disease Model Incorporating Organ-Organ Interaction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Spinal Cord Organoids using Body Axis Formation Platform

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modeling mesial temporal lobe epilepsy using hippocampal organoidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

in vitro generation of cortico-spinal tract using human pluripotent stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト多能性幹細胞由来の大脳新皮質組織を用いた霊長類に於ける神経回路の再構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト多能性幹細胞から6層構造を持つ成熟した大脳新皮質の分化誘導Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Organ Regeneration 3D Stem Cell Culture & Manipulation2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 大脳皮質オルガノイド ―発生学的観点からの解説とその将来的展望2016

Sakaguchi Hideya 坂口秀哉