Yokokawa Kazuki 横川和樹

Researcher Number	30781273
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 札幌医科大学, 医学部, 助教 2022: 札幌医科大学, 医学部, 助教 2017 – 2021: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Psychiatric science
Keywords	Principal Investigator アミロイドβ / ミクログリア / アルツハイマー病 / 間葉系幹細胞 / アセチルコリン受容体 / 重症筋無力症 / 筋萎縮性側索硬化症 / βアミロイド / 多発性硬化症 / 脳神経疾患 … More / 電子常磁性共鳴 / 骨髄間葉系幹細胞 / 酸化ストレス / 認知症 Less

筋における神経型アセチルコリン受容体の役割解明;難治性重症筋無力症治療に向けてPrincipal Investigator
- Principal Investigator
  
  横川和樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Sapporo Medical University
Elucidation of the immunomodulatory mechanism of bone marrow mesenchymal stem cell therapy for the development of new neurological disease treatmentsPrincipal Investigator
- Principal Investigator
  
  Yokokawa Kazuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Sapporo Medical University
Analysis of oxidative stress in the brain in Alzheimer's disease model mice and establishment of bone marrow mesenchymal stem cell therapyPrincipal Investigator
- Principal Investigator
  
  Yokokawa Kazuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Sapporo Medical University

All 2019 2018 2017

All Journal Article Presentation

[Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019
- Author(s)
  Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 68 Issue: 1 Pages: 323-337
- DOI
  10.3233/jad-180904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019
- Author(s)
  Yokokawa Kazuki、Iwahara Naotoshi、Hisahara Shin、Emoto Miho C.、Saito Taro、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Matsushita Takashi、Suzuki Syuuichirou、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 72 Issue: 3 Pages: 867-884
- DOI
  10.3233/jad-190817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019
- Author(s)
  Saito Taro、Hisahara Shin、Iwahara Naotoshi、Emoto Miho C.、Yokokawa Kazuki、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Suzuki Syuuichirou、Matsushita Takashi、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 145 Pages: 20-32
- DOI
  10.1016/j.freeradbiomed.2019.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019
- Author(s)
  Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
- Journal Title
  
  Journal of Alzheimer's disease
  
  Volume: 67 Issue: 3 Pages: 1079-1087
- DOI
  10.3233/jad-180985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-16K10291, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-17K16388
[Presentation] 骨髄間葉系幹細胞治療はミクログリアによる炎症応答を制御しAβ病理を改善する2019
- Author(s)
  横川和樹, 岩原直敏, 久原真, 齋藤太郎, 鈴木紘美, 松下隆司, 松村晃寛, 鈴木秀一郎, 下濱俊
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] Rat Bone Marrow-derived MSCs Attenuate Oxidative Stress and Neuroinflammation in APP/PS1 mice.2019
- Author(s)
  Kazuki Yokokawa, Naotoshi Iwahara, Miho C. Emoto, Shin Hisahara, Taro Saito, Mai Fujikura, Tatsuo Manabe, Takashi Matsushita, Akihiro Matsumura, Syuuichirou Suzuki, Jun Kawamata, Hirotada G. Fujii, Shun Shimohama
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] アルツハイマー病モデルマウスにおける骨髄間葉系幹細胞治療のメカニズム検討2018
- Author(s)
  横川和樹, 岩原直敏, 江本美穂, 久原真, 蒲生直希, 齋藤太郎, 藤倉舞, 眞部建郎, 鈴木紘美, 松下隆司, 松村晃寛, 鈴木秀一郎, 川又純, 藤井博匡, 下濱俊
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] Rat Bone Marrow-derived MSC Improve Oxidative Stress in Alzheimer’s Disease Mouse Model.2018
- Author(s)
  Kazuki Yokokawa, Naotoshi Iwahara, Miho C. Emoto, Shin Hisahara, Naoki Gamou, Taro Saito, Mai Fujikura, Tatsuo Manabe, Takashi Matsushita, Akihiro Matsumura, Syuuichirou Suzuki, Jun Kawamata, Hirotada G. Fujii, and Shun Shimohama
- Organizer
  第58回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] Rat Bone Marrow-derived MSC Improve Oxidative Stress in Alzheimer’s Disease Mouse Model.2018
- Author(s)
  Kazuki Yokokawa, Naotoshi Iwahara, Miho C. Emoto, Shin Hisahara, Naoki Gamou, Taro Saito, Mai Fujikura, Tatsuo Manabe, Takashi Matsushita, Akihiro Matsumura, Syuuichirou Suzuki, Jun Kawamata, Hirotada G. Fujii, Shun Shimohama
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] シンポジウム「認知症と再生医療」　間葉系幹細胞によるアルツハイマー病の治療　モデルマウスでの検討を通じて2018
- Author(s)
  横川和樹, 下濱俊
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] 骨髄間葉系幹細胞によるアルツハイマー病治療における脳内酸化ストレス動態の検討2017
- Author(s)
  横川和樹, 岩原直敏, 江本美穂, 久原真, 齋藤太郎, 藤倉舞, 眞部建郎, 鈴木紘美, 松下隆司, 松村晃寛, 鈴木秀一郎, 川又純, 藤井博匡, 下濱俊
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16388
[Presentation] Transplantation of Rat Bone Marrow-derived Mesenchymal Stem Cells Regulates Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model.2017
- Author(s)
  Kazuki Yokokawa, Naotoshi Iwahara, Miho C. Emoto, Shin Hisahara, Taro Saito, Mai Fujikura, Tatsuo Manabe, Hiromi Suzuki, Takashi Matsushita, Akihiro Matsumura, Syuuichirou Suzuki, Jun Kawamata, Hirotada G. Fujii, and Shun Shimohama
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16388

1. 下濱俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 藤井博匡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 江本美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 岩原直敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokokawa Kazuki 横川 和樹

Research Projects

Research Products

Co-Researchers

筋における神経型アセチルコリン受容体の役割解明;難治性重症筋無力症治療に向けてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the immunomodulatory mechanism of bone marrow mesenchymal stem cell therapy for the development of new neurological disease treatmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of oxidative stress in the brain in Alzheimer's disease model mice and establishment of bone marrow mesenchymal stem cell therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 骨髄間葉系幹細胞治療はミクログリアによる炎症応答を制御しAβ病理を改善する2019

Author(s)

Organizer

Data Source

[Presentation] Rat Bone Marrow-derived MSCs Attenuate Oxidative Stress and Neuroinflammation in APP/PS1 mice.2019

Author(s)

Organizer

Data Source

[Presentation] アルツハイマー病モデルマウスにおける骨髄間葉系幹細胞治療のメカニズム検討2018

Author(s)

Organizer

Data Source

[Presentation] Rat Bone Marrow-derived MSC Improve Oxidative Stress in Alzheimer’s Disease Mouse Model.2018

Author(s)

Organizer

Data Source

[Presentation] Rat Bone Marrow-derived MSC Improve Oxidative Stress in Alzheimer’s Disease Mouse Model.2018

Author(s)

Organizer

Data Source

[Presentation] シンポジウム「認知症と再生医療」 間葉系幹細胞によるアルツハイマー病の治療 モデルマウスでの検討を通じて2018

Author(s)

Organizer

Data Source

[Presentation] 骨髄間葉系幹細胞によるアルツハイマー病治療における脳内酸化ストレス動態の検討2017

Author(s)

Organizer

Data Source

[Presentation] Transplantation of Rat Bone Marrow-derived Mesenchymal Stem Cells Regulates Oxidative Stress in Alzheimer’s Disease Transgenic Mouse Model.2017

Author(s)

Organizer

Data Source

Yokokawa Kazuki 横川和樹

[Presentation] シンポジウム「認知症と再生医療」　間葉系幹細胞によるアルツハイマー病の治療　モデルマウスでの検討を通じて2018