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Hasebe Fumihito  長谷部 文人

Researcher Number 30781801
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1097-3813
Affiliation (Current) 2025: 福井県立大学, 生物資源学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2025: 福井県立大学, 生物資源学部, 助教
2017 – 2020: 静岡県立大学, 食品栄養科学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 38020:Applied microbiology-related / Applied microbiology
Except Principal Investigator
Transformative Research Areas, Section (II) / Applied microbiology
Keywords
Principal Investigator
生合成 / メチオニン / メチオニン生合成 / アミノ酸 / タンパク質間相互作用 / 活性制御 / フィードバック阻害 / 応用微生物学 / 生物有機化学 / トロピノン / 微生物生産 / アルカロイド … More
Except Principal Investigator
… More 二次代謝 / 生合成 / 非タンパク性アミノ酸 / 中分子ペプチド / 微生物 / 蛋白質 / 二次代謝産物 / malonyl-CoA / 大腸菌 Less
  • Research Projects

    (6 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (2 People)
  •  メチオニン生合成における硫黄キャリアタンパク質利用の分子基盤解明Principal Investigator

    • Principal Investigator
      長谷部 文人
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38020:Applied microbiology-related
    • Research Institution
      Fukui Prefectural University
  •  細菌における新規メチオニン生合成経路の解明Principal Investigator

    • Principal Investigator
      長谷部 文人
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38020:Applied microbiology-related
    • Research Institution
      Fukui Prefectural University
  •  Development of novel peptide compounds derived from microorganisms using new technology.

    • Principal Investigator
      丸山 千登勢
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Fukui Prefectural University
  •  Studies on novel feedback mechanism of methionine biosynthetic enzymePrincipal Investigator

    • Principal Investigator
      Hasebe Fumihito
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 38020:Applied microbiology-related
    • Research Institution
      Fukui Prefectural University
      University of Shizuoka
  •  Mechanistic analysis of high-yield protein production in E. coli for the production of natural products

    • Principal Investigator
      FUna Nobutaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied microbiology
    • Research Institution
      University of Shizuoka
  •  Study for screening enzymes involved in biosynthesis of ornithine-derived alkaloids, and microbial productionPrincipal Investigator

    • Principal Investigator
      Hasebe Fumihito
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied microbiology
    • Research Institution
      University of Shizuoka

All 2023 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-l-lysine production in Streptomyces albulus2023

    • Author(s)
      Hasebe Fumihito、Adachi Kazuya、Yamanaka Kazuya、Oikawa Tadao、Maruyama Chitose、Hamano Yoshimitsu
    • Journal Title

      The Journal of Antibiotics

      Volume: 76 Issue: 9 Pages: 522-531

    • DOI

      10.1038/s41429-023-00636-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K05412, KAKENHI-PLANNED-22H05122
  • [Journal Article] MetW regulates the enzymatic activity of MetX in Pseudomonas2021

    • Author(s)
      Hasebe Fumihito
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 2 Pages: 351-358

    • DOI

      10.1093/bbb/zbaa044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K15437
  • [Journal Article] Identification and characterization of bacterial enzymes catalyzing the synthesis of 1,8-dihydroxynaphthalene, a key precursor of dihydroxynaphthalene melanin, from Sorangium cellulosum2018

    • Author(s)
      Yusuke Sone, Shuto Nakamura, Makoto Sasaki, Fumihito Hasebe, Seung-Young Kim, and Nobutaka Funa
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 84 Issue: 9

    • DOI

      10.1128/aem.00258-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05447, KAKENHI-PROJECT-17K07726
  • [Presentation] CONSTITUTIVE EXPRESSION OF A GENE FOR LYSINE BIOSYNTHESIS ACCELERATED THE PRODUCTION OF Ε-POLY-L-LYSINE IN STREPTOMYCES ALBULUS2023

    • Author(s)
      F. Hasebe, K. Adachi, K. Yamanaka, T. Oikawa, C. Maruyama, Y. Hamano
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] Improvement of the cellular internalization of the canonical CPP-protein conjugates by ε-poly-L-lysine2023

    • Author(s)
      Y. Takeuchi, F. Hasebe, C. Maruyama, Y. Hamano
    • Organizer
      第60回ペプチド討論会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] Cytotoxicities of membrane-impermeable polar peptides modified with a polycationic isopeptide entering cells (PIECE)2023

    • Author(s)
      K. Kaneda, K. Suzuki, T. Ogura, F. Hasebe, C. Maruyama, Y. Hamano
    • Organizer
      第60回ペプチド討論会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] ε-poly-L-α-lysine-doxorubicin コンジュゲートを用いたDNA 導入技術の開発2023

    • Author(s)
      山中雅喜,武内大和,長谷部文人,丸山千登勢,濱野吉十
    • Organizer
      2023年度日本農芸化学会中部・関西支部合同大会
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] 抗生物質resormycinが有するβ-homolysineの生合成機構の解明2023

    • Author(s)
      今堀千咲, 山中一也, 小笠原泰志, 五十嵐雅之, 大利徹, 長谷部文人, 濱野吉十, 丸山千登勢
    • Organizer
      2023年度日本放線菌学会大会
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] 放線菌Streptomyces albulusにおける新規methionine生合成経路の解明2023

    • Author(s)
      足立和也, 丸山千登勢, 濱野吉十, 長谷部文人
    • Organizer
      2023年度日本放線菌学会大会
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] EPSILON-POLY-L-ALPHA-LYSINE, A BACTERIAL POLYCATIONIC ISOPEPTIDE, DIRECTLY PENETRATES THE MAMMALIAN CELL MEMBRANE AND SUPPORTS THE INTERNALIZATIONS OF CANONICAL CELL-PENETRATING PEPTIDES2023

    • Author(s)
      Y. Takeuchi, F. Hasebe, C. Maruyama, Y. Hamano
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05122
  • [Presentation] メチオニン生合成におけるMetWによるMetXの活性制御2021

    • Author(s)
      長谷部文人
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-20K15437
  • [Presentation] 大腸菌と酵母の共培養によるTropinone の生産2020

    • Author(s)
      室田健来,長谷部文人,大石和敬,鮒 信学
    • Organizer
      日本農芸化学会2020年度(令和2年度)大会
    • Data Source
      KAKENHI-PROJECT-17K18002
  • [Presentation] トロパンアルカロイド生合成を担うIII型ポリケチド合成酵素 CHSBの機能解析2019

    • Author(s)
      庄司 翼、長谷部 文人、弓場 穂香、鮒 信学
    • Organizer
      第37 回日本植物細胞分子生物学会(京都)大会
    • Data Source
      KAKENHI-PROJECT-17K18002
  • [Presentation] 組換え大腸菌を用いた flavonoid alkaloidの生産2018

    • Author(s)
      大石和敬, 川嶋智佳, 谷美生夏, 相沢光輝, 長谷部文人, 鮒信学
    • Organizer
      日本農芸化学会2018年度大会
    • Data Source
      KAKENHI-PROJECT-17K18002
  • [Presentation] オルニチン由来アルカロイドにおける生合成中間体の微生物生産2017

    • Author(s)
      長谷部文人、室田健来、大石和敬、川嶋智佳、谷美生夏、相沢光輝、鮒信学
    • Organizer
      酵素工学研究会第78回講演会
    • Data Source
      KAKENHI-PROJECT-17K18002
  • [Presentation] ニコチンの骨格形成反応を担う酵素の探索2017

    • Author(s)
      川嶋智佳, 長谷部文人, 鮒 信学
    • Organizer
      生合成リデザイン_第1回若手シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K18002
  • [Presentation] オルニチン由来アルカロイドの 微生物生産系の構築にむけて2017

    • Author(s)
      長谷部文人, 大石和敬, 室田健来, 川嶋智佳, 鮒 信学
    • Organizer
      生合成リデザイン_第1回若手シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K18002
  • 1.  FUna Nobutaka (70361574)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  丸山 千登勢 (20452120)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results

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