IEZAKI Takashi 家崎高志

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Iezaki Takashi 家崎高志

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Researcher Number	30784285
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 助教 2025: 岐阜薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2025: 愛知医科大学, 医学部, 助教 2022 – 2023: 愛知医科大学, 医学部, 助教 2021: 岐阜薬科大学, 薬学部, 助教 2018: 金沢大学, 先端科学・社会共創推進機構, 博士研究員 2016 – 2017: 金沢大学, 先端科学・イノベーション推進機構, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / Biological pharmacy
Keywords	Principal Investigator Lipid nano particle / 遺伝子治療 / 骨形成疾患 / 軟骨無形性症 / 核酸医薬 / 遺伝子疾患 / 自己増幅型RNA / リン酸化 / ユビキチンリガーゼ / グリオーマ … More / 骨格形成 / 骨関節疾患 / 軟骨細胞 / キナーゼ Less

ユビキチンリガーゼSmurf2による骨関節疾患治療法開発研究Principal Investigator
- Principal Investigator
  
  家崎高志
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Aichi Medical University
Research of new treatment for achondroplasia with self-amplifying RNA and lipod nano particle.Principal Investigator
- Principal Investigator
  
  Iezaki Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Aichi Medical University
  Gifu Pharmaceutical University
Smurf2によるグリオーマ幹細胞制御機構Principal Investigator
- Principal Investigator
  
  家崎高志
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kanazawa University
The MAPK Erk5 is necessary for proper skeletogenesis through a molecular axis that involves Smurfs-Smads-Sox9Principal Investigator
- Principal Investigator
  
  IEZAKI Takashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis.2023
- Author(s)
  Park G, Fukasawa K, Horie T, Masuo Y, Inaba Y, Tatsuno T, Yamada T, Tokumura K, Iwahashi S, Iezaki T, Kaneda K, Kato Y, Ishigaki Y, Mieda M, Tanaka T, Ogawa K, Ochi H, Sato S, Shi YB, Inoue H, Lee H, Hinoi E.
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 7
- DOI
  10.1172/jci.insight.154925
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06688, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455, KAKENHI-PROJECT-22K08660, KAKENHI-PROJECT-22K19545, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-23K24764, KAKENHI-PROJECT-23K27996
[Journal Article] The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis2022
- Author(s)
  Demura Satoru、Hinoi Eiichi、Kawakami Noriaki、Handa Makoto、Yokogawa Noriaki、Hiraiwa Manami、Kato Satoshi、Shinmura Kazuya、Shimizu Takaki、Oku Norihiro、Annen Ryohei、Kobayashi Motoya、Yamada Yohei、Nagatani Satoshi、Iezaki Takashi、Taniguchi Yuki、Tsuchiya Hiroyuki
- Journal Title
  
  Spine Surgery and Related Research
  
  Volume: 6 Issue: 4 Pages: 402-407
- DOI
  10.22603/ssrr.2021-0189
- NAID
  130008136374
- ISSN
  2432-261X
- Year and Date
  2022-07-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15350
[Journal Article] Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice2022
- Author(s)
  Iwahashi Sayuki、Lyu Jiajun、Tokumura Kazuya、Osumi Ryoma、Hiraiwa Manami、Kubo Takuya、Horie Tetsuhiro、Demura Satoru、Kawakami Noriaki、Saito Taku、Park Gyujin、Fukasawa Kazuya、Iezaki Takashi、Suzuki Akane、Tomizawa Akane、Ochi Hiroki、Hojo Hironori、Ohba Shinsuke、Hinoi Eiichi
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 237 Issue: 11 Pages: 4292-4302
- DOI
  10.1002/jcp.30883
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-20H03885
[Journal Article] SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability2022
- Author(s)
  Hiraiwa Manami、Fukasawa Kazuya、Iezaki Takashi、Sabit Hemragul、Horie Tetsuhiro、Tokumura Kazuya、Iwahashi Sayuki、Murata Misato、Kobayashi Masaki、Suzuki Akane、Park Gyujin、Kaneda Katsuyuki、Todo Tomoki、Hirao Atsushi、Nakada Mitsutoshi、Hinoi Eiichi
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 22-22
- DOI
  10.1038/s42003-021-02950-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-20H03407, KAKENHI-PROJECT-20J21092, KAKENHI-PROJECT-21K19502, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-21K20843
[Journal Article] Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood2022
- Author(s)
  Horie Tetsuhiro、Fukasawa Kazuya、Yamada Takanori、Mizuno Seiya、Iezaki Takashi、Tokumura Kazuya、Iwahashi Sayuki、Sakai Shiho、Suzuki Akane、Kubo Takuya、Osumi Ryoma、Tomizawa Akane、Ochi Hiroki、Sato Shingo、Kaneda Katsuyuki、Takahashi Satoru、Hinoi Eiichi
- Journal Title
  
  Stem Cells
  
  Volume: - Issue: 4 Pages: 011-011
- DOI
  10.1093/stmcls/sxac011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19J21335, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-21K20843, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455
[Journal Article] The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis2022
- Author(s)
  Yamada Takanori、Fukasawa Kazuya、Horie Tetsuhiro、Kadota Takuya、Lyu Jiajun、Tokumura Kazuya、Ochiai Shinsuke、Iwahashi Sayuki、Suzuki Akane、Park Gyujin、Ueda Rie、Yamamoto Megumi、Kitao Tatsuya、Shirahase Hiroaki、Ochi Hiroki、Sato Shingo、Iezaki Takashi、Hinoi Eiichi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Issue: 7 Pages: 1576-1588
- DOI
  10.1016/j.stemcr.2022.06.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-23K24455
[Journal Article] Phosphorylation of Smurf2 at Thr249 by Erk5 regulates TGF-β signaling2021
- Author(s)
  Iezaki Takashi、Hinoi Eiichi
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 156 Issue: 5 Pages: 271-274
- DOI
  10.1254/fpj.21029
- NAID
  130008081904
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15350
[Journal Article] CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway2021
- Author(s)
  Fukasawa K, Kadota T, Horie T, Tokumura K, Terada R, Kitaguchi Y, Park G, Ochiai S, Iwahashi S, Okayama Y, Hiraiwa M, Yamada T, Iezaki T, Kaneda K, Yamamoto M, Kitao T, Shirahase H, Hazawa M, Wong RW, Todo T, Hirao A, Hinoi E.
- Journal Title
  
  Oncogene
  
  Volume: ー Issue: 15 Pages: 2803-2815
- DOI
  10.1038/s41388-021-01745-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03407, KAKENHI-PROJECT-18J22107, KAKENHI-PUBLICLY-21H05744, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-21K19043, KAKENHI-PROJECT-21K19502, KAKENHI-PROJECT-21K15350
[Journal Article] Transcription Regulators and Bone Metabolism2019
- Author(s)
  Hinoi Eiichi、Iezaki Takashi、Fukasawa Kazuya、Kaneda Katsuyuki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 1 Pages: 15-18
- DOI
  10.1248/yakushi.18-00154-1
- NAID
  130007541685
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-01-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K14916
[Journal Article] Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells2019
- Author(s)
  Onishi Yuki、Hiraiwa Manami、Kamada Hikari、Iezaki Takashi、Yamada Takanori、Kaneda Katsuyuki、Hinoi Eiichi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 9 Issue: 2 Pages: 241-247
- DOI
  10.1002/2211-5463.12559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J13310, KAKENHI-PROJECT-18K14916
[Journal Article] The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.2018
- Author(s)
  Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E.
- Journal Title
  
  Development
  
  Volume: 145 Issue: 14 Pages: 164004-164004
- DOI
  10.1242/dev.164004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0051, KAKENHI-PROJECT-18K19404, KAKENHI-PUBLICLY-17H05510, KAKENHI-PUBLICLY-18H04971, KAKENHI-PROJECT-16H05131, KAKENHI-PROJECT-17H03984, KAKENHI-PROJECT-17H04399, KAKENHI-PROJECT-18J13309, KAKENHI-PROJECT-18J13310, KAKENHI-PROJECT-18K14916, KAKENHI-ORGANIZER-15H05935
[Journal Article] Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.2018
- Author(s)
  Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 11 Issue: 1 Pages: 228-241
- DOI
  10.1016/j.stemcr.2018.05.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0051, KAKENHI-PUBLICLY-18H04971, KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-16H05131, KAKENHI-PROJECT-18J13309, KAKENHI-PROJECT-18J13310, KAKENHI-PROJECT-18K14916, KAKENHI-ORGANIZER-15H05935
[Journal Article] The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.2017
- Author(s)
  Onishi Y, Park G, Iezaki T, Horie T, Kanayama T, Fukasawa K, Ozaki K, Hinoi E.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 482(2) Issue: 2 Pages: 329-334
- DOI
  10.1016/j.bbrc.2016.11.063
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06825
[Journal Article] Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain2017
- Author(s)
  Park Gyujin、Horie Tetsuhiro、Iezaki Takashi、Okamoto Maika、Fukasawa Kazuya、Kanayama Takashi、Ozaki Kakeru、Onishi Yuki、Sugiura Minoru、Hinoi Eiichi
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 81 Issue: 5 Pages: 1014-1017
- DOI
  10.1080/09168451.2017.1280661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06825
[Journal Article] Hypoxic Stress Upregulates the Expression of <b><i>Slc38a1</i></b> in Brown Adipocytes via Hypoxia-Inducible Factor-1α2017
- Author(s)
  Horie Tetsuhiro、Fukasawa Kazuya、Iezaki Takashi、Park Gyujin、Onishi Yuki、Ozaki Kakeru、Kanayama Takashi、Hiraiwa Manami、Kitaguchi Yuka、Kaneda Katsuyuki、Hinoi Eiichi
- Journal Title
  
  Pharmacology
  
  Volume: 101 Issue: 1-2 Pages: 64-71
- DOI
  10.1159/000480405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06825, KAKENHI-PROJECT-18J13309
[Journal Article] The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes2017
- Author(s)
  Park Gyujin、Horie Tetsuhiro、Kanayama Takashi、Fukasawa Kazuya、Iezaki Takashi、Onishi Yuki、Ozaki Kakeru、Nakamura Yukari、Yoneda Yukio、Takarada Takeshi、Hinoi Eiichi
- Journal Title
  
  The FEBS Journal
  
  Volume: 284 Issue: 5 Pages: 784-795
- DOI
  10.1111/febs.14019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04399, KAKENHI-PROJECT-16H06825
[Journal Article] Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin2017
- Author(s)
  Park G, Horie T, Fukasawa K, Ozaki K, Onishi Y, Kanayama T, Iezaki T, Kaneda K, Sugiura M, Hinoi E.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 7 Pages: 1116-1120
- DOI
  10.1248/bpb.b17-00161
- NAID
  130006846429
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06825
[Journal Article] Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.2017
- Author(s)
  Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E.
- Journal Title
  
  J Bone Miner Res.
  
  Volume: 32 Issue: 4 Pages: 872-881
- DOI
  10.1002/jbmr.3053
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-17H04399, KAKENHI-PROJECT-16H06825
[Journal Article] ATF3 controls proliferation of osteoclast precursor and bone remodeling.2016
- Author(s)
  Fukasawa K, Park G, Iezaki T, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Yoneda Y, Takarada T, Kitajima S, Vacher J, Hinoi E.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 30918-30918
- DOI
  10.1038/srep30918
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06825, KAKENHI-PROJECT-26460387, KAKENHI-PROJECT-15K08300
[Journal Article] Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-κB/NFATc1 Pathway.2016
- Author(s)
  Iezaki T, Fukasawa K, Park G, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Nakamura Y, Takarada T, Yoneda Y, Nakamura T, Vacher J, Hinoi E.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 36(19) Issue: 19 Pages: 2451-2463
- DOI
  10.1128/mcb.01075-15
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06825, KAKENHI-PROJECT-26460387
[Journal Article] ATF3 deficiency in chondrocytes alleviates osteoarthritis development.2016
- Author(s)
  Iezaki T, Ozaki K, Fukasawa K, Inoue M, Kitajima S, Muneta T, Takeda S, Fujita H, Onishi Y, Horie T, Yoneda Y, Takarada T, Hinoi E.
- Journal Title
  
  J Pathol.
  
  Volume: 239(4) Issue: 4 Pages: 426-437
- DOI
  10.1002/path.4739
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06825, KAKENHI-PROJECT-15K08300
[Presentation] Research of new treatment for rare genetic disorders with self-amplifying RNA.2024
- Author(s)
  Takashi Iezaki，Motohiko Sato
- Organizer
  第101回生理学会大会
- Data Source
  KAKENHI-PROJECT-21K15350

1. 増尾友佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 檜井栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 平尾敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 宝田剛志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 佐藤信吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 越智広樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IEZAKI Takashi 家崎 高志

Iezaki Takashi 家崎 高志

Research Projects

Research Products

Co-Researchers

ユビキチンリガーゼSmurf2による骨関節疾患治療法開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research of new treatment for achondroplasia with self-amplifying RNA and lipod nano particle.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Smurf2によるグリオーマ幹細胞制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The MAPK Erk5 is necessary for proper skeletogenesis through a molecular axis that involves Smurfs-Smads-Sox9Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of Smurf2 at Thr249 by Erk5 regulates TGF-β signaling2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription Regulators and Bone Metabolism2019

Author(s)

Journal Title

DOI

IEZAKI Takashi 家崎高志

Iezaki Takashi 家崎高志